Most of the current studies only conducts two-dimensional simulations of condensation heat transfer and flow outside enhanced tubes, which cannot accurately reflect the flow and heat transfer characteristics of liquid film outside enhanced tubes. In order to provide theoretical support for the design optimization of enhanced tubes, this study adopts the VOF multiphase model and Lee condensation model to simulate the condensation heat transfer(HTC) of refrigerants outside smooth and enhanced tubes. The instantaneous film flow characteristics of the liquid film outside the horizontal smooth and enhanced tubes are analyzed, and the thickness of the liquid film and the relationship with the condensation heat transfer coefficient of the smooth and enhanced tubes under different working conditions are calculated. The refrigerants are compared under the same working conditions, and the results are shown: The simulation results are in good agreement with the experimental data and the Nusselt analytical solution, and the error is all within 15%; the distribution of liquid film is highly sensitive to the magnitude of local condensation heat transfer coefficients, and the condensation HTC outside the enhanced tube is approximately six times of that of smooth tube. Combining the distribution of the liquid film and the thermophysical properties of the refrigerants, it was determined that R410A has the highest HTC, while R1234yf has the lowest HTC.