As a representative of metamaterials, negative Poisson’s ratio (NPR) material possesses special mechanical properties such as expansion, negative compression ratio and so forth. As a result, it is widely used in the fields of vehicles, aerospace, et al. In this paper, a novel space orthogonal concave honeycomb structure (OC) is designed based on traditional concave honeycomb structure (CHS). In order to explore the influence rule of OC structure on the deformation and energy absorption capacity of crash box under low-speed collision, mechanical analysis and parameter research on OC structure are conducted through quasi-static compression test and numerical simulation. The results suggest that the finite element results of OC structure fit well with the experimental results, and the FEM is highly credible. In addition, the novel OC sandwich structure can effectively enhance the deformation capacity and improve the energy absorption performance of the crash box. When the wall thickness ? of OC structure is 1mm and angle ? is 50°, the deformation and energy absorption capacity of the crash box increased by 25.6% and 19.3% respectively.