Production Losses Research Articles

Microscale urban heat variability and time-location patterns: Elevated exposure for bikers and rickshaw drivers beyond average city temperatures in megacity

Urban heat island effect creates diverse microclimates, influencing heat exposure and consequent health effects. Study measured heat exposure among delivery riders within their microclimate, comparing it with city's average temperature. We investigated how higher exposure affects work, health, and productivity of riders.For 21 days in winter and summer, we measured heat exposure during peak hours (under sun and shade) in riders' immediate environment, at seven high-traffic routes in Karachi, Pakistan. Recorded temperature were compared with city's ambient air temperature. In-depth interviews were conducted to assess the impacts on riders' health, welfare, and productivity.During winter, temperature was 5.0 °C higher under sun and 1.6 °C higher under shade, as compared to city average recorded temperatures. In summer temperature was 5.5 °C higher under sun and 1.8 °C higher in shade as compare to recorded city's average air temperature. Riders reported exhaustion, reduced productivity, income loss, and negative impacts on social wellbeing during hot days. For mitigation riders relied on strategies like staying hydrated and taking breaks from work under shades. Study demonstrated higher exposure to heat for riders in megacity as compare to city's recorded temperature. This led to reduced productivity and income losses, emphasizing need for urgent initiatives to safeguard riders' well-being.

Pecan-medicinal crops intercropping improved soil fertility and promoted interactions between soil microorganisms and metabolites

BackgroundPecan [Carya illinoinensis (Wangenh.) Koch] is a widely cultivated dried fruit and woody oil tree with high economic value. Continuous sole planting of pecan caused some land to lie idle and deterioration of soil conditions. Tree and medicinal crops intercropping represents an environmental-friendly and economically feasible solution to these issues. Thus, we aimed to explore the underlying mechanism by which intercropping improved soil condition by regulating the interactions of the soil microbiome and metabolome. In this study, pecans were intercropped with medicinal crops caper spurge and honeysuckle on a tree farm in China. A combined analysis of soil microbiomes and metabolomes was performed to discover the effects of intercropping on bulk and rhizosphere soils.ResultsThe results showed that intercropping improved the edaphic properties of bulk soil and promoted the growth of pecan and caper spurge. Intercropping also significantly altered the structures of both bacterial and fungal communities in bulk soil, stabilised the enrichment of nitrogen-cyclic bacteria, for instance, Bacillus, and decreased the relative abundances of plant–pathogenic fungi, for instance, Fusarium. In addition, the result of metabolomic analysis showed that intercropping promoted the synthesis of functional compounds, such as trehalose and ethanolamine, which enhanced plant disease resistance in bulk soils. Moreover, the co-occurrence networks of microbiomes and metabolomes of bulk soils revealed that Bacillus was significantly correlated with Fusarium, Alternaria, and trehalose under intercropping patterns. Furthermore, analysis of microbiomes and metabolomes in the rhizosphere soil of caper spurge and honeysuckle revealed that Penicillium and Rhizomicrobium were significantly increased by intercropping and showed more dynamic connections with other genera and metabolites compared with single planting.ConclusionsOverall, intercropping pecans with caper spurge and honeysuckle can improve soil conditions and promote plant growth through microbiological and metabolomics integrated analyses. This study provides valuable information and theoretical basis for optimizing land resource utilisation and improving soil conditions in tree fields like pecan fields via intercropping, thereby reducing production losses and ensuring economic benefits.Graphical

The longitudinal association of hand osteoarthritis with paid and unpaid work restrictions and related societal costs: The Hand Osteoarthritis in Secondary Care cohort

ObjectivesTo investigate the course of restrictions in paid and unpaid work and corresponding societal costs in patients with hand osteoarthritis (OA). MethodsPatients with data of at least baseline and one follow-up moment (year one up to year eight) of the Dutch Hand OSTeoArthritis in Secondary care cohort (HOSTAS) were included. The Health and Labour Questionnaire (HLQ) was used to assess over the last two weeks hand OA-related restrictions for paid and unpaid work. Societal costs of productivity loss were estimated with Dutch government data on 2021. Results351 patients were included (mean age 60 years, 84% women). At baseline, 166/351 (47%) had paid work, decreasing to 54/164 (33%) at year eight. Loss of productive time over the two-week period was reported by 32/166 (19%) patients with paid work at baseline, 17/104 (16%) at year four, among whom 12/104 (11%) patients at both moments. Any restrictions over this two-week period were experienced by 89/166 patients (54%) at baseline and 41/104 (39%) at year four for those with paid work.Regarding unpaid work, 157/351 (45%) reported replacement of tasks by others at baseline and 72/164 (44%) at year eight. 205/351 (59%) reported restrictions at baseline, and 99/164 (60%) at year eight.Mean total societal costs for loss of paid and unpaid work were, per patient, €89/two weeks (95% confidence interval (CI) 52;127) at baseline, and €47/two weeks (26;69) at year eight. ConclusionsThe proportion of patients with paid work decreases during follow-up, but restrictions at paid and unpaid work seem mostly stable.Keywords

Food handling practices and sanitary conditions of charitable food assistance programs in eThekwini District, KwaZulu-Natal, South Africa

Unsafe food handling practices by food handlers have dire health and financial implications worldwide. Each year, approximately 600 million people, or about 1 in 10 people, are said to become ill from eating contaminated food, and 420,000 people inadvertently die. According to the 2019 World Bank report on the economic burden of foodborne diseases, the annual cost of treating foodborne illnesses is estimated to be US$ 15 billion, and the total productivity loss caused by foodborne diseases in low- and middle-income countries is estimated to be US$ 95.2 billion annually. The purpose of this study was to assess the food handling practices and sanitary conditions of the charitable food assistance programs (CFAPs) in the eThekwini District of KwaZulu-Natal, South Africa. A descriptive cross-sectional study was conducted among 196 CFAPs in eight study settings across five municipal planning regions (MPRs) of the eThekwini District between January 2021 and May 2021. Data were collected using a standardized 37-item observational checklist and analysed through Stata Statistical Software (TX: StataCorp. 2021 LLC.: Release 17. College Station). Compliance levels were calculated using the compliance score (C-score), whereby 0.0–0.20 (0–20%), 0.21–0.40 (21–40%), 0.41–0.60 (41–60%), 0.61–0.80 (61–80%), and 0.81–1.00 (81–100%) were determined as very poor, poor, average, good, and very good, respectively. Statistically significant associations were declared at p < 0.05. Compliance with food hygiene, storage, and packaging was very poor (C-score = 0.003), as were personal hygiene and staff facilities (C-score = 0.147), as well as product information/labelling (C-score = 0.003). Similarly, waste management and pest control systems (C-score = 0.203), compliance with health and hygiene education/training (C-score = 0.335), as well as use and maintenance of transport (C-score = 0.333), all scored ‘poor’. Only the design of premises and facilities had an average compliance score (C-score = 0.43). Given CFAPs’ role in mitigating the impact of poverty, their strict compliance with hygiene protocols is of utmost importance. Systems for identifying and correcting common noncompliance in CFAPs are required.

Impact of chronic constipation symptoms on work productivity and daily activity: A large-scale internet survey.

Chronic constipation negatively impacts work productivity and patients' quality of life. This retrospective study assessed the correlation between symptoms of chronic constipation and work/activity impairment with and without the use of laxative treatment. This cross-sectional, observational, web-based survey was conducted using the Work Productivity and Activity Impairment-Chronic Constipation Questionnaire and included Japanese patients with chronic constipation receiving prescribed medication. Outcomes of interest included total work productivity and activity impairment and their correlation with constipation symptoms. Among the 2351 analyzed patients (mean [SD] age, 51.7 [13.8] years), 80.7% were females, 63.3% had a disease duration of ≥10 years, and 1424 were working. The averages of total activity impairment, total work productivity impairment, presenteeism, and absenteeism were 39.2%, 33.9%, 31.2%, and 5.0%, respectively. The annual work productivity loss per patient was estimated to be 1.343 million Japanese Yen. Symptoms that had a statistically significant positive correlation with total work impairment (P < 0.05) were abdominal discomfort/nausea, abdominal pain, abdominal bloating, and unpredictable defecation timing. Total activity impairment was significantly (P < 0.05) affected by abdominal discomfort/nausea, abdominal bloating, abdominal pain, incomplete defecation, unpredictable defecation timing, loss of defecation desire, and straining. Work productivity and daily activity had improved in 71.2% and 72.6% of patients, respectively, after they received treatment. Symptoms of constipation, particularly abdominal symptoms and unpredictable defecation timing, can have a negative impact on work productivity and daily activity. Treatment focused on these symptoms may reduce the socio-economic burden of chronic constipation in Japan.

Economic Burden of Late-Stage Age-Related Macular Degeneration in Bulgaria, Germany, and the US

Age-related macular degeneration (AMD) is a highly prevalent and debilitating retinal condition that affects more than 200 million people globally, with the severe late-stage forms-neovascular AMD (nAMD) and geographic atrophy (GA)-affecting more than 11 million people globally. However, much is unknown about the economic burden of the disease. To estimate the economic burden associated with late-stage AMD in Bulgaria, Germany, and the US at the societal level. This study used the prevalence approach cost-of-illness economic modeling to estimate costs attributable to late-stage AMD. Data on health care resource utilization, well-being, and productivity were obtained via primary data collection. Additional data required for the model were sourced from available published literature. Data were collected from January 2021 to March 2022, and analyzed from April to July 2022. Participants older than 50 years residing in Bulgaria, Germany, and the US who were diagnosed with late-stage AMD (nAMD or any form of GA) in 1 or both eyes and caregivers who care for people diagnosed with late-stage AMD were recruited through ophthalmological clinics in Bulgaria and Germany and via online newsletters and social media in the US. The main outcomes were direct medical costs (disease-related health care expenditures), indirect medical costs (care support and assistive technology), well-being cost (loss of well-being), and productivity cost (loss in productivity due to the diseases for both patient and caregivers). Of the 128 individuals with late-stage AMD in this study, 80 (62%) were female, and 120 (94%) were aged 60 years or older. Of the 61 caregivers, 43 (70%) were female and 55 (91%) were aged 45 years or older. Estimated per-annum total costs attributable to late-stage AMD were €449.5 million ($512.5 million) in Bulgaria, €7.6 billion ($8.6 billion) in Germany, and €43.2 billion ($49.4 billion) in the US. Across all countries, 10% to 13% of the total cost incurred was attributed to direct medical costs. In Germany and Bulgaria, the biggest contributor to the total economic burden was reduced well-being (67% and 76%, respectively), whereas in the US, loss of productivity (42%) was the biggest contributor. The findings of this study indicate a substantial burden of late-stage AMD on patients and caregivers in the US, Germany, and Bulgaria. Across the 3 countries, reduced well-being and loss of productivity were relatively large contributors to the total economic burden. Implementing measures to reduce AMD incidence, delay disease progression, and alleviate humanistic burden may help reduce the economic burden of late-stage AMD.

Development of Tuta absoluta (Meyrick, 1917) (Lepidoptera: Gelechiidae) in tomato genotypes

Tomato plants are the most widely cultivated fruit vegetables globally. The tomato leaf miner (Tuta absoluta) is the leading pest of this crop and can cause up to 100% loss of production. Therefore, the aim was to evaluate the development and resistance of antibiosis and non-preference types (antixenosis) for oviposition and feeding of T. absoluta in commercial tomato hybrids in choice and no-choice tests. For the experiments, an open-pollinated tomato cultivar was used as a control: ‘Santa Clara’ cultivar - susceptible - Italian type, along with eight commercial tomato hybrids were used: ‘Compack’ - salad type, ‘Caniati’ - Italian type, ‘Grazianni’ - Italian type, ‘Sweet Heaven’ - grape type, ‘Cascade’ - cherry type, ‘Ellen’ - salad type, ‘Bento’ - Italian type, and ‘Dominador’ - salad type, all having an indeterminate growth habit. According to the evaluated biological parameters (dendrogram and principal component analysis - PCA), the ‘Sweet Heaven’ hybrid showed a negative effect on the development of T. absoluta, with an increase in the duration of the larval, adult, and total phases, and low larval and total viability. The tomato hybrid ‘Cascade’ exhibited lower attractiveness for T. absoluta oviposition in no-choice tests. The tomato hybrids 'Sweet Heaven', 'Compack', and ‘Cascade’ showed a lower percentage of leaf area consumed. However, ‘Dominador’, ‘Santa Clara’, and ‘Ellen’ were the tomato genotypes that showed higher susceptibility to the development of T. absoluta, encompassing high larval, pupal, and total viability (larva-adult period). Concluding that the ‘Sweet Heaven’ hybrid negatively affected the development cycle of T. absoluta, while the ‘Cascade’ hybrid exhibited lower attractiveness for oviposition.

Ozonation procedure for removal of mycotoxins in maize: A promising screening approach for improvement of food safety.

Mycotoxins are well known secondary metabolites of various fungi. They pose a significant threat to human and animal when present in food or feed. They can be responsible for losses in grain production and in livestock or human intoxication. In this study, several mycotoxins were detected in Aspergillus fumigatus contaminated maize kernels. The contaminated kernels were treated with gaseous ozone at a concentration of 500 and 3000 ppm for 1 hour. Depending on the specific compound, the contamination level was reduced by up to 100%. This screening research showed that a concentration of ozone as high as 3000 ppm could be sufficient to completely remove several toxic compounds from the maize matrix.

Effects of Rainfall Variability and Land Cover Type on Soil Organic Carbon Loss in a Hilly Red Soil Region of Southern China

Rainfall intensity (RI) and land cover type are two important factors that affect soil erosion and thus the transfer and loss of soil organic carbon (SOC). However, the in situ quantitative monitoring of SOC loss under natural rainfall and various land cover types restored on eroded lands has not been thoroughly examined. In order to further study the effects of rainfall changes and vegetation types on SOC loss in the red soil region of Southern China, the Jiangxi Eco-Science Park of Soil and Water Conservation in De’an County, Jiangxi Province, was taken as the research object. Considering natural rainfall and based on the long-term field in situ monitoring of rainfall and runoff and sediment data, we studied the effects of three land cover types (bare land, orchards, and grass cover) on surface runoff, sediment production, and SOC loss in relation to 1 hour of RI during natural rainfall in the red soil region of Southern China during rainy seasons of 2020 and 2021 (March to August). Compared with bare land plots, the orchard and grass cover plots had surface runoff reductions of 67% and 98%, respectively, and sediment reductions of 79% and 99% over the two rainy seasons, respectively. With an increasing RI over 1 hour, total SOC loss increased for each of the three land cover types. More SOC loss was associated with sediments, and the enrichment ratio of SOC in the sediments (ERoc) decreased significantly. The ERoc values decreased in the following order: bare land (1.23) &gt; orchard (1.08) &gt; grass cover (0.81). Bare land exhibited the highest proportion of SOC associated with sediment in the total SOC loss (Ps), at 68.69%, followed by the orchard plots, at 55.02%, and then the grass cover plots at 49.24%. With the transfer of land cover type from bare land to orchard and to grass cover (decreased soil loss intensity, SLI), more SOC was lost associated with runoff in the form of dissolved organic carbon (DOC); the values of ERoc and organic carbon loss intensity (CLI) also decreased significantly. These findings are crucial to improving our understanding of the regulatory mechanisms of rainfall changes and land cover types on SOC loss during soil erosion.

Comparison of the Competitiveness for Danish, Dutch, and German Piglet Producers under Consideration of Country-Specific Methods of Piglet Castration with Anesthesia

Pig producers in Europe adopt different production methods for male pig fattening. More than half of the animals are surgically castrated. The different interpretations of animal welfare in different countries lead to market differentiation and economically different production conditions, which do not restrict trade, but economically lead to drastic competitive changes for local producers. While the Netherlands has already implemented surgical castration for the export market, using CO2 narcosis (NL), Denmark and Germany are each introducing their strategies with local anesthesia (DK) and isoflurane anesthesia (DE), respectively. Using typical pig farms from the agri benchmark Pig Network, the additional costs and economic impacts of animal welfare regulations are calculated. In Germany, isoflurane anesthesia increases costs by EUR 28.54 to EUR 49.86 per sow, or EUR 1.93 to EUR 3.81 per male piglet. This corresponds to a cost increase of around 5% per piglet. In Denmark, the costs of local anesthesia with procaine increase more moderately by EUR 3.55 to EUR 5.05 per sow, or around EUR 0.30 per male piglet. The cost increase here is less than 1% per piglet. The additional costs are leading to a loss of competitiveness for Denmark and Germany compared to the Netherlands. However, Germany is also losing profit significantly compared to Denmark. This study highlights that animal welfare regulations can negatively impact the competitiveness of the pig sector. It emphasizes the need for countries to implement such regulations carefully, ensuring that they do not lead to the loss of production or international competitiveness. A balanced approach that supports both animal welfare and economic sustainability is essential.

Literature Review to Understand the Burden and Current Non-surgical Management of Moderate-Severe Pain Associated with Knee Osteoarthritis.

To conduct a literature review exploring the humanistic burden, costs, and guideline recommendations for non-surgical management of moderate-severe pain in knee osteoarthritis (KOA). Published studies (2018-25 April 2023) assessing the burden of moderate-severe pain in KOA were identified by searching Medline, Embase, EconLit, and Cochrane database, supplemented with grey literature hand searches and reference list snowballing. Treatment guidelines were also identified for key countries. This review included 106 publications and 37 treatment guidelines. Patients with moderate-severe pain were found to experience a low quality of life (QoL) and an impaired ability to perform daily tasks. The economic burden of KOA was substantial, including cost of medical visits, non-operative treatment (physical therapy and hyaluronic acid [HA] being key drivers) and productivity losses. Non-steroidal anti-inflammatory drugs (NSAIDs) were among the most frequently used pharmacological treatments, with intra-articular (IA) injections used to varying degrees. Opioid use was also frequently reported. Guidelines universally recommended NSAIDs, albeit with limited dose and duration for oral NSAIDs. IA-corticosteroids were conditionally/moderately recommended for short-term use by most guidelines, while IA-HA and opioids were rarely recommended. Guidelines are not specific to patients with moderate-severe pain and do not distinguish between different KOA phenotypes. KOA with moderate-severe pain is associated with substantial humanistic and economic burden. Real-world data suggest that some treatments are regularly used at high cost regardless of the lack of evidence-based recommendations. There remains a need for new treatment options that successfully relieve pain, improve QoL and delay the need for surgery. Graphical abstract available for this article.

Role of District Central Cooperative Banks in Financial Inclusion: A Study on Two Selected Districts of West Bengal

Financial inclusion provides the legitimate provisions of basic banking services with adequate financial securities to the unbanked population at a reasonable cost. Since the early decade of the 20th century, the cooperative system has been engaged to percolate financial inclusion in various strata of our society. Several initiatives regarding financial inclusion have been implemented in the post-independence period; however, the Pradhan Mantri Jan-Dhan Yojana (PMJDY) 2014 has been considered as one of the most fruitful and effective initiatives by the Government of India for opening no-frill bank accounts with zero balance facilities for financially excluded people in our country, and the cooperative banks have been playing a vital role in the process of implementing the said Yojana. The present study, based on Hooghly District Central Cooperative Bank (HDCCB) and Burdwan Central Cooperative Bank (BCCB) of West Bengal, has comprehended to investigate the role of the DCCBs in the process of financial inclusion with respect to a number of financial operations and annual changes of savings accounts over the second decade of the 21st century. The study has identified statistically significant segments of the financial operations. Those segments are consequences of several fluctuations in financial operations due to the changes in banking policy, implementation of PMJDY, demonetisation, loss of agriculture production, adverse effects of COVID-19 and also the national economic downturn. Finally, it has been observed that the implementation of PMJDY significantly gave rise to the business of the HDCCB and also acted as a threshold point of financial inclusion than its counterpart in the Burdwan district of West Bengal.

The association of osteoarthritis with metabolic disorders

Osteoarthritis (OA) is the most common form of synovial joint arthritis that causes chronic pain and disability to a large number of people worldwide. Most often, osteoarthritis affects the joints of the knees, hips, spine and hands. The Global Burden of Disease (GBD, 2021) estimates that osteoarthritis will be the fourth leading cause of disability by 2030, with enormous healthcare costs for treatment, as well as significant indirect costs due to loss of productivity and premature retirement. The aim of our research is to determine in what way prevalent metabolic syndrome is among participants with osteoarthritis of one of the synovial joints (knees, hips, hands), and whether metabolic disorders are a risk factor for the development and worsening of osteoarthritis. A prospective clinical study was conducted at the Public Health Institution Health Center Živinice, from July 2022 to May 2024, on a random sample of 200 participants with a confirmed clinical diagnosis of osteoarthritis (OA), who were divided into a group with metabolic syndrome and a group without metabolic syndrome based on the NCEP ATP III panel criteria for metabolic syndrome. The prevalence of knee osteoarthritis is significantly higher compared to the prevalence of hip and hand osteoarthritis, and it is greater among participants with a higher BMI (in participants with the highest BMI, knee osteoarthritis occurs with a 100% probability) and with the presence of metabolic syndrome, especially in more severe forms, specifically radiologically confirmed osteoarthritis, regardless of age and gender. Unlike OA knees the prevalence of OA hips and hands shows no correlation with BMI and metabolic syndrome. Multiple comparative analysis of differences in the average severity of osteoarthritis of the knee of subjects with normal glycemia / prediabetes / diabetes type 2 it showed a statistically significant difference in the average severity of knee osteoarthritis in subjects with regular blood sugar compared to subjects with prediabetes/diabetes mellitus type 2 regardless of age and gender. This means that with an increase in blood sugar levels, the degree of severity of osteoarthritis of the knee increases, since each subsequent Group has a higher average value of this indicator (p&lt;0.05; CI 95%).

Patient-initiated follow-up supported by asynchronous telemedicine versus usual care in spondyloarthritis (TeleSpA-study): a randomised controlled trial of clinical and cost-effectiveness.

With rising health-care expenditures and workforce shortages, sustainable alternatives to traditional outpatient follow-up strategies are required to optimise care efficiency. We aimed to investigate the cost-effectiveness and clinical effectiveness of patient-initiated follow-up (PIFU) supported by asynchronous telemedicine for patients with spondyloarthritis compared with usual care in daily practice. TeleSpA was a multicentre, pragmatic, open-label, randomised controlled trial. Patients with spondyloarthritis and stable disease were randomly assigned (1:1) to either the PIFU and asynchronous telemedicine group or usual care group. All patients received a scheduled outpatient visit at baseline and after 1 year. Patients were monitored remotely at 6 months (PIFU and asynchronous telemedicine) or at the discretion of the treating rheumatologist (usual care). The primary outcome was the number of rheumatology visits within a 1-year period. A trial-based 1-year health-economic evaluation from a Dutch health-care perspective (only including health-care costs) and societal perspective (also including travel costs and work productivity losses), per the Dutch guidelines was used to estimate cost-effectiveness. The safety analysis was done in the intention-to-treat population and was based on spontaneous reports of adverse events and serious adverse events or as observed by the research team. The primary analysis was in the intention-to-treat population. Individuals with relevant lived experience were involved in the study design. This trial was registered with the Dutch National Trial Register (NL71041.068.19) and ClinicalTrials.gov (NCT04673825) and is completed. Between Dec 2, 2020, and June 20, 2022, 200 patients were randomly assigned to PIFU and asynchronous telemedicine (n=100) or usual care (n=100). 79 (40%) of 200 participants were women, 121 (60%) were men, and the mean age was 55·0 years (SD 11·9). After 1 year, the mean number of rheumatology visits was 1·9 (SD 1·5) for the PIFU and asynchronous telemedicine group and 2·6 (1·3) in the usual care group (mean difference -0·7 [95% CI -1·0 to -0·3]; 25·4% reduction; p<0·0001). PIFU and asynchronous telemedicine was cost-effective from a health-care perspective, saving health-care costs (-€180 [95% CI -921 to 560]) without a loss in quality-adjusted life-years (0·004 [95 % CI -0·022 to 0·030]). Seven non-trial-related adverse events occurred in the PIFU and asynchronous telemedicine group and eight in usual care group (including one death). PIFU and asynchronous telemedicine resulted in significant and clinically meaningful reductions in rheumatology visits. This was not at the expense of health outcomes and saved health-care costs. Dutch Arthritis Society.

An integrated CFD and machine learning analysis on pilots in-flight thermal comfort and productivity

In the cockpit, minimising the pilots' thermal discomfort due to solar exposure while ensuring clear visibility is essential. This study numerically examined the solar radiation effect on thermal fields of an Airbus A320 cockpit and assessed global and local thermal comfort of three aircrews using the Fanger model and the Equivalent Homogeneous Temperature (EHT) model. The productivity of aircrews based on thermal comfort was further estimated. A total of 27 cases, encompassing a combination of environmental and HVAC parameters were performed. This dataset was used for data analysis, employing an explainable machine, XGBoost, to highlight the significance of each variable on the pilot's thermal satisfaction. Outcomes proved that solar radiation penetrating the cockpit domain facilitated a non-homogeneous temperature distribution and thermal stratification. With strong solar exposure, it was recommended to set cockpit's maximum supply temperature smaller than 19 ∘ C, maintaining RH between 10–20% for appropriate global thermal environment. Aircrew productivity loss was estimated to decline by 2.7% to 5.6% due to solar intensity variation, with pilot being the most affected. Without solar radiation, the local comfort of lower body segments was compromised. Rising solar radiation resulted in significant EHT gradient changes in the upper torso compared to the lower body, highlighting the predominance of radiative heat transfer at the upper level. Analysis via XGBoost revealed that mean radiant temperature had the most substantial impact on thermal satisfaction in the cockpit, underscoring the efficiency of optimising cockpit materials for better absorption and reflection of radiative heat for enhanced thermal environment control.

Life After Invasive Meningococcal Disease: Insights from Survivors and Their Caregivers.

Invasive meningococcal disease (IMD) has a low incidence but is a life-threatening illness that is preventable via vaccination. Even with treatment, up to 10-15% of cases are fatal, and many survivors may experience severe long-term sequelae. Building upon the acute-phase findings presented in the Part1 manuscript for this study, we describe the long-term physical, social, psychological, and economic burden of IMD on US survivors and their caregivers in this Part2 manuscript. This was a novel, non-interventional, mixed-methods study among US survivors and their caregivers using a bespoke survey and qualitative interviews. Ten adult survivors, one adolescent survivor, and three caregivers participated in this study. Survivors described extensive physical, neurological, and systemic sequelae, including difficulty walking (11/11), repeat secondary infections (9/11), and numbness (6/11), among others, which were echoed by caregivers. Survivors shared that IMD had negatively impacted their long-term quality of life, citing long-term impacts including emotional impacts (11/11), social impacts (10/11), memory (7/11) and attention (5/11) problems, and difficulty with functional (10/11), self-care (7/11), and physical (6/11) activities. Caregivers were also impacted, describing emotional trauma (3/3), sleep problems (2/3), and day-to-day challenges (2/3). Long-term financial challenges related to healthcare resource utilization were substantial, with specialized care and rehabilitation therapy expenses (11/11), insurance challenges (8/11), and high out-of-pocket costs (6/11) for survivors. Productivity losses were also commonly described by survivors (9/11); sequelae hindered ability to attend school (9/11) or work full time (8/11). Caregivers (2/3) described taking leave from their employment, affecting family income. The humanistic burden of IMD on survivors and their caregivers is substantial and persistent. A comprehensive approach, including preventative measures (e.g., vaccination) and long-term medical, psychological, and financial support for those affected, is needed to mitigate the burden of IMD. A video abstract is available with this article. Video abstract (MP4 1,17,430kb).

Increasing the Oxygen Consumption in Hermetic Grain Storage Using Grain Weevils (Sitophilus granarius)

Loss of stored plant products due to insect infestation is a problem that is likely to increase with global warming. Improved storage under hermetic conditions in oxygen deficiency can prevent or control infestation and preserve product quality. Oxygen levels in hermetic storage decrease due to different factors, one of which is the oxygen consumption of the insects present. Experiments were carried out using varying numbers (25, 50, or 200) of all developmental stages of the grain weevil Sitophilus granarius L. (eggs, larvae, pupae, and adult beetles) caged and placed in sealed 30-L containers containing 22 kg of wheat for at least 21 weeks. Oxygen levels were measured at regular intervals. The oxygen consumption depended on the number of insects and went below the critical threshold of 3% for S. granarius survival in most of the trials. Some surviving beetles were observed at the end of the hermetic experiments and 12 weeks afterwards during control for progeny, when oxygen levels did not fall below the critical threshold or the low level could not be maintained for a sufficient time. Monitoring oxygen levels in hermetic storage is therefore essential to ensure safe storage over long periods.

Quantification of social metrics for use in optimization: An application to solid waste management

Solid waste management (SWM) is an interdisciplinary field which requires a range of metrics to make informed decisions. Social indicators are of high interest to decision-makers but are particularly difficult to integrate into optimization frameworks, largely due to challenges of quantification. This study presents a methodology for quantifying a social metric for integration into sustainability assessment of solid waste management (SWM) systems using optimization. To identify social indicators, waste managers were consulted in Columbia, Missouri, USA. Meetings were held prior to indicator creation and reviewed mid-project with stakeholders. A number of concerns that could be categorized as social were raised. For the two most pressing issues to managers, quantitative metrics were created. First, SWM experiences high employee turnover, largely due to low wages. Turnover leads to less efficiency in collection and treatment, gaps in service, and cost to citizens. Hence, the first social metric proposed represents turnover of employees including loss of productivity, hiring and replacement costs, and quit rate. Second, this work estimated the value of exposure risk associated with manual material handling activities. This second social metric considered a worker's physical exposure to risk via activities of lifting, carrying, placing, emptying, and sitting. These social metrics were used within a multi-criterion decision-making framework for SWM, extending the traditional focus on economic and environmental objective functions. Results illustrate the trade-offs among these conflicting criteria and provide managerial insights into the costs and benefits of different waste management strategies.

Stress timing, trauma exposure, and family resilience differentially affect internalizing and externalizing symptoms at 3, 5, and 7 years of age

Mental health disorders are associated with decreased quality of life, economic productivity loss, and increased mortality. The association between stressful experiences and psychopathology is well documented. However, studies are needed to understand the impact of timing of stressful events, types of traumatic experiences, and of family resilience on internalizing and externalizing symptoms in early childhood. The present study used a longitudinal design towards this end. Parents (N = 456) completed study measures at infancy, 2 years, 3 years, 5 years, and 7 years. At 3 years, greater stressful events during the prenatal period, 1-2 years, and 2-3 years (B = 0.833–0.369, p = 0.028–0.046) predicted internalizing symptoms for female participants only. For externalizing symptoms at 3 years, every time point assessed was significantly associated with more symptoms across both sexes (B = 1.071–0.414, p < 0.001). At 5 years, both internalizing and externalizing symptoms were associated with a greater number of stressful events at every time point and across sexes (B = 1.372–0.465, p < 0.001–0.002). There was evidence for timing effects, including cumulative effects, sensitive periods, and recency effects. Exposure to interpersonal trauma associated with greater internalizing symptoms (B = 2.120, p = 0.002), whereas both interpersonal (B = 1.879, p = 0.005) and non-interpersonal (B = 1.223, p = 0.032) traumatic experiences were associated with greater externalizing symptoms. Aspects of family resilience including higher levels of family commitment, ability to face challenges, and sense of control reduced risk for internalizing symptoms (B = –0.496, p = 0.004) while only greater sense of control (B = –0.838, p = 0.040) reduced risk for externalizing symptoms at age 7 years, including in the context of trauma.

Interactions between fungi and other microorganisms for better fungal products: a review

Under natural conditions, substrates are occupied by sets of different micro-organisms that interact with one another in synergistic or antagonistic relationships. These interactions can influence the growth, development, and biochemistry of economically important fungi, enhance their beneficial properties, stimulate the growth of fruiting bodies, or accelerate the growth of mycelium used for the production of various products and biotechnology processes where fungi are involved. The paper presents a literature review covering known interactions between fungi and bacteria, fungi and actinomycetes, and between different fungi that can be used to promote the production of fungal products or that need to be taken into account in order to avoid production losses. A brief overview of fungi and micro-organism co-culture strategies is provided as well.