This research aims to analyze the relationship between population density and health in the quality of life of 22 cities in Sumatra. The data used in this study are secondary and primary. This research is a qualitative descriptive analysis, to analyze the correlation between population density and health on the quality of life within a year (Cross Section) in 2020. The analytical model used in this research is the Klassen Typology model or the scatter plot. The results of this study indicate that several cities fall into different categories in each quadrant with descriptions: quadrant (1) region included in the classification of population density and high health, high quality of life; (2) regions in the second quadrant with low-level population density and health but high-level quality of life; (3) regions with a low level of population density and health and low level in the quality of life classifications; (4) regions that have high population density and health but low in the quality of life. It is recommended that the government set a policy to pay more attention to cities that are included in the quadrant IV category so that the high quality of life in quadrant I can be balanced with a low population density.