Long-term Prospects Research Articles

ANALYSIS OF THE FUNCTIONS OF THE ADAPTIVE PROPERTY MANAGEMENT SYSTEM

The classification of management functions according to their essence in the property relations regulation system has been improved, namely: forecasting and planning (prediction of future changes in the middle of the state property management system and in the external environment and determination of their impact on state property objects, development of key directions for the development of the management system owned by the state, formation of interrelated management goals and tasks, determination of indicators of achievement of set goals); organization (establishment of a system of mutual relations and interconnection between various elements of the system of property relations regulation); motivation (encouraging individual subjects of state property management to act in favor of the effective implementation of the goals and objectives of the integrated system); coordination (ensuring consistency of actions between different elements of the system in time and space); accounting and control (establishing the fact of the presence and number of state-owned objects, systematization and registration of information about them. implementation of measures aimed at determining the degree and quality of achievement of set (planned) goals and tasks). The modern system of strategic management of the socio-economic development of territories is focused on solving a number of tasks, the essence and content of which is reduced to ensuring the achievement of such effects as increasing the awareness and awareness of business entities about the medium-term and long-term prospects of socio-economic development, minimizing investment and other risks, ensuring coherence and eliminating contradictions between the goals and tasks of subjects of different levels of the management hierarchy at all time horizons of planning, synchronization of development cycles of various elements of infrastructure, labor markets, capital and other factors of production, and even their balancing. The objective prerequisites for the development of an adaptive system of state policy for the regulation of property relations as the property basis of the regional reproductive system have been determined. First, the strategic uncertainty of the state policy of regional development management. Secondly, unreliable or erroneous goal setting during the development of strategic planning documents is a restraining factor of socio-economic development with the help of irrational use of limited resources. A whole series of indicators used as control or targets are either not related to strategic goals (increasing the level and quality of life of the population), or do not allow us to clearly judge the presence of progress. In order to ensure the transfer of the existing regional development management model to a model based on the principles of spatial economy, systemic measures are needed, which involve the improvement of the program-targeted approach to management and the expansion of the practice of applying the project approach, revision and expansion of the set of target management indicators. Management influence measures should be aimed at stimulating the development of business networks, the basis of which is not "artificially designated" clusters, separated according to the principle of geographical proximity, but real networks of interaction of business entities that carry out joint or distributed use of assets.

Анализ и оценка результатов реализации стратегии социально-экономического развития Республики Северная Осетия-Алания

The article is devoted to the analysis and evaluation of the results of the implementation of the socio-economic development strategy of the Republic of North Ossetia-Alania. The strategy of socio-economic development of the republic is a set of measures implemented jointly by government and business, and aimed at implementing long–term goals and objectives of the region, taking into account its characteristics: weaknesses and strengths, opportunities and limitations. The relevance of the article is due to the fact that in order to effectively use existing opportunities and search for long-term prospects of the region, it is necessary to search for effective forms and methods of strategic management of the development of the region. The problem of strategic planning is a very important aspect of activity, to which public administration bodies and the expert community are paying more and more attention. After all, it is the development of the regions that contributes to the development of the country as a whole, and to increasing its importance on the world stage. The purpose of the article is to analyze and evaluate the results of the implementation of the socio-economic development strategy of the Republic of North Ossetia-Alania, based on analytical and statistical data. The research materials are federal laws directly related to the topic of the article, statistical data from official sources of information, as well as the works of various authors on the socio-economic development of the region were used in this article. General scientific research methods were used as methods during the study of this topic: quantitative and qualitative methods, comparative and statistical analysis, analysis of the structure and dynamics of indicators; as well as special research methods such as: system analysis, SWOT analysis, strategic planning. The strategy of socio-economic development of the region occupies a central place among the strategic documents of the subject, since the level of development of the region depends on its effective implementation.

ВОПРОСЫ АДАПТАЦИИ ТРАНСПОРТНОЙ ИНФРАСТРУКТУРЫ РОССИИ В УСЛОВИЯХ САНКЦИЙ

The practice of adapting the transport infrastructure of Russia in the context of sanctions is considered. Problems that have a significant impact on the process of such adaptation are identified. The external and internal risks and factors of the development of transport infrastructure are analyzed, and the medium and long-term prospects for its development are characterized. Solutions to practical and conceptual issues of the development of Russia's transport infrastructure in the context of sanctions are proposed.

Determination of optimal warranty length for smart wearable device considering customer complaint

ABSTRACT This study investigates optimal warranty length for a new type of smart wearable device to maximize manufacturer’s profit in a competitive market. Most studies explore optimal warranty length based on product performance without considering customer complaints. In this study, unlike existing models, the optimal warranty length is obtained by maximizing an expected profit function comprising essential factors such as customer complaints, early and late warranty periods, product reliability, and reduced profit, using Bayesian analysis. Managers can effectively integrate these factors, and can be more confident about the accuracy of estimated optimal warranty length. This study’s contribution is to propose a methodology to develop new types of smart wearable devices considering their long-term commercial prospects. Sensitivity analyses indicate that in the early warranty period, managers should be more concerned about average reduced profit due to customer complaints and reduced profit percentage due to complaint handling costs. In the late warranty period, improved profit percentage due to good response to complaints is essential in smart wearable device sales. Consequently, managers should adequately deal with customer complaints about smart wearable devices, whether in the early or late warranty period.

Model "Triple Helix" in Optics of Expert Estimates of Scientific and Pedagogical Community of the Russian Higher Education Institutions

Relevance. The model of " triple helix" is more than 10 years a subject of theoretical judgment and development of applied techniques of her assessment and realization. However, philosophical and sociocultural aspects of her functioning, and also reflexive features among institutional agents remain on the periphery of the scientific analysis.The purpose an objective of this research is the analysis of expert positions of representatives of scientific and pedagogical community of higher education institutions about separate aspects of functioning of model of " triple helix". Objectives: To reveal expert estimates of representatives of scientific and pedagogical community of higher education institutions about separate aspects of functioning of model of "triple helix".Methodology. Research is executed on the basis of existing techniques of an assessment of innovative development of subjects of " triple helix " and empirical methods of poll.Results. Among barriers and contradictions in "spiral" integration of institutes of the power, business and science / education on the basis of expert positions are defined: 1) for the power ‒ vertical isolation and low density of horizontal cross-contacts; 2) for business ‒ scientific researches are focused on short-term prospect, values of a private property; 3) for science / education ‒ scientific researches are focused on long-term prospect, the principles of universality of scientific knowledge, objects of intellectual property.Conclusions. As a result of a situation of civilization and cultural antagonism of social codes "traditions and innovations" the functional mimicry of institutes can act, is actually realized in morphology of values traditionally Russian bureaucracies – a paternalism – corruption. Such imitations can be characterized as the institutional mutations arising in the conditions of an anomy when there is a deconstruction of traditional values, and imperatives of innovative development exists it is only declarative.

GRAIN MARKET OBSTACLES WITHIN THE BLACK SEA REGION

The Black Sea region is a major producer and exporter of wheat, in addition to being an extremely significant hub for international trade with agricultural goods. In this respect the region's influence on the global grain market is steadily increasing. Ukraine is one of the largest producers of grain commodities not only in the Black Sea region, but also in the world. Тhe physical supply of goods, the disrupted logistics structure, the food security of the population, the damaged port infrastructure, as well as the long-term prospects are only few of the challenges, which are facing the grain market in the conditions of a military invasion. The impact of the conflict within the region is having a lasting influence on global grain trade due to the disrupted international food supply chain. The purpose of the publication is to present key aspects of the impact of the grain market in the Black Sea region on the world economy with an emphasis on the challenges arising from the interaction between the participating countries, including Russia and Ukraine. The subject of the research are the trends and challenges facing the grain market in the Black Sea region. The subject of the publication is the Black Sea region with a focus on Ukraine

Fabrication of soy protein isolate - High methoxyl pectin composite emulsions for improving the stability and bioavailability of carotenoids

A handy and efficient emulsifying emulsion was developed based on self-assembled soy protein isolate (SPI) and high methoxy pectin (HMP) for entrapping and loading carotenoids. The complex, ca. 195 nm, showed a significant improvement in solubility, emulsification (32.42 m2/g) and stability (83.86%). Moreover, the physical stability of torularhodin was remarkably improved after entrapping into the SPI-HMP complex. The retention rate for entrapped torularhodin could be up to 66.03%, 95.14% and 84.31% under treatment with ultraviolet irradiation for 8 h, thermal stock at 25 and 50 °C for 28 days, respectively. Increase of two affinities, enhancement of intermolecular hydrogen bond and hydrophobic interaction and charge changes caused by the preparation process of the complex were the main reasons for improving the properties of emulsion. At the same time, composite lotion encapsulation significantly improves the bioavailability of torularhodin, including the absorption of carotenoids in the small intestine, the content in the systemic circulation and the storage capacity in the liver. Therefore, the preparation of low price, safer, green and efficient SPI-HMP complex emulsion has long-term application prospects on the development, transportation and application of antioxidants.

Analysis of a multi-type resurgence of Mycobacterium bovis in cattle and badgers in Southwest France, 2007-2019

Although control measures to tackle bovine tuberculosis (bTB) in cattle have been successful in many parts of Europe, this disease has not been eradicated in areas where Mycobacterium bovis circulates in multi-host systems. Here we analyzed the resurgence of 11 M. bovis genotypes (defined based on spoligotyping and MIRU-VNTR) detected in 141 farms between 2007 and 2019, in an area of Southwestern France where wildlife infection was also detected from 2012 in 65 badgers. We used a spatially-explicit model to reconstruct the simultaneous diffusion of the 11 genotypes in cattle farms and badger populations. Effective reproduction number R was estimated to be 1.34 in 2007–2011 indicating a self-sustained M. bovis transmission by a maintenance community although within-species Rs were both < 1, indicating that neither cattle nor badger populations acted as separate reservoir hosts. From 2012, control measures were implemented, and we observed a decrease of R below 1. Spatial contrasts of the basic reproduction ratio suggested that local field conditions may favor (or penalize) local spread of bTB upon introduction into a new farm. Calculation of generation time distributions showed that the spread of M. bovis has been more rapid from cattle farms (0.5–0.7 year) than from badger groups (1.3–2.4 years). Although eradication of bTB appears possible in the study area (since R < 1), the model suggests it is a long-term prospect, because of the prolonged persistence of infection in badger groups (2.9–5.7 years). Supplementary tools and efforts to better control bTB infection in badgers (including vaccination for instance) appear necessary.

&lt;i&gt;MENEGAZZIA TEREBRATA&lt;/i&gt; (PARMELIACEAE) AT THE NORTHERN BORDER OF ITS RANGE (KIVACH NATURE RESERVE, REPUBLIC OF KARELIA)

Menegazzia terebrata is a foliose macrolichen listed in the Red Data Books of most European countries and in the Red Book of the Russian Federation. The species is stenotopic, for which the variety of suitable biotopes is limited; therefore, habitat disturbance under natural and anthropogenic factors is the main reason for decreasing its population. Most records of the species in European Russia were made in the mid 19th – mid 20th centuries. The purpose of this study was to assess the state of coenopopulations and ecological features of M. terebrata in the communities of the Kivach Nature Reserve (Republic of Karelia). The studies were carried out in the territory of Kivach Nature Reserve on sample plots of 625 m2, where general characteristics of plant communities and habitat characteristics were recorded. The size of each coenopopulation was determined as well as the coverage area on the surface of the substrate (cm2), the number of thalli, their ontogenetic state, associated species in lichen synusia. For the first time in the last 80 years, 4 habitats of M. terebrata were found on the territory of the Republic of Karelia. Based on literature and own data, a map of the species distribution in Northern Europe was compiled. The discovered population is the northernmost of all currently existing in the territory of the European part of Russia. M. terebrata prefers more shaded and humid conditions, occupying vertical surfaces of mossy rocks in deciduous forests with the last fire 93–120 years ago. The lichen occurs in communities with bryophytes, in lichen synusia with common species of shady habitats: Lepraria sp., Cystocoleus ebeneus, Peltigera sp. Totally 144 thalli of M. terebrata with a total area of 1228 cm2 were identified at four ontogenetic states assigned to two age periods: pregenerative (two variants of virginal state – \({{v}_{1}}\), \({{v}_{2}}\)), and postgenerative (subsenile – ss, senile – s). These coenopopulations follow the strategy of vegetative reproduction, as evidenced from the presence of soralia and fragmentation of the thalli. The size of the thalli and the predominance of virginal and subsenile thalli with abundant soralia indicate a long-term good prospect for the development of the coenopopulations, and allow us to assess the state of the species as normal. The existence in a specially protected area, the presence of a suitable substrate (vertical rock outcrops of significant size), as well as forest communities with a certain microclimate (shading, high relative humidity) create the necessary conditions for the conservation of M. terebrata. The results obtained are the basis for changing the status of M. terebrata in the Red Data Book of the Republic of Karelia from “0” (probably extinct) to “1” (endangered).

Justification for the development of measures to neutralize sanctions pressure and further development of the Russian economy

An unprecedented number of sanctions have been imposed against Russia over the past year. The sanctions imposed against our country by Western countries have affected almost all spheres of the economy. From industry and agriculture to the banking sector, from the blatant discrimination of our athletes in the international arena to the attempt to abolish Russian culture. The article analyzes the impact of sanctions on various sectors of the economy, including the energy sector, mechanical engineering, agriculture, banking and IT spheres, and others. The strengths and weaknesses of the domestic economy are assessed, the directions in which the countries of the world critically depend on Russia are presented, among them the production of agricultural products, fertilizers, chemical, metallurgical, machine-building and other industries. The analysis of macroeconomic indicators of Russia and some Western countries that imposed sanctions is carried out. Macroeconomic analysis showed the stability of the domestic economy, while the decline in gross domestic product was less than predicted, and domestic inflation was lower than in some Western countries. A large section of the article is devoted to areas to reduce the country's dependence on Western products and technologies, presents the main measures to neutralize sanctions pressure and further development of the Russian economy, which the authors divided into three areas: measures in the short, medium, and long-term prospects. The list of measures to reduce the negative impact of sanctions, among other things, included ensuring budget revenues through the sale of energy resources, import substitution of products of departed Western companies, ensuring the sustainability of the economy, the development of a digital, and subsequently an innovative economy. All this should ensure the socio-economic prosperity of the state and ensure its sustainable development for many years.

Assessment of Long-Term Prospects for Demand in the Plastics Market in the Face of Industry Transformation

Assessment of Long-Term Prospects for Demand in the Plastics Market in the Face of Industry Transformation

Theoretical basis of budget policy formation

Relevance of the research topic. The soundness of the budget policy is an important prerequisite for ensuring the socio-economic development of the country. In modern conditions, it is expedient to strengthen the adaptability of budget policy to socio-economic processes. The task of increasing the quality level of the budget mechanism has become important. Formulation of the problem. The budget policy should correspond to both tactical tasks and long-term prospects of the country's socio-economic development. Analysis of recent research and publications. The problem of the theoretical foundations of budget policy formation is quite widespread in scientific research. These are the works of famous domestic and foreign scientists: J. Keynes, P. Samuelson, I. Chugunov, T. Kaneva, L. Lysiak, I. Lukyanenko, A. Mazaraki, V. Makogon, M. Pasichno, V. Fedosov and others. Highlighting unexplored parts of the general problem. In modern economic conditions, it is important to use budget policy as an effective tool for influencing the socio-economic processes of the state. Activation of budget policy possibilities in the system of state regulation requires a more rational use of its regulatory potential. Setting the task, the goal of the research. The tasks of the research are: to reveal the role of budget policy in regulating the socio-economic development of administrative-territorial units; justify the theoretical foundations of budget policy; to carry out an analysis and assessment of revenues and expenditures of the State Budget of Ukraine. The purpose of the study is to reveal the theoretical foundations of budget policy formation. Method or methodology of research. The article uses a set of scientific research methods: system approach, statistical analysis, structuring, synthesis, etc. Presentation of the main material (results of work). The role of budget policy in regulating the socio-economic development of administrative-territorial units is revealed. The theoretical foundations of budget policy are substantiated. An analysis and assessment of revenues and expenditures of the State Budget of Ukraine was carried out. The theoretical foundations of budget policy formation are revealed. Field of application of results. The results of the study can be used in the process of formation and implementation of budget policy. Conclusions according to the article. Budgetary policy is actively used by the state to manage economic processes. It plays an important role in increasing the concentration of funds in the most important areas of socio-economic development of the country, improving the sectoral and territorial structure of the economy, accelerating the intensification of production in accordance with the level of development of society.

Роль пигментного эпителия сетчатки в лечении субмакулярных кровоизлияний

Objective. To evaluate the structural and functional changes in the retina depending on the duration of the morphological structure disorder of the retinal pigment epithelium (RPE) after treatment of patients with submacular hemorrhage (SMH) against the background of age-related macular degeneration (AMD). Material and methods. Depending on the duration of AMD, the patients were divided into two groups: Group 1 (24 patients) – SMH with newly diagnosed AMD; group 2 (19 patients) – SMH with AMD with an established diagnosis for more than 12 months. All patients underwent two-port 27 G surgery with subretinal injection of a fibrinolytic agent with air tamponade of the vitreal cavity. Then all patients were prescribed antivasoproliferative therapy. Results. After 2 weeks, the indices of maximally corrected visual acuity in the 1st group increased to 0.18 ± 0.05 and in the 2nd group to 0.15 ± 0.03. At the end of the 12-month follow-up period, the 1st group demonstrated stable visual acuity at the same levels, and the 2nd group showed a significant decrease in visual functions to 0.1 ± 0.04. The central retinal thickness before therapy was 826.2 ± 168, 9 in the 1st and 778.7 ± 151.9 µm in the 2nd group. One year after the start of treatment, a decrease to 231.3 ± 22.4 and 305.2 ± 57.6 µm was demonstrated in the 1st and 2nd groups, respectively. Before vitreoretinal intervention, the average height of RPE detachment was 167.2 ± 79.9 µm in the 1st group and 184.4 ± 85.1 µm in the 2nd group. and after 12 months – up to 38.8 ± 6.2 and 63.9 ± 11.6 microns in the 1st and 2nd groups, respectively. Conclusion. Vitreoretinal intervention followed by antivasoproliferative therapy in patients with SMH associated with AMD can improve the morphological and functional prognosis of the course of the disease. However, the long-term prospects for the restoration of visual function largely depend on the initial state of RPE and the duration of AMD. Keywords: submacular hemorrhage, tissue plasminogen activator, pneumodislocation

Engineered Peptides Enable Biomimetic Route for Collagen Intrafibrillar Mineralization

Overcoming the short lifespan of current dental adhesives remains a significant clinical need. Adhesives rely on formation of the hybrid layer to adhere to dentin and penetrate within collagen fibrils. However, the ability of adhesives to achieve complete enclosure of demineralized collagen fibrils is recognized as currently unattainable. We developed a peptide-based approach enabling collagen intrafibrillar mineralization and tested our hypothesis on a type-I collagen-based platform. Peptide design incorporated collagen-binding and remineralization-mediating properties using the domain structure conservation approach. The structural changes from representative members of different peptide clusters were generated for each functional domain. Common signatures associated with secondary structure features and the related changes in the functional domain were investigated by attenuated total reflectance Fourier-transform infrared (ATR-FTIR) and circular dichroism (CD) spectroscopy, respectively. Assembly and remineralization properties of the peptides on the collagen platforms were studied using atomic force microscopy (AFM). Mechanical properties of the collagen fibrils remineralized by the peptide assemblies was studied using PeakForce-Quantitative Nanomechanics (PF-QNM)-AFM. The engineered peptide was demonstrated to offer a promising route for collagen intrafibrillar remineralization. This approach offers a collagen platform to develop multifunctional strategies that combine different bioactive peptides, polymerizable peptide monomers, and adhesive formulations as steps towards improving the long-term prospects of composite resins.

The first encounter with "the black swan": how the pandemic affects the mood of graduates

The first ILO report against the background of the Covid-19 pandemic names youth among the most anxious groups. Russian sociologists also spoke about this, linking such a reaction with the greenhouse conditions created by Russian families for children. Graduation from a university is a serious life milestone, especially in the context of the pandemic that has required long periods of distance learning and dramatically accelerated the digitalization of the economy. According to the research conducted by the authors, more than two-thirds of students believe that the pandemic has changed our lives forever, and also that in the modern world it is impossible to have one profession for all your life. Medium-term and long-term prospects for specialists with their education do not seem very optimistic to students. But and in the short term, the majority of graduates assess their competitiveness in the labor market as average and foresee high competition for vacancies (or their shortage) and the offer of low wages. For many, the problems of future employment are laid down at the stage of choosing a profession: a significant part goes to study where there are affordable budget places, but poorly understand the essence of the profession and its relevance. Today, half of the graduates would choose another profession and do not plan to work in their specialty. High proportion of those who expected successful employment before the pandemic has noticeably decreased against its background. With regard to employment problems, almost half of the respondents have an internal locus of control, the rest are divided in equal proportions into those who have an external locus of control, or both loci of control are expressed or not expressed. For older students, problems with employment are more often seen as a combination of external factors and their own shortcomings. Among those looking for problems in themselves or both in themselves and in the external environment, there are quite a lot of expecting difficulties in finding a job. Acting within the framework of the "ontological security", young people implement practices that allow them to adapt, but do not reduce uncertainty.

CHOICE OF COMMUNICATION STRATEGY ON THE DIFFERENT STAGES OF DEVELOPMENT OF BRAND AS CONSTITUENT OF DATAFLOW OF ENTERPRISE

In the modern terms of work the special importance is got by the dataware of enterprise as pre-condition of him effective functioning. Effective means is application of communications, as systems of support of informative cooperation of enterprise with his internal and external business-environment. Communications of subject of economic activity play an important role realization of strategic aims of enterprise. The report of the correctly set forth communicative reports of subject to his target groups forms favourable basis for activity in the system of economic relations, helps to secure support of public for defence of interests and reputation of subject of economic activity. On the modern stage of development of economy the question of determination of quality and efficiency of communications of enterprise gets up very important. Determination of correct strategic course is the most responsible business for an enterprise, as forms priorities of his activity on relatively long-term prospect. It is extremely important to walk up the That management of company self-weighted to the process of choice and realization of communication strategy, taking into account many internal and external factors and accenting attention on some from them. Today it is very difficult to attract attention business entities to the brands, that is why it will be them to search the methods of organization of reports to the consumers about itself and the products. On the basis of it the question of choice of communication strategy becomes very important on the different stages of development of brand. Not having regard to the far of scientific publications from this range of problems, to the choice of communication strategy on the different stages of development of brand as a constituent of dataflow of enterprise it remains not fully studied. It stipulated the theme of the article. The basic types of communication strategies, the use of that allows to improve of communication activity of enterprise, are presented in the article. Design of communication strategy times are described and the complex of operating offers on every design time for every type of communication strategy. The basic stages of forming and development of brand are considered. For each the use of corresponding of communication strategy offers of the considered stages of development of brand.

Long-Term Prospects for Telemedicine in Opioid Use Disorder (OUD) Treatment: Results from a Longitudinal Survey of OUD Clinicians.

During the pandemic, there was a dramatic shift to telemedicine for opioid use disorder (OUD) treatment. Little is known about how clinician attitudes about telemedicine use for OUD treatment are evolving or their preferences for future use. To understand OUD clinician views of and preferences regarding telemedicine. Longitudinal survey (wave 1, December 2020; wave 2, March 2022). National sample of 425 clinicians who treat OUD. Self-reported proportion of OUD visits delivered via telemedicine (actual vs. preferred), comfort in using video visits for OUD, impact of telemedicine on work-related well-being. The mean reported percentage of OUD visits delivered via telemedicine (vs. in person) dropped from 56.9% in December 2020 to 41.5% in March 2022; the mean preferred post-pandemic percentage of OUD visits delivered via telemedicine was 34.8%. Responses about comfort in using video visits for different types of OUD patients remained similar over time despite clinicians having substantially more experience with telemedicine by spring 2022 (e.g., 35.8% vs. 36.0% report being comfortable using video visits for new patients). Almost three-quarters (70.9%) reported that most of their patients preferred to have the majority of their visits via telemedicine, and 76.7% agreed that the option to do video visits helped their patients remain in treatment longer. The majority (58.7%) reported that telemedicine had a positive impact on their work-related well-being, with higher rates of a positive impact among those who completed training more recently (68.5% of those with < 10years, 62.1% with 10-19years, and 45.8% with 20 + years, p < 0.001). While many surveyed OUD clinicians were not comfortable using telemedicine for all types of patients, most wanted telemedicine to account for a substantial fraction of OUD visits, and most believed telemedicine has had positive impacts for themselves and their patients.

Contemporary outcomes for branch renal artery repair

BackgroundThe purpose of this study was to provide an updated description of demographics, technical details, and clinical outcomes of 101 consecutive branch renal artery repairs in 98 patients using cold perfusion. MethodsA single-institution, retrospective analysis branch renal artery reconstructions was performed between 1987 and 2019. ResultsPatients were predominantly Caucasian (80.6%) women (74.5%) with a mean age of 46.8 ± 15.3 years. The mean preoperative systolic and diastolic blood pressures were 170.4 ± 33.0 mm Hg and 99.2 ± 19.9 mm Hg, respectively, requiring a mean of 1.6 ± 1.1 antihypertensive medications. The estimated glomerular filtration rate was 84.0 ± 25.3 mL/min. Most patients (90.2%) were not diabetic and never smokers (68%). Treated pathology included aneurysm (87.4%) and stenosis (23.3%) with histology demonstrating fibromuscular dysplasia (44.4%), dissection (5.1%), and degenerative not otherwise specified (50.5%). The right renal arteries were most frequently treated (44.2%), with a mean of 3.1 ± 1.5 branches involved. Reconstruction was accomplished using bypass in 90.3% of cases using aortic inflow in 92.7% and a saphenous vein conduit in 92%. Branch vessels served as outflow in 96.9% and syndactylization of branches was used to decrease the number of distal anastomoses in 45.3% of repairs. The mean number of distal anastomoses was 1.5 ± 0.9. Postoperatively, the mean systolic blood pressure improved to 137.9 ± 20.8 mm Hg (mean decrease of 30.5 ± 32.8 mm Hg; P < .0001) and the mean diastolic blood pressure improved to 78.4 ± 12.7 mm Hg (mean decrease of 20.1 ± 20.7 mm Hg; P < .0001) with patients requiring a mean of 1.4 ± 1.0 antihypertensive medications (mean decrease of 0.2 ±1.0 medications; P = .048). The postoperative estimated glomerular filtration rate was 89.1 mL/min (mean increase of 4.1 mL/min; P = .08). The mean length of stay was 9.0 ± 5.8 days and 96.1% of patients were discharged home. The mortality rate was 1% (one patient with liver failure) and the major morbidity rate was 15%. There were five infectious complications (pneumonia, Clostridium difficile, and wound infection) and five patients required return to the operating room (one for nephrectomy, one for bleeding, two for thrombosis, and one for second trimester pregnancy loss requiring dilation and curettage and splenectomy). One patient required temporary dialysis owing to graft thrombosis. Two patients developed arrhythmias. No patients suffered a myocardial infarction, stroke, or limb loss. After 30 days, follow-up data were available for 82 bypasses. At this time, three reconstructions were no longer patent. Intervention was required to retain patency for five bypasses. After 1 year, patency data were available for 61 bypasses and five were no longer patent. Of the five grafts with loss of patency, two underwent intervention in attempt to maintain patency, which subsequently failed. ConclusionsRepair of renal artery pathology involving the branches can be performed with short- and long-term technical success and significant prospect of decreasing an elevated blood pressure. The operations required to fully address the presenting pathology are often quite complex involving multiple distal anastomoses and consolidation of small secondary branches. The procedure carries a small but significant risk of major morbidity and mortality.

Prospects for the development of investment and innovation activity in Ukraine

The article is based on general and special scientific knowledge methods by means of which the main investment trends in Ukraine and in the leading economies of the world are revealed. It highlights the prerequisites for stable economic development of the country and, at the same time, investigates the factors of investment attraction. The main problems of the development of investment activities on the territory of Ukraine are described and strategic guidelines for the formation of a positive investment climate are given. As a result of the research, the short- and long-term policy prospects for improving investment and innovation activities in war and post-war times have been determined. In addition, the priority directions of foreign capital investments are considered, which include defense industry, energy, information technologies, processing industry, financial activity and trade. It was concluded that stimulation of intellectual and investment activities in Ukraine requires the introduction of an effective tax system, promotion of international cooperation, improvement of legislation and provision of adequate protection of intellectual property rights.

Pendampingan Ke SMA Pax Patriae Untuk Membangun Ekonomi Kreatif di Era Pandemi

A creative economy is related to human creativity that can generate profits and is considered to improve the national economy. One area of the creative economy is the fashion sector, which includes clothing such as T-shirts, accessories, hats, wallets, and other souvenirs. Becoming a well-known brand takes a long time because the most difficult thing is building public trust that the products sold are of good quality. However, most businesses engaged in the creative economy have good long-term prospects. This can be seen from the benefits obtained because the products offered usually will not run out in time because they are durable and have endless creative ideas. Therefore, it is very interesting for us to discuss and educate the public about the importance of the creative economy.