Low Filtration Research Articles

XPS, structural and antimicrobial studies of novel functionalized halloysite nanotubes

A novel robust preparation method based on thermal salt decomposition has been elaborated for synthesis of halloysite nanotubes (HNTs) impregnated with silver and iron oxide nanoparticles. The developed method is simple, time-effective, and can be employed for large scale material fabrication. Different characterization techniques, including X-ray diffraction (XRD), scanning and transmission electron spectroscopy (SEM and TEM) and energy dispersive X-ray spectroscopy (EDS) have been used to characterize the functionalized HNTs composite materials. Surface elemental and chemical state analysis was conducted using X-ray photoelectron spectrometer (XPS). The functionalized HNTs exhibit enhanced total surface area (by 17.5%) and pore volume (by 11%) compare to the raw HNTs calculated by using the Brunauer–Emmett–Teller (BET) method. It was shown that functionalized HNTs possess high antimicrobial properties towards both gram- positive and gram-negative bacteria species. The enhanced surface area and bactericidal properties of functionalized HNTs could be beneficial for employing of the prepared material as low cost filtration media for water treatment applications. Molecular dynamics (FPMD) were performed to obtain insights about possible physiochemical mechanisms for chemical adsorption and on the HNT thermal stability.

Performance of polycarbonate, cellulose nitrate and polyethersulfone filtering membranes for culture-independent microbiota analysis of clean waters

Demineralized and disinfected waters may have very low microbial loads, requiring that large volumes of water are filtered to recover enough biomass for further analysis. Extended filtration periods, often interrupted by clogging, are a major limiting factor to concentrate samples’ microbiota for further examination, besides hindering the work pace. In this study, we investigated the performance of three types of filtering membranes – polycarbonate (PC), cellulose nitrate (CN), and polyethersulfone (PES) with 0.22 µm pore size for culture-independent microbiological analysis (quantitative PCR of seven housekeeping and integrase genes) of tap water, recirculating tap water in a bottle washing loop, and of demineralized water. Compared to PC membranes, CN or PES required lower filtration periods, although had slightly lower DNA extraction yields. However, genes abundance per volume of water was, in general, not significantly different. The exception was observed for bottle washing water in which PC membranes supported significantly higher quantification values than PES membranes. These differences were lower than ∼ 0.5 log-units and did not hamper the distinction of the types of water based on genes profile. Also, the type of membrane did not significantly affect the profile of the bacterial community determined for tap and demineralized water. A major conclusion is that CN membranes, cheaper, allowing shorter filtration periods, and producing results that are not significantly different from those obtained with PC or PES, can be a good alternative to analyze waters with low biomass loads.

Binary Polyamide-Imide Fibrous Superelastic Aerogels for Fire-Retardant and High-Temperature Air Filtration.

Fibrous air filtration materials are highly desirable for particle removal from high-temperature emission sources. However, the existing commercial filter materials suffer from either low filtration efficiency or high pressure drop, due to the difficulty in achieving small fiber diameter and high porosity simultaneously. Herein, we report a facile strategy to fabricate mechanical robust fibrous aerogels by using dual-scale sized PAI/BMI filaments and fibers, which are derived from wet spinning and electrospinning technologies, respectively. The creativity of this design is that PAI/BMI filaments can serve as the enhancing skeleton and PAI/BMI fibers can assemble into high-porosity interconnected networks, enabling the improvement of both mechanical property and air filtration performance. The resultant dual-scale sized PAI/PBMI fibrous aerogels show a compressive stress of 8.36 MPa, a high filtration efficiency of 90.78% (particle diameter of 2.5 μm); for particle diameter over 5 μm, they have 99.99% ultra-high filtration efficiency, a low pressure drop of 20 Pa, and high QF of 0.12 Pa-1, as well as thermostable and fire-retardant properties (thermal decomposition temperature up to 342.7 °C). The successive fabrication of this material is of great significance for the govern of industrial dust.

Predictors of change in hypoglycemia unawareness among patients with type 1 diabetes.

To analyse predictors of hypoglycemia unawareness (HU) and improvement in Clarke score in clinical practice. We retrospectively identified patients with type 1 diabetes (T1D) at an academic T1D clinic who completed HU surveys 6-12months apart. HU (Clarke score ≥4) and improvement in Clarke score (decrease by ≥1 point or more clinically relevant ≥2 point) were assessed in univariable relationships and using multivariable logistic regression. Of the 300 participants, median diabetes duration was 19years, 47 had HU at baseline, and 91 had an improvement by 1 point while 21 had an improvement by 2 points. Patients with baseline Clarke score ≥4 who had ≥1 or ≥2 point improvement had lower filtration rate (eGFR) than those who did not. After adjustment for other variables, gender (male OR 0.33, 95% CI 0.15, 0.74), log diabetes duration (OR 6.40, 95% CI 2.84, 14.5), and eGFR <60ml/min/1.73m2 (5.56, 95% CI 1.98, 15.6) were independent predictors of baseline HU. Continuous glucose monitoring use (OR 2.04, 95% CI 1.20, 3.48) and log diabetes duration (OR 1.78, 95% CI 1.22, 2.60) were independent predictors of 1 point improvement and eGFR <60ml/min/1.73m2 (OR 10.5, 95% CI 3.64, 30.0) and an education visit (OR 2.64, 95% CI 1.01, 6.89) were independent predictors of 2 point improvement in Clarke score. Diabetes duration, gender, and eGFR were independent predictors of HU. Improvement in Clarke score is possible in patients with long-standing T1D, underscoring the need for additional study.

Study of a High-Temperature and High-Density Water-Based Drilling Fluid System Based on Non-sulfonated Plant Polymers.

The environment-friendly water-based drilling fluid system developed for the petroleum development industry cannot successfully withstand temperatures up to 180 °C, and most high temperature-resistant additives with sulfonic acid groups that have been successfully applied to water-based drilling fluid are not good for environmental protection. In order to solve the above technical problems, a non-sulfonated filtrate reducer and viscosity reducer with resistance to high temperature were prepared by using humic acid, lignin and a multifunctional monomer as raw materials. In laboratory experiments, the molecular weights of the FLO-H filtrate reducer and the VR-H viscosity reducer were 5.45 × 105 g/mol and 8.51 × 103 g/mol, respectively, and all of them showed good high-temperature resistance. The API filtration loss of the bentonite-base slurry with 3.0 wt% FLO-H was only 6.2 mL, which indicated that FLO-H had a prominent reduction in filtration loss after aging at high temperature. When the dosage of VR-H was 1.0 wt%, the plastic viscosity of the water-based drilling fluid after aging at 200 °C decreased from 71 mPa·s to 55 mPa·s, which provided excellent dispersion and dilution. The high-temperature and high-density water-based drilling fluid containing the FLO-H filtrate reducer and the VR-H viscosity reducer had good suspension stability and low filtration performance at the high temperature of 200 °C, which can meet the requirements of high-temperature deep well drilling.

An improved algorithm for three-dimensional reconstruction of nonwoven microstructures by using multi-focus images

The filtration performance of nonwovens, such as virus protection and air purification, depends largely on their microstructure, that is, their internal structure. With the development of manufacturing techniques, nonwovens can be produced with complex microstructures to deliver low air resistance and high filtration efficiency. Therefore, it seems important to reconstruct an accurate three-dimensional (3D) model to describe the various microstructures for performance evaluation and product development. Multi-focus image fusion is one of the most effective ways used for the 3D nonwoven reconstruction. However, the overlapping and crossing of fibers in multi-focus images taken on an optional microscope make 3D fiber reconstruction incomplete and discontinuous. In this study, we developed a novel fiber segmentation and 3D nonwoven reconstruction algorithm to restore fiber continuity. The fiber web image was firstly thinned into the fiber mid-axis or skeleton, and fiber fragments were detected by searching the intersections. The features, such as the angle and depth, of each fiber fragment were obtained using Harris corner detection. A cluster technique was used to group the head-points of the fiber fragments that have similar features into one cluster. All fiber fragments in the same cluster are fitted with a polynomial curve to form a complete fiber in the 3D space. The experimental results show that this new method is suitable for the reconstruction of nonwovens with complex structures, such as fiber bonding or crossing, and can automatically detect and connect fiber fragments in 3D space. It provides an effective way for the subsequent simulation/evaluation of filtration characteristics.

The development a fully-balanced current-tunable first-order low-pass filter with Caprio technique

This paper presents the development and design of a fully-balanced current-tunable first-order low-pass filter with Caprio technique, which could include the design and implementation of a first-order low-pass filter circuits. The filter consists of six bipolar junction transistor (BJT) and a single capacitor. The filter construction uses a bipolar junction transistor (BJT) as the main device and a single capacitor. A fully-balanced current-tunable first-order low-pass filter with Caprio technique developed. The architecture of the circuit is quite simple and proportional, symmetrical with signs of difference. Circuits developed into integrated circuits act like basic circuits for frequency filter circuits, current modes with Caprio techniques, obtained by improving the first-order low-pass filter for signal differences with incoming impedances. Adjusting the parameters of the circuit with the caprio technique achieves the optimal parameter value for correcting the total harmonic distortion value.&#x0D; The results of testing the operation of the circuit, a fully-balanced current-tunable first-order low-pass filter with Caprio technique developed and designed using the PSpice program. The simulation results showed good results in line with predicted theoretical analysis. The sensitivity of the device to the center frequency (ω0) response is low and independent of variables, the angular frequency is linear with wide current adjustment throughout the sweeping range of a wide frequency range, with a wide range of over tree orders of magnitude. Therefore, fully-balanced current-tunable first-order low-pass filter developed is very suitable to apply various applications regarding low frequency signal filtration, for example in biomedical systems, for example.

Nanotechnology-Enhanced Face Masks: Future Scopes and Perspectives

The coronavirus disease 2019 pandemic has shown that a disposable surgical face mask is a good protective wall against infection due to its ability to prevent virus transmission from sick to healthy people. Nevertheless, these surgical masks are disposable, not ecofriendly, and are single-use items. The use and disposal of traditional masks lead to high secondary risks such as environmental pollution, pathogen transmission, overload demands, and user discomfort. Nanotechnology is one of the most investigated strategies to safely and economically reuse masks in the 21st century. These strategies are based on four key elements as follows: (1) super mechanical properties that give masks flexibility, durability, and good lifetime storage; (2) high thermal properties that give masks heat self-sterilization; (3) an electric charge controller that gives masks triboelectric (TE) filtration; and (4) response to the antimicrobial effect that stays in the mask before, during, and after safe use. These properties give new-generation masks the ability to remove the drawbacks of traditional surgical masks, such as microbial growth and low filtration efficiency. The graphene family has introduced the self-sterilization and TE effects of surgical masks. Silver nanoparticles have supported antimicrobial effects. Nanofiber membranes are fabricated to have a high surface area that improves the fiber diameter and porosity ratio. A traditional mask could only block a maximum of 50% of the exhaled viruses, but a nanofiber-based mask has been tested to intercept 90% to 99% of particle viruses while breathing during use. Complex nanocomposite materials have succeeded in collecting all these advantages.

SchoolVent pilot ventilation system with indirect adiabatic cooling and high efficiency filtering

Existing schools are badly insulated and often suffer from inadequate ventilation and cold in winter and too high temperatures in summer. Further schools nearby a busy road require high efficiency filtering, which traditionally lead to high pressure drops and installation noise. Current ventilation systems suitable for renovation often require expensive commissioning measurements and lack monitoring facilities during the use phase.With the development of the SchoolVent system we have solved these problems in an energy efficient manner. Core of the system is a balanced ventilation system with heat recovery. The heat exchanger is also used for indirect adiabatic cooling. For filtering a high efficiency and low pressure drop electrostatic filtration system is scaled up to 10.000 m3/hour. With this airflow 5 classrooms can be conditioned. The components have first been tested in the TNO laboratory. After that a pilot has been started on the Montessori Lyceum in Zeist. The main results of the monitoring during 2019/2020 are a heat recovery efficiency between 60 and 75%. With regard to the indoor climate class A of the “PvE Frisse scholen” has been achieved for summer and winter temperature and for CO2 concentration. With regard to filtration depending on the flowrate the specifications of an E10 – E11 filter have been obtained. In the climatized class rooms this lead to a 70 – 96% lower PM2.5 concentration compared to a reference classroom. The system has been further optimized with regard to installation costs and in 2021 another 14 classrooms are equipped with the SchoolVent system.

THE INFLUENCE OF THE GEOLOGICAL STRUCTURE OF THE TERRITORY ON THE FLOODING OF BUILDING BASEMENTS

The article deals with the construction of buildings in relatively shallow pits (up to 5 m), passed in the connected soils of water - glacial deposits with layers of sand and gravel material. It is noted that the features of these soils include the possibility of forming a sporadically developed aquifer in them with a very low filtration coefficient (less than 0.01 m/day). Due to this circumstance, this horizon is not always fixed in engineering and geological surveys and, as a result, is not always taken into account in the design. Therefore, in order to save money during construction, they are usually limited to the device of waterproofing the walls of the basement, and bulk material is used as soils for backfilling the sinuses of the pit. Thus, in the buried sinuses of the pit, an environment capable of accumulating water is formed. With the gradual filling of this tank, in conditions of impossibility of diverting water into the soil mass of the base, due to the low filtration coefficient and when creating appropriate pressure gradients, as well as in the presence of possible defects in waterproofing, there are stable leaks in the basements of buildings already ready for use. The article deals with the occurrence of such situations on a number of examples of erected buildings. The main sources of water supply to the buried sinuses of the pit are indicated and a number of practical measures are given to avoid such situations in the future.

Ceiling impact on air disinfection performance of Upper-Room Germicidal Ultraviolet (UR-GUV)

This study used Computational Fluid Dynamics (CFD) to investigate air disinfection for SARS-CoV-2 by the Upper-Room Germicidal Ultraviolet (UR-GUV), with focus on ceiling impact. The study includes three indoor settings, i.e., low (airport bus), medium (classroom) and high (rehearsal room) ceilings, which were ventilated with 100% clean air (CA case), 80% air-recirculation with a low filtration (LF case), and 80% air-recirculation with a high filtration (HF case). According to the results, using UR-GUV can offset the increased infection risk caused by air recirculation, with viral concentrations in near field (NF) and far field (FF) in the LF case similar to those in the CA case. In the CA case, fraction remaining (FR) was 0.48–0.73 with 25% occupancy rate (OR) and 0.49–0.91 with 45% OR in the bus, 0.41 in NF and 0.11 in FF in the classroom, and 0.18 in NF and 0.09 in FF in the rehearsal room. Obviously, UR-GUV performance in NF can be improved in a room with a high ceiling where FR has a power relationship with UV zone height. As using UR-GUV can only extend the exposure time to get infection risk of 1% (T1%) to 8 min in NF in the classroom, and 47 min in NF in the rehearsal room, it is necessary to abide by social distancing in the two rooms. In addition, T1% in FF was calculated to be 18.3 min with 25% OR and 21.4% with 45% OR in the airport bus, showing the necessity to further wear a mask.

Improving the Efficiency of Downhole Uranium Production Using Oxygen as an Oxidizer

The features occurring during borehole uranium mining in deposits with low filtration characteristics, as well as the conditions and reasons for the reduction of geotechnological parameters of uranium mining by the well are considered in this study. Core material samples were taken from the productive horizon of the Chu-Sarysui province deposit and granulometric compositions were established. The contents of uranium, aluminum, calcium, magnesium, iron and carbonate minerals in the samples were determined by atomic emission spectroscopy. The X-ray phase analysis method established the features and quantitative and qualitative characteristics of ore-containing minerals. A special technique has been developed for conducting experiments in laboratory conditions using core samples, where the intensity of uranium leaching in tubes is determined. The results of laboratory studies are analyzed and discussed and graphs are constructed, to show the dependencies of change in: the filtration coefficients of Kf; the uranium content in solution; the extraction coefficient; and the specific consumption of sulfuric acid on the values of L:S (the ratio of liquid to solid) in the experiments. The effectiveness of using a mild acidity regime, with the addition of oxygen as an oxidizer, is determined and shown. The values of the uranium content in the productive solution, with the addition of oxygen as an oxidizer, reached 220 mg/L, which exceeds the design parameters. The results of uranium extraction from ore show a positive trend, reaching 68%, with L:S from 1.7 to 3.0, low acidity values and the addition of oxygen as an oxidizer. The specific consumption of sulfuric acid reaches the minimum values when using leaching solutions with reduced acidity of 26 kg/kg. The obtained results, on the flow rate of the solution in the tube, the extraction of uranium from ore and the specific consumption of sulfuric acid, indicate a decrease in sedimentation in a porous medium and increased filtration characteristics, with reduced acidity values in the leaching solution.

Evaluating the filtration efficiency of close-coupled catalyzed gasoline particulate filter (cGPF) over the WLTC and simulated RDE cycles.

Gasoline particulate filter (GPF) is a cost-effective solution to particle number emissions from gasoline direct injection vehicles. Filtration efficiency, as a key parameter of GPF, was usually assessed at chassis level over regulatory drive cycles. However, the promulgation of real driving emission (RDE) requirements in the EU and Chinese regulations necessitates evaluations based on non-legislative cycles to guarantee the on-road emissions are compliant to regulatory requirements. In this research, two aggressive drive cycles, RTS95 at 23degC and modified RDE at 0degC, were complemented to the WLTC to evaluate the filtration efficiency of a catalyzed GPF (cGPF) in fresh conditions to obtain the so-called "worst-case" filtration efficiency. In the WLTC, RTS95, and simulated RDE tests, the filtration efficiency of the test cGPF was 51.1%, 41.3%, and 85.1% respectively. In the simulated RDE test, the test cGPF filtrated solid particles with a diameter above 23nm and 10nm at a similar efficiency. Increased filtration efficiency with heavier soot load could offset the relatively low filtration efficiency in cold-start and warm-up durations, hence the filtration efficiency for a clean cGPF showed higher sensitivity to cycle length over driving dynamics and testing temperature. In acceleration events with cGPF mounted, the particle diameter where number concentration peaked decreased as the engine warmed up. In deceleration events, bimodal and trimodal particle number size distributions with much lower concentrations were observed.

Dust collection efficiency of commercial gas collection tubes

Gas sampling tubes are essential tools for the evaluation of air quality in work environments. It adsorbs toxic gaseous matters onto the surface of various granular adsorbents, such as silica gel or activated carbon packed in a thin glass tube, for quantitative analysis by gas chromatography. Currently, most of the semi-volatile matters are evaluated via aerosol filtration or solid-phase gas adsorption depending on the main phase of the substances; however, only a few substances have a sampling protocol regarding both solid and gaseous phases. Therefore, semi-volatile components evaluated by the solid-phase adsorption may result in the underestimation of the component concentrations due to particulate components passing through and remaining in the adsorbent. To highlight issues on sampling of semi-volatile matters by the solid-phase adsorption method, the collection efficiency of aerosol particles by 17 commercial gas sampling tubes were measured via pressure drop. To measure the particle collection efficiency of the gas collection tubes, precise control and dilution of the aerosol particle monitors are essential. However, we cannot apply typical filter test methods at a lower filtration flow rate than that of the aerosol particles monitors. Therefore, we developed a new experimental method that considers flow adjustment between the aerosol monitors. By assuming two specific particle size distributions and five inlet conditions, the collection efficiencies of total mass particles are estimated. From the gas-particle partitioning ratio of 16 polycyclic aromatic hydrocarbons (PAHs) in a coal tar pitch manufacturing industry, the underestimation of the concentration of semi-volatile matters using the gas collection tubes has been discussed. The aerosol particles were collected in all kinds of layers in the gas sampling tubes, such as in the glass wool cap, gas adsorbent granular bed, and polyurethane foam. Furthermore, the collection efficiency curve of all 17 gas sampling tubes tested showed similar trends; a valley around particle sizes ranging from 0.2-0.3 μm between high collection zones below 0.1 μm and above 1 μm was observed. The observations suggested granular bed filters collection mechanisms such as inertial impaction, Brownian diffusion, gravity, and interception as same as air filters. Solid-phase collection can underestimate the concentrations of multi-phase matters. Thus, we wish to highlight the importance of solid-phase collection methods along with filtration collection methods to collect all phases of semi-volatile matters.

International Intercomparison of In Situ Chlorophyll-a Measurements for Data Quality Assurance of the Swedish Monitoring Program

Chlorophyll-a is an essential climate variable. Chlorophyll-a in situ measurements are usually used for the validation of satellite images. Previous intercomparisons have shown that there can be substantial differences between in situ laboratories. In order to shed light on these differences, we arranged international chlorophyll-a intercomparisons with eight participating laboratories during 1–2 July 2021. We performed two dedicated transects through Bråviken bay (NW Baltic proper) and sampled four stations in each transect along a chlorophyll-a gradient. We took three surface replicates per laboratory and per station, i.e., 24 samples per laboratory. The samples were filtered through Whatman GF/F filters, and filters were frozen in liquid nitrogen and distributed in dry ice to all laboratories together with chlorophyll-a standards. The results between labs compared quite well. The mean normalized bias (MNB) of the standard measurements ranged between −23% and +19% for all laboratories and −7% to +19% for the Baltic Sea laboratories compared to high-performance liquid chromatography. The MNB of the two Bråviken transects ranged between −23 and +17% for all laboratories (compared to the median of all spectrophotometric and fluorometric measurements) and between −2 and +17% for the Baltic Sea laboratories. On average, the chlorophyll-a concentrations measured by the fluorometric method were about 13% higher than those measured by spectrophotometry, and fluorometry samples tended to have more scatter. The largest uncertainties seem to be caused by variable storage and extraction methods and are not fully captured in this intercomparison. This is demonstrated by analyzing historical comparisons revealing very large uncertainties (root mean square difference (RMSD) up to 109% and bias up to 68%), possibly due to too low filtration volumes and due to different extraction and storage methods. Our recommendation is to flash-freeze samples in liquid nitrogen and store them at −80°C. After storage, they should be extracted and measured at room temperature within 6–24 h. Our results also indicate that ethanol is much more efficient in extracting Chl-a than acetone. Last but not least, we would like to point out that the uncertainties in measuring chlorophyll-a by satellite are now within the range of in situ data, as shown here by comparing the in situ results from this study with published remote sensing results from the literature.

Ternary‐Porous Conjugated N‐Halamine Nanofibers/Graphene Aerogels for Rechargeable Degradation of Mustard Gas

AbstractChemical warfare agents (CWAs) are significant threats to human peace and global safety. Most of the personal protective equipment in service used to barrier CWAs is devoid of decontamination activity. Rechargeable N‐halamine‐based detoxifying nanofibers/graphene chemical protective aerogels (HNAs) with ternary pores bearing π‐conjugation galleries that can effectively capture mustard gas through halogen bonds and convert them into the nontoxic products are proposed. Microporous nanofibers together with graphene construct a robust lamellar conjugated system dominated by π‐π interactions, providing interconnected channels for rapid dispersion and diffusion of contaminated fluid. The resulting HNAs exhibit integrated performances of low density, hierarchical porosity, a speedy recovery after a significant deformation, rechargeable vesicants decontamination (half‐life of 1.52 min), and low filtration resistance. The successful fabrication of the intriguing materials provides new insights into the generation of reliable, rechargeable, structurally adaptable, and long‐term usable real‐time detoxifying adsorbents for chemical personal protective equipment application.

A graph based approach for mining significant places in trajectory data

Significant place mining in spatiotemporal trajectory data is a key task for mobile pattern mining, useful for supporting location-aware services. State-of-the-art trajectory clustering algorithms utilize a density-based distance measure. However, some major problems with this approach are that (1) results are often inaccurate, especially on data of varying density, (2) the user must fine-tune many thresholds that are unintuitive to set, and (3) boundary points between clusters are often assigned to the wrong locations. Performance is also a major issue as many state-of-the-art algorithms have a very high time complexity. Motivated by these issues, this paper proposes an approach inspired by the data field theory and community detection. It is a graph-based significant place mining algorithm, called GB-SPM, for capturing and characterizing the essence of similarity between nodes. GB-SPM first applies a novel low index neighborhood velocity point filtration method to extract characteristic points. Then, a characteristic point index neighborhood is used to map them to graph nodes. In this way, the original problem is transformed into a community detection problem in complex community networks. Finally, a new edge weight metric is proposed to capture and characterize the nature of similarity between nodes. To evaluate clustering quality, we used the Silhouette (SI) for unannotated data to value inter-cluster separation and intra-cluster homogeneity. To evaluate mining effectiveness, we used Matthew’s correlation coefficient (MCC) for annotated data. Numerous experiments were carried out on real world datasets, and the accuracy and performance of the designed algorithm was compared with the state-of-the-art algorithms. Results show that GB-SPM improves on average SI by 13.9%, MCC by 20.7%, and runtime by 5.15 times.

Brief Early Life Angiotensin-Converting Enzyme Inhibition Offers Renoprotection in Sheep with a Solitary Functioning Kidney at 8 Months of Age.

Children born with a solitary functioning kidney (SFK) are predisposed to develop hypertension and kidney injury. Glomerular hyperfiltration and hypertrophy contribute to the pathophysiology of kidney injury. Angiotensin-converting enzyme inhibition (ACEi) can mitigate hyperfiltration and may be therapeutically beneficial in reducing progression of kidney injury in those with an SFK. SFK was induced in male sheep fetuses at 100 days gestation (term=150 days). Between 4 and 8 weeks of age, SFK lambs received enalapril (SFK+ACEi; 0.5mg/kg per day, once daily, orally) or vehicle (SFK). At 8 months, we examined BP, basal kidney function, renal functional reserve (RFR; GFR response to combined amino acid and dopamine infusion), GFR response to nitric oxide synthase (NOS) inhibition, and basal nitric oxide (NO) bioavailability (basal urinary total nitrate and nitrite [NOx]). SFK+ACEi prevented albuminuria and resulted in lower basal GFR (16%), higher renal blood flow (approximately 22%), and lower filtration fraction (approximately 35%), but similar BP, compared with vehicle-treated SFK sheep. Together with greater recruitment of RFR (approximately 14%) in SFK+ACEi than SFK animals, this indicates a reduction in glomerular hyperfiltration-mediated kidney dysfunction. During NOS inhibition, the decrease in GFR (approximately 14%) was greater among SFK+ACEi than among SFK animals. Increased (approximately 85%) basal urinary total NOx in SFK+ACEi compared with SFK animals indicates elevated NO bioavailability likely contributed to improvements in kidney function and prevention of albuminuria. Brief and early ACEi in SFK is associated with reduced glomerular hyperfiltration-mediated kidney disease up to 8 months of age in a sheep model.

Comparative Analysis of Dopaminergic and Cholinergic Mechanisms of Sensory and Sensorimotor Gating in Healthy Individuals and in Patients With Schizophrenia.

Sensory and sensorimotor gating provide the early processing of information under conditions of rapid presentation of multiple stimuli. Gating deficiency is observed in various psychopathologies, in particular, in schizophrenia. However, there is also a significant proportion of people in the general population with low filtration rates who do not show any noticeable cognitive decline. The review article presents a comparative analysis of existing data on the peculiarities of cholinergic and dopaminergic mechanisms associated with lowering gating in healthy individuals and in patients with schizophrenia. The differences in gating mechanisms in cohorts of healthy individuals and those with schizophrenia are discussed.

The Fabrication of Oleophobic Coating and Its Application in Particulates Filtration

The stir-frying process in Chinese cooking has produced serious emissions of oily particles, which are an important source of urban air pollution. In particular, the complex composition of fine particulate may pose a threat to human respiratory and immune systems. However, current filtration methods for oily particulate fumes have low filtration efficiency, high resistance, and high equipment costs. In polypropylene (PP) electret filters, efficiency rapidly decreases and pressure drop (wind resistance) sharply increases after the adsorption of oily particles, due to the oleophilic properties of the PP fibre. We addressed this issue of filter performance degradation by fabricating a sodium perfluorooctanoate (SPFO) oleophobic coating on polyvinylidene fluoride (PVDF) fibre membranes for oily particle filtration. The SPFO coating showed a promising oleophobic effect even at low concentrations, which suggests it has oleophobic properties for different oil types and can be modified for different substrates. This fabricated oleophobic coating is thermostable and the oleophobic effect is unaffected by temperatures from 0 to 100 °C. By modifying the SPFO coating on the PVDF membrane, a high filtration efficiency (89.43%) and low wind resistance (69 Pa) was achieved without oil adhesion, so the proposed coating can be applied in the filtration and purification of oily fine particles and offers a potential strategy for preventing atmospheric oil pollution.