In order to study the effect of liquid nitrogen jet cooling on the deterioration of mechanical properties of high temperature rocks, the cyclic liquid nitrogen jet (LNJ) cooling and liquid nitrogen immersion (LNI) cooling were carried out on 200 °C and 400 °C granite. The variations of ultrasonic velocity, tensile strength, acoustic emission and energy evolution were analyzed. The results showed that with the increase of rock temperature and cooling cycles, the deterioration of mechanical properties of high temperature rock was enhanced by cyclic LNJ and LNI cooling. Differently, the deterioration effect of LNI cooling on mechanical properties was weakened with the increase of cycles. On the contrary, the deterioration effect caused by LNJ cooling was significantly enhanced with the increase of cycles. For example, when the LNI cooling cycles exceeded 5 times for 200 °C sample and 3 times for 400 °C sample, the tensile strength and absorbed energy at failure decreased limitedly with the growth of cooling cycles. However, the deterioration degree of rock mechanical properties at 400 °C showed a linear decline trend with the increase of LNJ cooling cycles. The temperature and the number of cycles had significant effects on mechanical properties, with temperature having the greatest influence. The difference between LNJ and LNI cooling became more pronounced with increasing cycles. LNJ cooling, by creating localized high thermal stresses and non-uniform heat transfer, led to continuous deterioration of mechanical properties with each cycle. In contrast, LNI cooling's effect saturated after initial cycles. The multi-cycle LNJ cooling method could improve the fracture degree of high temperature rock under low load level, so as to improve the efficiency of high temperature hard rock formation drilling.