Lower Peak Research Articles

Detonation structure in the presence of mixture stratification using reaction-resolved simulations

Many investigations of detonation-based combustors have identified reactant mixture inhomogeneity as having a leading-order impact on wave dynamics and combustion efficiency. To examine this phenomenon in a simplified context, an array of two- and three-dimensional channel detonation simulations are conducted in the present work. The reactant mixture consists of stratified fuel and air, wherein the randomly distributed equivalence ratio field features a characteristic stratification length scale. Detailed chemical kinetics are implemented in an adaptive mesh refinement solution framework where the region near the shock front is resolved with O(100) cells per representative ZND induction length. The results show that in comparison to baseline cases with uniform reactant mixtures, reactant stratification has a marked impact on the detonation structure. Increasing the stratification length scale increases the size and irregularity of the detonation cells, yielding larger variations in wave speed. Triple point collisions in fuel-rich regions lead to local wave speeds above the notional mean CJ speed, but wave passage through inert regions causes the local wave speed and strength to diminish. Conditional statistics show that increasing the stratification length scale increases the variance in pressure and temperature in the primary reaction zone, as well as the variance in heat release over a range of mixture conditions. In addition to the reactant mixture, the impact of the boundary condition behind the detonation is also investigated. The results show that an inflow boundary condition acts to over-drive the wave, leading to higher peak pressures, smaller detonation cells, and increased reactant consumption. On the other hand, cases with a wall behind the wave exhibit weaker waves with lower peak pressures and heat release rates, as well as greater variance in conditional quantities. Comparisons between complementary two- and three-dimensional simulations show reasonable qualitative agreement in wave structure, speed, and conditional statistics.Novelty and significance statement: The present work considers two- and three-dimensional simulations of detonations propagating through stratified reactant mixtures using detailed chemical kinetics with O(100) cells per representative ZND induction length. To the authors’ knowledge, it is the first study to analyze this type of configuration at this resolution and detail, as well as the first to compare two- and three-dimensional simulations of this configuration. The results have implications for the detonation wave behavior observed in practical propulsion and power-generating applications, such as rotating detonation engines.

Clot time ratio (CTR) and treatment outcomes in Apixaban-treated atrial fibrillation patients

There are clinical situations where information about the anticoagulant effects of Apixaban could be useful. Specialised methods for measuring Apixaban concentrations are not available at all medical laboratories while methods for measuring the functional effects of Apixaban, using clot time ratio (CTR), can be performed in most medical laboratories around the clock using well-established measurement procedures. The aim of this study was to investigate CTR in trough and peak samples during Apixaban treatment of atrial fibrillation and to correlate the findings to bleeds and thrombotic events. Three trough- and three peak samples from 61 patients (31 on Apixaban 5 mg twice daily and 30 on Apixaban 2.5 mg twice daily) were analysed with MRX PT DOAC. Patients were followed for 30 + /-15 months, and bleeds and thrombotic events were documented. The effect of Apixaban could be measured with MRX PT DOAC and there was a statistically significant difference between CTR in trough samples compared to peak samples (p < 0.001). A total of 21 patients suffered bleeds during follow-up; two patients suffered major bleeds, and 19 suffered minor bleeds. Patients with major bleeds had both mean peak- and mean trough CTR above the respective first to third quartile (Q1–Q3) range. Four patients suffered thromboembolic events. Generally, the peak CTRs were below or in the lower end of the peak Q1–Q3 for these patients. The new test MRX PT DOAC can be used to measure the effect of Apixaban during the treatment of atrial fibrillation. High mean peak- and mean trough CTR were seen in 2 patients with major bleeds, and low peak CTR was seen in 4 patients with thromboembolic events.

Optimization of dispersions in benzene-core square photonic crystal fibers for mid-infrared supercontinuum generation with very low peak power

An ultra-broadband, very low peak power supercontinuum source is proposed based on a novel benzene-filled structured photonic crystal fiber. The modification of the structural parameters has been highly effective in improving dispersion properties, an ultra-flat all-normal dispersion is achieved with fluctuations of ±1.174 ps/(nm.km) in the 0.458 µm wavelength region. Three fibers with suitable optical properties best meet the requirements of supercontinuum generations with low peak power based on numerical simulation results. With anomalous dispersion regime, the first fiber offers the supercontinuum spectra in the mid-infrared region spanning from 0.784 µm to 3.973 µm (2.539 µm bandwidth at 30 dB) using laser pulses excited at 1.55 µm has a peak power of 150 W. A pulse with a peak power of 280 W propagates in a 5 cm length of the second fiber results in a supercontinuum spectrum covering from 0.744 µm to 1.859 (bandwidth 1.063 µm at 30 dB) at a pump wavelength of 1.3 µm with all-normal dispersion regime. A smooth, highly coherent supercontinuum spectrum spanning from 0.843 µm to 2.517 µm (bandwidth at 30 dB of 1.608 µm) is achieved when the third fiber has all-normal ultra-flat dispersion profile pumped at 1.75 µm wavelength with laser pulse peak power of 350 W. With very low peak power, these proposed three-fiber based broadband supercontinuum sources could be a low-cost alternative to traditional glass-core fiber, which has great potential for mid-infrared spectroscopy.

Spatiotemporal analysis and forecasting of lumpy skin disease outbreaks in Ethiopia based on retrospective outbreak reports.

Lumpy skin disease is a viral disease that affects cattle belonging to genus Capripoxvirus (Poxviridae) and lead to significant economic losses. The objective of this study was to evaluate the distribution of lumpy skin disease (LSD) outbreaks and predict future patterns based on retrospective outbreak reports in Ethiopia. Data were collected through direct communication with regional laboratories and a hierarchical reporting system from the Peasant Associations to Ministry of Agriculture. Time-series data for the LSD outbreaks were analyzed using classical additive time-series decomposition and STL decomposition. Four models (ARIMA, SARIMA, ETS, STLF) were also used to forecast the number of LSD outbreaks that occurred each month for the years (2021-2025) after the models' accuracy test was performed. Additionally, the space-time permutation model (STP) were also used to study retrospective space-time cluster analysis of LSD outbreaks in Ethiopia. This study examined the geographical and temporal distribution of LSD outbreaks in Ethiopia from 2008 to 2020, reporting a total of 3,256 LSD outbreaks, 14,754 LSD-positive cases, 7,758 deaths, and 289 slaughters. It also covered approximately 68% of Ethiopia's districts, with Oromia reporting the highest LSD outbreaks. In the LSD's temporal distribution, the highest peak was reported following the rainy season in September to December and its lowest peak in the dry months of April and May. Out of the four models tested for forecasting, the SARIMA (3, 0, 0) (2, 1, 0) [12] model performed well for the validation data, while the STLF+Random Walk had a robust prediction for the training data. Thus, the SARIMA and STLF+Random Walk models produced a more accurate forecast of LSD outbreaks between 2020 and 2025. From retrospective Space-Time Cluster Analysis of LSD, eight possible clusters were also identified, with five of them located in central part of Ethiopia. The study's time series and ST-cluster analysis of LSD outbreak data provide valuable insights into the spatial and temporal dynamics of the disease in Ethiopia. These insights can aid in the development of effective strategies to control and prevent the spread of the disease and holds great potential for improving efforts to combat LSD in the country.

Development of Dy3+ doped lithium magnesium borate glass system for thermoluminescence based neutron dosimetry applications

Abstract The manuscript reports the synthesis of Dy3+ incorporated lithium magnesium borate glass by melt quenching technique. FTIR study revealed the presence of both BO3 as well as tetrahedral BO4 units through their characteristic frequencies. Photoluminescence (PL) study of unirradiated samples confirmed the presence of Dy dopant in the ‘+3’ oxidation states from the characteristic emissions at 482, 578, 666 and 716 nm corresponding to 4F9/2 → 6H15/2, 4F9/2 → 6H13/2 and 4F9/2 → 6H11/2, 4F9/2 → 6H9/2 transitions, respectively. Thermal neutron and gamma irradiated PL emission and lifetime characteristics were discussed in details based on the different defect centers. Thermal neutron irradiated TL study showed that the material has a broad and single dosimetry glow peak at about 450 K which showed high fading due to low temperature peak. TL based neutron sensitivity of LMB: Dy3+ was found to be about 37.4 times less than that of standard TLD-100 (LiF: Mg, Ti) powder. The net TL response from about 3 to 83 mSv of neutron dose was found to be linear (Adj. R2 = 0.9994) which is one of the most desirable properties for dosimetry applications. In addition, the TL trap parameters were evaluated using both deconvolution of TL glow curve and peak shape method as suggested by Chen which were found to be matching with each other.

Knee Biomechanics During Cutting Maneuvers and Secondary ACL Injury Risk: A Prospective Cohort Study of Knee Biomechanics in 756 Female Elite Handball and Soccer Players.

An athlete who returns to sport after an anterior cruciate ligament (ACL) injury has a substantially high risk of sustaining a new secondary ACL injury. Because ACL injuries most frequently occur during cutting maneuvers, such movements should be at the center of research attention. To investigate whether knee biomechanical parameters during side-step cutting maneuvers differ between female elite athletes with and without a history of ACL injury and to evaluate whether such parameters are associated with future secondary ACL injury. Cohort study; Level of evidence, 2. A total of 756 female elite handball and soccer players, of whom 76 had a history of ACL injury, performed a sport-specific cutting task while 3-dimensional kinematics and kinetics were measured. ACL injuries were registered prospectively over an 8-year follow-up period. Seven knee-specific biomechanical variables were the basis for all analyses. Two-way analyses of variance were applied to assess group differences, whereas logistic regression models served to evaluate associations between the knee-specific variables and future secondary ACL injury. When players with a previous ACL injury performed the cutting maneuver with their ipsilateral leg, they exhibited lower knee abduction angles (mean difference [MD], 1.4°-1.5°; 95% CI, 0.2°-2.9°), lower peak knee flexion moments (MD, 0.33 N·m/kg-1; 95% CI, 0.18-0.48 N·m/kg-1), lower peak knee abduction moments (MD, 0.27 N·m/kg-1; 95% CI, 0.12-0.41 N·m/kg-1), and lower peak knee internal rotation moments (MD, 0.06 N·m/kg-1; 95% CI, 0.01-0.12 N·m/kg-1) compared with injury-free players. When players performed the cut with their contralateral leg, no differences were evident (P < .05). None of the 7 knee-specific biomechanical variables was associated with future secondary ACL injury in players with an ACL injury history (P < .05). Approximately 4 years after ACL injury, female elite team-ball athletes still unloaded their ipsilateral knee during cutting maneuvers, yet contralateral knee loading was similar to that of injury-free players. Knee biomechanical characteristics were not associated with future secondary ACL injury.

Untangling the biotic stress in the late Maastrichtian Deccan-benchmark interval of Bidart (France)

The late Maastrichtian witnessed substantial surges in Deccan volcanism, prompting the hypothesis that these voluminous pulses may have instigated repeated episodes of ocean acidification during this period. The Cretaceous-Palaeogene (K/Pg) boundary at Bidart (France) is preceded by a ∼0.5 m thick interval with geochemical and taphonomic vestiges of an ocean acidification event linked with Deccan volcanism. New planktic foraminifera census and morphometric data now confirm biotic stress conditions related to acidification in the Deccan benchmark interval. The absolute abundance data of larger (>150 μm) heavily calcified planktic morphogroups show fluctuating populations throughout zone CF1 (spanning the final ∼225 ky), lowest peaks within the Deccan benchmark, and a demographic collapse (>90%) at the K/Pg boundary. The analyzed species are generally reduced in size, with thinner test walls in this ∼0.5 m interval, indicating the likelihood of calcification stress as a contributor to the overall biotic stress. At the K/Pg boundary, maximum biotic stress is recorded in all the tested faunal proxies. A preliminary graphic correlation of zone CF1 at Bidart with the auxiliary GSSP at Elles (Tunisia) constrains the Deccan benchmark interval of high biotic stress to the final ∼58 ky of the late Maastrichtian, culminating in the K/Pg mass extinction. The volcanogenic Hg peaks coincident with faunal and taphonomic evidence of ocean acidification strengthen the Deccan-related ocean acidification hypothesis.

SERCA1 Overexpression in Skeletal Muscle Attenuates Muscle Atrophy and Improves Motor Function in a Mouse Model of ALS.

Amyotrophic lateral sclerosis (ALS) is characterized by progressive loss of muscle mass and muscle function. Previous work from our lab demonstrated that skeletal muscles from a mouse model of ALS show elevated intracellular calcium (Ca2+) levels and heightened endoplasmic reticulum (ER) stress. To investigate whether overexpression of sarcoplasmic reticulum (SR) Ca2+ ATPase 1 (SERCA1) in skeletal muscle would improve intracellular Ca2+ handling, attenuate ER stress, and improve motor function ALS transgenic mice. B6SJL-Tg (SOD1*G93A)1Gur/J (ALS-Tg) mice were bred with skeletal muscle α-actinin SERCA1 overexpressing mice to generate wild type (WT), SERCA1 overexpression (WT/+SERCA1), ALS-Tg, and SERCA1 overexpressing ALS-Tg (ALS-Tg/+SERCA1) mice. Motor function (grip test) was assessed weekly and skeletal muscles were harvested at 16 weeks of age to evaluate muscle mass, SR-Ca2+ ATPase activity, levels of SERCA1 and ER stress proteins - protein disulfide isomerase (PDI), Grp78/BiP, and C/EBP homologous protein (CHOP). Single muscle fibers were also isolated from the flexor digitorum brevis muscle to assess changes in resting and peak Fura-2 ratios. ALS-Tg/+SERCA1 mice showed improved motor function, delayed onset of disease, and improved muscle mass compared to ALS-Tg. Further, ALS-Tg/+SERCA1 mice returned levels of SERCA1 protein and SR-Ca2+ ATPase activity back to levels in WT mice. Unexpectedly, SERCA-1 overexpression increased levels of the ER stress maker Grp78/BiP in both WT and ALS-Tg mice, while not altering protein levels of PDI or CHOP. Lastly, single muscle fibers from ALS-Tg/+SERCA1 had similar resting but lower peak Fura-2 levels (at 30 Hz and 100 Hz) compared to ALS-Tg mice. These data indicate that SERCA1 overexpression attenuates the progressive loss of muscle mass and maintains motor function in ALS-Tg mice while not lowering resting Ca2+ levels or ER stress.

102 Estradiol and follicular growth are associated with estrous behavior monitored by an accelerometer in grazing beef cows

Abstract In beef cattle, 40% of cows that display estrus do not remain pregnant after embryo transfer (ET). Estrus is a physiological behavior influenced by the concentration of sex-steroids. The use of accelerometer devices for estrus detection is a common practice in dairy operations. It remains unclear if this same artificial intelligence software can accurately measure reproductive behavior in beef females. We hypothesized that estrous variables detected by an accelerometer are associated with ovarian, hormonal, pregnancy outcome, and fertility-related variables measured in the cow. Fifty Bos indicus-influenced, cyclic, primiparous cows were fitted with an accelerometer collar (SCR Engineers, Israel) and a breeding indicator (Estrotectâ) to detect estrus after a synchronization protocol in five subsequent experimental replicates (n = 50*5 = 250). Only cows that showed estrus (d 0) remained in the study. The following variables were used from the accelerometer software: Activity Peak, Rumination Nadir, Estrus Duration, and Heat Index, calculated by proprietary algorithms. Dominant follicle (DF) diameter and plasma concentration of estradiol were measured on d -2 (day of progesterone device removal) and on d 0. On d -1 and d 4, endometrial thickness and luminal fluid accumulation were measured by ultrasonography. On d 7, two embryos were transferred/cow. Pregnancies were diagnosed on d 45 and terminated. After 30 d, a new replicate started. Cows included in at least two replicates that remained pregnant 100%, 99-50%, or less than 50% were classified as fertile, sub fertile, and infertile, respectively. Estrus display was recorded for 166 cows (66%). Estrus detection by accelerometer and Estrotect had excellent agreement rate (kappa coefficient 0.76). Cows detected in estrus only by Estrotect had 66% less pregnancy/ET than cows in estrus by both (9/21 vs. 97/145; P = 0.01). The DF diameter on d 0 was not associated with accelerometer variables. Cows with greater and moderate Activity Peak had a greater growth rate of the DF from d -2 to d 0 than lower Activity Peak cows (interaction day*Activity Peak; P = 0.06). Estradiol on d -1 was positively associated with the Activity Peak (P &amp;lt; 0.0001). Cows with lower Activity Peak had a thicker endometrium on both d -1 and d 4 (P=0.02), and greater uterine luminal fluid score on d -1 (P=0.03). Fertility status was not associated with any accelerometer variables. In conclusion, the Activity Peak is associated positively with estradiol concentration and DF growth, however no association was found with pregnancy outcome and fertility. Therefore, the main advantage of accelerometers in beef ranches is the ability to detect estrus at a similar accuracy as breeding indicators, using less labor. Future enhancements in hardware and software to allow prediction of pregnancy outcomes are expected to increase reproductive efficiency in cow-calf operations.

Dynamic responses of steady-state transition structures under impact loading

Advancements in materials science and mechanical system have spurred widespread investigation into non-traditional structures. In particular, engineers have shown interest in steady-state transition structures with phase transition properties. In this paper, a three-dimensional steady-state transition structure was established using the genetic algorithm and three-dimensional expansion, on which the low-velocity impact tests were carried out. Force response and energy absorption of the steady-state transition structures under impact were studied. From the force response and energy absorption curves, it can be seen that the steady-state transition structures absorb and store portion of impact energy temporarily, gradually releasing it after impact peak. This unique energy behavior results in a steady state transition structure with a long impact response time and a low peak impact force under impact. In addition, investigation into energy transfer within these structures reveals that energy oscillations occur among multilayered bistable surfaces during steady-state transitions, further improving the energy dissipation. Further, the dynamic response and damage modes of the honeycomb structure and the steady state transition structure were compared, showing that the damage mode of the steady state transition structure under the impact is an overall damage, in contrast to the penetration damage of the honeycomb structure. Notably, the steady-state transition structures showcase a higher proportion of elastic strain energy during impacts, effectively delaying structural damage onset, and dispersing impact energy, thus enhancing impact resistance. In light of these findings, the demonstrated behavior of steady-state transition structures in absorbing and dissipating impact energy showcases their potential as promising avenues for the development of more effective impact protection strategies.

Electrochemical Sensing of Cadmium and Lead Ions in Water by MOF-5/PANI Composites.

For the first time, composites of metal-organic framework MOF-5 and conjugated polymer polyaniline (PANI), (MOF-5/PANI), prepared using PANI in its conducting (emeraldine salt, ES) or nonconducting form (emeraldine base, EB) at various MOF-5 and PANI mass ratios, were evaluated as electrode materials for the electrochemical detection of cadmium (Cd2+) and lead (Pb2+) ions in aqueous solutions. Testing of individual components of composites, PANI-ES, PANI-EB, and MOF-5, was also performed for comparison. Materials are characterized by Raman spectroscopy, scanning electron microscopy (SEM) and dynamic light scattering (DLS), and their electrochemical behavior was discussed in terms of their zeta potential, structural, morphology, and textural properties. All examined composites showed high electrocatalytic activity for the oxidation of Cd and Pb to Cd2+ and Pb2+, respectively. The MOF/EB-1 composite (71.0 wt.% MOF-5) gave the highest oxidation currents during both individual and simultaneous detection of two heavy metal ions. Current densities recorded with MOF/EB-1 were also higher than those of its individual components, reflecting the synergistic effect where MOF-5 offers high surface area for two heavy metals adsorption and PANI offers a network for electron transfer during metals' subsequent oxidation. Limits of detection using MOF/EB-1 electrode for Cd2+ and Pb2+ sensing were found to be as low as 0.077 ppm and 0.033 ppm, respectively. Moreover, the well-defined and intense peaks of Cd oxidation to Cd2+ and somewhat lower peaks of Pb oxidation to Pb2+ were observed at voltammograms obtained for the Danube River as a real sample with no pretreatment, which implies that herein tested MOF-5/PANI electrodes could be used as electrochemical sensors for the detection of heavy metal ions in the real water samples.

Spatio-temporal distribution and transmission dynamics of sheep pox and goat pox diseases in South Wollo zone north East Ethiopia

Sheep pox (SP) and goat pox diseases (GP) are highly transmittable, malignant systemic and economically significant caused by the genus Capripoxvirus. using The spatio-temporal distribution of SP and GP outbreaks in South Wollo zone from September 2013 to December 2019 was determined retrospectively using SP and GP outbreaks report Kombolcha regional laboratory. A follow up study was also conducted from December 2019 to March 2021 to estimate the transmission parameter of SP and GP outbreaks in South Wollo zone of Kutaber district, Amhara region. Tissue samples from outbreaks in Kundi and Haroye kebele of Kutaber district were taken to confirm the outbreak by conventional polymerase chain reaction (PCR). The transmission parameters were estimated using Generalized linear model (GLM) based on stochastic Susceptible Infected and Recovered (SIR) model. In South Wollo zone, 249 SGP outbreaks were reported from 2013 to 2019. The incidence differed between months, with a highest peak in October and November and a lowest peak in February. The basic reproduction ratios (R0) of the SGP disease outbreaks were 1.84 and 3 for Haroye and Kundi kebele outbreaks, respectively. The disease is distributed throughout the zone and the investigated active outbreaks had moderate transmission between animals. Hence, it needs a great effort which focuses on the application of control measures that reduce the transmission of the disease.

Changing absorption intensity ratios for methylene violet Bernthsen in normal alcohols and at different temperatures

Absorption spectra of methylene violet Bernthsen (MVB) are reported, obtained in normal alcohols, methanol through 1-octanol, and at different temperatures, 15 °C to 75 °C. Two distinct absorption intensities are apparent. The 565 nm intensity increases relative to the 598 nm intensity as alcohol chain length increases. For each solvent, increasing temperature causes similar intensity ratio effects. Computational spectra of MVB in methanol indicates a decrease in hydrogen-bonding as temperature increases with a corresponding loss of intensity in the low energy peak consistent with the experimental observations. Hydrogen-bonding is indicated as playing a role in the alcoholic solvent effects.

Impacts of global biogenic isoprene emissions on surface ozone during 2000–2019

Biogenic isoprene is an important precursor of tropospheric ozone (O3). Here, a coupled chemistry–vegetation model was used to quantify the contributions of isoprene emissions to surface O3 pollution on the global scale during 2000–2019. The biogenic isoprene emissions showed high values in mid–low latitudes and seasonal peaks in the summer hemispheres. They promote global surface O3 concentrations by 1.75 ppbv annually with regional hotspots of 4.39 ppbv (8.8%) in China and 5.36 ppbv (11.1%) in the U.S. in boreal summer. In the past two decades, isoprene emissions increased by 1.32 TgC yr−1 (0.67% yr−1) in the Northern Hemisphere but decreased by 0.71 TgC yr−1 (0.44% yr−1) in the Southern Hemisphere. Such changes of isoprene made opposite contributions to the surface O3 trend, with 0.26 ppbv yr−1 in eastern China but −0.32 ppbv yr−1 in the southeastern U.S. due to the changes in the background regime of chemical reactions. The impact of anthropogenic changes on the O3 trend is consistent with that of biogenic isoprene, but two to four times stronger in magnitude. This study revealed that the effective control of anthropogenic NOx emissions could mitigate regional O3 pollution even with the increased isoprene emissions under global warming.

Machine learning for analysis of wind farm noise

Two challenges associated with analyzing acoustical data from wind farms are: 1) separating turbine sounds from environmental sounds and 2) classifying acoustical samples into different types of wind turbine noise based on acoustic characteristics. Machine-learning methods for classifying general environmental sounds have been developed using large human classified databases (e.g., YAMNet), but only a few studies have targeted classification of wind farm noise (WFN) specifically. Techniques for classifying wind farm noise have focused on identification of amplitude modulation (AM) using both traditional methods such as low frequency peak prominence (IOA method) and machine learning methods using both targeted AM acoustics features and more general deep acoustic features. To address these two challenges, we are developing a multi-echelon machine learning framework to identify and classify noise from wind farms using publicly available windfarm data and open-source software. The first echelon provides an automated method for identifying WFN samples that are free of environmental sounds. The second echelon uses machine learning to classify these wind farm noises according to the degree of AM, prominent tones, and other factors that might contribute to the human response and are incorporated in the metrics used or potentially used to assess compliance with regulations.

The Improvement in Exercise Performance during Reduced Muscle Mass Exercise is Associated with an Increase in Femoral Blood Flow in Older and Younger Endurance-Trained Athletes.

This study investigated whether the improved performance observed with maximal self-paced single-leg (SL), compared with double-leg (DL) cycling, is associated with enhanced femoral blood flow and/or altered tissue oxygenation. The hyperaemic response to exercise was assessed in younger and older athletes. Power output was measured in 12 older (65 ± 4 y) and 12 younger (35 ± 5 y) endurance-trained individuals performing 2 x 3 min maximal self-paced exercise using SL and DL cycling. Blood flow (BF) in the femoral artery was assessed using Doppler ultrasound and muscle oxygenation was measured using near-infrared spectroscopy on the vastus lateralis. SL cycling elicited a greater power output (295 ± 83 vs 265 ± 70 W, P < 0.001) and peak femoral BF (1749.1 ± 533.3 vs 1329.7 ± 391.7 ml/min, P < 0.001) compared with DL cycling. Older individuals had a lower peak BF in response to exercise (1355.4 ± 385.8 vs 1765.2 ± 559.6 ml/min, P = 0.019) compared with younger individuals. Peak BF in response to exercise was correlated with power output during SL (r = 0.655, P = 0.002) and DL (r = 0.666, P = 0.001) cycling. The greater exercise performance during SL compared with DL cycling may be partly explained by a greater hyperaemic response when reducing active muscle mass. Despite regular endurance training, older athletes had a lower femoral BF in response to maximal self-paced exercise compared with younger athletes.

Data-driven modal decomposition of R134a refrigerant cavitating flow in Venturi tube

This study utilized high-speed camera and large eddy simulation methods to explore the cavitating flow mechanisms and turbulence structures of R134a refrigerant inside a Venturi tube under varying cavitation numbers (CNs). Data-driven modal analysis approaches, proper orthogonal decomposition (POD) and dynamic mode decomposition (DMD), were introduced to identify and extract the energy hierarchy and transient characteristics within the cavitating flow. The analysis of grayscale images indicated that the cavitating flow gradually transitioned from quasi-periodic to unsteady flow as the CN decreased, and the severity of cavitation correlates with lower peak frequencies. The POD analysis facilitated the extraction of coherent structures in the cavity's temporal evolution, and the results indicate that the quasi-ordering shedding and collapse of large-scale cavity clouds predominantly occur under low cavitation intensity conditions. As the CN increases, the influence of small-scale cavity shedding becomes more significant. The first 30 most energetic modes occupied over 75% of the entire energy, and they were used to reconstruct the cavitating flow, achieving good consistency with transient flow snapshots. Additionally, the DMD results of the cavitating flow yield three frequency spans, including several prominent characteristic frequencies. These spans are closely linked to the cavity cloud structures of varying scales, unveiling the structural characteristics of unsteady cavitating flow.

High temperature synthesis, surface characterization, and photoluminescence property of boron carbon nitride

The present study demonstrates the synthesis of boron carbon nitride (BCN) by molten salt method which utilizes melamine (source of carbon and nitrogen), boric acid (source of boron) and potassium chloride as the salt. The synthesis is performed at 915 °C for 4 h under N2-atmosphere. The synthesized material is further acid-treated. The physicochemical characterization data for as-synthesized and acid-treated materials confirm successful synthesis of BCN. SEM and AFM data display that synthesized BCN pre and post acid-treatment exhibit sheet-type morphology. Thermogravimetric analysis data confirm that the acid-treated material is thermally stable up to 800 °C, with only 2 % mass-loss is observed till 800 °C. Water contact angle measurement study demonstrates that acid-treatment significantly improves the surface hydrophilicity. Additionally, the low photoluminescence peak intensity of the acid-treated material indicates low electron-hole pair recombination rate. The synthesized material may be useful for the photocatalytic degradation of potentially toxic chemicals from water.

Cardiorespiratory fitness in persons with lower limb amputation.

The aim of this study is to gain insight in the cardiorespiratory fitness of persons with lower limb amputation (LLA) during rehabilitation, and in potential factors influencing their cardiorespiratory fitness. We performed a retrospective cohort study using data from cardiopulmonary exercise tests. Included participants were adults with LLA. Main outcome was cardiorespiratory fitness expressed as O 2 peak (ml/min/kg) and was directly determined using breath-by-breath gas analysis. O 2 peak was compared to reference values for able-bodied controls. Multivariate regression analysis was performed to investigate potential factors related to O 2 peak in persons with LLA. Potential factors were age, BMI adjusted, gender, level of amputation, aetiology of amputation, unilateral/bilateral, type of ergometry and use of beta blockers. Data of 74 participants with LLA are presented; 84% male (n = 62), mean age 58.9 (SD 11.6), mean BMI 26.7 (SD 5.6), 44 participants have a LLA above the knee, 30 below the knee. Overall O 2 peak was lower in persons with LLA compared to reference values for able-bodied controls, with mean O 2 peak for the total LLA group of 14.6 ± 4.1 ml/kg/min. In the multivariate regression analysis, only age was a significant predictor for lower O 2 peak (regression coefficient: -0.15, 95% CI [0.23-0.069], r 2 = 0.166). These results indicate that the cardiorespiratory fitness in persons with LLA is low, while they actually need more energy to walk and perform other daily activities. Cardiorespiratory fitness is not closely associated with the analysed demographic or clinical factors and will have to be determined on an individual basis for use in daily practice.

Rechallenge With High-Dose Methotrexate After Treatment With Glucarpidase in Adult Patients With Lymphoma.

Limited evidence exists regarding methotrexate (MTX) resumption after patients with lymphoma receive glucarpidase for toxic MTX levels and acute kidney injury (AKI). This retrospective review included adults with lymphoma treated with glucarpidase after MTX at Mayo Clinic between January 31, 2020, and October 10, 2022. Descriptive statistics summarize patient characteristics and clinical outcomes. Of 11 patients treated with glucarpidase after MTX, seven (64%) were rechallenged with MTX. Indications for MTX rechallenge included confirmed CNS disease (n = 6, 86%) and intravascular lymphoma (n = 1, 14%). Compared with the nonrechallenged subgroup, before receiving MTX that required glucarpidase rescue, the rechallenged patients had lower median pretreatment serum creatinine (Scr; 0.7 v 1.2 mg/dL), and none had AKI with previous MTX doses, n = 0 (0%) versus n = 2 (50%). During the MTX dose requiring glucarpidase rescue, the rechallenged group had lower median peak Scr (1.26 v 3.32 mg/dL) and lower incidence of AKI stage III (n = 1 [14%] v n = 3 [75%]), and none of the rechallenged patients required renal replacement therapy (RRT; n = 0 [0%] v n = 1 [25%]). At the first rechallenge after glucarpidase administration, the median MTX dose reduction was 56% (range, 46%-75%), and the lowest used dose when prescribed according to each treatment protocol schedule was 1.5 g/m2. Two (29%) patients experienced AKI (n = 1 stage I, n = 1 stage II) after MTX rechallenge. Zero patients required RRT, and zero required another glucarpidase administration. Six (86%) patients completed all recommended MTX doses. In selected adults with lymphoma who required glucarpidase for toxic MTX levels after administration of high-dose MTX, resumption of MTX therapy at lower doses is safe. Patients selected for MTX resumption had experienced less severe AKI during the previous cycle compared with those not selected for MTX resumption.