Low Flow Velocity Research Articles

Features of portal hemodynamics in patients with fatty liver disease: mechanisms of formation, clinical significance

There are few data in the literature on the state of portal and hepatic blood flow in patients with fatty liver disease, and portal hemodynamics at the pre-cirrhotic stage is practically not covered. The aim of the study was to study the features of portal hemodynamics in patients with fatty liver disease at the pre-cirrhotic stage. Materials and methods. The study included 43 patients (25 - patients with fatty liver disease and 18- a comparison group who applied to outpatient clinics of therapeutic profile aged 18-89 years (41.9% of men, 58.1% of women). The average age of the patients was 45.1± 19.4 years. Criteria for inclusion in the study: age 18 years and older; presence of fatty liver disease associated with metabolic conditions. Criteria for not being included in the study: the presence of viral hepatitis, alcoholic liver disease, autoimmune liver diseases, pregnancy, lactation, taking any medications, narcotic drugs, the presence of acute or exacerbation of chronic diseases. The anthropometric indicators of patients were evaluated: waist circumference (OT), body mass index (BMI), steatotic indices (St-index, Fatty Liver Index), liver fibrosis index (Fib 4). Portal hemodynamics was assessed using ultrasound Dopplerography on a Philips Affiniti 50 device. Sensor C5-1. The following criteria were evaluated: vessel diameter (mm), its cross-sectional area (PPP, cm2), time-averaged maximum velocity (TAMX, cm/s), time-averaged average blood flow velocity (TAV, cm/s), Doppler perfusion index was calculated using the formula: V vol SPA / V vol SPA + V vol BB), the stagnation index was calculated using the formula: PPP/TAV. The results obtained. In patients with fatty liver disease, structural and hemodynamic shifts in the portal blood flow system are recorded: an increase in the diameter of the portal and inferior vena cava, a larger cross-sectional area, a low time-averaged maximum blood flow velocity and time-averaged average blood flow velocity, an increase in the stagnation index for these vessels, which reflects the process of remodeling the liver as a target organ in fatty liver disease and its vascular bed, forming a “stagnant liver”. Patients have lower values of the time-averaged average blood flow rate through the splenic vein, which indicates the initiation of collateral blood flow. Portal hemodynamics indicators correlate with metabolic parameters (anthropometric characteristics of patients (OT, BMI), steatotic indices (St index, FLI), but not with the liver fibrosis index (Fib 4). These hemodynamic features at the pre-cirrhotic stage of the disease, correlating with the severity of metabolic disorders, exacerbate structural changes in the liver and necessitate their correction in patients with fatty liver disease.

Numerical study on hydrodynamic characteristics of deep sea microfluidic eel energy capture device

Ocean current energy is a stable, reliable, and highly predictable renewable energy source. The effective development of ocean current energy conversion technology is beneficial in addressing the issue of power shortage. However, the majority of current velocities worldwide are below 1.5 m/s, limiting the feasibility of using conventional current energy capture devices. This paper presents a vortex induced vibration based deep sea microfluidic eel energy capture device (VIV-EEL) designed to efficiently harness energy in low-speed current environments. The system employs Computational Fluid Dynamics (CFD) to develop a series of computational models that couple underwater multibody fluid-solid interactions. These models are subsequently validated through experiments. The study analyzed the flow field of VIV-EEL under different working conditions and discussed the impact of several dimensional parameters of the elastically supported cylinders, structural parameters of raft plates, and flow velocity on the hydrodynamic performance. The results demonstrate that the energy capture efficiency of VIV-EEL is enhanced by the vorticity vibration effect. It is evident that there exists an optimal radius size for the elastic support column to achieve the most favorable resonance effect in the flow field of VIV-EEL. The energy capture characteristics of the raft plate show a linear relationship with its structural parameters, enabling quantitative design according to the requirements of the power take-off system (PTO). Moreover, VIV-EEL exhibits a lower start-up flow velocity compared to traditional current energy capture devices, enabling it to initiate and capture energy at a flow rate of 0.3 m/s. This innovative solution offers technical support for efficient low-speed current energy capture.

Experimental Study of Non-Darcian Flow Characteristics in Low-Permeability Coal Pillar Dams.

The safe operation of underground reservoirs and environmental protection heavily rely on the water flow through coal pillar dams in coal mines. Meanwhile, research on the flow characteristics in coal pillar dams has been limited due to their low hydraulic conductivity. To address this gap, this study assembled a novel seepage experimental device and conducted a series of carefully designed seepage experiments to examine the characteristics of low-permeability in coal pillar dams. The experiments aim to explore the relationship between water flux and hydraulic gradient, considering varying core lengths and immersion times. Flow parameters were determined by fitting observed flux-gradient curves with predictions from both Darcy and non-Darcian laws. Several significant results were obtained. First, a noticeable non-linear relationship between water flux and hydraulic gradient was observed, particularly evident at low flow velocities. Second, the non-Darcy laws effectively interpreted the experimental data, with threshold pressure gradients ranging 13.60 to 58.64 for different core lengths. Third, the study established that water immersion significantly affects the flow characteristics of coal pillar dams, resulting in an increased hydraulic conductivity and flow velocity. These findings carry significant implications for the design of coal pillar dams within underground coal mine reservoirs, providing insights for constructing more stable structures and ensuring environmental protection.

Remodeling of extracranial veins and venous-arterial imbalance in extrinsic stenosis and hypoplasia of the internal jugular veins

The aim of the study was to compare hemodynamic parameters, the sequence of remodeling of the jugular and extrajugular outflow tracts of cerebral venous circulation in extrinsic stenosis and hypoplasia of the internal jugular vein (IJV). Material and methods. Groups with external compression and IJV stenosis (n = 50), with IJV hypoplasia (n = 27), and after IJV ligation/resection (n = 6) as a model of IJV occlusion with a minimal cerebral venous insufficiency and venous encephalopathy and control group (n = 31) were compared. All patients underwent a neurological examination, ultrasound duplex scanning of the IJV (J2 and at the level of stenosis), common carotid and vertebral artery (V2), 2DToF or 3DToF magnetic resonance venography of the neck veins. The degree of stenosis of the IJV, the crosssectional area and the time average blood flow velocity, the calculated indicator of the venous-arterial balance (VAB) were determined according to the modified formula. Results and discussion. In the group of external compression of the IJV, stenosis averaged 64.52 %. The area of the IJV at the site of stenosis was 6 times, and at the standard place (J2) – 3 times less than the area of the opposite IJV. The hypoplastic IJV throughout its entire length (from J1 to J3) had the same area (0.21 ± 0.12 cm2 ), smooth contours, without local expansions or narrowings. A very low blood flow velocity (10.2 ± 11.67 cm/s) is characteristic for stenosis, in contrast to the normal velocity in the hypoplastic vein and in the control group. The blood flow velocity in the contralateral IJV with external stenosis does not differ from normal, but it is increased with hypoplasia (34.62 ± 12.23 cm/s). With MR venography, it is possible to detect a stenosing factor, symptoms of a filling defect, a decrease or loss of a blood flow signal, and an assessment of the overall picture of remodeling of the venous network of the neck. A decrease in the IJV area on the side of the lesion/anomaly corresponds to negative remodeling, while an expansion of the opposite IJV corresponds to positive remodeling. If the obstruction persists, the homolateral, then the contralateral external jugular vein expands, then the vertebral veins and plexuses, spinal epidural veins, anterior jugular and posterior cervical veins expand too. The magnitude of the IJV on the side of the anomaly/pathology with hypoplasia did not differ from the value with stenosis (9 %), but was slightly less than on the opposite IJV (53.39 ± 13.40 and 67.24 ± 18.02 %, respectively, p < 0.06) and significantly less compared to the control (24.16 ± 8.06 % on the left and 33.15 ± 8.27 % on the right, p < 0.0001), which makes this indicator a good additional criterion for outflow abnormality according to the IJV of one side.

Effect of movability of water on the low-velocity pre-Darcy flow in clay soil

Water seepage in soil is a fundamental problem involving various scientific and engineering fields. According to the literature, low-velocity water seepage in low-permeability porous media, such as clay, does not follow Darcy's law, also known as pre-Darcy flow. The formation of immovable water due to water adsorption on the pore wall is believed to be responsible for the formation of pre-Darcy flow. However, this view lacks direct solid evidence. To investigate the pre-Darcy water flow in clay, head permeability experiments are conducted on six clay samples with different densities. The results indicate that water seepage in clay at low hydraulic gradients does not follow Darcy's law. A clear nonlinear relationship between flow velocity and hydraulic gradient is observed. Water flow in clay can be divided into the pre-Darcy flow and Darcy flow regions by the critical hydraulic gradient, which is 10–12 for the Albic soil with dry density between 1.3 g/cm3 and 1.8 g/cm3. According to the disjoining pressure theory, immovable water due to water adsorption on the pore wall is the primary reason for water flow deviating from Darcy's law in clay. The results indicate that the percentage of movable water ranges from 39.7% to 59.3% for the six samples at a hydraulic gradient of 1. As the hydraulic gradient increases, the percentage of moveable water also increases. Additionally, there is a strong correlation between the percentage of movable water and the variation in hydraulic conductivity with the hydraulic gradient. Furthermore, a quantitative relationship between the percentage of movable water and the hydraulic conductivity has been established. The results of this study suggest that water adsorption on the pore wall not only affects the water movability, but is also closely related to the pre-Darcy flow phenomenon in clay.

Numerical simulation of diesel particulate filter flow characteristics optimization: From the perspective of pore structure parameters and inlet velocity

The diesel particulate filter (DPF) with porous media structure has become an essential component for diesel engines to satisfy increasingly strict emission standards. This study constructed a porous media structure model of DPF, and optimized its boundary to conduct a simulation on the flow characteristic with different influencing parameters using the lattice Boltzmann method (LBM). Results showed that the increase of the average flow velocity of the DPF model reduced the pressure drop, indicating that the flow probability of model improved. In addition, the porosity application range was expanded. The visualization and quantization of the velocity and pressure distribution with the DPF revealed that an increase of the wall thickness resulted in a higher pressure drop of the DPF, but a lower flow velocity. Further, the fractal dimension of the porous media exhibited no direct relationship with the DPF pressure and velocity performance; however, the outlet velocity and pressure drop of the model were optimized within the different porosity. Moreover, both the increase in the spectral dimension and model optimization improved the DPF permeability. The impact of increasing the inlet velocity on the pressure drop was particularly significant as it accelerated the rate of pressure drop, illustrating that a smoother porous media boundary was conducive to improve the flow performance of DPF, which facilitated a better scheme for the design of DPF porous media.

Effect of field viscometer dial readings on the estimation of drilling fluid frictional pressure loss using Herschel–Bulkley model

The main objective of this study is to investigate how uncertainties in dial readings would affect the frictional pressure loss estimation of the flow of drilling fluid in drill pipe. In this study, a new calculation procedure for determination of frictional pressure loss using the Herschel–Bulkley model is presented and verified with experimental data. A Monte Carlo simulation study is conducted to investigate the sensitivity of each dial reading on the estimation of frictional pressure drop for different circulation velocities. The results show that for the low yield fluids, 1o dial reading error introduces more than 6% error to the frictional pressure gradient prediction, especially at low flow velocity. While the errors in dial readings result in much smaller error in pressure gradient estimation for fluids with high yield stress, typically less than 5%. In addition, the readings at lower rotational speeds, i.e., 3 and 6 RPM, have a significant effect on the estimation of the frictional pressure loss, especially for low flow velocity and low yield stress fluids. More importantly, the uncertainty in dial readings has less effect on the frictional pressure drop estimation at moderately high flow velocity. This research also emphasizes the importance of rheological model parameter estimation using all available dial readings with the assistance of computational tools to better capture the rheological response of drilling fluids for better hydraulic calculation.

Study on the effect of wall roughness on the flow characteristics of liquid film in airflow

During the flight, water flows under the action of shear force to form the overflow liquid film and freezes to form overflow ice. Overflow ice will change the aerodynamic shape of the aircraft and affect the safety and stability. In this paper, the three-dimensional structure of the liquid film in airflow was measured transiently with the digital image projection technology. The effects of different flat wall roughnesses, airflow velocities, and liquid film flow rates on the flow characteristics of the liquid film were analyzed. The experimental results show that the lower the wall roughness, the more pronounced the liquid film contraction toward the central axis. When the liquid flow rate drops to 0.228 l/min, the continuous liquid film transforms into rivulets on the surface of a large contact angle or low roughness. The average thickness of the liquid film on the flat is greater than that on the rough flat at low airflow velocity and low liquid flow rate, but smaller than that on the rough flat at high airflow velocity and high liquid flow rate. The wave near the inlet has an obvious acceleration process, and after reaching the peak speed, it gradually decreases and stabilizes near a certain value. The smoother the surface, the faster the acceleration of the wave at the inlet, and the greater the final stable wave speed.

Very short time Fourier transform for turbulent analysis

Nominally stationary acoustic sensors, e.g., buoy suspended or bottom anchored, are subject to various environmental flows. Direct numerical simulation of hydrodynamic flow around the acoustic sensor housing show turbulence along the housing surface. Time-space analysis of pressure variation along the surface of the housing shows significant acoustic-like surface interaction at low frequencies, even at very low mean flow velocity. In this case turbulence manifests as intermittently generated, irregular, coherent vortex structures that separate from the surface of the housing and advect downstream. These structures drive rapid surface pressure transients that propagate within the housing to the acoustic sensors as noise. Fractional Fourier Analysis provides joint time-frequency methods to extract transient features of turbulence. Use of Hermite-Gauss functions and phase relations are of particular interest. [This research is supported by 6.2 NRL base program sponsored by the Office of Naval Research. Distribution Statement A: Approved for public release. Distribution unlimited.]

Revealing Multiple Nested Molecular Outflows with Rotating Signatures in HH270mms1-A with ALMA

We present molecular line observations of the protostellar outflow associated with HH270mms1 in the Orion B molecular cloud with ALMA. The 12CO (J = 3−2) emissions show that the outflow velocity structure consists of four distinct components of low (≲10 km s−1), intermediate (∼10–25 km s−1) and high (≳40 km s−1) velocities in addition to the entrained gas velocity (∼25–40 km s−1). The high- and intermediate-velocity flows have well-collimated structures surrounded by the low-velocity flow. The chain of knots is embedded in the high-velocity flow or jet, which is the evidence of episodic mass ejections induced by time-variable mass accretion. We could detect the velocity gradients perpendicular to the outflow axis in both the low- and intermediate-velocity flows. We confirmed the rotation of the envelope and disk in the 13CO and C17O emission and found that their velocity gradients are the same as those of the outflow. Thus, we concluded that the velocity gradients in the low- and intermediate-velocity flows are due to the outflow rotation. Using observational outflow properties, we estimated the outflow launching radii to be 67.1–77.1 au for the low-velocity flow and 13.3–20.8 au for the intermediate-velocity flow. Although we could not detect the rotation in the jets due to the limited spatial resolution, we estimated the jet launching radii to be (2.36–3.14) × 10−2 au using the observed velocity of each knot. Thus, the jet is driven from the inner disk region. We could identify the launching radii of distinct velocity components within a single outflow with all the prototypical characteristics expected from recent theoretical works.

Flame visualization and spectral analysis of combustion instability in a premixed methane/air-fueled micro-combustor

The present study experimentally explores the combustion instability characteristics of premixed methane/air flames in a planar micro-combustor by utilizing the high-speed camera and the noise data acquisition system. It aims to identify the sound pressure fluctuation of unstable flames and shed light on the relationship between flame structure and thermoacoustic instability under micro-scale conditions. Four types of flame structures, i.e., flame with repetitive extinction and ignition (FREI), weak flame, steady flame, and oscillating flame, are experimentally observed by varying operating parameters. Among them, the weak flame at low flow velocities and the oscillating flame at high flow velocities form thermoacoustic oscillation. For weak flames, the collision with the wall and the local deformation of the flame result in high-frequency harmonics. Varying the inlet velocity from 0.14 m/s to 0.15 m/s leads to the pressure fluctuation of the weak flame being reduced by 10 Pa, and the dominant frequency being changed from 125 Hz to 167 Hz. As for oscillating flame, the variation of the inlet velocity plays a decisive role in the sound pressure fluctuation. At the equivalence ratio of 0.7, an increase of 0.01 m/s in the inlet velocity reduces the pressure fluctuation by 4 Pa.

Investigation on the thermal-fluidic characteristics of ice slurry in sinusoidal corrugated plate heat exchangers

The sinusoidal plate heat exchangers (SCPHEs) using ice slurry as coolant have a critical role for building air conditioning. However, the thermal-hydraulic properties of ice slurry in SCPHEs are still unclear. Therefore, its flow and heat transfer performances in SCPHEs are studied using Euler-Euler model in this paper. The results show that with increasing corrugation pitch (P), the velocity of the mainstream direction and the flow dead zone decrease. As enlarging the corrugation amplitude (H), the low-velocity flow zone and flow dead zone increase. The average resistance coefficient (fave) of ice slurry reduces with increasing P and volume flow rate. When volume flow rate is between 0.144 m3/h and 1.44 m3/h, fave decreases more significantly than other stages. In addition, fave increases with increasing H and ice concentration (αin). The mass transfer of ice particles is increased at higher H and smaller P. The average Nusselt number (Nuave) of ice slurry, heat transfer rate (Qw) and total heat transfer coefficient (U) of SCPHEs increase as enlarging H, αin and volume flow rate, and decrease with increasing P. While the U and Qw are less affected by ice particle concentration. In addition, the empirical correlations of fave and Nuave in SCPHEs are developed.

The effect of groyne field on trapping macroplastic. Preliminary results from laboratory experiments

Macroplastic, a precursor of microplastic pollution, has become a new scope of research interest. However, the physical processes of macroplastic transport and deposition in rivers are poorly understood, which makes the decisions of where to locate macroplastic trapping infrastructure difficult. In this research, we conducted a series of experiments in a laboratory channel, exploring the impact of groynes and flexible artificial vegetation on the floating macroplastic litter. The goal was to investigate the litter paths with different obstruction arrangements, which was done by implementing a particle tracking technique on video recordings from each experimental run. We found that increasing discharge correlated with the number of plastic litter floating into the recirculation zone within the groyne fields, especially if the upstream groyne had an extended length. This produced a strong mixing interface between the main flow and the groyne field, while a vegetation patch added in the same groyne field changed the paths of plastic litter by deflecting the flow. We noticed that during a moderate discharge rate, the litter pieces flowing into the groyne field with the vegetation circulated there for the longest period, and some of them got entangled between floating stems when discharge was at its lowest. This phenomenon points to the conclusion that low flow velocity paired with the presence of vegetation can be a primer for plastic deposition and consequently, its degradation. The insights from the experiment allowed us to recommend a place downstream of an extended groyne as the desirable (efficient) area for installing a plastic trapping infrastructure or conducting plastic cleaning actions.

Superb Microvascular Imaging in Pediatric Focal Nodular Hyperplasia.

To investigate superb microvascular imaging (SMI), a novel Doppler ultrasound technique that can visualize low-velocity microvascular flow, for assessing pediatric focal nodular hyperplasia (FNH). Nine FNH lesions in 6 patients were enrolled. On SMI and color Doppler imaging (CDI), intralesional vascularity was assessed visually and categorized as typical spoke-wheel pattern (central vessel radiating from the center to the periphery), multifocal spoke-wheel pattern, and nonspecific pattern. We compared the vascular features of the lesions between SMI and CDI and evaluated vascular patterns according to lesion size. In terms of vascularity pattern, the typical spoke-wheel pattern of FNH was noted more frequently on SMI (67%) than on CDI (11%; P < 0.05). In addition, a multifocal spoke-wheel pattern was noted in all remaining lesions (33%) on SMI. On the contrary, a nonspecific vascular pattern was detected in the majority (78%) of CDI. Regarding the lesion size and vascularity on SMI, the typical spoke-wheel pattern was seen more frequently in the small FNH group than in the large FNH group. The intralesional vascular signal was detected more frequently on SMI (100%) than on CDI (89%). SMI is feasible in evaluating FNH in children and has a greater ability to demonstrate the spoke-wheel pattern than CDI.

Ultrasonography monitoring with Superb Microvascular Imaging during cerebrovascular surgery

IntroductionUltrasonography (US) is used as a real-time dynamic imaging modality during neurosurgery. A novel Doppler US technique, Superb Microvascular Imaging (SMI), can be used to visualize low-velocity flow of small vessels at high resolution with high frame rates. We visualized vessel flow using this US SMI technique and contrast agent during cerebrovascular surgery. MethodsForty-three patients with an unruptured cerebral aneurysm (control), ischemic and hemorrhagic moyamoya disease, carotid artery stenosis, hemangioblastoma, severe stenosis of the middle cerebral artery, venous angioma, and intracerebral hemorrhage (ICH) underwent neurosurgery with US SMI monitoring using a contrast agent. The diameter, length, and number of penetrating vessels were analyzed in patients with an unruptured cerebral aneurysm (control), moyamoya disease, and ICH. ResultsDiameter and length of cerebral penetrating vessels were significantly increased in patients with moyamoya disease and ICH compared to control patients. The number of penetrating vessels was increased in moyamoya disease patients compared to control and ICH patients. In hemorrhagic moyamoya disease, flow in the penetrating vessels originated from a deep periventricular point and extended to the cerebral surface. Pulsatile cerebral aneurysms during clipping surgery and carotid artery stenosis during carotid endarterectomy were easily identified by SMI. Drastically increased vessel flow in patients with a hemangioblastoma or a venous angioma was observed. ConclusionUsing the US SMI technique and contrast agent, we obtained useful flow information of the vascular disease structure and intracerebral deep small vessels during cerebrovascular surgery. Further quantitative analysis will be informative and helpful for cerebrovascular surgery.

Simulation Analysis and Experimental Study on Airfoil Optimization of Low-Velocity Turbine

By combining computational fluid dynamics (CFD) and surrogate model method (SMM), the relationship between turbine performance and airfoil shape and flow characteristics at low flow rate is revealed. In this paper, the flow velocity tidal energy airfoil model is designed based on the Kriging model, and the original airfoil with a relative thickness of 12% and a relative curvature of 2.5% is obtained. The parameter optimization is carried out by setting the 4th CST equations through the surrogate model; the maximum lift-drag ratio is the optimization goal, the optimization design variable is 10, the maximum number of iterations is 100, and the maximum number of sub-optimization iterations is 200. The results show that the hydrodynamic performance of the airfoil with thinner thickness and more curvature is better, the maximum thickness part is shifted forward by 4.58%, and the lift-drag ratio is improved by 4.03%. The flow field and the efficiency are more stable, which provides an engineering reference for the optimal design of hydraulic turbine airfoils under low flow velocity. It supplements the research on the performance of turbine blades in low velocity.

Plasma Actuators Based on Alumina Ceramics for Active Flow Control Applications

Plasma actuators have demonstrated great potential for active flow control applications, including boundary layer control, flow separation delay, turbulence control, and aircraft noise reduction. In particular, the material used as a dielectric barrier is crucial for the proper operation of the device. Currently, the variety of dielectrics reported in the literature is still quite restricted to polymers including Kapton, Teflon, poly(methyl methacrylate) (PMMA), Cirlex, polyisobutylene (PIB) rubber, or polystyrene. Nevertheless, several studies have highlighted the fragilities of polymeric dielectric layers when actuators operate at significantly high-voltage and -frequency levels or for long periods. In the current study, we propose the use of alumina-based ceramic composites as alternative materials for plasma actuator dielectric layers. The alumina composite samples were fabricated and characterized in terms of microstructure, electrical parameters, and plasma-induced flow velocity and compared with a conventional Kapton-based actuator. It was concluded that alumina-based dielectrics are suitable materials for plasma actuator applications, being able to generate plasma-induced flow velocities of approximately 4.5 m/s. In addition, it was verified that alumina-based ceramic actuators can provide similar fluid mechanical efficiencies to Kapton actuators. Furthermore, the ceramic dielectrics present additional characteristics, such as high-temperature resistance, which are not encompassed by conventional Kapton actuators, which makes them suitable for high-temperature applications such as turbine blade film cooling enhancement and plasma-assisted combustion. The high porosity of the ceramic results in lower plasma-induced flow velocity and lower fluid mechanical efficiency, but by minimizing the porosity, the fluid mechanical efficiency is increased.

Polarity switch of PMMA powder transported through a PMMA duct

During pneumatic conveying, powder electrifies rapidly due to the high flow velocities. In our experiments, the particles even charge if the conveying duct is made of the same material, which might be caused by triboelectrification between two asymmetric contact surfaces. Surprisingly, we found the airflow rate to determine the polarity of the overall powder charge. This study investigates the charging of microscale PMMA particles in turbulent flows passing through a square PMMA duct. The particles are spherical and monodisperse. A Faraday at the duct outlet measured the total charge of the particles. At low flow velocities, the particles charged negatively after passing through the duct. However, the powder’s overall charge switched to a positive polarity when increasing the flow velocity.

Determinants and Prognoses of Visual-Functional Mismatches After Mechanical Reperfusion in ST-Elevation Myocardial Infarction.

Discordance between the anatomy and physiology of the coronary has important implications for managing patients with stable coronary disease, but its significance in ST-elevation myocardial infarction has not been fully elucidated. The retrospective study involved patients diagnosed with ST-elevation myocardial infarction (STEMI) who underwent percutaneous coronary intervention (PCI), along with quantitative coronary angiography (QCA) and quantitative flow ratio (QFR) assessments. Patients were stratified into four groups regarding the severity of the culprit vessel, both visually and functionally: concordantly negative (QCA-diameter stenosis [DS] ≤ 50% and QFR > 0.80), mismatch (QCA-DS > 50% and QFR > 0.80), reverse mismatch (QCA-DS ≤ 50% and QFR ≤ 0.80), and concordantly positive (QCA-DS > 50% and QFR ≤ 0.80). Multivariable logistic regression analyses were conducted to identify the clinical factors linked to visual-functional mismatches. Kaplan‒Meier analysis was conducted to estimate the 18-month adverse cardiovascular events (MACE)-free survival between the four groups. The study involved 310 patients, with 68 presenting visual-functional mismatch, and 51 exhibiting reverse mismatch. The mismatch was associated with higher angiography-derived microcirculatory resistance (AMR) (adjusted odds ratio [aOR]=1.016, 95% CI: 1.010-1.022, P<0.001). Reverse mismatch was associated with larger area stenosis (aOR=1.044, 95% CI: 1.004-1.086, P=0.032), lower coronary flow velocity (aOR=0.690, 95% CI: 0.567-0.970, P<0.001) and lower AMR (aOR=0.947, 95% CI: 0.924-0.970, P<0.001). Additionally, the mismatch group showed the worst 18-month MACE-free survival among the four groups (Log rank test p = 0.013). AMR plays a significant role in the occurrence of visual-functional mismatches between QCA-DS and QFR, and the mismatch group showed the worst prognosis.

Flow velocity and light intensity combination is important for Microcystis aeruginosa physical suppression.

The cyanobacterial response to flow velocity or light intensity deviates from the combined effect of both factors. The responses of Microcystis aeruginosa to different combinations of flow velocities and light intensities were tested. Growth (OD730 and protein), stress (catalase, ascorbate peroxidase, and glutathione peroxidase), and photosynthetic ability (chlorophyll-a and fluorescence) parameters of M.aeruginosa were measured to evaluate the effects of different combinations. Exposure to different flow velocity-light combinations significantly affected the growth and physiology of M.aeruginosa. Flow velocities of 0.4m s-1 showed a prominent influence on most of the measured parameters compared with no flow velocity or higher flow velocity conditions. The 1.2-m s-1 flow velocity and high light intensity (1200 μmol m-2 s-1 ) exposure caused a significant elevation in oxidative stress. Lower velocities are beneficial for M.aeruginosa at light stress, whereas extreme velocities are adverse and elevate the stress. Two categories of light-velocity combinations were identified as preferred and extreme categories, depending on whether they suppressed or supported M.aeruginosa growth. In controlling cyanobacteria blooms using flow or high-intensity light, it is imperative to consider the interaction of these two factors, as their combined effects can significantly vary the stress levels in cyanobacteria. A new system, designed to minimize mechanical damage on M.aeruginosa, was used to generate flow velocities. Additionally, the combined effects of flow velocities and light intensities have been considered for the first time. PRACTITIONER POINTS: Flow velocity can influence the effect of light on Microcystis aeruginosa. High light exposure effect on Microcystis aeruginosa can be reduced by low flow velocity. High flow velocity and high light exposure increase the stress on Microcystis aeruginosa. Different light intensities and flow velocity combinations changed Microcystis aeruginosa stress physiology.