Hemodialysis is the most widely used renal replacement therapy globally1. The dialyzer used in hemodialysis treatment is one of the important determinants of the effectiveness of dialysis 2. Three general types of dialysis membranes are available for hemodialysis procedure: unmodified cellulose (low flux; namely “bio incompatible” membranes), modified/regenerated cellulose (low flux or high flux; namely, “relatively biocompatible”), and synthetic membrane (low flux or high flux; namely “relatively biocompatible”). This study investigates the high flux versus low flux membranes for adequacy of hemodialysis. A total of 40 patients were included in the study of which 28 were males (60%). The mean age of the patients was 42 years. The mean Kt/V was 1.3 ± 0.3 in high flux membrane and 1.2 ± 0.2 in low flux membrane hemodialysis whose differences were statistically significant (P=0.05). The mean of URR was 64.2 ± 10.3 in high flux membrane and 61.1 ± 9.8 in low flux membrane HD whose differences were also statistically significant (P=0.05).