Abstract Introduction: Cancer is the second leading cause of death in Arizona. While there was a 7% decrease in cancer mortality among Arizonans from 2016-2020, more work is needed to decrease cancer incidence and mortality among racial and ethnic minorities, including Black and Hispanic/Latino populations. Further, it is critical to engage community members to identify cancer-related priorities, brainstorm feasible and acceptable community-based interventions, and co-create community-academia-healthcare solutions to reduce cancer disparities. Methods: The team conducted a series of Design Studios for Health (DSH) – guided listening sessions to foster community involvement, facilitate knowledge exchange, and identify the priorities and concerns for cancer prevention and control in the Black and Hispanic/Latino communities. Each DSH session included introductions, information dissemination, and breakout sessions with a moderator and a notetaker. The first DSH sessions were held in February 2024 via Zoom, one for Black community members (n=14) and one for Hispanic/Latino community members (n=14). In March 2024, an in-person DSH aimed to bring together all previous participants from both communities (n=27). This session deepened collaborations and knowledge exchange, building on insights from the initial sessions. The iterative nature of DSH ensured continuous refinement and co-creation of precision health solutions based on feedback and the data collected. Results: DSH participants identified the following cancer priorities: breast, skin, cervical, prostate, colorectal, and stomach cancers. They emphasized the need for community-shared information on survivorship resources, prevention (shared via social media), symptoms, costs, payment options, resource guides for community health workers, and guidance on navigating medical and insurance payments. Recommendations for academic partners included offering workshops and educational seminars on cancer prevention, using university space to host community cancer prevention events, alternating event locations in the metropolitan region to reach multiple underserved communities, hosting community fairs with multiple cancer education and screening opportunities, forming community advisory boards focused on cancer prevention and control, and organizing local forums to share cancer prevention and control resources. To support local organizations and health education outreach, they recommended creating additional training on cancer, e.g. for community health workers, to enhance public dissemination. Future directions: Based on these findings, our team is developing interactive, virtual, games-based cancer education to help dispel myths about cancer prevention and control. We are collaborating with community health workers to increase the accessibility of cancer prevention, screening, and resource education at pop-up cancer screening events (October and November 2024) held in areas of Phoenix serving low-income, racially, and ethnically diverse communities. Citation Format: Alexis M. Koskan, Maricarmen Vizcaino, Maissa Khatib, Tina M. Brown, Dorothy D. Sears. Design Studios for Health to identify distinct outreach events and interventions to reduce the burden of cancer among Hispanic/Latino and Black adults in a major southwestern metropolitan region [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr B082.