Pulse-jet cartridge filters are widely used in industrial dust removal. However, the accumulation of highly sticky dust can cause irreversible blockage of cartridges. This is primarily due to the humidity of the air on the cleaning performance of the filter cartridge. Therefore, this article proposed a new method to solve it by changing the injection air source (nitrogen, compressed air after suction dryer treatment and compressed air after cold dryer treatment), the influence of humidity on system strength and dust residues was assessed. We define absolute humidity above 10 g m−3 as a high humidity condition and vice versa as a low humidity condition. The conclusions are that the injection effect only considers the water content of the injection air source: nitrogen > compressed air after suction dryer treatment > compressed air after cold dryer treatment. In low humidity conditions, the injection air source is the main influence factor, plus the water content of the injection air source, the greater the resistance of the system and the dust residues. In high humidity conditions, the humidity of the air is the most important influence. When the gas-solid concentration and filtration wind speed are constant, the system strength and dust residues increase with the increase in humidity. This study provides new ideas and reliable data sources for the industrial collection of adhesive dust.