Low-hanging Fruit Research Articles

2204. Excess Antibiotic Therapy for 5 Common Conditions in Primary Care: Low-Hanging Fruit for Outpatient Antibiotic Stewardship

Abstract Background Improving duration can be a key intervention in outpatient antibiotic stewardship as most conditions require only 5 days of therapy or less. Cellulitis, acute otitis media (AOM), sinusitis, community-acquired pneumonia (CAP), and uncomplicated urinary tract infections (UTI) encounters account for the majority of outpatient antibiotic prescriptions and have been associated with durations longer than necessary. We characterized the duration of antibiotic prescriptions associated with these conditions in our primary care (PC) network. Methods We retrospectively evaluated prescribing practices for cellulitis, AOM, sinusitis, CAP, and UTI encounters among patients ≥ 3 years-old from January 1st, 2022 – December 31st, 2022 in the Intermountain Health (IH) PC network. IH is an integrated healthcare system operating 119 PC clinics (69 family medicine, 22 internal medicine, 23 pediatric). System-specific evidence-based ambulatory guidelines for the conditions of interest during the study recommended 5-7 days of therapy. Encounters, patient characteristics, and prescription information were electronically extracted from the electronic health record. We analyzed duration of therapy by categories (≤5 days, 6-9 days, 10-14 days, or 14+ days) for each condition in pediatric (≥ 3-18 years-old) and adult (≥ 19 years-old) patients. Results There were 14,918 and 38,790 encounters for the studied conditions among pediatric and adult patients, respectively. The mean age of pediatric patients was 9.0 years and among adults, 56.8. Pediatric and adult patients were predominantly White, non-Hispanic, female, and preferred speaking English (Table 1). Overall, only 10.4% (8,965) of all prescriptions were ≤ 5 days and consistent with the recommended duration. Duration of prescriptions associated with each condition are presented in Figure 1. UTI exhibited the highest percentage of ≤ 5 day prescriptions (22.1% pediatrics, 29.1% adults) while sinusitis had the lowest (0.9% pediatrics, 2.6% adults).Table 1.Total encounters for all studied conditions and patient characteristicsFigure 1.Duration of antibiotic prescriptions associated with cellulitis, acute otitis media (AOM), sinusitis, community-acquired pneumonia (CAP), and uncomplicated urinary tract infection (UTI) encounters for patients 3-18 years-old (pediatric) and ≥19 years-old (adult) in the Intermountain Health primary care network. Conclusion Duration of therapy for cellulitis, AOM, sinusitis, CAP, and UTIs is almost always longer than the recommended 5 days of therapy in our PC network. There is substantial opportunity to improve duration for these conditions. Disclosures Payal K. Patel, MD MPH, qiagen: Honoraria

Reaching beyond low-hanging fruit: Basic research and innovativeness

In this paper we examine the relationship between basic research and the innovativeness of innovations and how this relationship varies between internally- and externally-sourced innovations. In addition, building on Nelson's argument on the economics of basic research, we examine how the relation between basic research and innovativeness is conditioned by whether or not the firm is diversified and whether arguments about basic research and diversification built from Nelson (1959) hold for differently-sourced innovations. Using data from a large-scale survey of U.S. manufacturing firms, we provide some empirical evidence showing that basic research is associated with more innovative innovations. Furthermore, we show that for internally-generated innovations, this relation is moderated by whether or not the firm is diversified, consistent with Nelson's argument. However, for externally-sourced innovations, basic research has a direct association with more innovative innovations, consistent with the absorptive capacity argument regarding superior technical evaluation, with the moderation of diversification not observed. The results contribute to a better understanding of the different mechanisms through which basic research is related to the type of innovations commercialized by for-profit firms.

To pick (or not to pick) the high-hanging fruits: Cleaner production audits and firm total factor energy efficiency

The “low-hanging fruits” measures that easily and quickly reduced pollution and energy intensity over the past decades are now giving rise to issues. Cleaner production may provide new opportunities to gain the “high-hanging fruits”—more challenging or costly actions that have greater environmental and energy benefits but require advanced technologies or management for implementation. This study provides empirical evidence on the effects of cleaner production audits (CPAs) on Chinese manufacturing firms' total factor energy efficiency (TFEE), whose enhancement synergizes climate mitigation and green productivity growth. The study analyzes the effects of CPAs by employing a staggered difference-in-difference strategy combined with propensity score matching to compare samples of treated and untreated industrial firms for the period of 2000–2014. The findings show that regulated firms experience a 10.4% increase in TFEE. The contributions of green pure technical efficiency and green technical progress are 7.9% and 2.7%, respectively. Additionally, non-heavy polluters, small firms, and private firms demonstrate the greatest improvements in TFEE. However, CPAs do not significantly impact the TFEE of firms with high dependence on fossil energy. Finally, the mechanism analyses demonstrate that inner resource allocation optimization may be the main solution for improving TFEE by enhancing green pure technical efficiency. Green technological innovations in energy alternatives are the most promising paths for increasing TFEE by promoting green technical progress. These findings illuminate how manufacturing firms pick the “high-hanging fruits” of energy efficiency in more cost-effective ways and suggest useful insights for cleaner production promotion.

Access to Justice and Civil-Procedural Bargaining

There is a virtual consensus that there is an ‘access-to-justice’ crisis in Canada. Some of the more concerning elements of the crisis – namely, the inaccessibility of courts – were brought into sharp focus at the onset of the global COVID-19 pandemic, wherein the already strained Ontario courts seemed poised to incur more ‘case debt’ and add to their already lengthy backlog. Responsively, governments and courts mounted a series of immediate reforms that were aimed at coping with the acute crisis, many of which were generally helpful measures that access-to-justice proponents advocated for even in non-emergency contexts. The relatively swift, frictionless nature of the changes – surely abetted by the emergency context – suggests that access-to-justice proponents, who often advocate large-scale legal, policy, and regulatory reforms, should consider what other such immediate, ‘low-hanging fruit’ interventions are available. Civil procedure offers fertile ground for such interventions. To this end, this article seeks to inform future reform efforts with three contributions. First, I argue that the access-to-justice problem is properly characterized as a civil-procedural problem. Second, I offer a new typology of civil procedural rules to fill conceptual gaps in the scholarship. Third, relying on an emergent literature about the concept of ‘procedural flexibility,’ I argue that procedural rules are more negotiable than traditional accounts contemplate, which presents opportunities for the practice of procedural bargaining as an access-to-justice tool.

LEARNING TO COLLABORATE: ANALYZING SPECIFICITYOFMANAGINGCOLLABORATIVESPECIFICITY OF MANAGING COLLABORATIVE LEARNINGINHIGHERINSTITUTIONSOFLEARNINGLEARNING IN HIGHER INSTITUTIONS OF LEARNING –ALITERATUREREVIEW– A LITERATURE REVIEW

The space in which higher educaƟ on insƟ tuƟ ons thrive is fast changing, and the demands and expectaƟ ons from society are rapidly increasing (Hazelkorn, 2015). A wide thirst for 21st-century skills, the connec-Ɵ on between research and development, the need for innovaƟ on, knowledge transfer, and stakeholder networks have raised the interest in collaboraƟ ve learning within HEIs. This is therefore propagaƟ ng a desire to do more with less as public spending on the educaƟ on sector conƟ nues to dip.To this end, collaboraƟ ve learning or otherwise referred to as cooperaƟ ve learning, becomes a low-hanging fruit to explore in the circumstances saƟ sfying both the needs of the insƟ tuƟ on (Knowledge generaƟ on) and of those that embrace it (innovators, employers, governments, etc.) to obtain the benefi ts of the valued life-trans-forming educaƟ on. Through this study, three objecƟ ves, which include: – ascertaining the ability of lecturers tomanage collaboraƟ ve learning environments, establishing the need for insƟ tuƟ onal frameworks for collaboraƟ ve learning management, and ascertaining the eff ecƟ veness of curriculum design and management in ensuring col-laboraƟ ve learning, are invesƟ gated. Literature on these aspects is elaborately reviewed to answer the research quesƟ on.The study makes a case for the need to build the capacity of lecturers to enable collaboraƟ on among learners. It also idenƟ fi es a need for insƟ tuƟ onalised pracƟ ces to embed a collaboraƟ ve learning atmosphere as well as an integrated curriculum design approach to make learning content more exploratory and Ɵ me relevant.

Can micropolitan areas bridge the urban-rural divide?

Abstract In this Article, we explore a subset of the urban-rural divide and propose a mechanism for reducing its economic and political effects within that limited realm. Specifically, we focus on the subset of rural areas that lie within what the Office of Management and Budget defines as micropolitan areas. Micropolitan areas are characterized by an urban area with a population between 10,000 and 50,000, and adjacent rural counties. Data suggest that rural areas within micropolitan regions do better economically than rural areas unconnected to urban areas, though not as well as the principal city within the micropolitan area. If the objective is to reduce the economic, and perhaps also the political, divide between urban and rural areas, then micropolitan areas may represent low-hanging fruit for redress. This Article argues that micropolitan areas are an important window into understanding the relationship between urban and rural economies, explores the characteristics of those areas that are likely to generate economic success, and recommends policies that would capture those benefits. Additionally, we speculate that increased opportunities for economic interaction between the urban and rural parts of micropolitan areas could also address the political aspects of the urban-rural divide. Recognizing the complexity of the relationship between urban and rural economies, we identify various obstacles to realizing the kinds of interlocal cooperation that we believe are necessary to reduce the economic and political divide within micropolitan areas. We conclude with suggestions for a research agenda to remedy the underdeveloped study of micropolitan areas.

Plasmodium falciparum infection and naturally acquired immunity to malaria antigens among Ghanaian children in northern Ghana

BackgroundThe surge in malaria cases and deaths in recent years, particularly in Africa, despite the widespread implementation of malaria-control measures could be due to inefficiencies in malaria control and prevention measures in malaria-endemic communities. In this context, this study provides the malaria situation report among children in three Municipalities in Northern Ghana, where Seasonal Malaria Chemotherapy (SMC) is implemented by Ghana Health Service (GHS). MethodsA cross-sectional household survey was carried out to assess the malaria knowledge, attitudes, and practices (KAP) and malaria prevalence in 394 households in 13 rural communities in the Kumbugu, Nanton and Tolon Municipalities, Northern Region, Ghana. This was followed by screening for P. falciparum infection with anti-HRP2 RDT and PCR among children 1–17 years in the households. Plasma levels of IgG specific for crude P. falciparum antigen (3D7) and four recombinant malaria antigens (CSP, GLURP, MSP3, and Pfs230) were assessed by ELISA. The malaria and parasitaemia data were converted into frequency and subgroup proportions and disaggregated by study sites and demographic information of the participants. The ELISA data was converted to arbitrary units (AU) and similarly compared across study sites and demographic information. ResultsThe P. falciparum infection rate and frequency of malaria were high in the study areas with significant age-dependent and inter-community differences, which were reflected by differences in plasma levels of P. falciparum-specific IgG. Over 60% of households reported the use of bed nets and indoor insecticide sprays/coils, and 14% mentioned bush clearing around homes (14%) as malaria preventive measures. Community health centres were the preferred place for households (88%) to seek malaria treatment but over-the-counter drug stores were the major source (66%) of their antimalarials. Overall, malaria preventive and treatment practices were sub-optimal. ConclusionsP. falciparum infection and malaria are still high in the studied communities, indicating that preventive and control measures against the disease in the region remain inadequate. Efforts to ensure high SMC compliance and to improve preventative and treatment practices thus seem cost-beneficial “low-hanging fruits” in the fight against malaria in the Northern Region of Ghana.

A novel allocation method of regional carbon allowance in building sector: Perspective from coupling equity and efficiency

Equitable and effective allocation of provincial carbon allowances is the key to achieving carbon peaking and carbon neutrality targets and addressing the prominent issue of resource and environmental constraints, while reasonable coupling of equity and efficiency is its prerequisite. The study first assessed the effectiveness of the mainstream allocation methods when applied to the building sector. Then, Monte Carlo simulation is used to properly couple the principles of equity and efficiency in the process of carbon allowance allocation in the building sector, and on this basis, a novel Allocation method of Regional Carbon Allowance in Building sector (ARCAB) is constructed to provide an inter-provincial allocation scheme of building carbon emission allowances in 2030 for China. The results show that the mainstream allocation methods are not applicable to the building sector, and their allocation results often appear the phenomenon of “low-hanging fruit” or “high-hanging fruit”. In addition, the coupling degree of equity-efficiency is 12% in China's 2030 allocation scheme, indicating that provincial governments should formulate more stringent carbon reduction policies to achieve this goal. The proposed ARCAB and our findings can assist decision-makers to formulate reasonable carbon allowances and differentiated emission-reduction strategies and will be of national and global significance.

A pharmacist-led penicillin allergy de-labelling project within a preoperative assessment clinic: the low-hanging fruit is within reach

Having a false penicillin-allergy label is linked to longer hospital stays and to an increased risk of Clostridioides difficile and meticillin-resistant Staphylococcus aureus infection. To assess a penicillin-allergy de-labelling tool designed for use by the non-allergist. Patients attending the surgical preoperative assessment clinic (POAC) at a large UK teaching hospital, who reported a penicillin allergy, were directly de-labelled by nursing or pharmacy staff, where appropriate. A penicillin-allergy de-labelling tool designed for use by the non-allergist was adapted and applied; nursing staff were provided with supporting information and education to enable removal of spurious labels. Antimicrobial pharmacists (AMPs) provided follow-up, cross-checked prophylactic antibiotics administered, interrogated clinical notes, and telephoned patients following their surgery, for details of any adverse reactions suffered. A total of 163 patients reporting a penicillin allergy were identified for intervention. Twenty-nine (17.8%) patients reported a penicillin-allergy history appropriate for direct de-labelling, of whom eight (27.6%) declined to consent. The remaining 21 patients (12.8%) were directly de-labelled, with 12 (7.4%) patients consenting during their POAC appointment; the remaining nine (5.5%) patients were consented and de-labelled after their surgery by an AMP. The POAC was identified as an appropriate location and time-point in the patient pathway to enable the direct removal of spurious penicillin-allergy labels prior to surgery. Results suggest that this could be undertaken by nursing staff, although support from AMPs enabled a greater number of patients to be de-labelled.

Fungal Drug Discovery for Chronic Disease: History, New Discoveries and New Approaches.

Fungal-derived drugs include some of the most important medicines ever discovered, and have proved pivotal in treating chronic diseases. Not only have they saved millions of lives, but they have in some cases changed perceptions of what is medically possible. However, now the low-hanging fruit have been discovered it has become much harder to make the kind of discoveries that have characterised past eras of fungal drug discovery. This may be about to change with new commercial players entering the market aiming to apply novel genomic tools to streamline the discovery process. This review examines the discovery history of approved fungal-derived drugs, and those currently in clinical trials for chronic diseases. For key molecules, we discuss their possible ecological functions in nature and how this relates to their use in human medicine. We show how the conservation of drug receptors between fungi and humans means that metabolites intended to inhibit competitor fungi often interact with human drug receptors, sometimes with unintended benefits. We also plot the distribution of drugs, antimicrobial compounds and psychoactive mushrooms onto a fungal tree and compare their distribution to those of all fungal metabolites. Finally, we examine the phenomenon of self-resistance and how this can be used to help predict metabolite mechanism of action and aid the drug discovery process.

Doom or Deliciousness: Challenges and Opportunities for Visualization in the Age of Generative Models.

Generative text-to-image models (as exemplified by DALL-E, MidJourney, and Stable Diffusion) have recently made enormous technological leaps, demonstrating impressive results in many graphical domains-from logo design to digital painting to photographic composition. However, the quality of these results has led to existential crises in some fields of art, leading to questions about the role of human agency in the production of meaning in a graphical context. Such issues are central to visualization, and while these generative models have yet to be widely applied in visualization, it seems only a matter of time until their integration is manifest. Seeking to circumvent similar ponderous dilemmas, we attempt to understand the roles that generative models might play across visualization. We do so by constructing a framework that characterizes what these technologies offer at various stages of the visualization workflow, augmented and analyzed through semi-structured interviews with 21 experts from related domains. Through this work, we map the space of opportunities and risks that might arise in this intersection, identifying doomsday prophecies and delicious low-hanging fruits that are ripe for research.

Pharmacokinetic Research in Pregnancy: Ethical Low-Hanging Fruit?

None

Popular but exclusive: How can lower socio-economic status groups win access to urban green spaces?

Territorial conflicts related to the use of urban green spaces typically result from conflicting preferences and institutions not being able to account for the equitable distribution of benefits. Our study focuses on the value conflicts and contestations around using an urban green space as a “social good” and the political processes of defining what makes it “good.” It investigates the institutional setting and the preferences of 415 forest users in a series of entertainment events organized in a large municipal forest (Lagiewniki) in Lodz, Poland. The low socio-economic status group benefited at the cost of the high socio-economic group, whose members typically chose to change their routes in the forest to avoid the nuisance related to these events. The fact that the lower socio-economic status group benefited seems to have been an unplanned side effect of leasing the deteriorating site (to reduce municipal costs) to a company that chose to pick a low-hanging fruit and not invest in developing the site but only cater to the less picky clientele. The local authorities responsible for leasing the site turned a blind eye to the various nuisances caused by these events and disregarded local conservation provisions. We put this case in the context of the “lumpengeography of capital” (Walker, 1978), which suggests that due to the relative scarcity of capital and the abundance of green spaces, some areas remain in a stage of disinvestment, perhaps only temporarily awaiting the next wave of capitalist redevelopment.

The Kuzari and Early Kabbalah: Between Integration and Interpretation regarding the Secrets of the Sacrificial Rite

AbstractThe proper place of Judah Halevi’s thought in the initial emergence and subsequent development of medieval kabbalah has been the subject of debate for centuries. The general consensus has it that the Kuzari was not much more than a convenient repository of terms. This study measures the extent of Halevi’s impact on early kabbalah by using the Kuzari’s reasons for the sacrificial rite as a test case.Halevi offered an exoteric, more rationalistic explanation and alluded to an esoteric one. Catalonian kabbalists in fact engaged for generations with these two reasons offered by the Kuzari, displaying a shared yet variable approach to Halevi’s thought. Unsurprisingly, some grabbed the low-hanging fruit by interpreting Halevi’s esoteric reason, which he refused to disclose, in terms of theosophical kabbalah. More unexpected, however, is the possible conceptual indebtedness of the earliest Catalonian kabbalists, like Ezra of Gerona, to Halevi’s theurgic conception of the commandments and doctrine of the Godhead. Of particular interest, too, is the fact that later generations of kabbalists interpreted the Kuzari using paradigms they also employed in their conceptualization of theosophical kabbalah, such as astral magic or neoplatonic psychology and spiritual eschatology.Halevi’s work was not simply scavenged for its well-wrought nomenclature. If one looks closely, evidence for the Kuzari’s significant and lasting imprint can be found throughout kabbalah: in the doctrine of the Godhead, in the theurgic conception of religious ritual, in the development of an esoteric interpretation of religious praxis, in the establishment of an esoteric reading of Sefer yeẓirah, and more.

Blood- and Imaging-Derived Biomarkers for Oncological Outcome Modelling in Oropharyngeal Cancer: Exploring the Low-Hanging Fruit

To assess whether CT-based radiomics and blood-derived biomarkers could improve the prediction of overall survival (OS) and locoregional progression-free survival (LRPFS) in patients with oropharyngeal cancer (OPC) treated with curative-intent RT. Consecutive OPC patients with primary tumors treated between 2005 and 2021 were included. Analyzed clinical variables included gender, age, smoking history, staging, subsite, HPV status, and blood parameters (baseline hemoglobin levels, neutrophils, monocytes, and platelets, and derived measurements). Radiomic features were extracted from the gross tumor volumes (GTVs) of the primary tumor using pyradiomics. Outcomes of interest were LRPFS and OS. Following feature selection, a radiomic score (RS) was calculated for each patient. Significant variables, along with age and gender, were included in multivariable analysis, and models were retained if statistically significant. The models' performance was compared by the C-index. One hundred and five patients, predominately male (71%), were included in the analysis. The median age was 59 (IQR: 52-66) years, and stage IVA was the most represented (70%). HPV status was positive in 63 patients, negative in 7, and missing in 35 patients. The median OS follow-up was 6.3 (IQR: 5.5-7.9) years. A statistically significant association between low Hb levels and poorer LRPFS in the HPV-positive subgroup (p = 0.038) was identified. The calculation of the RS successfully stratified patients according to both OS (log-rank p < 0.0001) and LRPFS (log-rank p = 0.0002). The C-index of the clinical and radiomic model resulted in 0.82 [CI: 0.80-0.84] for OS and 0.77 [CI: 0.75-0.79] for LRPFS. Our results show that radiomics could provide clinically significant informative content in this scenario. The best performances were obtained by combining clinical and quantitative imaging variables, thus suggesting the potential of integrative modeling for outcome predictions in this setting of patients.

Information-Based Plastic Material Tracking for Circular Economy—A Review

At the moment, it looks like the plastics recycling industry is skimming only low-hanging fruits of its business. To reach intended targets, a greater effort and disruptive innovations are necessary. Physical- or digital-information-based solutions for tracking plastic material can support the circular economy and help to overcome hurdles along the value chain. In this paper, the scientific literature and initiatives in four different technology areas for information-based tracking solutions are reviewed and analyzed. Physical markers can improve sorting efficiencies on short notice but adhere some technical difficulties. Blockchain as a new concept promises high transparency and security, with the drawbacks of energy-intense verification and technical uncertainties. As a third group, the digital product passport claims a combination of physical and digital solutions with open questions on data ownership. The fourth and last group includes standards and certification systems that aim for maximum consensus with slow market implementation. To enable an integrated circular economy of plastics, plastic material tracking solutions must experience broad acceptance by all players along the value chain in the plastics industry and they should additionally be supported by society.

“Low-Hanging Fruits” against Food Waste and Their Status Quo in the Food Processing Industry

Food processing companies have a financial interest in saving resources. However, they have different perceptions of the relevance of the issue of food waste. Hence, companies deal with the topic of waste in different ways. Some companies do implement measures systematically, others do not. The aim of this study is to analyze which recommendations against food loss and waste are effective, easy to implement, and are already part of the status quo in the food processing industry. For this purpose, based on the results of a previous exploratory study, a standardized questionnaire was developed and sent to food processing companies. From the 82 participating companies, 19 of 53 recommendations were classified as basic recommendations and 22 of the 53 recommendations were classified as ‘low-hanging fruits’. The results showed that companies rated the recommendations that were best implemented as very effective and easy to implement. Moreover, the results showed that the food processing industry’s strength in preventing food waste relate to the internal processes. However, at the borders of the value chain, there are still deficits in terms of exchange and communication with other stakeholders.

Technology Focus: Artificial Lift (March 2023)

Selecting artificial lift papers for the Tech Focus feature of JPT can be a daunting exercise when technologies and innovations abound, more so post-pandemic, with 157 submitted abstracts covering 2021–2022. In narrowing the offerings to three, the criteria of conformance to guidelines and novelty of information, technical equipment, and application were considered. Industry indicators and interest were also factors. Gas lift remains of high global interest, whether in long horizontal shale oil wells or vertical ones because of the cost to operate lower lifting. Declining production and high gas/oil ratios (GORs) present a challenge for conversion to secondary lift forms. Paper SPE 209721 provides an innovative solution combining gas lift with sucker rod lift to enhance and exploit low-productivity wells in high-GOR fields. Permanent magnet motors (PMMs) have made quite the technical splash in the industry over the past decade. PMMs are one-third shorter and result in higher power densities and power savings of up to 18% just by changing out the induction motor. PMMs are again grabbing attention for the direct 1:1 ratio of electrical to carbon footprint. Current environmental, social, and governance concerns are placing demands on all operators, and PMMs are positioned to help with carbon reduction as a low-hanging fruit in paper SPE 209736. In paper SPE 209763, we look at all-metal progressing cavity pumps (aka M2M), which consist of a metal rotor and metal stator. Incremental advances in geometry and materials continue to see operators use high-temperature fluids with low operational expenditure in mind. Reliability is always a concern, and now a novel condition indicator has been developed and tested that offers a better indicator than pump efficiency alone. Recommended additional reading at OnePetro: www.onepetro.org. SPE 206909 Successful Progressing Cavity Pump Reliability Improvement Project in an Oman Steamflood by Shauna Noonan, Oxy, et al. SPE 211782 Maximizing Marginal Fields Profitability Through Drilling Multilateral Wells To Reduce Well Count and Well Cost: Dual Lateral Well With Single ESP and Smart Lower Completion by Mahmoud Mohamed Abdelhay Mostafa, ADNOC, et al. SPE 209748 Gas Pump—A Gas-Driven Positive Displacement Pump Artificial Lift System by Stephen W. Turk, ELC Energy Services, et al.

Carbon capture and utilization: More than hiding CO2 for some time

Carbon capture and utilization: More than hiding CO2 for some time

Overview of the Galileo Project

The Galileo Project is the first systematic scientific research program in the search for potential astro-archaeological artifacts or remnants of extraterrestrial technological civilizations (ETCs) or potentially active equipment near Earth. Taking a path not taken, it conceivably may pick some low-hanging fruit, and without asserting probabilities — make discoveries of ETC-related objects, which would have far-reaching implications for science and our worldview.