Low Retention Research Articles

Carrier-free self-assembled nanoparticles based on prochloraz and fenhexamid for reducing toxicity to aquatic organism

Nanoformulations of pesticides are an effective way to increase utilization efficiency and alleviate the adverse impacts on the environments caused by conventional pesticide formulations. However, the complex preparation process, high cost, and potential environmental risk of nanocarriers severely restricted practical applications of carrier-based pesticide nanoformulations in agriculture. Herein, carrier-free self-assembled nanoparticles (FHA-PRO NPs) based on fenhexamid (FHA) and prochloraz (PRO) were developed by a facile co-assembly strategy to improve utilization efficiency and reduce toxicity to aquatic organism of pesticides. The results showed that noncovalent interactions between negatively charged FHA and positively charged PRO led to core-shell structured nanoparticles arranged in an orderly manner dispersing in aqueous solution with a diameter of 256 nm. The prepared FHA-PRO NPs showed a typical pH-responsive release profile and exhibited excellent physicochemical properties including low surface tension and high max retention. The photostability of FHA-PRO NPs was improved 2.4 times compared with free PRO. The FHA-PRO NPs displayed superior fungicidal activity against Sclerotinia sclerotiorum and Botrytis cinerea and longer duration against Sclerotinia sclerotiorum on potted rapeseed plants. Additionally, the FHA-PRO NPs reduced the acute toxicity of PRO to zebrafish significantly. Therefore, this work provided a promising strategy to develop nanoformulations of pesticides with stimuli-responsive controlled release characteristics for precise pesticide delivery.

Solving the retention time repeatability problem of hydrophilic interaction liquid chromatography

Hydrophilic interaction (liquid) chromatography (HILIC) has become the first choice LC mode for the separation of hydrophilic analytes. Numerous studies reported the poor retention time repeatability of HILIC. The problem was often ascribed to slow equilibration and insufficient re-equilibration time to establish the sensitive semi-immobilized water layer at the interface of the polar stationary phase and the bulk mobile phase. In this study, we compare retention time repeatability in HILIC for borosilicate glass and PFA (co-polymer of tetrafluoroethylene and perfluoroalkoxyethylene) solvent bottles. During this study, we observed peak patterns shifting towards higher retention times (for metabolites and peptides) and lower retention times (oligonucleotide sample) with ongoing analysis time when standard borosilicate glass bottles were used as solvent reservoirs. It was hypothesized that release of ions (sodium, potassium, borate, etc.) from the borosilicate glass bottles leads to alterations (thickness and electrostatic screening effects) in the semi-immobilized water layer which is adsorbed to the polar stationary phase surface under acetonitrile-rich eluents in HILIC with concomitant shifts in retention. When PFA solvent bottles were employed instead of borosilicate glass, retention time repeatability was greatly improved and changed from average 8.4 % RSD for the tested metabolites with borosilicate glass bottles to 0.14 % RSD for the PFA solvent bottles (30 injections over 12 h). Similar improvements were observed for peptides and oligonucleotides. This simple solution to the retention time repeatability problem in HILIC might contribute to a better acceptance of HILIC, especially in fields like targeted and untargeted metabolomics, peptide and oligonucleotide analysis.

Association between Variants of the TRPV1 Gene and Body Composition in Sub-Saharan Africans.

In humans, the transient receptor potential vanilloid 1 (TRPV1) gene is activated by exogenous (e.g., high temperatures, irritating compounds such as capsaicin) and endogenous (e.g., endocannabinoids, inflammatory factors, fatty acid metabolites, low pH) stimuli. It has been shown to be involved in several processes including nociception, thermosensation, and energy homeostasis. In this study, we investigated the association between TRPV1 gene variants, sensory perception (to capsaicin and PROP), and body composition (BMI and bioimpedance variables) in human populations. By comparing sequences deposited in worldwide databases, we identified two haplotype blocks (herein referred to as H1 and H2) that show strong stabilizing selection signals (MAF approaching 0.50, Tajima's D > +4.5) only in individuals with sub-Saharan African ancestry. We therefore studied the genetic variants of these two regions in 46 volunteers of sub-Saharan descent and 45 Italian volunteers (both sexes). Linear regression analyses showed significant associations between TRPV1 diplotypes and body composition, but not with capsaicin perception. Specifically, in African women carrying the H1-b and H2-b haplotypes, a higher percentage of fat mass and lower extracellular fluid retention was observed, whereas no significant association was found in men. Our results suggest the possible action of sex-driven balancing selection at the non-coding sequences of the TRPV1 gene, with adaptive effects on water balance and lipid deposition.

Enhanced low-temperature resistance of lithium-ion batteries based on methyl propionate-fluorinated ethylene carbonate electrolyte

Low temperature has been a major challenge for lithium-ion batteries to maintain satisfied electrochemical performance, as it leads to poor rechargeability and low capacity retention. Traditional carbonate solvents, vinyl carbonate and dimethyl carbonate are indispensable components of commercial electrolytes. However, the higher melting point of these carbonate solvents causes their electrical conductivity to be easily reduced when temperatures drop below zero, limiting their ability to facilitate lithium ion transport. In this work, we demonstrate that the use of methyl propionate (MP) carboxylate and fluorocarbonate vinyl (FEC) electrolytes can overcome the limitations of low temperature cycling. Compared with carbonate electrolyte, MP has the characteristics of low melting point, low viscosity and low binding energy with Li+, which is crucial to improve the low temperature performance of the battery, while FEC is an effective component to inhibit the side reaction between MP and lithium metal. The carefully formulated MP-based electrolyte can generate a solid electrolyte interface with low resistance and rich in inorganic substances, which is conducive to the smooth diffusion of Li+, allowing the battery to successfully cycle at a high rate of 0.5 C at −20 °C, and giving it a reversible capacity retention rate of 65.3% at −40 oC. This work designs a promising advanced electrolyte and holds the potential to overcome limitations of lithium-ion batteries in harsh conditions.

Receptor-Targeted Peptide Conjugates Based on Diphosphines Enable Preparation of 99mTc and 188Re Theranostic Agents for Prostate Cancer.

Benchtop 99Mo/99mTc and 188W/188Re generators enable economical production of molecular theranostic 99mTc and 188Re radiopharmaceuticals, provided that simple, kit-based chemistry exists to radiolabel targeting vectors with these radionuclides. We have previously described a diphosphine platform that efficiently incorporates 99mTc into receptor-targeted peptides. Here, we report its application to label a prostate-specific membrane antigen (PSMA)-targeted peptide with 99mTc and 188Re for diagnostic imaging and systemic radiotherapy of prostate cancer. Methods: Two diphosphine-dipeptide bioconjugates, DP1-PSMAt and DP2-PSMAt, were formulated into kits for radiolabeling with 99mTc and 188Re. The resulting radiotracers were studied invitro, in prostate cancer cells, and invivo in mouse xenograft models, to assess similarity of uptake and biodistribution for each 99mTc/188Re pair of agents. Results: Both DP1-PSMAt and DP2-PSMAt could be efficiently radiolabeled with 99mTc and 188Re using kit-based methods to furnish the isostructural compounds M-DP1-PSMAt and M-DP2-PSMAt (M = [99mTc]Tc, [188Re]Re). All 99mTc/188Re radiotracers demonstrated specific uptake in PSMA-expressing prostate cancer cells, with negligible uptake in prostate cancer cells that did not express PSMA or in which PSMA uptake was blocked. M-DP1-PSMAt and M-DP2-PSMAt also exhibited high tumor uptake (18-30 percentage injected dose per gram at 2 h after injection), low retention in nontarget organs, fast blood clearance, and excretion predominantly via a renal pathway. Importantly, each pair of 99mTc/188Re radiotracers showed near-identical biologic behavior in these experiments. Conclusion: We have prepared and developed novel pairs of isostructural PSMA-targeting 99mTc/188Re theranostic agents. These generator-based theranostic agents have potential to provide access to the benefits of PSMA-targeted diagnostic imaging and systemic radiotherapy in health care settings that do not routinely have access to either reactor-produced 177Lu radiopharmaceuticals or PET/CT infrastructure.

The voice quality of pedagogical agent impacts learning and agent perceptions

AbstractBackgroundThe voices virtual on‐screen characters use has been shown to impact learning and perception outcomes. Recent replication research on these voices showed that synthetic voices were not a detriment if produced by a high‐quality engine with clear articulation. The current manuscript examines previous accent research that utilized now outdated engines, to determine if the impact of accents still holds with high‐quality engines and voice actors.ObjectivesTo investigate the impact on learning and perceptions with pedagogical agents speaking in accented voices, synthetic voices, and the interaction between the two using modern voice engines.MethodsThis study is a between‐subjects two (accent) by two (type) factorial design to determine the impact the voice accent, voice type, and the interaction have on learning retention, learning transfer, mental effort efficiency, and perception measures. 197 participants were recruited from the online Amazon's Mechanical Turk with qualifications of 18 years of age, “normal or corrected‐to‐normal hearing”, and located with the continental United States of America.Results and ConclusionsThere were no significant differences between the accented conditions or interaction effects, deviating from previous research that showed impact of accents on learning. The synthetic condition had significantly lower knowledge retention, knowledge transfer, mental effort efficiency, and perception measures than the human professional. These findings demonstrate the importance of considering voice quality when designing pedagogical agents. Previous research showed synthetic voices perform as well as the average voice, and this research continues the narrative of voice quality by showing professional recordings outperform modern synthetic engines.

Tuning of Ultrasmall Gold Nanoparticles Surface Properties Affect Their Biological Fate

AbstractUltrasmall nanoparticles of 10 nm or less in size have been shown to have great potential in the biomedical field due to their high surface area and strong tissue penetration. Their easy functionalization and unique behavior at the nanoscale, such as the reduced corona formation and lower liver retention allow them to be a potential tool for precision targeting. In this study, PEGylated ultrasmall gold nanoparticles (GNPs) with a 4 nm core size are developed. They are functionalized with the cyclic RGD (cRGD) targeting peptide, which provides high binding affinity toward αVβ3 integrin receptor, often overexpressed in solid tumors. Further evidence is presented that cRGD functionalized GNPs partially escape lysosomes while penetrating deeper into the liver parenchyma. These particles provide a potential future strategy for specific αVβ3 integrin targeting.

A bibliometric analysis on gamifying adult learning: past, present and future trends of learner-centered pedagogies

Purpose The psychological theory of self-determination postulated that gamification enhances learning engagement by intrinsically motivating learners to undertake tasks spontaneously. Gamification has then been integrated into adult learning as part of the initiative of learner-centred pedagogies to curb the low retention rates of adult learners who struggle with heavy work commitments, family obligations and financial pressure. Gamification, being one of the technological mediations, assumes the crucial role of engaging and retaining adult learners. Adult learners have received less attention in research when compared with conventional university students. The purpose of this study is to conduct a bibliographic analysis to assess the past, present and future publication trends of gamifying adult learning and to identify the research gap. Design/methodology/approach This study included publications related to gamification and adult learning from 2014 to 2022, extracted from Dimensions. A total of 79,864 publications were retrieved initially, and 3,469 publications were ultimately selected for final analysis after the refinement of the keyword search. VOSviewer was used for bibliographic coupling, keyword co-occurrence, clustering and co-citation analysis of countries. Findings The number of publications related to gamification in adult learning has decreased since its peak in 2020. The saturation is mainly concentrated in the USA, the UK and China, with similar levels of national income and technology advancement skills. However, gamification in adult learning remains a popular and growing research area in developing countries like Malaysia, which has huge potential due to government investments in education, technology and lifelong learning. There is also an evident research gap on gamification, adult learning and personality traits, which have not been covered in previous studies. Originality/value Prior research mostly focused on systematic literature reviews, while the use of bibliometric analysis could be a missing link in this research domain. This paper unveils the evolution of publications on this topic over time by scientifically analysing a large number of publications and rigorously identifying research gaps contributing to future research avenues.

Making waves: How to clean surface water with photogranules

Global surface waters are in a bad ecological and chemical state, which has detrimental effects on entire ecosystems. To prevent further deterioration of ecosystems and ecosystem services, it is vital to minimize environmental pollution and come up with ways to keep surface water healthy and clean. Recently, photogranules have emerged as a promising platform for wastewater treatment to remove organic matter and nutrients with reduced or eliminated mechanical aeration, while also facilitating CO2 capture and production of various bioproducts. Photogranules are microbial aggregates of microalgae, cyanobacteria, and other non-phototrophic organisms that form dense spheroidic granules. Photogranules settle fast and can be easily retained in the treatment system, which allows increased amounts of water and wastewater to be treated. So far, photogranules have only been tested on various “high-strength” wastewaters but they might be an excellent choice for treatment of large volumes of polluted surface water as well. Here, we propose and tested for the first time photogranules on their effectiveness to remove nutrients from polluted surface water at unprecedented low concentrations (3.2 mg/L of nitrogen and 0.12 mg/L of phosphorous) and low hydraulic retention time (HRT = 1.5 h). Photogranules can successfully remove nitrogen (<0.6 mg/L, ∼80 % removal) and phosphorous (<0.01 mg/L, 90–95 % removal) to low levels in sequencing batch operation even without the need for pH control. Subjecting photogranules to surface water treatment conditions drastically changed their morphology. While, under “high-strength” conditions the photogranules were spherical, dense and defined, under polluted surface water conditions photogranules increased their surface area by forming fingers. However, this did not compromise their excellent settling properties. Finally, we discuss the future perspectives of photogranular technology for surface water treatment.

Microstructure, rheology and freeze-thaw behavior of double (W1/O/W2) emulsions prepared with palm oil: Effect of Tween 80/sodium caseinate ratio

The objective was to study the effect of the variation of Tween 80/sodium caseinate ratio on the microstructure, rheology and freeze-thaw behavior of double (W1/O/W2) emulsions prepared with palm oil. Particularly, the impact of the composition of the outer interfacial film on partial coalescence and retention of inner water droplets was investigated. Partial coalescence was restrained in the emulsion prepared with sodium caseinate only, because aggregation of oil globules was prevented due to electrostatic and steric repulsions and a resistant interfacial film. The inclusion of Tween 80 produced competitive adsorption of emulsifiers, promoting partial coalescence and increasing the elastic and viscous modules of the system. A higher Tween 80 proportion led to lower retention of inner water droplets after cold storage, attributed to the formation of smaller oil globules and a thinner interfacial film. A cooling-heating-cooling cycle was applied by differential scanning calorimetry, showing that a higher oil globule aggregation degree led to higher retention of inner water droplets during freezing and higher release of inner water droplets during thawing. The findings expand the knowledge regarding the influence of the composition of the outer interfacial film on both partial coalescence and retention of inner water droplets in W1/O/W2 emulsions.

Trends in NCCN enforcement of financial conflict of interest policies for guidelines panelists.

11070 Background: Financial conflict of interest (FCOI) among authors of clinical practice guidelines is a potential concern for the independence and integrity of guideline recommendations. The National Comprehensive Cancer Network (NCCN) Guidelines policy stipulates limits on physician-industry FCOI among its panelists (&lt;$50,000 overall and &lt;$20,000 from each individual company, annually). Those in violation will be asked to resign. However, COI policies reliant on physician self-report may be difficult to enforce. The increased transparency of FCOI resulting from Open Payments – and the ensuing attention in 2016 on high levels of FCOI among guideline-writing bodies including the NCCN – may have enabled and motivated increased enforcement of existing FCOI policy. We describe trends in FCOI among NCCN Guidelines panelists and in enforcement when violations occur. Methods: We manually extracted NCCN Guidelines panelist names and terms of service for the 20 most prevalent cancers, 2013-22. We manually linked each physician to their Open Payments records, a federal archive of financial transactions from industry to physicians. For each panelist, we included only the categories of industry payments deemed relevant by the NCCN COI policy: ownership payments and some General Payments categories (eg., speaking fees, consulting) but not others (eg., free meals). We measured payments during each full calendar year of service. If a panelist received payments above NCCN limits (“violation”), we assessed whether their term of service continued for at least 1 additional full calendar year (“retained"), inferring that panelists who were retained had not been asked to resign as stipulated. We assessed whether retention post-violation was less likely after 2016. Results: There were 978 eligible physician-guideline pairs. Mean industry payments increased from $6175 in 2014 to $9169 in 2019, then declined to $6492 in 2021 following the COVID-19 pandemic. There were 143 panelist-years in violation of NCCN FCOI limits. Violations occurred among 99 unique panelists; 32 panelists had multiple observed violations. Across the full study period, panelists with a violation were less likely to be retained versus those without a violation (OR 0.21, 95% CI 0.15-0.31). However, likelihood of post-violation retention was lower after 2016 compared to before. 81% were retained during 2014-15 (versus 89% for those without violation, OR 0.55, 95% CI 0.26-1.31) compared to 47% during 2017-20 (versus 89% without violation, OR 0.10, 95% CI 0.06-0.17). Conclusions: Lower retention among panelists receiving excessive industry payments is consistent with NCCN enforcement of its COI policy. Lower post-violation retention after 2016 is consistent with stricter enforcement following that year. However, even in 2017-20, in 47% of violations, the panelist continued to serve, suggesting that enforcement remains incomplete.

Unveiling oncologists' geographical journey: Analyzing hematology/oncology fellowship graduates' relocation patterns and their impact on regional disparities in cancer care.

9006 Background: The geographical distribution of Hematology/Oncology fellowship graduates (HOFs) is essential for shaping healthcare delivery and illuminating regional health disparities in cancer care. This study explores the relocation patterns of HOFs during key transitions: from medical school to residency (T1), residency to fellowship (T2), and fellowship to the first attending position (T3). The aim is to gain insights into the geographical aspects of cancer care disparities. Methods: This study analyzes the transitions of 329 graduates from 61 ACGME-accredited HOF programs that offered public data about their alumni from 2019-2022. Geographical relocation was measured by the straight-line distance in miles, with the U.S. divided into four regions for retention assessment. A Welch two-sample t-test was conducted to compare average travel distance between each transition. Additionally, relocation patterns were compared between graduates from top 50 NIH-funded medical schools (T50MS) and others (nonT50MS). Results: During T1, HOFs covered a significant distance (661.7 miles), which decreased during T2 (436.5 miles) and T3 (344 miles) (p&lt;.001). Retention analysis revealed a decrease in the percentage of trainees traveling more than 200 miles from T1 (57%) to T2 (46%) to T3 (35%). No significant distance difference was observed between T50MS and nonT50MS during T1 (616 vs 693 miles) and T2 (431 vs 439 miles). However, T3 showed T50MS graduates traveling less (262 miles) compared to their nonT50MS counterparts (401 miles, p&lt;.05). Regional retention increased from T1 (57.5%), to T2 (70%) to T3 (75.4%), with the Western region demonstrating the highest retention across all transitions (T1: 78%, T2: 92%, T3: 83%). The Southern region displayed the lowest retention rates during T1: (44%) and T2: (48%), whereas the Northern region had the lowest during T3 (62%). Conclusions: The preference for relocation beyond 200 miles during T1 reflects a commitment to expanding clinical expertise and gaining varied perspectives critical in addressing complex cancer challenges. As trainees progress, a shift towards establishing roots near previous training sites suggests the allure of established professional and personal networks. T50MS graduates' inclination to stay within a smaller radius during T3 suggests expertise retention in resource-rich areas, potentially exacerbating regional disparities. Marked retention differences, particularly the Southern region’s low retention during training and the Northern region's during practice establishment, reveal a concerning workforce distribution trend. These findings emphasize the necessity for targeted policy interventions aimed at improving equitable distribution of the oncology workforce, thus ensuring uniform access to quality cancer care nationwide.

MoS2, WS2, and MoWS2 Flakes as Reversible Host Materials for Sodium-Ion and Potassium-Ion Batteries.

Transition-metal dichalcogenides (TMDs) and their alloys are vital for the development of sustainable and economical energy storage alternatives due to their large interlayer spacing and hosting ability for alkali-metal ions. Although the Li-ion chemically correlates with the Na-ion and K-ion, research on batteries with TMD anodes for K+ is still in its infancy. This research explores TMDs such as molybdenum disulfide (MoS2) and tungsten disulfide (WS2) and TMD alloys such as molybdenum tungsten disulfide (MoWS2) for both sodium-ion batteries (NIBs) and potassium-ion batteries (KIBs). The cyclic stability test analysis indicates that in the initial cycle, the MoS2 NIB demonstrates exceptional performance, with a peak charge capacity of 1056 mAh g-1, while retaining high Coulombic efficiency. However, the WS2 KIB underperforms, with the least charge capacity of 130 mAh g-1 in the first cycle and exceptionally low retention at a current density of 100 mA g-1. The MoWS2 TMD alloy exhibits a moderate charge capacity and cyclic efficiency for both NIBs and KIBs. This comparison study shows that decreasing sizes of alkali-metal ions and constituent elements in TMDs or TMD alloys leads to decreased resistance and slower degradation processes as indicated by cyclic voltammetry and electrochemical impedance spectroscopy after 10 cycles. Furthermore, the study of probable electrochemical intercalation and removal processes of Na-ions and K-ions demonstrates that large geometrically shaped TMD flakes are more responsive to intercalation for Na-ions than K-ions. These performance comparisons of different TMD materials for NIBs and KIBs may promote the future development of these batteries.

Utilization of Language Strategies in Teaching Grade 10 Mathematics of Narvacan National Central High School

This study aimed to evaluate the utilization of Language Strategies in teaching Grade 10 Mathematics at Narvacan National Central High School during the 4th quarter of the SY 2022-2023. Specifically, it focused on the profile of the students, their level of performance in language strategies, and their mathematics performance. It further determined the relationship between the students’ profile and the level of performance in language strategies, the students’ profile and their level of participation, the students’ performance in language strategies and their mathematics performance, and the problem encountered by the teachers in teaching mathematics using language strategies. This study used a quantitative research approach employing the correlational research design. The research design is a combined description, evaluative and correlational design. This study made use of a questionnaire consisting of two parts, the performance of the students when using language strategies and the 4th quarter grades of the learners in Mathematics. Hence, it is recommended students will participate in every activity or discussion related to the different language strategies. The performance of the students may be improved by sustaining the utilization of Language Strategies in Teaching Mathematics. Teachers and school heads are encouraged to innovate programs or activities that address issues related to low comprehension and low retention of students.

Barriers to exclusive breastfeeding practice among HIV-positive mothers in Tanzania. An exploratory qualitative study.

Ensuring optimal nutrition through early breastfeeding is vital for infant mental development and overall health. HIV infections complicate decisions regarding exclusive breastfeeding, jeopardizing effective infant and young child feeding, which affects nutrition and health outcomes. Recognizing the lack of evidence on barriers to infant feeding in the context of HIV in Tanzania, this study was conducted to explore individual, household, and community obstacles in the Ilala district, Dar es Salaam. A case study design employing a qualitative approach was used. The study was executed at the Reproductive and Child Health (RCH) Clinic within Amana Regional Referral Hospital, Mnazi Mmoja Health Centre, and Buguruni Health Centre. Data collection ensued through the purposive sampling of healthcare providers and HIV-positive mothers, utilizing in-depth interview techniques. The textual data accrued were analyzed using inductive and deductive content analysis strategies, thereby enabling the delineation and formulation of principal thematic constructs. The study involved interviews with twenty-seven key informants, encompassing HIV-positive mothers, nurses, clinicians, and community-based healthcare workers. The analysis of these interviews resulted in the identification of three major themes. Firstly, individual barriers to exclusive breastfeeding were delineated, encompassing sub-themes such as occupation-related hectic schedules, early motherhood-related non-compliance to safe infant feeding directives, postpartum depression, and issues related to breast sores and abscesses. Secondly, household-level barriers were identified, highlighting challenges like food insecurity and inaccessibility to key resources, the influence of male partners and family members on decision-making, and barriers arising from non-disclosure of HIV status affecting Exclusive Breastfeeding (EBF) support. Lastly, community-level barriers were explored, revealing a sub-theme related to the low retentivity of HIV-positive women in the Prevention of Mother-to-Child Transmission (PMTCT) programs. Individual barriers encompass practical, psychological, and physical challenges, while household-level obstacles include food insecurity, limited resources, and family dynamics influencing decisions. At the community level, there's a concern about the low retentivity of HIV-positive women in PMTCT programs, indicating broader societal challenges in supporting exclusive breastfeeding. There is a need for tailored interventions at individual, household, and community levels to promote and support optimal infant feeding practices among HIV-positive women.

Groundwater solutes influence the adsorption of short-chain perfluoroalkyl acids (PFAA) to colloidal activated carbon and impact performance for in situ groundwater remediation

Subsurface injection of colloidal activated carbon (CAC) is an in situ remediation strategy for perfluoroalkyl acids (PFAA), but the influence of groundwater solutes on longevity is uncertain, particularly for short-chain PFAA. We quantify the impact of inorganic anions, dissolved organic matter (DOM), and stabilizing polymer on PFAA adsorption to a commercial CAC. Surface characterization supported PFAA chain-length dependent adsorption results and mechanisms are provided. Inorganic anions decreased adsorption for short-chain PFAA (<7 perfluorinated carbons) due to competitive effects, while long-chain PFAA (≥ 7 perfluorinated carbons) were less impacted. DOM decreased adsorption of all PFAA in a chain-length dependent manner. High DOM concentrations (10 mg/L, ∼5 mg OC/L) decreased PFOA adsorption by a factor of 2, PFPeA by one order of magnitude, and completely hindered PFBA adsorption. High MW DOM has less impact on short-chain PFAA than low MW DOM, possibly due to differences in the ability to access CAC micropores. Low DOM concentrations (1 mg/L, ∼0.5 mg OC/L) did not impact adsorption. CMC (90 kDa average MW) had negligible impact on PFAA adsorption likely due to minimal CAC surface coverage. Longevity modeling demonstrated that groundwater solutes limit the capacity for PFAA in a CAC barrier, particularly for short-chain PFAA.

Unicorn paradox: Understanding undergraduate Black men's leader identity, capacity, and efficacy.

This study highlights opportunities for developing programs and initiatives to assist Black men in understanding leadership and seeing themselves as leaders, and for decreasing low college retention and persistence rates. The themes from this qualitative narrative inquiry highlight leader identity, capacity, and efficacy for undergraduate Black men. Narrative inquiry was appropriate for this study because the researchers sought to better understand how Black undergraduate male student leaders make meaning of their experience in higher education related to their comprehension of leadership and identity as leaders.

Effects of Combining Microwave with Infrared Energy on the Drying Kinetics and Technofunctional Properties of Orange-Fleshed Sweet Potato

The aim of the study was to determine the effects of oven, microwave (MW), and infrared (IR) drying technology on the drying kinetics, physicochemical properties, and β-carotene retention of the dried orange-fleshed sweet potato flour (OFSP). Fresh OFSP slices were dried in an oven (40°C), MW (80 W), IR (250 W), MW-IR (80 W+250 W), and freeze-drying (-45°C, 100 kPa) and milled into flour. Hot air at a constant temperature was applied to all thermal drying technologies (40°C, 4.5 m/s air velocity). The drying rate of the MW-IR drying method was the fastest (45 min), followed by MW (60 min), IR (120 min), and oven (180 min). The Page model was most suitable for the oven-drying method, the Lewis model for IR drying, and Henderson and Pabis for IR and Logarithmic for the MW-IR method. The pasting and thermal properties of the flours were not significantly (p&gt;0.05) affected by the different drying methods. However, IR- and MW-IR-dried flours showed a higher final viscosity when compared to other drying methods. MW-IR drying methods, IR, and MW showed a higher water solubility index, while the oven and freeze-drying methods showed a lower solubility index. MW-IR drying methods showed a higher retention of β-carotene (85.06%). MW also showed a higher retention of β-carotene (80.46%), followed by IR (66.04%), while oven and freeze-drying methods showed a lower retention of β-carotene. High β-carotene retention in the produced flour is due to the faster drying method, and these flours can be used in food-to-food fortification to address vitamin A deficiency.

Prospective associations between breast feeding, metabolic health, inflammation and bone density in women with prior gestational diabetes mellitus

IntroductionThe aim of the study is to investigate prospective associations between breastfeeding and metabolic outcomes, inflammation, and bone density in women with prior gestational diabetes mellitus (GDM).Research design and methodsWe...

Case report of ADEM in an adult patient with chikungunya

AbstractAcute Disseminated Encephalomyelitis (ADEM) is a demyelinating immune‐mediated disease characterized by bilateral and confluent lesions in white matter (WM), with an acute onset. This condition may arise due to a myriad of etiological factors, encompassing mainly vaccines and viral infections. This case report describes a 39‐y‐old patient who presented with a sudden onset of fever, confusion, and reduced level of consciousness, associated with paraparesis in the lower limbs and urinary retention, 2 d before admission to the neurological emergency department. The work‐up included analysis of the cerebrospinal fluid (CSF), which showed 1.6 cells/mm3 and elevated proteins (91 g/dL); in addition to magnetic resonance imaging (MRI) of the brain and the spinal cord, in which hyperintense ovoid lesions with asymmetrical and bilateral distribution in the WM and basal ganglia were observed in the T2 and FLAIR. Later, chikungunya virus was detected in a molecular viral panel in the CSF. The patient exhibited an improvement radiologically, and in his condition following pulse with methylprednisolone and intravenous immunoglobulin therapy, and 40 mg of prednisone was prescribed for management during outpatient follow‐up. This study highlights arbovirus infections as a possible cause of acute neurological conditions, involving both the brain and the spinal cord. Furthermore, the findings observed in the report were compared with those described in the literature, including other arboviruses. In conclusion, it was observed that the majority of patients responded to treatment with corticosteroids or immunoglobulins, with some neurological deficits eventually persisting. Therefore, more studies are needed to better investigate therapeutic options.