Low Field Strength Research Articles

Relaxation measurements of an MRI system phantom at low magnetic field strengths

ObjectiveTemperature controlled T1 and T2 relaxation times are measured on NiCl2 and MnCl2 solutions from the ISMRM/NIST system phantom at low magnetic field strengths of 6.5 mT, 64 mT and 550 mT.Materials and methodsThe T1 and T2 were measured of five samples with increasing concentrations of NiCl2 and five samples with increasing concentrations of MnCl2. All samples were scanned at 6.5 mT, 64 mT and 550 mT, at sample temperatures ranging from 10 °C to 37 °C.ResultsThe NiCl2 solutions showed little change in T1 and T2 with magnetic field strength, and both relaxation times decreased with increasing temperature. The MnCl2 solutions showed an increase in T1 and a decrease in T2 with increasing magnetic field strength, and both T1 and T2 increased with increasing temperature.DiscussionThe low field relaxation rates of the NiCl2 and MnCl2 arrays in the ISMRM/NIST system phantom are investigated and compared to results from clinical field strengths of 1.5 T and 3.0 T. The measurements can be used as a benchmark for MRI system functionality and stability, especially when MRI systems are taken out of the radiology suite or laboratory and into less traditional environments.

Single-Voxel MR Spectroscopy of Gliomas with s-LASER at 7T.

Magnetic resonance spectroscopy (MRS)-a method of analysing metabolites in vivo-has been utilized in several studies of brain glioma biomarkers at lower field strengths. At ultra-high field strengths, MRS provides an improved signal-to-noise-ratio and spectral resolution, but 7T studies on patients with gliomas are sparse. The purpose of this exploratory study was to evaluate the potential clinical implication of the use of single-voxel MRS at 7T to assess metabolic information on lesions in a pilot cohort of patients with grade II and III gliomas. We scanned seven patients and seven healthy controls using the semi-localization by adiabatic-selective refocusing sequence on a Philips Achieva 7T system with a standard dual-transmit head coil. The metabolic ratios were calculated relative to water and total creatine. Additionally, 2-hydroxyglutarate (2-HG) MRS was carried out in four of the patients, and the 2-HG concentration was calculated relative to water. When comparing the tumour data to control regions in both patients and healthy controls, we found that the choline/creatine and myo-inositol/creatine ratios were significantly increased and that the N-acetylaspartate/creatine and the neurotransmitter glutamate/creatine ratios were significantly decreased. The N-acetylaspartate/water and glutamate/water ratios were also significantly decreased. The lactate/water and lactate/creatine ratios showed increases, although not significant. The GABA/water ratio was significantly decreased, but the GABA/creatine ratio was not. MRS spectra showed the presence of 2-HG in three of the four patients studied. Three of the patients, including the MRS 2-HG-negative patient, were operated on, and all of them had the IDH mutation. Our findings were consistent with the existing literature on 3T and 7T MRS.

Letter: Evaluating Brain Tumor Surgical Management Capacity in Sub-Saharan Africa.

Letter: Evaluating Brain Tumor Surgical Management Capacity in Sub-Saharan Africa.

Ramping down a clinical 3 T scanner: a journey into MRI and MRS at 0.75 T

ObjectLower-field MR is reemerging as a viable, potentially cost-effective alternative to high-field MR, thanks to advances in hardware, sequence design, and reconstruction over the past decades. Evaluation of lower field strengths, however, is limited by the availability of lower-field systems on the market and their considerable procurement costs. In this work, we demonstrate a low-cost, temporary alternative to purchasing a dedicated lower-field MR system.Materials and MethodsBy ramping down an existing clinical 3 T MRI system to 0.75 T, proton signals can be acquired using repurposed 13C transmit/receive hardware and the multi-nuclei spectrometer interface. We describe the ramp-down procedure and necessary software and hardware changes to the system.ResultsApart from presenting system characterization results, we show in vivo examples of cardiac cine imaging, abdominal two- and three-point Dixon-type water/fat separation, water/fat-separated MR Fingerprinting, and point-resolved spectroscopy. In addition, the ramp-down approach allows unique comparisons of, e.g., gradient fidelity of the same MR system operated at different field strengths using the same receive chain, gradient coils, and amplifiers.DiscussionRamping down an existing MR system may be seen as a viable alternative for lower-field MR research in groups that already own multi-nuclei hardware and can also serve as a testing platform for custom-made multi-nuclei transmit/receive coils.

PO-04-092 SAFETY AND EFFICACY OF DIFFERENT FIELD STRENGTHS OF PULSED-FIELD ABLATION IN ACHIEVING DURABLE CAVOTRICUSPID ISTHMUS BLOCK: A PRECLINICAL STUDY

Pulsed-field ablation (PFA) is an emerging modality for pulmonary vein isolation. There is limited data on the effect of different field strengths of PFA in achieving durable cavotricuspid isthmus block. This study examines the safety and efficacy of three different field strengths of PFA in achieving durable CTI block. In this study, eleven healthy swine (mean weight= 36.6 ± 3.8 kg) underwent a CTI ablation and followed up for a minimum of 12 weeks. An 8-French, 6-electrode purpose-designed steerable linear catheter, and an integrated PFA system were used to deliver biphasic bipolar PFA of three different field strengths and a predefined number of applications. The CTI ablation was performed using low, intermediate, and high field strengths of PFA, 1800 (n=4), 2300 (n=3), and 2800 Volts (n=4), respectively. PFA was applied 6, 8, or 11 times for each CTI line using low, intermediate, and high PFA field strengths. A three-dimensional electro-anatomical map (3D-EAM) was obtained at baseline, and three months after index ablation. Acute bidirectional CTI conduction block was achieved at 100% of the animals with a mean of 8.7 ± 2.1 applications per line. Repeated 3D-EAM at 12 weeks showed a persistent bidirectional CTI block in 10 of 11 animals (91%). There was only one CTI reconnection demonstrated at follow-up with voltage mapping. This was previously ablated with the lowest PFA dose (6 applications of 1,800V). No PFA-related complication was observed in the animals during the peri- and post-procedural periods. This study demonstrated the safety and efficacy of PFA in CTI ablation. The higher field strength of PFA was associated with a durable bidirectional CTI block. The lower PFA field strength with the higher number of applications was associated with the durable lesion sets. A lower PFA field strength with fewer applications resulted in acute reversible electroporation.

PO-02-039 THE EFFECT OF PULSED-FIELD ABLATION FIELD STRENGTH AND NUMBER OF APPLICATIONS IN ACUTE PULMONARY VEIN ISOLATION: A PRECLINICAL STUDY

Pulsed-field ablation (PFA) is an emerging non-thermal tissue-selective ablative technology that can be used for pulmonary vein isolation (PVI). A single pulse of PFA can result in reversible electroporation. The PFA field strength and the number of applications required to transform reversible electroporation into irreversible require further investigation. This study evaluates the effect of PFA field strengths and the number of PFA applications on acute PVI. An 8-French purpose-designed adjustable loop 10-electrode catheter was used to deliver three different PFA field strengths to fifteen healthy swine pulmonary veins (mean weight= 37.8 ± 3.8kg). The procedures were performed under general anesthesia. The animals were divided into three groups, each group receiving low, intermediate, and high field strength of PFA: 1800 (n= 4), 2300 (n= 4), and 2800 Volts (n=7), respectively. Each field strength was applied 6, 8, and 11 times, respectively. The number of PFA applications were predefined. Acute success was determined by immediate bi-directional PVI. The right phrenic nerve integrity was tested pre and post-ablation. Successful acute PVI was achieved in 26 out of 27 veins (96.3%) without any evidence of PFA-related adverse events. The only vein not electrically isolated was in the intermediate voltage group (2300V) with a total number of 8 applications. In contrast, other veins that were ablated with the lowest and highest voltage and ablation repetitions demonstrated immediate electrical isolation. No phrenic nerve palsy was observed at the end of the procedures. PFA effectively achieves PVI with low voltage and adequate ablation repetitions. The highest voltage with the highest ablation repetitions was demonstrated to be safe.

Magnetic fields inferred by Solar Orbiter: A comparison between SO/PHI-HRT and SDO/HMI

Context. The High Resolution Telescope (HRT) of the Polarimetric and Helioseismic Imager on board the Solar Orbiter spacecraft (SO/PHI) and the Helioseismic and Magnetic Imager (HMI) on board the Solar Dynamics Observatory (SDO) both infer the photospheric magnetic field from polarised light images. SO/PHI is the first magnetograph to move out of the Sun–Earth line and will provide unprecedented access to the Sun’s poles. This provides excellent opportunities for new research wherein the magnetic field maps from both instruments are used simultaneously. Aims. We aim to compare the magnetic field maps from these two instruments and discuss any possible differences between them. Methods. We used data from both instruments obtained during Solar Orbiter’s inferior conjunction on 7 March 2022. The HRT data were additionally treated for geometric distortion and degraded to the same resolution as HMI. The HMI data were re-projected to correct for the 3° separation between the two observatories. Results. SO/PHI-HRT and HMI produce remarkably similar line-of-sight magnetograms, with a slope coefficient of 0.97, an offset below 1 G, and a Pearson correlation coefficient of 0.97. However, SO/PHI-HRT infers weaker line-of-sight fields for the strongest fields. As for the vector magnetic field, SO/PHI-HRT was compared to both the 720-second and 90-second HMI vector magnetic field: SO/PHI-HRT has a closer alignment with the 90-second HMI vector. In the weak signal regime (< 600 G), SO/PHI-HRT measures stronger and more horizontal fields than HMI, very likely due to the greater noise in the SO/PHI-HRT data. In the strong field regime (≳600 G), HRT infers lower field strengths but with similar inclinations (a slope of 0.92) and azimuths (a slope of 1.02). The slope values are from the comparison with the HMI 90-second vector. Possible reasons for the differences found between SO/PHI-HRT and HMI magnetic field parameters are discussed.

Dilation of the superior sagittal sinus detected in rat model of mild traumatic brain injury using 1 T magnetic resonance imaging.

Mild traumatic brain injury (mTBI) is a common injury that can lead to temporary and, in some cases, life-long disability. Magnetic resonance imaging (MRI) is widely used to diagnose and study brain injuries and diseases, yet mTBI remains notoriously difficult to detect in structural MRI. mTBI is thought to be caused by microstructural or physiological changes in the function of the brain that cannot be adequately captured in structural imaging of the gray and white matter. However, structural MRIs may be useful in detecting significant changes in the cerebral vascular system (e.g., the blood-brain barrier (BBB), major blood vessels, and sinuses) and the ventricular system, and these changes may even be detectable in images taken by low magnetic field strength MRI scanners (<1.5T). In this study, we induced a model of mTBI in the anesthetized rat animal model using a commonly used linear acceleration drop-weight technique. Using a 1T MRI scanner, the brain of the rat was imaged, without and with contrast, before and after mTBI on post-injury days 1, 2, 7, and 14 (i.e., P1, P2, P7, and P14). Voxel-based analyses of MRIs showed time-dependent, statistically significant T2-weighted signal hypointensities in the superior sagittal sinus (SSS) and hyperintensities of the gadolinium-enhanced T1-weighted signal in the superior subarachnoid space (SA) and blood vessels near the dorsal third ventricle. These results showed a widening, or vasodilation, of the SSS on P1 and of the SA on P1-2 on the dorsal surface of the cortex near the site of the drop-weight impact. The results also showed vasodilation of vasculature near the dorsal third ventricle and basal forebrain on P1-7. Vasodilation of the SSS and SA near the site of impact could be explained by the direct mechanical injury resulting in local changes in tissue function, oxygenation, inflammation, and blood flow dynamics. Our results agreed with literature and show that the 1T MRI scanner performs at a level comparable to higher field strength scanners for this type of research.

Characterization of Experimentally Observed Complex Interplay between Pulse Duration, Electrical Field Strength, and Cell Orientation on Electroporation Outcome Using a Time-Dependent Nonlinear Numerical Model.

Electroporation is a biophysical phenomenon involving an increase in cell membrane permeability to molecules after a high-pulsed electric field is applied to the tissue. Currently, electroporation is being developed for non-thermal ablation of cardiac tissue to treat arrhythmias. Cardiomyocytes have been shown to be more affected by electroporation when oriented with their long axis parallel to the applied electric field. However, recent studies demonstrate that the preferentially affected orientation depends on the pulse parameters. To gain better insight into the influence of cell orientation on electroporation with different pulse parameters, we developed a time-dependent nonlinear numerical model where we calculated the induced transmembrane voltage and pores creation in the membrane due to electroporation. The numerical results show that the onset of electroporation is observed at lower electric field strengths for cells oriented parallel to the electric field for pulse durations ≥10 µs, and cells oriented perpendicular for pulse durations ~100 ns. For pulses of ~1 µs duration, electroporation is not very sensitive to cell orientation. Interestingly, as the electric field strength increases beyond the onset of electroporation, perpendicular cells become more affected irrespective of pulse duration. The results obtained using the developed time-dependent nonlinear model are corroborated by in vitro experimental measurements. Our study will contribute to the process of further development and optimization of pulsed-field ablation and gene therapy in cardiac treatments.

Magnetic Control of Protein Expression via Magneto-mechanical Actuation of ND-PEGylated Iron Oxide Nanocubes for Cell Therapy.

Engineered cells used as smart vehicles for delivery of secreted therapeutic proteins enable effective treatment of cancer and certain degenerative, autoimmune, and genetic disorders. However, current cell-based therapies use mostly invasive tools for tracking proteins and do not allow for controlled secretion of therapeutic proteins, which could result in unconstrained killing of surrounding healthy tissues or ineffective killing of host cancer cells. Regulating the expression of therapeutic proteins after success of therapy remains elusive. In this study, a noninvasive therapeutic approach mediated by magneto-mechanical actuation (MMA) was developed to remotely regulate the expression of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein, which is secreted by transduced cells. Stem cells, macrophages, and breast cancer cells were transduced with a lentiviral vector encoding the SGpL2TR protein. SGpL2TR comprises TRAIL and GpLuc domains optimized for cell-based applications. Our approach relies on the remote actuation of cubic-shape highly magnetic field responsive superparamagnetic iron oxide nanoparticles (SPIONs) coated with nitrodopamine PEG (ND-PEG), which are internalized within the cells. Cubic ND-PEG-SPIONs actuated by superlow frequency alternating current magnetic fields can translate magnetic forces into mechanical motion and in turn spur mechanosensitive cellular responses. Cubic ND-PEG-SPIONs were artificially designed to effectively operate at low magnetic field strengths (<100 mT) retaining approximately 60% of their saturation magnetization. Compared to other cells, stems cells were more sensitive to the interaction with actuated cubic ND-PEG-SPIONs, which clustered near the endoplasmic reticulum (ER). Luciferase, ELISA, and RT-qPCR analyses revealed a marked TRAIL downregulation (secretion levels were depleted down to 30%) when intracellular particles at 0.100 mg/mL Fe were actuated by magnetic fields (65 mT and 50 Hz for 30 min). Western blot studies indicated actuated, intracellular cubic ND-PEG-SPIONs can cause mild ER stress at short periods (up to 3 h) of postmagnetic field treatment thus leading to the unfolded protein response. We observed that the interaction of TRAIL polypeptides with ND-PEG can also contribute to this response. To prove the applicability of our approach, we used glioblastoma cells, which were exposed to TRAIL secreted from stem cells. We demonstrated that in the absence of MMA treatment, TRAIL essentially killed glioblastoma cells indiscriminately, but when treated with MMA, we were able to control the cell killing rate by adjusting the magnetic doses. This approach can expand the capabilities of stem cells to serve as smart vehicles for delivery of therapeutic proteins in a controlled manner without using interfering and expensive drugs, while retaining their potential to regenerate damaged tissue after treatment. This approach brings forth new alternatives to regulate protein expression noninvasively for cell therapy and other cancer therapies.

Targeted Compound Selection with Increased Sensitivity in 13C-Enriched Biological and Environmental Samples Using 13C-DREAMTIME in Both High-Field and Low-Field NMR.

Chemical characterization of complex mixtures by Nuclear Magnetic Resonance (NMR) spectroscopy is challenging due to a high degree of spectral overlap and inherently low sensitivity. Therefore, NMR experiments that reduce overlap and increase signal intensity hold immense potential for the analysis of mixtures such as biological and environmental media. Here, we introduce a 13C version of DREAMTIME (Designed Refocused Excitation And Mixing for Targets In Vivo and Mixture Elucidation) NMR, which, when analyzing 13C-enriched materials, allows the user to selectively detect only the compound(s) of interest and remove all other peaks in a 13C spectrum. Selected peaks can additionally be "focused" into sharp "spikes" to increase sensitivity. 13C-DREAMTIME is first demonstrated at high field strength (500 MHz) with simultaneous selection of eight amino acids in a 13C-enriched cell free amino acid mixture and of six metabolites in an extract of 13C-enriched green algae and demonstrated at low field strength (80 MHz) with a standard solution of 13C-d-glucose and 13C-l-phenylalanine. 13C-DREAMTIME is then applied at high-field to analyze metabolic changes in 13C-enrichedDaphnia magna after exposure to polystyrene "microplastics," as well as at low-field to track fermentation of 13C-d-glucose using wine yeast. Ultimately, 13C-DREAMTIME reduces spectral overlap as only selected compounds are recorded, resulting in the detection of analyte peaks that may otherwise not have been discernable. In combination with focusing, up to a 6-fold increase in signal intensity can be obtained for a given peak. 13C-DREAMTIME is a promising experiment type for future reaction monitoring and for tracking metabolic processes with 13C-enriched compounds.

Magnetosheath Jet Formation Influenced by Parameters in Solar Wind Structures.

Magnetosheath jets are dynamic pressure enhancements observed in the terrestrial magnetosheath. Their generation mechanisms are currently debated but the majority of jets can be linked to foreshock processes. Recent results showed that jets are less numerous when coronal mass ejections (CMEs) cross the magnetosheath and more numerous when stream interaction regions (SIRs) cross it. Here, we show for the first time how the pronounced substructures of CMEs and SIRs are related to jet production. We distinguish between compression and magnetic ejecta (ME) regions for the CME as well as compression region associated with the stream interface and high-speed streams (HSSs) for the SIR. Based on THEMIS and OMNI data covering 2008-2021, we show the 2D probability distribution of jet occurrence using the cone angle and Alfvén Mach number. We compare this distribution with the values within each solar wind (SW) structure. We find that both high cone angles and low Alfvén Mach numbers within CME-MEs are unfavorable for jet production as they may inhibit a well-defined foreshock region. 1D histograms of all parameters show, which SW parameters govern jet occurrence in each SW structure. In terms of the considered parameters the most favorable conditions for jet generation are found for HSSs due to their associated low cone angles, low densities, and low magnetic field strengths.

Conservative second-order accurate finite-difference scheme for the coupled Maxwell-Dirac equations

The recent development of nanoelectronic devices that incorporate Dirac materials has highly increased the need for adequate simulation and modelling tools. This paper introduces an accurate, multiphysics finite-difference time-domain method to solve the pertinent Maxwell-Dirac equations. The stability criterion for the Dirac equation with electromagnetic fields is derived, which reduces to the Courant-Friedrichs-Lewy condition in the absence of electromagnetic fields. Validation examples show the second-order accuracy of the novel fully coupled Maxwell-Dirac scheme and illustrate that total norm and energy are caonserved within a relative error of order 10−4. The method is applied to a ZrTe5 waveguide and it is found that even at low field strengths, the charge carriers can be accelerated to 80% of the Fermi velocity. Furthermore, the flexibility of the advocated method allows for the seamless integration into existing computational electromagnetics frameworks and the possible extension to higher-order schemes.

Theoretical Investigations on the Plasmon-Mediated Dissociation of Small Molecules in the Presence of Silver Atomic Wires.

Plasmonic nanoparticles can promote bond activation in adsorbed molecules under relatively benign conditions via excitation of the nanoparticle's plasmon resonance. As the plasmon resonance often falls within the visible light region, plasmonic nanomaterials are a promising class of catalysts. However, the exact mechanisms through which plasmonic nanoparticles activate the bonds of nearby molecules are still unclear. Herein, we evaluate Ag8-X2 (X = N, H) model systems via real-time time-dependent density functional theory (RT-TDDFT), linear response time-dependent density functional theory (LR-TDDFT), and Ehrenfest dynamics in order to better understand the bond activation processes of N2 and H2 facilitated by the presence of the atomic silver wire under excitation at the plasmon resonance energies. We find that dissociation is possible for both small molecules at high electric field strength. Activation of each adsorbate is symmetry- and electric field-dependent, and H2 activates at lower electric field strengths than N2. This work serves as a step toward understanding the complex time-dependent electron and electron-nuclear dynamics between plasmonic nanowires and adsorbed small molecules.

Discovery of Two Polars from a Crossmatch of ZTF and the SRG/eFEDS X-Ray Catalog

Magnetic cataclysmic variables (CVs) are luminous Galactic X-ray sources, which have been difficult to find in purely optical surveys due to their lack of outburst behavior. The eROSITA telescope on board the Spektr-RG mission is conducting an all-sky X-ray survey and recently released the public eROSITA Final Equatorial Depth Survey (eFEDS) catalog. We crossmatched the eFEDS catalog with photometry from the Zwicky Transient Facility and discovered two new magnetic CVs. We obtained high-cadence optical photometry and phase-resolved spectroscopy for each magnetic CV candidate and found them both to be polars. Among the newly discovered magnetic CVs is eFEDS J085037.2+044359/ZTFJ0850+0443, an eclipsing polar with orbital period P orb = 1.72 hr and WD mass M WD = 0.81 ± 0.08M ⊙. We suggest that eFEDS J085037.2+044359/ZTFJ0850+0443 is a low magnetic field strength polar, with B WD ≲ 10 MG. We also discovered a non-eclipsing polar, eFEDS J092614.1+010558/ZTFJ0926+0105, with orbital period P orb = 1.47 hr and magnetic field strength B WD = 36–42 MG.

A Broadband X-Ray Study of the Rabbit Pulsar Wind Nebula Powered by PSR J1418-6058

We report on broadband X-ray properties of the Rabbit pulsar wind nebula (PWN) associated with the pulsar PSR J1418−6058 using archival Chandra and XMM-Newton data, as well as a new NuSTAR observation. NuSTAR data above 10 keV allowed us to detect the 110 ms spin period of the pulsar, characterize its hard X-ray pulse profile, and resolve hard X-ray emission from the PWN after removing contamination from the pulsar and other overlapping point sources. The extended PWN was detected up to ∼20 keV and is described well by a power-law model with a photon index Γ ≈ 2. The PWN shape does not vary significantly with energy, and its X-ray spectrum shows no clear evidence of softening away from the pulsar. We modeled the spatial profile of X-ray spectra and broadband spectral energy distribution in the radio to TeV band to infer the physical properties of the PWN. We found that a model with low magnetic field strength (B ∼ 10 μG) and efficient diffusion (D ∼ 1027 cm2 s−1) fits the PWN data well. The extended hard X-ray and TeV emission, associated respectively with synchrotron radiation and inverse Compton scattering by relativistic electrons, suggest that particles are accelerated to very high energies (≳500 TeV), indicating that the Rabbit PWN is a Galactic PeVatron candidate.

Sepiolite reinforced PEO layer on AZ 31

The present work deals with the investigation of the incorporation of nanosized ceramic particles (sepiolite) into an oxide layer formed on magnesium alloy AZ31 by plasma electrolytic oxidation (PEO). The actual (true) surface area of the sepiolite particles was determined to be 300 m2 g−1. The particles were exclusively electrostatically stabilized in the used electrolyte without visible sedimentation, at least over 27 days. Using a current controlled pulse regime, the particles are incorporated into the oxide layer simultaneously to the PEO process. The study clearly reveals that the movement and deposition of the particles is based on electrophoresis. Considering the measured mobility of the particles of μ ≈ 6 μm cm V−1 s−1 and a very low field strength in the electrolyte (0.4 V cm−1) the particles velocity was calculated to υ ≈ 2.4 μm s−1. The mass of deposited sepiolite was estimated to approximately 1.2 mg cm−2 under the chosen conditions. The fixation of the deposited particles is caused by sintering due to the heat development of the plasma discharge events.

Enhanced 129 Xe T1 relaxation in whole blood and in the presence of SPIONs at low magnetic field strengths.

To compare the effect of superparamagnetic iron oxide nanoparticles (SPIONs) on the T1 of 129 Xe and 1 H and to measure the relaxation of 129 Xe in blood at low and high magnetic field strengths. 129 Xe and 1 H T1 relaxometry was performed at low- and high-field strengths in samples containing different SPION concentrations, while imaging was used to compare the contrast obtainable in these two field regimes. In vivo experiments at variable field strengths were performed to determine the depolarization of 129 Xe in blood and the feasibility of in vivo dissolved-phase spectroscopy and imaging at low field. The SPION relaxivity was substantially greater at low field for 1 H, increasing from 0.92 ± 0.06 mM s-1 at 11.7T to 31.5 ± 1.8 mM s-1 at 0.6 mT, and for 129 Xe, which increased from 0.13 ± 0.03 mM s-1 at 11.7T to 7.32 ± 0.71 mM s-1 at 2.1 mT. The additional MR signal loss increased from 0.7% at 9.4T to 20.6 ± 4.2% at 0.6 mT for 1 H and from -0.7 ± 3.4% at 9.4T to 12.7 ± 3.5% at 2.1 mT for 129 Xe. Blood was found to depolarize 129 Xe below 3T in a manner inversely proportional to the field strength. In vitro studies at 2.1 mT suggest 129 Xe relaxation times below 5s in blood dilutions as low as 0.4% volume. SPIONs longitudinal relaxivity increases at low field both for 1 H and 129 Xe. The depolarization of xenon in blood, which is found to increase below 3T, effectively prevents in vivo dissolved-phase spectroscopy and imaging at low-field strengths.

X-ray non-detection of PSR J0250 + 5854

ABSTRACT We conducted a deep XMM–Newton observing campaign on the 23.5-s radio pulsar PSR J0250 + 5854 in order to better understand the connection between long-period, radio-emitting neutron stars and their high-energy-emitting counterparts. No X-ray emission was detected resulting in an upper limit in the bolometric luminosity of PSR J0250 + 5854 of &amp;lt;1031 erg s−1 for an assumed blackbody with a temperature of 85 eV, typical of an X-ray Dim Isolated Neutron Star (XDINS). We compared the upper limit in the bolometric luminosity of PSR J0250 + 5854 with the known population of XDINSs and found that the upper limit is lower than the bolometric luminosity of all but one XDINS. We also compared PSR J0250 + 5854 with SGR 0418+5729, the magnetar with low dipole magnetic field strength, where the upper limit suggests that if PSR J0250 + 5854 has a thermal hotspot like SGR 0418 + 5729, it would have a blackbody temperature of &amp;lt;200 eV, compared to 320 eV of the magnetar.

Hyperpolarized 129Xe MRI at low field: Current status and future directions

Magnetic Resonance Imaging (MRI) is dictated by the magnetization of the sample, and is thus a low-sensitivity imaging method. Inhalation of hyperpolarized (HP) noble gases, such as helium–3 and xenon-129, is a non-invasive, radiation-risk free imaging technique permitting high resolution imaging of the lungs and pulmonary functions, such as the lung microstructure, diffusion, perfusion, gas exchange, and dynamic ventilation. Instead of increasing the magnetic field strength, the higher spin polarization achievable from this method results in significantly higher net MR signal independent of tissue/water concentration. Moreover, the significantly longer apparent transverse relaxation time T2* of these HP gases at low magnetic field strengths results in fewer necessary radiofrequency (RF) pulses, permitting larger flip angles; this allows for high-sensitivity imaging of in vivo animal and human lungs at conventionally low (<0.5 T) field strengths and suggests that the low field regime is optimal for pulmonary MRI using hyperpolarized gases.In this review, theory on the common spin-exchange optical-pumping method of hyperpolarization and the field dependence of the MR signal of HP gases are presented, in the context of human lung imaging. The current state-of-the-art is explored, with emphasis on both MRI hardware (low field scanners, RF coils, and polarizers) and image acquisition techniques (pulse sequences) advancements. Common challenges surrounding imaging of HP gases and possible solutions are discussed, and the future of low field hyperpolarized gas MRI is posed as being a clinically-accessible and versatile imaging method, circumventing the siting restrictions of conventional high field scanners and bringing point-of-care pulmonary imaging to global facilities.