In this study, high-temperature properties of two newly developed Al-Si-Cu alloys (2Cu and 3.5Cu alloys) were investigated and compared to the commercial-grade A356 + 0.5Cu alloy (R alloy). 3.5Cu alloy exhibited the highest strength, outperforming R alloy by over 50 MPa at room temperature and by more than 20 MPa at elevated temperatures in ultimate tensile strength. However, R alloy demonstrated three to four times higher elongation than 3.5Cu alloy at room temperature, though this difference diminished at high temperatures. The minimum creep rate of 3.5Cu alloy was 2.4 times lower than that of 2Cu alloy and 14.5 times lower than that of R alloy, showing the superior creep resistance. Under low cycle fatigue loadings, the fatigue lifetimes of R and 2Cu alloys were similar, and slightly longer than that of 3.5Cu alloy. Conversely, in the high cycle fatigue regime, 3.5Cu alloy exhibited the highest fatigue resistance, followed by 2Cu and R alloys. The superior high-temperature performances of 3.5Cu alloy were attributed to the enhanced thermal stability of θ' precipitates compared to β' precipitates in R alloy, as confirmed during long-term thermal exposures at 250 and 300 °C. These findings suggest that 3.5Cu alloy is a promising candidate to replace the traditional A356 + 0.5Cu alloy for cylinder head applications.