According to existing research, in addition to the second deviatoric stress invariant, Lode angle parameter (hereinafter abbreviated as Lode angle), which is related to the third deviatoric stress invariant, is also required to be taken into account when studying plastic flow and failure of metal materials. In order to study the effect of incorporating Lode angle into fracture criterion on predicting ballistic resistance of 6061-T651 aluminum alloy plates, a one-stage gas gun system was used to conduct ballistic tests of 6061-T651 aluminum alloy plates with different thicknesses when struck by the blunt projectile with a diameter of 12.66 mm and a mass of 34.0 g. Meanwhile, Abaqus/Explicit finite element software with user-defined material subroutine (VUMAT) was used to establish corresponding finite element models. Under the same constitutive model, numerical simulations were carried out by using Lode independent MJC fracture criterion and Lode dependent WMJC fracture criterion. It is found that when using MJC fracture criterion, not only the ductility of material is overestimated in low stress triaxiality state, resulting in significantly higher predicted ballistic limits; but also the predicted material fracture strain in high stress triaxiality state is negative, sometimes causing irrational predictions. Therefore, some modifications to MJC fracture criterion are needed to reasonably predict the impact process. By contrast, the predicted results of Lode dependent WMJC fracture criterion are more consistent with experiments. Besides, as the thickness of the target increases, the ballistic limit shows an “S” shaped growth trend. Overall, for ballistic tests of targets with different thicknesses, WMJC criterion has a better predictive effect than MJC criterion, indicating the importance of incorporating Lode angle into fracture criteria.