SESSION TITLE: Advances in the Care of Mechanically-Ventilated Patients SESSION TYPE: Original Investigations PRESENTED ON: October 18-21, 2020 PURPOSE: Critical-illness myopathy and polyneuropathy (CIMP) is a condition causing significant morbidity and mortality amongst patients admitted to the critical care units. CIMP can either be a single factor, or may be associated with concomitant risk factors. It can lead to failed weaning trials and longer duration of Mechanical Ventilation (MV). We aimed to estimate the temporal trends and predictors of CIMP in hospitalized patients receiving MV using a nationally representative database for the last decade. METHODS: Study cohort is derived from the Nationwide Inpatient Sample (NIS) for the years 2008-2017. Adult hospitalizations with length of stay (LOS) ≥7 days and who received mechanical ventilation were identified using International Classification of Diseases (9th/10th Editions) Clinical Modification (ICD-9/10-CM) procedures codes. CIMP and other diagnosis of interests were identified by either ICD-9/10-CM diagnosis codes or Elixhauser comorbidity software. We then utilized the Cochran Armitage trend test and multivariate survey logistic regression models to analyze temporal incidence trends, predictors, and outcomes. RESULTS: Out of a total 5,846,573 hospitalizations who had LOS ≥7 days and received mechanical ventilation, 71684(1.23%) developed CIMP. Incidence of CIMP increased from 5/1000 in 2008 to 19/1000 in 2017 with 13% yearly increase (OR 1.13; 95%CI 1.1-1.5; p<0.001). Patients who developed CIMP had lower mean age (61 vs 63; p<0.001) and higher LOS (31d Vs. 19d, p<0.001). Furthermore, in multivariable regression analysis, predictors of CIMP are female sex (OR 1.1; 95%CI 1.1-1.2; p<0.0001) and caucasian race (OR 1.5; 95%CI 1.4-1.6;p<0.001), on-Teaching Hospital (OR 1.2; 95%CI 1.1-1.3; p<0.005), MV ≥ 96 hours (OR 2.3; CI 2.1-2.4; p<0.0001), ventilator associated pneumonia (OR 1.6; 95%CI 1.5-1.8; p<0.0001), Septicemia (OR 1.5; 95%CI 1.5-1.6; p<0.0001), weight loss (OR 1.5; 95%CI 1.5-1.6; p<0.0001) and electrolyte imbalance (OR 1.4; 95%CI 1.3- 1.4; p<0.0001). Amongst the patients who developed CIMP, 69.47% were discharged to long term facilities and 14.7% died during the hospitalization. CONCLUSIONS: In this nationally representative study, we observed that the incidence of CIMP has been increasing. We identified several risk factors strongly associated with development of CIMP, some of which may be potentially modifiable. CLINICAL IMPLICATIONS: Our study highlights the need for early diagnosis, better risk stratification and need for complex long-term care in these vulnerable patients. Further studies are warranted to consider factoring some of the modifiable factors into account and to ameliorate the incidence and outcomes of CIMP. DISCLOSURES: No relevant relationships by Mohammed Abdulqader, source=Web Response No relevant relationships by Sohiel Deshpande, source=Web Response no disclosure on file for Preetam Jolepalem; No relevant relationships by Varshitha Kondapaneni, source=Web Response No relevant relationships by Faizan Malik, source=Web Response No relevant relationships by Uvesh Mansuri, source=Web Response No relevant relationships by Achint Patel, source=Web Response No relevant relationships by Harshil Shah, source=Web Response No relevant relationships by Venus Sharma, source=Web Response