Each year, approximately 5000 Albertans die of a heart-related disorder, making it one of the leading causes of death in the province. The activity of the heart is controlled by electrical processes which are mediated primarily by ion channels. The KCNQ1 potassium channel regulates the delayed-rectifier IKs current of the cardiac action potential. Loss of function or aberrant gain of function in this channel causes several different arrhythmias, which include long QT syndrome (LQTS), a heart disorder that causes ventricular fibrillation and sudden cardiac death in children and young adults. In this study, computational tools were used aiming to design new potent modulators for this channel. A virtual screening was carried out; several properties including bioavailability and binding free energies were estimated. This study identifies regions for ligand binding optimization and further experimental validation.