From the *University of Louisville School of Medicine, Louisville, KY; †Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom. Supported, in part, by the National Institutes of Health (R01AG017173), the Joseph and Florence Mandel Research Fund, and the Nickman Family. The authors have no conflicts of interest to report. The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript. Address for reprints: Robert Friedland, MD, 500 South Preston Street, Room 120 HSC, Louisville, KY 40292; e-mail: [email protected].