In this paper, considering the coupling effects of the crosshead slipper-guide system and the piston skirt-liner system, a new tribodynamic model is established for the low-speed two-stroke marine diesel engine. Firstly, a dynamic model including the crosshead slipper, the piston, the piston rod, and the crosshead pin is proposed. Then, considering the disciplinary coupling between the dynamic model and the lubrication models, the stiff and nonlinear tribodynamic model is solved with the modified extended backward differentiation formulae (MEBDF). Finally the tribodynamic performances of the crosshead slipper and the piston skirt are analyzed. The simulation results show that the crosshead slipper bears the thrust force and its friction power loss is obviously larger than that of the piston skirt.