ABSTRACT Culture-led regeneration, understood as a range of policies using cultural activity as a catalyst for urban regeneration, has been widely implemented by many European cities. The interest of local businesses and politicians in these processes seems undiminished despite the various systemic crises hitting European cities. In the meantime, the ways in which culture-led regeneration and its promoters interact with, shape and manipulate local discourses and meanings have become critical for its successful implementation. Drawing upon the literature on the politics of urban development, this paper looks at how culture-led regeneration promulgates, negotiates and manipulates local discourses and meanings. It takes the example of European maritime port cities, where these processes have often served as a means to address the challenges associated with shifting meanings and practices surrounding port-city relationships. We argue that culture-led regeneration schemes operating in port cities in the twenty-first century strive to engage directly with local discourses and meanings associated with past economic activities but, in doing so, renegotiate them, producing hybridized models of regeneration that mirror and align with the agenda of culture-led urban growth coalitions.