In this work, the antimony promoted Vanadia-Ceria catalysts have been prepared by homogeneous precipitation method for the selective catalytic reduction of NOx with NH3. With an introduction of Sb into Vanadia-Ceria, the catalysts showed an improvement in the low temperature NOx conversion below 250°C. These high activities of the Sb promoted catalysts were related to the increase of acid sites and redox properties of the catalysts, which were investigated by the NH3-TPD (temperature programmed desorption), H2-TPR (temperature programmed reduction) and in-situ NH3-DRIFTS (diffused reflectance infrared Fourier transformed spectroscopy) spectra. In addition, structural and morphological properties of these catalysts were examined by X-ray diffraction, BET surface area and FE-SEM (Field emission scanning electron microscopy). After the addition of Sb to Vanadia-Ceria, the increase of surface area with a smaller, uniform sized particles and high dispersion of vanadia were indicated in the optimized 4wt.%V2O5–2wt.% Sb-CeO2 catalyst. Furthermore, the Lewis and Brønsted acid sites were enhanced in the 4wt.%V2O5–2wt.% Sb-CeO2 catalyst to promote NOx conversion at a wide temperature range of 175–400°C. XPS results also indicated an improvement in the active oxygen species of this catalyst due to the enhancement of surface oxidation species of V4+/V5+, Sb3+/Sb5+ and Ce3+/Ce4+.