Long-term Combined Effects Research Articles

Cumulative Burden of Lifestyle Risk Factors on Cancer in Older Korean Men: A Nationwide Retrospective Cohort Study

Background/Objectives: Cancer prevalence is increasing globally due to aging populations. Certain lifestyles are associated with cancer; however, the long-term combined effects of lifestyle factors on cancer has not been investigated. This study aimed to investigate the cumulative effect of lifestyle risk factors over 8 years on cancer in older Korean men. Methods: We assessed 64,756 men aged ≥65 years at the baseline year (2008–2009) using data from the National Health Insurance Service-Senior Cohort. Lifestyle factors, including smoking status, alcohol consumption, and physical activity, were evaluated over four consecutive phases (2002–2003, 2004–2005, 2006–2007, and 2008–2009) of health check-ups, and each participant’s overall lifestyle risk score was calculated after considering the value of a single poor lifestyle factor in each phase as 1, with a cumulative score ranging between 0 and 12. According to the lifestyle risk scores, the hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazard regression analysis. Results: Of the 64,756 men, 13,130 cases of cancer developed. The risk of cancer increased as the number of poor lifestyle factors and lifestyle risk score increased from the baseline year during the four phases. Compared to a score of 0–2, the HRs for cancer were 1.10 (0.98–1.23), 1.54 (1.37–1.73), and 1.72 (1.48–1.99) for scores of 3–5, 6–8, and 9–12, respectively. Conclusions: The risk of cancer increased as the cumulative burden of poor lifestyle habits over 8 years increased. Therefore, practicing and maintaining healthy lifestyles is crucial to preventing cancer in older Korean men.

Heterogeneous influences of urban compactness on air pollution: evidence from 285 prefecture-level cities in China

Fine particulate matter (PM2.5) pollution can harm the climate, the environment, and human health. With sustainability initiatives receiving increasing attention, whether compact urban development can yield green environmental benefits has become an essential research proposition among urban planners. The compact city theory advocates energy efficiency enhancement through the mutual superposition of urban functions. First, a theoretical analysis framework for the effect of urban compactness on environmental quality was constructed. Second, on the basis of panel data from 285 prefecture-level cities in China from 2010 to 2021, exploratory spatial data analysis (ESDA) was applied to reveal the spatiotemporal nonstationary distribution of urban PM2.5 pollution. Finally, the heterogeneous influence mechanisms of compact urban factors on PM2.5 pollution were empirically studied through the geographical and temporal weighted regression (GTWR) model. The main findings are as follows: (1) From 2010 to 2021, the proportion of cities in China with good air quality significantly increased. The cities with high–high pollution clustering are currently located mainly in Beijing–Tianjin–Hebei, Shandong, and Henan. (2) Economic and transportation compactness factors mitigated PM2.5 pollution in most cities, whereas the long-term combined effects of the population and land compactness factors may have exacerbated urban PM2.5 pollution. (3) There was significant spatial and temporal heterogeneity in the effects of urban compactness factors on air pollution. Cities where land-use compactness exerts a pollution mitigation effect were located east of the Hu line. Cities in Northeastern China had the strongest pollution mitigation effect from transportation compactness, followed by the cities in Southwestern China.

Application of Steel-Fiber-Reinforced Self-Stressing Concrete in Prefabricated Pavement Joints

Prefabricated pavement, with its advantages of a high paving speed, low material consumption, low carbon emissions, high strength, and easy construction, has gradually been used to address issues associated with traditional cement pavement construction. However, even under the long-term combined effects of vehicle loads and environmental loads, the joints between pavement slabs remain prone to various problems. This paper proposes the use of steel-fiber-reinforced self-stressing concrete (SFRSSC) with a certain level of self-stress for joint pouring and connection to control the development of cracks in the joints and achieve seamless integration between the slabs. Additionally, the self-stress generated by SFRSSC is utilized to enhance the continuity of the prestressed design in precast slabs, thereby extending their service life. Through laboratory experiments and field tests, the self-stress magnitude, mechanical strength, and long-term applicability of SFRSSC were studied. The results indicate that SFRSSC can achieve self-stress levels of over 7 MPa under standard curing conditions, but the values decrease significantly when removed from the standard curing environment. SFRSSC exhibits a compressive strength of over 60 MPa and a flexural strength of over 9 MPa, both of which exceed the requirements of the relevant standards, making it suitable for use as a pavement joint material. During long-term monitoring in the field, SFRSSC demonstrates favorable expansion effects and high stability. The longitudinal expansion remains stable at 100 με, while the transverse expansion exhibits minor shrinkage, maintained at around 25.2 με. Therefore, the application of SFRSSC in assembly-type prestressed pavement joints shows high applicability.

Combined effects of alkaline pH and high Ca concentration on root morphology, cell-wall polysaccharide concentrations and blueberry plant performance

The appropriate soil pH for blueberry production is <5.5. However, the exact factors involved in the retardation of blueberry growth at higher pH levels have not yet been completely identified. In this study, we examined the short- and long-term combined effects of pH level and Ca concentrations on root morphology and development in relation to blueberry plant performance. Southern highbush blueberry (Vaccinium corymbosum, cv. Windsor) plants were grown in solutions of pH 4.5 or 7.5 that contained 0, 5, 10, 50 or 100 mg L-1 of Ca. The dimensions of the epidermal cell walls of the roots and the levels of pectin and hemicellulose 1 and 2 in those cells were determined after 1 and 3 days. Concentrations of essential macro and micro-elements in the plant organs, chlorophyll concentrations in the leaves and whole-plant biomass production were measured after 12 weeks. The results demonstrate a rapid (3 days) negative response of root tips at pH 7.5 expressed as reduced dimensions and deformation of the epidermal cell walls. This response was accompanied by reduced concentrations of pectin and hemicellulose 1 in those cell walls. These negative effects of pH 7.5 were amplified by a 100 mg L-1 of Ca over the long term (12 weeks), where the concentrations of P and Ca on the epidermal cell of the root were increased. Additionally, the translocation of Mn from the root to the shoot was retarded. The negative effect of the pH level on roots development and on the Mn translocation were associated with significant reductions in chlorophyll concentrations and biomass production. The results presented in this study demonstrate, for the first time, the negative effect of the combination of slightly alkaline pH and a high Ca concentration on root development, which associated with retarding blueberry plants performance.

Long-term effects of combination of organic and inorganic fertilizer on soil properties and microorganisms in a Quaternary Red Clay

Quaternary Red Clay (QRC) is the most common planting soil with low soil fertility and low crop yields in Southeast China, with low soil fertility and low crop yields. Many factors can impact the fertility and utilization efficiency of QRC. Here, we conducted a long-term fertilization experiment from 1984 to 2013. Five fertilization measures were carried out, including non-fertilization group; chemical Fertilizer group; 70% chemical and 30% organic fertilizer group; 50% chemical and 50% organic fertilizer group; 30% chemical and 70% organic fertilizer group. Soil organic matter (OM), total nitrogen (TN), total phosphorus (TP), total potassium (TK), soil microbial biomass carbon (SMBC) and nitrogen (SMBN), and soil enzymes activity were measured to evaluate the changes of soil. In addition, soil microorganisms were determined by high-throughput sequencing technology, and the dominant microbes were screened. The higher the proportion of organic fertilizer was, the higher the soil OM content was. The OM content of the non-fertilization group was the lowest. Similarly, SMBC and SMBN showed a consistent trend with OM content. Illumina sequence results showed that the application of organic fertilizer reduced the relative abundance of Chloroflexi, Acidobacteria and Nitrospirae, but increased Proteobacteria and Actinobacteria. The relative abundance of Acremonium and Mortierella were also greatly increased by different fertilization strategies. However, when high proportion of organic fertilizer was applied, the abundance of Acremonium and Mortierella decreased. Long-term balanced inorganic fertilization (NPK, 60%N:20%P:20%K) can effectively improve the quality and fertility of QRC. The effect of different fertilization strategies on fungi was greater than that on bacteria. The change of soil microorganism also proved the validity of inorganic fertilizer application.

Effects of land use and climate change on water scarcity in rivers of the Western Ghats of India.

This paper assesses the long-term combined effects of land use (LU) and climate changeon river hydrology and water scarcity of two rivers of the Western Ghats of India. The historical LU changes were studied for four decades (1988-2016) using the maximum likelihood algorithm and the long-term LU (2016-2075) was estimated using the Dyna-CLUE prediction model. Five General Circulation Models (GCMs) were utilized to assess the effects of climate change (CC) and the Soil and Water Assessment Tool (SWAT) model was used for hydrological modeling of the two river catchments. To characterize granular effects of LU and CC on regional hydrology, a scenario approach was adopted and three scenarios depicting near-future (2006-2040), mid-future (2041-2070), and far-future (2071-2100) based on climate were established. The present rate of LU change indicated a reduction in forest cover by 20% and an increase in urbanized areas by 9.5% between 1988 and 2016. It was estimated that forest cover in the catchments may be expected to halve compared to the present-day LU (55% in 2016 to 23% in 2075), along with large-scale conversion to agricultural lands (13.5% in 2016 to 49.5% in 2075). As a result of changes to LU and forecasted climate, it was found that rivers in the Western Ghats of India might face scarcity of fresh water in the next two decades until the year 2040. However, because of large-scale LU conversion toward the year 2050, streamflow in rivers might increase as high as 70.94% at certain times of the year. Although an increase in streamflow is perceived favorable, the streamflow changes during summer and winter may be expected to affect the cropping calendar and crop yield. The changes to streamflow were also linked to a 4.2% increase in ecologically sensitive wetlands of the Aghanashini river catchment.

Combination Therapy of FLT3 Tyrosine Kinase Inhibitors and BH3 Mimetics Targeting Antiapoptotic MCL-1 Synergistically Eliminates FLT3-ITD Acute Myeloid Leukemia Cells in Vitro and In Vivo

Combination Therapy of FLT3 Tyrosine Kinase Inhibitors and BH3 Mimetics Targeting Antiapoptotic MCL-1 Synergistically Eliminates FLT3-ITD Acute Myeloid Leukemia Cells in Vitro and In Vivo

ХРАП И СИНДРОМ ОБСТРУКТИВНОГО АПНОЭ СНА КАК ВОЗМОЖНЫЕ ПРИЧИНЫ СЛУХОВЫХ И ТУБАРНЫХ РАССТРОЙСТВ

Introduction. Snoring occurs in 20,5% of the population, and obstructive sleep apnea syndrome occurs in 5–7% of the population. Primary snoring and obstructive sleep apnea syndrome contribute to the development of a number of diseases of internal organs, among which impairment of auditory and tubal function seems to be understudied. Aim. The aim of the study was to determine the effect of obstructive sleep apnea syndrome and primary snoring on auditory and tubal functions. Material and methods. The study was conducted in two groups: the first group consisted of 30 patients with obstructive sleep apnea syndrome, and the second group consisted of 50 patients with primary snoring. The control group consisted of 50 observed patients without primary snoring and obstructive sleep apnea syndrome. The study protocol included patient questionnaires, examination of oropharyngeal structures, evaluation of auditory function with tonal threshold audiometry and tympanometry. Subgroup assignment was performed after registration of an apnea index of more than 5 episodes per hour. Identified forms of auditory impairment in patients of the study and control groups were processed using StatTech online software with a 95% confidence interval. Results and discussion. The results of the study revealed a statistically significant association between the risk factor (snoring) and the development of tubal dysfunction in both study groups. It was also determined that there were no significant differences in the frequency of hearing loss in the primary snoring and obstructive sleep apnea groups, but when comparing with the control group, it ВЕСТНИК СОВРЕМЕННОЙ КЛИНИЧЕСКОЙ МЕДИЦИНЫ 2021 Том 14, вып. 6 47ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ was found that the proportion of patients with reduced hearing in the study group was significantly higher. Correlation data were obtained between the duration of snoring and the occurrence of auditory and tubal dysfunction, due to which it can be argued that the form and severity of auditory dysfunction is influenced by the duration of snoring, the time of snoring during the sleep period, and the intensity (loudness) of snoring. The results obtained can be explained by long-term combined effects of noise and hypoxia in sleep in this category of patients, as well as by morphological and functional changes in oropharyngeal structures occurring in primary snoring and obstructive sleep apnea syndrome. Conclusion. In all cases of chronic tubal dysfunction, especially those accompanied by hearing loss, it is advisable to examine the patient for the presence of snoring and apnea.

Long-term combined effects of tillage and rice cultivation with phosphogypsum or farmyard manure on the concentration of salts, minerals, and heavy metals of saline-sodic paddy fields in Northeast China

Soil sodicity is a major ecological problem in the western Songnen Plain of Northeast China and rice cultivation is the main approach used to mitigate saline-sodic soils. However, rice cultivation alone may not be the most effective practice. This study aimed to investigate the combined effects of annual tillage and rice cultivation with either phosphogypsum or farmyard manure on soil salinity, mineral status, and concentration of heavy metals in saline-sodic paddy fields. Treatments were: 1) untreated (no amendments), untilled, and uncultivated (no rice) saline-sodic native grasslands (UG); 2) untreated, tilled, rice-cultivated paddy fields (PFU); 3) tilled, rice-cultivated, amended paddy fields with phosphogypsum (PFPG); and 4) tilled, rice-cultivated, amended paddy fields with farmyard manure (PFFM). The effectiveness of these treatments on soil improvement was evaluated after a 10-year field experiment. Compared to the UG control, the 0–20 cm topsoil layer of PFU, PFPG, and PFFM had respective decreases in Na+ concentrations of 42.9%, 61.5%, and 60.9%; in CO32- + HCO3- concentrations of 18.9%, 63.2%, and 57.9%; in Cl- concentration of 64.6%, 75.7%, and 79.9%; in pH units of 0.57, 1.05, and 1.30; in soil electrical conductivity (EC1:5) of 18.3%, 49.1%, and 48.3%; and in exchange sodium percentage (ESP) of 47.2%, 66.9%, and 72.5%. Also, the 0–20 cm topsoil layer of PFPG and PFFM had its concentrations of soil organic matter (SOM), available nitrogen (AN), and available phosphorus (AP) significantly (P < 0.05) increased compared to the UG control. However, the concentrations of five heavy metals (As, Pb, Cd, Cr, and Hg) were kept within a safe range in saline-sodic paddy fields amended with phosphogypsum or farmyard manure and were far below the environmental quality standard held for Chinese soils. Therefore, phosphogypsum and farmyard manure significantly decreased soil salinity and sodicity while increased soil fertility and SOM. Because these amendments are locally available and affordable to farmers, their use is deemed suitable for large-scale soil reclamation and the mitigation of salinity and sodicity in soils destined for rice cultivation in Northeast China.

Long-Term Combined Effects of Crude Oil and Dispersant on Sediment Bacterial Community

To better understand long-term combined effects of crude oil and dispersant on bacterial community, sediments microcosms were set up in triplicates and treated with dispersant (Corexit 9500A), crude oil, and Corexit 9500A plus crude oil. After 60 days exposure, there was a significant change in the bacterial community structure in all treatments. The shift in the bacterial community structure in Corexit 9500A plus crude oil treatment was considerably different from those by either Corexit 9500A or crude oil. DNA sequence analysis showed that Hydrocarboniphaga effuse, Parvibaculum lavamentivorans,and Alicyclobacillus ferrooxydans were the major bacterial species in crude oil treatment. Pandoraea thiooxydans, Janthinobacterium sp. and Hyphomicrobium nitrativorans were the most dominant species in Corexit 9500A treatment. The species Janthinobacterium sp., Parvibaculum lavamentivorans, and Dyella sp. were enriched in Corexit 9500A plus crude oil treatment. The majority of the detected species were hydrocarbons degraders. The study showed that Corexit 9500A addition enhanced the biodegradation rate by increasing the diversity and richness of hydrocarbons degrading species. Corexit A9500 application should be considered during crude oil spills to evaluate environmental impacts.

Long-Term Effect of Combination of Creatine Monohydrate Plus β-Hydroxy β-Methylbutyrate (HMB) on Exercise-Induced Muscle Damage and Anabolic/Catabolic Hormones in Elite Male Endurance Athletes.

Creatine monohydrate (CrM) and β-hydroxy β-methylbutyrate (HMB) are widely studied ergogenic aids. However, both supplements are usually studied in an isolated manner. The few studies that have investigated the effect of combining both supplements on exercise-induced muscle damage (EIMD) and hormone status have reported controversial results. Therefore, the main purpose of this study was to determine the effect and degree of potentiation of 10 weeks of CrM plus HMB supplementation on EIMD and anabolic/catabolic hormones. This study was a double-blind, placebo-controlled trial where participants (n = 28) were randomized into four different groups: placebo group (PLG; n = 7), CrM group (CrMG; 0.04 g/kg/day of CrM; n = 7), HMB group (HMBG; 3 g/day of HMB; n = 7), and CrM-HMB group (CrM-HMBG; 0.04 g/kg/day of CrM plus 3 g/day of HMB; n = 7). Before (baseline, T1) and after 10 weeks of supplementation (T2), blood samples were collected from all rowers. There were no significant differences in the EIMD markers (aspartate aminotransferase, lactate dehydrogenase, and creatine kinase) among groups. However, we observed significant differences in CrM-HMBG with respect to PLG, CrMG, and HMBG on testosterone (p = 0.006; η2p = 0.454) and the testosterone/cortisol ratio (T/C; p = 0.032; η2p = 0.349). Moreover, we found a synergistic effect of combined supplementation on testosterone (CrM-HMBG = −63.85% vs. CrMG + HMBG = −37.89%) and T/C (CrM-HMBG = 680% vs. CrMG + HMBG = 57.68%) and an antagonistic effect on cortisol (CrM-HMBG = 131.55% vs. CrMG + HMBG = 389.99%). In summary, the combination of CrM plus HMB showed an increase in testosterone and T/C compared with the other groups after 10 weeks of supplementation. Moreover, this combination presented a synergistic effect on testosterone and T/C and an antagonistic effect on cortisol compared with the sum of individual or isolated supplementation.

Long-term exposure to antibiotic mixtures favors microcystin synthesis and release in Microcystis aeruginosa with different morphologies

The ecological risks of antibiotics in aquatic environments have raised great concerns worldwide, but the chronic effect of antibiotic contaminants on cyanotoxin production and release remains unclear. This study investigated the long-term combined effects of spiramycin (SP) and ampicillin (AMP) on microcystin (MC) production and release in both unicellular and colonial Microcystis aeruginosa (MA) through semi-continuous exposure test. At exposure concentration of 300 ng L−1, MA growth rates were stimulated till the end of exponential phase accompanied with the up-regulation of photosynthesis-related gene. The exponential growth phases of unicellular and colonial MA were prolonged for 2 and 4 days, respectively. The stimulation rate of growth rate and MC content in unicellular MA were significantly higher than that in colonial MA. The highest concentrations of intracellular MC (IMC) and extracellular MC (EMC) were observed in the binary mixture at equivalent SP/AMP ratio (1:1). The promotion of IMC concentration was in consistent with the stimulated expression of MC-synthesis-related gene and nitrogen-transport-related gene. The malondialdehyde content and activities of superoxide dismutase and catalase in unicellular MA were significantly higher than those in colonial MA. The EMC concentration and the antioxidant responses of both unicellular and colonial MA significantly increased with exposure time. Long-term exposure to mixture of SA and AMP at environmentally relevant concentrations would aggravate the disturbance to aquatic ecosystem balance through the stimulation of MA proliferation as well as the promotion of MC production and release.

Long-term trends in trait structure of riverine communities facing predation risk increase and trophic resource decline.

Many large European rivers have undergone multiple pressures that have strongly impaired ecosystem functioning at different spatial and temporal scales. Global warming and other environmental changes have favored the success of invasive species, deeply modifying the structure of aquatic communities in large rivers. Some exogenous species could alter trophic interactions within assemblages by increasing the predation risk for potential prey species (top-down effect) and limiting the dynamics of others via resource availability limitation (bottom-up effect). Furthermore, large transboundary rivers are complex aquatic ecosystems that have often been poorly investigated so that data for assessing long-term ecological trends are missing. In this study, we propose an original approach for investigating long-term combined effects of global warming, trophic resource decrease, predation risk, and water quality variations on the trait-based structure of macroinvertebrate and fish assemblages over 26yr (1985-2011) and 427-km stretch of the river Meuse (France and Belgium). The study of temporal variations in biological, physiological, and ecological traits of macroinvertebrate and fish allowed identifying community trends and distinguishing impacts of environmental perturbations from those induced by biological alterations. We provide evidence, for this large European river, of an increase in water temperature (close to 1°C) and a decrease in phytoplankton biomass (-85%), as well as independent effects of these changes on both invertebrate and fish communities. The reduction of trophic resources in the water column by invasive molluscs has dramatically affected the density of omnivorous fish in favor of invertebrate feeders, while scrapers became the major feeding guild among invertebrates. Macroinvertebrate and fish communities have shifted from large-sized organisms with low fecundity to prolific, small-sized organisms, with early maturity, as a response to increased predation pressure.

INFLUENCE OF COMBINED INJECTION OF THYROXIN AND PROPYLTHIOURACILUM ON SCTRUCTURAL INDICATORS OF RENAL PARENCHYMA

THE AIM: to study of the dynamics of structural changes in renal parenchyma of rats exposed to long-term combined effects of thyroxine and propylthiouracilum (PTU). MATHERIAL AND METHODS – studies were performed on mongrel white male rats weighing 250-300g. Hyperthyroidism was caused by daily intragastric administration of thyroxine (T4) in amount of 50g per 100g of body weight over 30 days. On the first day of the experiment animals were divided into 2 groups. Animals of the first group (n = 25) received only T4. The rats of the second group (n = 25) were administrated propylthiouracilum and T4 daily. PTU was administered intragastric in amount of 1 mg per 100g of body weight. Kidney tissue samples were collected on the 10th, 20th and 30th days of the experiment. In addition, there were collected kidney tissue samples of the animals treated with only T4 after 20 days after cessation of hormone. Obtained tissue samples were fixed and treated by the usual method, followed by filling in paraffin. Sections were stained with hematoxylin and eosin. RESULTS – it was established that course of experimental hyperthyroidism leads to significant structural abnormalities of the renal parenchyma. Leading features of kidneys pathology at a hyperthyroidism are rough structural damages of the nephron tubular epithelium. CONCLUSIONS – combined administration in rats of thyroxin and propylthiouracilum has weakly expressed beneficial effect by limiting the development of structural damages to the renal parenchyma and clot formation.

Mitochondrial DNA deletions in the peripheral blood of workers at the Mayak PA who were exposed to long-term combined effects of external γ- and internal α-radiation

The levels of large deletions in the mitochondrial DNA of workers at the Mayak Production Association (Mayak PA) who were exposed to external and combined occupational (external γ- and internal α-rays) radiation during the course of their duties were investigated. Peripheral blood-derived DNA samples were provided by the Radiobiological Human Tissue Repository of the Southern Urals Biophysics Institute (Russia). The samples were analyzed using long-extension PCR. The number of large-scale deletions in the mitochondrial DNA of workers who, in addition to external γ-radiation, were exposed to extra doses of irradiation due to incorporated 239Pu with a Pu body burden of 0.77–4.32 kBq, was 2.5-times lower compared to that of individuals who received only external γ-radiation. No significant gender-associated effects on the number of mitochondrial DNA deletions were detected among age-matched individuals.

The long-term effects of tillage practice and phosphorus fertilization on the distribution and morphology of corn root

Relevant soil properties and nutrient distributions influencing crop root growth might be different under no-till (NT) and mouldboard plough (MP) management. The possible different root systems within different managements might have key impact on crop nutrient uptake and consequently crop production. Our objective was to assess the long-term combined effects of tillage and phosphorus (P) fertilization on corn (Zea mays L.) root distribution and morphology. Corn root and soil samples were collected during the silking stage at five depths (0–5, 5–10, 10–20, 20–30 and 30–40 cm) and three horizontal distances perpendicular to the corn row (5, 15 and 25 cm) under MP and NT with three P fertilizations (0, 17.5, and 35 kg P ha−1) for a long-term (22 years) experiment in eastern Canada. Root morphology and soil properties were determined. NT practice decreased corn root biomass by −26 % compared to MP, mainly by decreasing the primary and secondary roots. Additionally, corn roots in NT tend to be more expansive on the surface layer with higher root length and surface densities for the depth of 0–5 cm at two sampling distances of 15 and 25 cm. The 35 kg P ha−1 rate increased the root biomass by 26 and 41 % compared to the 0 and 17.5 kg P ha−1 rates. No-tillage practice and low rates of P fertilization reduce corn roots. This is probably caused by the weed competition in NT and the continued downward P status with low P rates over 22 years.

Efficacy of Muscle Energy Technique in Combination with Strain-counterstrain Technique on Deactivation of Trigger Point Pain

Objective: To establish the best possible long term effective choice of treatment program for deactivating MTrP's by using the combination of muscle energy technique with strain-counterstrain technique Design: Pretest-Posttest control group design Setting: Outpatient physiotherapy department, Taneja Hospital, Preet Vihar New Delhi. Patients: Fourty five subjects (only male) with Myofascial Trigger Points Pain. Subjects were randomly placed into three groups: Experimental group A (n=15), Experimental group B (n=15) and a Control group C (n=15). Intervention: The experimental group A received muscle energy technique in combination with straincounterstrain technique and experimental group B received muscle energy technique alone whereas control group received conventional treatment only. Main Outcome Measures: Pain pressure threshold was assessed with the pressure threshold meter (PTM). Pain and functional status of the patients were measured by a visual analogue scale (VAS) and the Neck Disability Index scores respectively. Results: Within group analysis revealed significant improvement in pain pressure threshold, functional status and reduction in pain intensity in all groups. Between group analysis revealed significant difference between group A, group B and group C. Further post hoc analysis revealed significant difference between group A and B, group A and C and group B and C for all variables even after one week of follow up after the termination of intervention. Conclusion: The combination of muscle energy technique with strain-counterstrain has been shown to produce greater improvement in pain pressure threshold on pressure threshold meter, function status on neck disability index scores and reduction in pain intensity on visual analogue scores even after one week of the termination of intervention. This shows the long term effectiveness of combination of two manual techniques deactivating the myofascial trigger point's pain.

Effects of fishing, market price, and climate on two South American clam species

MEPS Marine Ecology Progress Series Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout the JournalEditorsTheme Sections MEPS 469:71-85 (2012) - DOI: https://doi.org/10.3354/meps10016 Effects of fishing, market price, and climate on two South American clam species Leonardo Ortega1, Juan Carlos Castilla2, Marco Espino3, Carmen Yamashiro3, Omar Defeo1,4,* 1Dirección Nacional de Recursos Acuáticos (DINARA), Constituyente 1497, 11200 Montevideo, Uruguay 2Departamento de Ecología, Facultad de Ciencias Biológicas and Centro Interdisciplinario de Cambio Global, Pontificia Universidad Católica de Chile, Casilla 114-D, Santiago, Chile 3Instituto del Mar del Perú, Apartado 22, Callao, Perú 4Unidad de Ciencias del Mar (UNDECIMAR), Facultad de Ciencias, Iguá 4225, 11400 Montevideo, Uruguay *Corresponding author. Email: odefeo@dinara.gub.uy ABSTRACT: Coastal shellfish are being threatened by several drivers acting at multiple temporal and spatial scales, including fishing, climate, and globalization of markets. We evaluated large-scale and long-term combined effects of fishing, climate, and economic variables on 2 congeneric clams that inhabit sandy beaches of the Pacific (Mesodesma donacium) and the Atlantic (M. mactroides) in South America. Bioeconomic and climatic variables, such as coastal sea surface temperature anomalies (SSTA) and broad-scale climatic indices (Pacific Decadal Oscillation and Atlantic Multidecadal Oscillation), were related to variations in clam populations in a differential way according to latitude and oceanographic features. For M. donacium, the nature and sign of the relationships between landings and explanatory predictors markedly differed between bioclimatic units. El Niño Southern Oscillation events negatively affected landings in Peru and northern Chile, whereas landings increased in southern Chile and showed a positive correlation with increasing SSTA, suggesting a positive effect at the southernmost edge of the species distribution. Long-term trends in the abundance of M. mactroides were related to fishing intensity and SSTA. As anticipated by basic economic theory, deficit of supply relative to demand, exacerbated by very low harvesting costs, pushed the price up and has driven these clam species to levels close to extinction (anthropogenic Allee effect). The lack of response of the stocks to long-term closures suggests that these systems exceeded critical thresholds (tipping points). Information on early warnings of tipping points is needed to help manage coastal shellfisheries that are increasingly threatened by long-lasting and large-scale stressors. KEY WORDS: Intertidal clams · Sandy beaches · Climate variability · Fisheries bioeconomics Full text in pdf format Supplementary material PreviousNextCite this article as: Ortega L, Castilla JC, Espino M, Yamashiro C, Defeo O (2012) Effects of fishing, market price, and climate on two South American clam species. Mar Ecol Prog Ser 469:71-85. https://doi.org/10.3354/meps10016 Export citation RSS - Facebook - Tweet - linkedIn Cited by Published in MEPS Vol. 469. Online publication date: November 26, 2012 Print ISSN: 0171-8630; Online ISSN: 1616-1599 Copyright © 2012 Inter-Research.

Costo Efectividad de Posaconazol versus Fluconazol/Itraconazol en el Tratamiento Profiláctico de las Infecciones Fúngicas Invasivas en México

Cost effectiveness of posaconazole versus fluconazole/itraconazole therapy in the prophylaxis against invasive fungal Infections among high-risk neutropenic patients in Mexico. ObjectiveTo estimate the cost effectiveness and long-term combined effects of Posaconazole versus fluconazole/itraconazole (standard azole) therapy in the prophylaxis against invasive fungal Infections among high-risk neutropenic patients in Mexico. MethodsA previously validated Markov model was used to compare the projected lifetime costs and effects of two theoretical groups of patients, one receiving Posaconazole and the other receiving standard azole. The model estimates total costs, numbers of IFIs, and QALY per patient in each prophylaxis group. To extrapolate trial results to a lifetime horizon, the model was extended with one-month Markov cycles in which mortality risk is specific to the underlying disease. Data on the probabilities of IFI were obtained from Study Protocol PO1899. Drug costs were taken from average wholesale drug reports for 2009. Cost and health effects were discounted at 5% according to the Mexican guideline. The analysis was conducted from the Mexican healthcare perspective using 2008 unit cost prices. ResultsOur model projects an accumulated cost to the Mexican healthcare system per patient receiving the Posaconazol regimen of $US 5,634 compared to $US 7,463 for the standard azole regimen. The accumulated discounted effect is 3.13 LY or 2.25 QALYs per patient receiving Posaconazol, compared to 2.96 LY or 2.13 QALYs per patient receiving standard azole. Posaconazol remained the dominant strategy across each scenario. Probabilistic sensitivity analysis tested numerous assumptions about the model cost and efficacy parameters and found that the results were robust to most changes. ConclusionPosaconazole provides modest incremental benefits compared with standard azole therapy in the prophylaxis against IFIs among high-risk neutropenic patients. Routine Posaconazole use appears a cost saving when the likelihood of IFIs or the cost of treatment medications is high.

A Comparison of Combination Therapy (Cyclosporine plus Prednisolone) with Sole Prednisolone Therapy in 7 Dogs with Necrotizing Meningoencephalitis

Administration of immunosuppressive doses of glucocorticosteroids is the traditional primary treatment in necrotizing meningoencephalitis (NME) in dogs. However, response is variable and clinical signs often recur quickly with tapering dosage. Prognosis is poor and long-term therapy causes many complications. In the present study, we compared the long-term effects of combination (cyclosporine plus prednisolone) therapy with sole prednisolone therapy in management in dogs with NME. All NME cases in this study were examined with magnetic resonance imaging and cerebrospinal fluid analysis, and confirmed by histopathologic examination. The mean survival time of combination therapy group was 305.7 +/- 94.7 days. The mean survival time of sole prednisolone therapy group was 58.3 +/- 30.5 days. This case report demonstrates that combination treatment of cyclosporine with prednisolone is more effective in survival time than administration of only prednisolone in NME cases.