Local Repair Research Articles

Long-term outcome of local muscles transposition for the functional restoration of large upper or lower lip defects

Background Although more than 200 techniques have been reported for the reconstruction of their and lower lip defects since 1000 BC, none of them is ideal. Local flaps come at the expense of extra skin scarring and, in some cases, the surgeon may be confronted with the lack of sufficient tissues for the reconstruction of large defects. It has been reported that several methods exist for performing near-total lip reconstruction. Currently, free micro-vascular tissue transfer and local flap repair (the Bernard von Burrow-Webster method) are the two most prominent methods. Aim To evaluate the functional results of using local muscles transposition-assisted dermal fat flap and muco-buccal flap to treat upper or lower lip defects. Patients and methods This study was carried out on 128 patients, who presented to us with malignant tumors affecting the lips. Results Lip defect sizes ranged from four to 6 cm in length. There was no evidence of flap failure, and the aesthetic and functional outcomes are very well. All patients healed successfully, and 100% of the flaps survived. No cases of microstomia were reported. Conclusion The use of local muscle transposition, assisted with dermal fat flap and muco-buccal flap technique, showed excellent results in regaining, oral competence, and lip mobility, and as much as possible, increasing the aesthetic outcome.

Analysis of 3 Surgical Approaches for the Treatment of Cerebrospinal Fluid Otorrhea: A Case Series Report.

Background: This case series report aimed to present three surgical approaches used for the treatment of cerebrospinal fluid (CSF) otorrhea, providing less invasive surgical options for managing this condition. Methods: Clinical data of 26 patients with CSF otorrhea, who underwent treatment using three surgical methods between June 2012 and June 2022, were retrospectively analyzed. The study collected information on patients' basic demographic characteristics, chief complaints, location of the defect, results of otorrhea endoscopic examination, findings from skull base thin-slice computed tomography (CT) examination, and causes of CSF otorrhea. Postoperative outcomes of CSF otorrhea were followed up. Results: Among the 26 cases of CSF otorrhea, there were 13 (50%) males and 13 (50%) females who underwent treatment using the three surgical methods. The etiology of CSF otorrhea included 10 (38%) cases of spontaneous CSF otorrhea, including 2 (8%) cases of congenital inner ear deformity and 8 (31%) cases without obvious inducement. Additionally, there were 5 (19%) cases of trauma, 6 (23%) cases of cholesteatoma complications, 3 (12%) cases of postoperative complications of brain tumor, 1 (4%) case of radiotherapy, and 1 (4%) case of a malignant tumor. A total of 12 (46%) cases of CSF otorrhea were treated by local repair of the defect. Furthermore, 3 (12%) cases underwent local repair of the defect combined with sealing of the tympanic sinus entrance, while 11 (42%) cases underwent local repair of the defect combined with sealing of the eustachian tube and the external auditory canal. No recurrence of CSF otorrhea was observed during the 6-month to 10-year follow-up period after surgery. Conclusion: The three methods for CSF otorrhea, including local defect repair, local defect repair combined with sealing of the tympanic sinus entrance, and sealing of the eustachian tube and the external auditory canal, demonstrated successful outcomes in appropriately selected patients.

Outcome of Transvaginal Local Repair of Vesicovaginal Fistula

Background: Vesicovaginal fistula (VVF) is a significant cause of physical & psychological disability with social stigmatization especially in low- and middle-income countries. Over 80% of such cases result from neglected prolonged and obstructed labour. Objective: The purpose of the study was to observe the outcome of transvaginal local repair of vesicovaginal fistula (VVF). Methods: This descriptive study was carried out at the Department of Obstetrics & Gynaecology, Sylhet M.A.G. Osmani Medical College Hospital, Bangladesh, from July 2007 to June 2008, on 50 patients of vesicovaginal fistula. We included women who were suffering from VVF and who were operated before and diagnosed as a failed repair of VVF. We excluded those patients who had VVF with associated problem like rectovaginal fistula (RVF), any repair through transabdominal route and unwilling to take part in this study. Before surgery, each woman was assessed by medical and surgical history, examination and necessary investigations. Typically, regional anesthesia was utilized for the fistula surgery. However, general anesthesia was given when required. During surgery, transvaginal approach was taken for repair. The vagina was packed for haemostasis. Vaginal pack was removed after 1-2 days depending on instruction of the surgeon. Repacking of vagina was also done sometimes when there was some leaking during post-operative period. Few patients developed severe constipation post operatively. Results: The participants aged between 16 and 70 years. Among them, majority of the patient belongs to the age 31-35 years (26%) followed by 2nd common group 26-30 years of age (20%) and 3rd one in between 21-25 years of age (16%). Among them 44% patients were primipara and 22% patients were grand multipara. The mobilization during operation was excellent in 30%, satisfactory 64% cases and not enough in 6% cases. After mobilization fistula closed in double layer in 10% and in single layer 90% cases, labial fat graft was given 38% and peritoneal graft was given in 2% cases. During operation bleeding was minimum in 92% cases and in 34% cases catheter was block, urine leakage occurred in 30% cases. Among all patients 14% suffered from fever postoperatively. There was vaginal discharge in 10% cases and UTI in 12%cases which was evidenced by urine culture. Operation was fully successful in 60 percent cases, urethral incontinence in 22% cases & failed in 18% women. Conclusion: In this study, majority of the transvaginal local repair of VVF operations were successful; however, few difficult cases were observed. Mugda Med Coll J. 2023; 6(1): 25-29

PARylated PDHE1α generates acetyl-CoA for local chromatin acetylation and DNA damage repair.

Chromatin relaxation is a prerequisite for the DNA repair machinery to access double-strand breaks (DSBs). Local histones around the DSBs then undergo prompt changes in acetylation status, but how the large demands of acetyl-CoA are met is unclear. Here, we report that pyruvate dehydrogenase 1α (PDHE1α) catalyzes pyruvate metabolism to rapidly provide acetyl-CoA in response to DNA damage. We show that PDHE1α is quickly recruited to chromatin in a polyADP-ribosylation-dependent manner, which drives acetyl-CoA generation to support local chromatin acetylation around DSBs. This process increases the formation of relaxed chromatin to facilitate repair-factor loading, genome stability and cancer cell resistance to DNA-damaging treatments in vitro and in vivo. Indeed, we demonstrate that blocking polyADP-ribosylation-based PDHE1α chromatin recruitment attenuates chromatin relaxation and DSB repair efficiency, resulting in genome instability and restored radiosensitivity. These findings support a mechanism in which chromatin-associated PDHE1α locally generates acetyl-CoA to remodel the chromatin environment adjacent to DSBs and promote their repair.

AIMED: An automatic and incremental approach for business process model repair under concept drift

Real-life business processes may change over time in response to new business requirements, market changes, new policies or regulations, etc., which is called concept drift in the data mining area. How to identify and deal with the concept drift problem is a significant challenge in business process mining. Currently, the research mainly focuses on the problems of concept drift detection. However, the proposed approaches do not intuitively explain how the process changes. In this paper, we provide an integrated framework whose core technique is an Automatic and Incremental approach for business process Model rEpair under concept Drift (AIMED). AIMED streamlines the functions of concept drift detection, localization and model repair. More specifically, when concept drift is detected, it updates the process model automatically by precisely localizing the sub-structure of the process model that concept drift affects and updating this sub-structure accordingly. Concept drift is explained intuitively by presenting the repaired model. In particular, AIMED can resist the noise that greatly affects the performance of current concept drift detection and process model repair techniques. The properties of AIMED are theoretically proven. We also conduct extensive experiments on synthetic logs as well as real-life logs. The experiment results show that AIMED outperforms the state-of-the-art methods in both concept drift detection and process model repair and works well even when there is noise in logs.

Performance evaluation and comparative analysis of CrowWhale-energy and trust aware multicast routing algorithm

Multipath routing helps to establish various quality of service parameters, which is significant in helping multimedia broadcasting in the Internet of Things (IoT). Traditional multicast routing in IoT mainly concentrates on ad hoc sensor networking environments, which are not approachable and vigorous enough for assisting multimedia applications in an IoT environment. For resolving the challenging issues of multicast routing in IoT, CrowWhale-energy and trust-aware multicast routing (CrowWhale-ETR) have been devised. In this research, the routing performance of CrowWhale-ETR is analyzed by comparing it with optimization-based routing, routing protocols, and objective functions. Here, the optimization-based algorithm, namely the Spider Monkey Optimization algorithm (SMO), Whale Optimization Algorithm (WOA), Dolphin Echolocation Optimization (DEO) algorithm, Water Wave Optimization (WWO) algorithm, Crow Search Algorithm (CSA), and, routing protocols, like Ad hoc On-Demand Distance Vector (AODV), CTrust-RPL, Energy-Harvesting-Aware Routing Algorithm (EHARA), light-weight trust-based Quality of Service (QoS) routing, and Energy-awareness Load Balancing-Faster Local Repair (ELB-FLR) and the objective functions, such as energy, distance, delay, trust, link lifetime (LLT) and EDDTL (all objectives) are utilized for comparing the performance of CrowWhale-ETR. In addition, the performance of CrowWhale-ETR is analyzed in terms of delay, detection rate, energy, Packet Delivery Ratio (PDR), and throughput, and it achieved better values of 0.539 s, 0.628, 78.42%, 0.871, and 0.759 using EDDTL as fitness.

Recent failures of external prestressing grouted tendons: when the ducts take on water…

AbstractThe article describes recent cases of tendon ruptures by corrosion and investigations carried out on some bridges in France. Several causes related to HDPE ducts have been identified such as damages during handling, threading and tensioning of strands, defective connection of the duct to the anchorage, damage during construction or operation, low quality of HDPE material, etc. These cases of tendon rupture exclusively concern ducts injected with cement grout. To our knowledge, no structure built after the application of the 2001 circular [1] (prohibiting cement grout for the injection of external prestressing) is currently exhibiting major disorders.A warning note on existing structures with external prestressing has been updated by Cerema in November 2018 [2]. It describes the diagnosis methodology based on analysis of documentation, thorough visual inspection, destructive and nondestructive investigations. New non‐destructive techniques such as guided‐wave ultrasonic technique and magnetic leakage field test using permanent magnets and induction coils are presented. Innovative methods of local repair of the ducts are also described. Finally, different protective devices are analysed in terms of worker safety in the event of a sudden failure of tendon.

Applicability Verification of Restoration by Welding to Extend the Lifetime of Railway Wheel

Railway wheels, when subjected to wear beyond their designated usage standards due to the operation of railway vehicles, are traditionally managed through a turing maintenance method. This process involves turing the entire worn portion to secure the requisite cross-sectional shape. This approach often leads to disposal after just 2 to 3 turing maintenance cycles. Excessive turing, extending beyond the worn parts, can cause the wheels to fail to meet railway operating specifications. Discarded railway wheels, which contain a high carbon content essential for driving performance, are not repurposed but are instead entirely stockpiled. This research introduces a novel welding restoration technology for railway wheels, targeting the flange portion, a principal area of wear. Utilizing submerged arc welding techniques, this method enables the localized repair of worn parts, minimizing the turing thickness and thus extending the useful life fo railway wheel. To evaluate the on-site applicability and dependability of this welding restoration method, real rail vehicle driving tests were conducted using both conventionally turned and welding-restored railway wheels. Analysis of the wheel profiles substantiated that the welding restoration method delivers mechanical performance comparable to that achieved by traditional turning maintenance.

Engineering of a NIR-activable hydrogel-coated mesoporous bioactive glass scaffold with dual-mode parathyroid hormone derivative release property for angiogenesis and bone regeneration.

Osteogenesis, osteoclastogenesis, and angiogenesis play crucial roles in bone regeneration. Parathyroid hormone (PTH), an FDA-approved drug with pro-osteogenic, pro-osteoclastogenic and proangiogenic capabilities, has been employed for clinical osteoporosis treatment through systemic intermittent administration. However, the successful application of PTH for local bone defect repair generally requires the incorporation and delivery by appropriate carriers. Though several scaffolds have been developed to deliver PTH, they suffer from the weaknesses such as uncontrollable PTH release, insufficient porous structure and low mechanical strength. Herein, a novel kind of NIR-activable scaffold (CBP/MBGS/PTHrP-2) with dual-mode PTHrP-2 (a PTH derivative) release capability is developed to synergistically promote osteogenesis and angiogenesis for high-efficacy bone regeneration, which is fabricated by integrating the PTHrP-2-loaded hierarchically mesoporous bioactive glass (MBG) into the N-hydroxymethylacrylamide-modified, photothermal agent-doped, poly(N-isopropylacrylamide)-based thermosensitive hydrogels through assembly process. Upon on/off NIR irradiation, the thermoresponsive hydrogel gating undergoes a reversible phase transition to allow the precise control of on-demand pulsatile and long-term slow release of PTHrP-2 from MBG mesopores. Such NIR-activated dual-mode delivery of PTHrP-2 by this scaffold enables a well-maintained PTHrP-2 concentration at the bone defect sites to continually stimulate vascularization and promote osteoblasts to facilitate and accelerate bone remodeling. In vivo experiments confirm the significant improvement of bone reparative effect on critical-size femoral defects of rats. This work paves an avenue for the development of novel dual-mode delivery systems for effective bone regeneration.

Substrate stiffness can affect the crosstalk between adipose derived mesenchymal stem cells and macrophages in bone tissue engineering.

Purpose: This study aimed to explore the effect of biomaterials with different stiffness on Adipose Derived Mesenchymal Stem Cells (ADSC)-macrophage crosstalk in bone tissue engineering and its role in bone repair. Methods: Biomaterials with Young's modulus of 64 and 0.2kPa were selected, and the crosstalk between ADSCs and macrophages was investigated by means of conditioned medium treatment and cell co-culture, respectively. Polymerase chain reaction (PCR) and flow cytometry were used to evaluate the polarization of macrophages. Alkaline phosphatase (ALP) and alizarin red staining (ARS) solutions were used to evaluate the osteogenic differentiation of ADSCs. Transwell assay was used to evaluate the chemotaxis of ADSCs and macrophages. Moreover, mass spectrometry proteomics was used to analyze the secreted protein profile of ADSCs of different substrates and macrophages in different polarization states. Results: On exploring the influence of biomaterials on macrophages from ADSCs on different substrates, we found that CD163 and CD206 expression levels in macrophages were significantly higher in the 64-kPa group than in the 0.2-kPa group in conditioned medium treatment and cell co-culture. Flow cytometry showed that more cells became CD163+ or CD206+ cells in the 64-kPa group under conditioned medium treatment or cell co-culture. The Transwell assay showed that more macrophages migrated to the lower chamber in the 64-kPa group. The proteomic analysis found that ADSCs in the 64-kPa group secreted more immunomodulatory proteins, such as LBP and RBP4, to improve the repair microenvironment. On exploring the influence of biomaterials on ADSCs from macrophages in different polarization states, we found that ALP and ARS levels in ADSCs were significantly higher in the M2 group than in the other three groups (NC, M0, and M1 groups) in both conditioned medium treatment and cell co-culture. The Transwell assay showed that more ADSCs migrated to the lower chamber in the M2 group. The proteomic analysis found that M2 macrophages secreted more extracellular remodeling proteins, such as LRP1, to promote bone repair. Conclusion: In bone tissue engineering, the stiffness of repair biomaterials can affect the crosstalk between ADSCs and macrophages, thereby regulating local repair immunity and affecting bone repair.

Observation of Demographic Factors, Labor Characteristics, and Outcomes in Vesicovaginal Fistula

Introduction: Vesicovaginal fistula (VVF) is a significant public health issue, particularly in areas with inadequate access to quality emergency obstetric care. This study aimed to examine the demographic and obstetric factors associated with VVF in a specific population and to evaluate the outcomes of VVF surgery. Methods: This cross-sectional study was conducted at the Dhaka Medical College Fistula Centre from April to July 2013. From a total of 47 admissions, 27 patients were selected based on specific inclusion criteria. Data were collected on demographic factors, obstetric history, cause of VVF, and surgery-related characteristics. The primary outcome was the success or failure of VVF surgery. Result: The study included women with an average age of 33.78 years and an average height of 144.67 cm. Majority were classified as poor (66.67%). Most had primary education (62.96%) and were housewives (92.59%). Vaginal deliveries were most common (59.26%). Stillbirths accounted for the majority of outcomes (77.78%). Obstetrical causes were the primary reason for vesicovaginal fistula (VVF) (70.37%). Local repair was the most common mode of surgical repair (59.26%), and the majority of surgeries were successful (85.19%). Conclusion: The study highlights the significant burden of VVF among women of lower socioeconomic status and educational level. It underscores the need for improved surgical techniques and decision-making in obstetric and gynecological care, and the importance of access to quality obstetric care. Further research is needed to develop and implement effective strategies to prevent and treat VVF, particularly in resource-limited settings.

A Reliable Low-Latency Multipath Routing Algorithm for Urban Rail Transit Ad Hoc Networks

With the advancement of urban rail transit towards intelligence, the demand for urban rail transit communication has increased significantly, but the traditional urban rail transit vehicle–ground communication system has been unable to meet the future vehicle–ground communication requirements. To improve the performance of vehicle–ground communication, the paper proposes a reliable low-latency multipath routing (RLLMR) algorithm for urban rail transit ad hoc networks. First, RLLMR combines the characteristics of urban rail transit ad hoc networks and uses node location information to configure a proactive multipath to reduce route discovery delay. Second, the number of transmission paths is adaptively adjusted according to the quality of service (QoS) requirements for vehicle–ground communication, and then the optimal path is selected based on the link cost function to improve transmission quality. Third, in order to enhance the reliability of communication, a routing maintenance scheme has been added, and the static node-based local repair scheme is used in routing maintenance to reduce the maintenance cost and time. The simulation results show that compared with traditional AODV and AOMDV protocols, the proposed RLLMR algorithm has good performance in improving latency and is slightly inferior to the AOMDV protocol in improving reliability. However, overall, the throughput of the RLLMR algorithm is better than that of the AOMDV.

P-219 Non-operative management of localized mismatch repair deficient colon cancer: A real-world perspective

P-219 Non-operative management of localized mismatch repair deficient colon cancer: A real-world perspective

Vascular Reconstruction and Limb Loss in Military Tibial Artery Injuries

Selective operative management of injuries to the tibial arteries is controversial, with the necessity of revascularization in the face of multiple tibial arteries debated. Tibial artery injuries are frequently encountered in military trauma, but revascularization practices and outcomes are poorly defined. We aimed to investigate associations between the number of injured vessels and reconstruction and limb loss rates in military casualties with tibial arterial trauma. A US military database of lower extremity vascular injuries from Iraq and Afghanistan (2004-2012) was queried for limbs sustaining at least one tibial artery injury. Injury and intervention characteristics and limb outcomes were analyzed by the number of tibial arteries injured (one, T1; two, T2; three, T3). We included 221 limbs (194 T1, 22 T2, 5 T3). The proportions with concomitant venous, orthopedic, nerve, or proximal arterial injuries were similar between groups. Arterial reconstruction (vs ligation) was performed in 29% of T1, 63% of T2, and universally in T3 limbs (P < .001) (Figure). Arterial reconstruction was via vein graft (vs localized repair) in 62% of T1, 54% of T2, and 80% of T3 (P = .59). T3 received greater blood transfusion volume (P = .02) and fasciotomy was used universally (vs 34% T1 and 14% T2; P = .05). Amputation rates were 23% for T1, 26% for T2, and 60% for T3 (P = .16), and amputation was not significantly predicted by arterial ligation in T1 (P = .08) or T2 (P = .34) limbs. Infection was more common in T3 (80%) than T1 (25%) or T2 (32%, P = .02), but other limb complication rates were similar. In this series of military lower extremity injuries, an increasing number of tibial arteries injured was associated with increasing use of arterial reconstruction. Limbs with all three tibial arteries injured had high rates of complex vascular reconstruction and eventual amputation. Limb loss was not predicted by arterial ligation in one- and two-vessel injuries, suggesting that selective reconstruction in these cases is advisable.

Treatment of Rectovaginal Fistula.

Rectovaginal fistula (RVF) is a challenging complication with unsatisfactory success and a significant burden for the patients. With insufficient clinical data due to the rare entity, the present state of treatments for RVFs was reviewed especially form the point of factors to determine management, classifications, principle of treatment, conservative and surgical treatments with outcomes. Size, fistula localization and etiology, type of fistula; "simple" or "complex," status of anal sphincter complex and surrounding tissue, presence or absence of inflammation, presence of diverting stoma, previous attempted repair and radiation therapy, patient's condition with co-morbidities, and surgeon's experience are important factors to determine the management of RVF. The inflammation should initially subside in cases with infection. Starting with conservative surgical options and interposing healthy tissue for complex or recurrent fistulas, invasive procedures will be performed if conservative treatment failed. Conservative treatment may be effective in RVFs with minimal symptoms and should be done for small RVFs for a 36 months usual period. Anal sphincter damage might need a repair of sphincter muscles along with RVF repair. Diverting stoma can initially be constructed in patients with severe symptoms and larger RVFs to relief the patient's pain. Simple fistula is usually indicated for local repair. Local repairs to transperineal and transabdominal approaches can be used for complex RVFs. Interposition of healthy, well-vascularized tissue can be required for more complex fistulas and abdominal procedures for high RVFs.

Corrosion control by autonomous self-healing epoxy coatings based on superabsorbent healing agents

Metallic corrosion is an all-time dangerous and extremely expensive problem. Here, we present an autonomous self-healing polymer coating based on an epoxy resin and superabsorbent polymer (SAP) blend as an anticorrosion coating. Tailor-made coatings were manufactured by controlling the location of the SAP on the surface, middle, and bottom of the coating. The corrosion behavior and self-healing process of the coatings were analyzed at the macro, micro, and sub-micro scales using Electrochemical Impedance Spectroscopy (EIS). The SAP preferentially located at the bottom showed coating resistance values higher than 1 × 1011 Ωcm2 over 10 days of immersion with 3-point defects. This configuration provided the best anticorrosion performance, preventing coating delamination, and protecting the metal from corrosion after surface damage, indicating better barrier properties. The SAP enabled local repair of the crack when in contact with water, minimizing the diffusion of oxygen and electroactive species, which are responsible for the corrosion of a metal.

Effects of multiple post cure cycles on properties of composite carbon fibre and epoxy materials

Post-curing cycles have an effective impact on the thermal and mechanical properties of thermoset composite materials. Typically, post-cure cycles use heat to expose cured resin parts to high temperatures in an attempt to maximize their final properties. In most cases, these processes allow composite parts to achieve the highest possible strength and become stable. In industrial practice, however, it has been found that there are potential consequences of performing localized repairs on composite parts in an autoclave where the localized repair undergoes a normal curing process while the parent part undergoes an additional curing process. Thus, for the parent part, prolonged exposure to high temperatures can trigger a process of decomposition of the resin matrix, as could be the aging phenomena of composites in service. In such a scenario, two practical questions are worth asking: (1) to what extent can a resin matrix be post cured without risking degrading its thermal properties? (2) what are the residual mechanical and physical properties resulting from prolonged exposure of composite parts to elevated temperatures? In this work, an analysis was carried out to estimate the potential adverse effects on thermoset composite parts made of carbon fibre and epoxy resin materials commonly used in aerospace, in terms of thermal, physical and mechanical properties after a long exposure to high temperatures caused by multiple post cure cycles. Two types of prepreg laminates were used to make monolithic test panels using twill and plain weave architectures for the M21 and 8552 test panels respectively. Thermal tests were conducted to evaluate the evolution of the degree of cure, the glass transition temperature and the inter-laminar shear strength of post-cured panels, which were subjected to a different number of post cure cycles. The study found that multiple post cure cycles alter thermal properties, which in turn have adverse effects on physical and mechanical properties. The results demonstrated that the two types of composite materials respond differently to changes in properties. Twill weave panels quickly reach full cure after three stages while plain weave panels have undergone gradual curing. This difference in the curing process of the resin matrix clearly influenced the changes in the measurements of shear, surface hardness and compressive strengths.

Real-Time Instance Segmentation Models for Identification of Vehicle Parts

Automated assessment of car damage is a major challenge in the auto repair and damage assessment industries. The domain has several application areas, ranging from car assessment companies, such as car rentals and body shops, to accidental damage assessment for car insurance companies. In vehicle assessment, the damage can take many forms, from scratches, minor dents, and major dents to missing parts. Often, the assessment area has a significant level of noise, such as dirt, grease, oil, or rush, which makes accurate identification challenging. Moreover, in the repair industry, identifying a particular part is the first step in obtaining an accurate labor and part assessment, where the presence of different car models, shapes, and sizes makes the task even more challenging for a machine-learning model to perform well. To address these challenges, this study explores and applies various instance segmentation methodologies to determine the best-performing models. This study focuses on two genres of real-time instance segmentation models, namely, SipMask and YOLACT, owing to their industrial significance. These methodologies were evaluated against a previously reported car parts dataset (DSMLR) as well as an internally curated dataset extracted from local car repair workshops. The YOLACT-based part localization and segmentation method outperformed other real-time instance mechanisms with an mAP of 66.5. For the workshop repair dataset, SipMask++ reported better accuracy for object detection with a mAP of 57.0, with outcomes for A P I o U = . 50 and A P I o U = . 75 reporting 72.0 and 67.0, respectively, whereas YOLACT was observed to be a better performer for A P s with 44.0 and 2.6 for object detection and segmentation categories, respectively.

Sustained delivery of IL-10 by self-assembling peptide hydrogel to reprogram macrophages and promote diabetic alveolar bone defect healing.

Delayed regeneration of alveolar bone defects because of prolonged inflammation under diabetic conditions remains a challenge for dental rehabilitation in clinic, and effective therapies are required. Cytokines-based immuotherapies might be a potential strategy to regulate inflammation and bone regeneration. Here, we report that local delivery of interleukin-10 (IL-10) by injectable self-assembling peptide (SAP) hydrogel is efficient to promote proinflammatory (M1)-to-anti-inflammatory (M2) phenotype conversion, thereby enhancing bone regeneration in diabetic alveolar bone defects. Characteristics of SAP hydrogel were evaluated by morphology, injectable and rheological properties. The loading and release of IL-10 from the SAP hydrogel were evaluated over time in culture. The local inflammatory response and bone repair efficacy of the SAP/IL-10 hydrogel was evaluated in vivo using an alveolar bone defect model of diabetic mice. Finally, the direct effects of M2 macrophage on M1 phenotype and mineralization of MSCs were investigated. In vitro, encapsulated IL-10 could be sustainedly released by SAP hydrogel with preserved bioactivities. In vivo, SAP/IL-10 hydrogel showed significantly higher efficacy to attenuate M1 polarization and proinflammatory factors levels, and enhance expressions of osteogenic factors. As a result, diabetic bone regeneration induced by SAP/IL-10 hydrogel was significantly faster. Mechanistically, M2 macrophages induced by sustained IL-10 delivery might promote diabetic bone regeneration by reprogramming M1 phenotype, suppressing local inflammation and enhancing the osteogenic differentiation of mesenchymal stem cells (MSCs). This study highlights that the SAP hydrogel is a promising drug delivery platform for treatment of alveolar bone defects, which might have translational potential in future clinical applications.

BugBuilder: An Automated Approach to Building Bug Repository

Bug-related research, e.g., fault localization, program repair, and software testing, relies heavily on high-quality and large-scale software bug repositories. The importance of such repositories is twofold. On one side, real-world bugs and their associated patches may inspire novel approaches for finding, locating, and repairing software bugs. On the other side, the real-world bugs and their patches are indispensable for rigorous and meaningful evaluation of approaches to software testing, fault localization, and program repair. To this end, a number of software bug repositories, e.g., iBUGS and Defects4J, have been constructed recently by mining version control systems and bug tracking systems. However, fully automated construction of bug repositories by simply taking bug-fixing commits from version control systems often results in inaccurate patches that contain many bug-irrelevant changes. Although we may request experts or developers to manually exclude the bug-irrelevant changes (as the authors of Defects4J did), such extensive human intervention makes it difficult to build large-scale bug repositories. To this end, in this paper, we propose an automatic approach, called BugBuilder, to construct bug repositories from version control systems. Different from existing approaches, it automatically extracts complete and concise bug-fixing patches and excludes bug-irrelevant changes. It first detects and excludes software refactorings involved in bug-fixing commits. BugBuilder then enumerates all subsets of the remaining part, and discards invalid subsets by compilation and software testing. If exactly a single subset survives the validation, this subset is taken as the complete and concise bug-fixing patch for the associated bug. In case multiple subsets survive, BugBuilder employs a sequence of heuristics to select the most likely one. Evaluation results on 809 real-world bug-fixing commits in Defects4J suggest that BugBuilder successfully extracted complete and concise bug-fixing patches from forty-three percent of the bug-fixing commits, and its precision (99%) was even higher than human experts. We also built a bug repository, called GrowingBugs, with the proposed approach. The resulting repository serves as evidence of the usefulness of the proposed approach, as well as a publicly available benchmark for bug-related research.