This study endeavors to establish a transient mixed lubrication model for time-varying wear of main bearings under dynamic loading conditions during the startup process. This model accounts for variations in oil film thickness attributable to deformation, wear profiles, and journal misalignment throughout the operational cycle. The evolution of main bearing lubrication characteristics during the startup process was analyzed, as well as the evolution of wear profiles and their effects on lubricating properties under different numbers of startups. The results indicate that as the number of startup cycles increases, the wear rate gradually levels off. With increasing startup times, there is a decrease in contact pressure and a slight reduction in oil film pressure, resulting in enhanced lubricating performance. Furthermore, the influence of startup duration on wear is significantly greater than that of radial clearance.