This article presents a methodical approach for designing a circularly polarized multiple-input-multiple-output (MIMO) dielectric resonator antenna (DRA) with triple frequency bands and low mutual electromagnetic (EM) coupling. The MIMO configuration is composed of two identical circularly polarized DRA elements in an orthogonal arrangement. To achieve circular polarization (CP) radiation, each rectangular DR element is modified and rotated with respect to the feeding-aperture. Meanwhile, the low mutual coupling is obtained by arranging the DRA elements orthogonally, and also by etching a Y-shaped slot on the ground plane. The Y-shaped slot facilitates the increase of the coupling current path, which decreases the inter-port coupling. The simulated outcomes are validated through an experimental test of the fabricated prototype. The proposed concept provides triple impedance bands as well as triple CP bands with low EM coupling ( < −25 dB). This article fills a research gap by developing a circularly polarized triple-band MIMO-DRA that can be used for a variety of wireless applications, including WiMAX, Wi-Fi, WLAN, and satellite communication.