Pyogenic Granuloma Research Articles

Extragingival pyogenicgranuloma: Case report

Pyogenicgranuloma (PG) is a frequent cause of soft tissue outgrowth in the oral cavity, mainly in the gingiva. Extra-gingival localizationremainsexceptional. Itstypicalclinicalpresentation and gingival distribution in over 80% of cases [3 ;4]. This suggests a diagnosisthatwillbeconfirmed by anatomopathologicalstudy of the excision specimen. Extra-gingival lesions are considered rare in the literature and are diagnosedlate. We report the case of a 68-year-old patient with an extra-gingival pyogenicgranuloma of the floor of the mouth. Surgical management consisted of excision undergeneralanaesthetic. The post-operative course wasstraightforward, and no recurrencewasnoted at one yearfollow-up.

P18-13 The use of Aloe vera gel as anti-inflammatory adjunctive herbal remedy for lobular capillary hemangioma: a case report

P18-13 The use of Aloe vera gel as anti-inflammatory adjunctive herbal remedy for lobular capillary hemangioma: a case report

Zosteriform Cutaneous Metastasis from Breast Cancer: A Case Report

Introduction: Cutaneous metastases are observed in approximately 10% of oncology patients, often indicating either a persistent solid tumor or the recurrence of neoplastic disease. The most prevalent cause of cutaneous metastases in females is breast cancer. Patients with breast cancer may exhibit cutaneous manifestations at the initial diagnosis; however, these metastases more frequently emerge well after the initial diagnosis and treatment. The cutaneous lesions resulting from metastatic breast carcinoma display considerable variability in appearance. Typically, they manifest as firm, flesh-colored to red, smooth or ulcerated, or crusted nodules, papules, and plaques on the ipsilateral chest wall and breast. Additionally, unusual sites for breast cancer cutaneous metastases include the eyelids, inframammary folds, ipsilateral lymphedematous arm, scalp, subungual nail bed, and umbilicus. Skin metastases can also occur in mastectomy scars and radiation therapy ports. Several distinct patterns of skin metastases are recognized in breast cancer patients: carcinoma erysipelatoides, carcinoma telangiectoides, and carcinoma encuirasse. Recently, carcinoma hemorrhagiectoides has also been documented. The pleomorphic nature of breast cancer metastases can mimic various benign and malignant conditions, such as collision tumors, cysts, dermatofibromas, milia-en-plaque, melanoma, non-melanoma skin cancers, cellulitis, folliculitis, herpes zoster, paronychia, erythema annulare centrifugum, urticaria, alopecia areata, dermatitis, hidradenitis suppurativa, scleroderma, angiokeratoma, angiosarcoma, lymphangioma circumscriptum, purpura, and pyogenic granuloma. Consequently, it is crucial to consider the possibility of cutaneous metastasis from breast cancer in any patient, whether previously diagnosed with breast cancer or not, who presents with new or treatment-resistant cutaneous lesions. Confirmation of the diagnosis necessitates a biopsy of the skin lesion. ...........

Angiosarcoma of External Auditory Canal Masquerading as Pyogenic Granuloma

Sarcomas are rare and heterogeneous mesenchymal tumours that occur in deep soft tissue and bone

Clinicopathologic Correlation and Routine Immunostains Help Distinguish Congenital Disseminated Pyogenic Granuloma From Other Cutaneous Disseminated Vascular Proliferations of Infancy: Case Report and Literature Review.

The presence of multiple cutaneous vascular lesions in infancy can signal the possibility of visceral involvement. Dermatopathologists must appreciate how the differential diagnosis includes entities that have distinct therapeutic and prognostic implications. Fortunately, these rare entities can be distinguished histopathologically with the help of clinicopathologic correlation and immunohistochemistry. In this article, we discuss congenital disseminated pyogenic granuloma, multifocal infantile hemangioma, and multifocal lymphangioendotheliomatosis with thrombocytopenia. Subtle morphologic and immunophenotypic features permit their distinction, which in turn is important for identifying extracutaneous manifestations and effective treatments. We present a case of a 3-week-old infant with congenital disseminated pyogenic granuloma involving the skin and the liver whose lesions regressed without therapeutic intervention over 6 months of close follow-up. We review the literature on these rare, overlapping entities and present an approach to resolving the differential diagnosis.

A Case of Pyogenic Granuloma in a 12-Year-Old Girl: Clinical Presentation, Diagnosis, and Treatment

This case report presents a 12-year-old girl with a papule on her cheek that had been evolving for three months. The papule was excised, and histopathological examination revealed a pyogenic granuloma characterized by vascular proliferation in loose conjunctival tissue. This case highlights the importance of considering pyogenic granuloma in the differential diagnosis of persistent skin lesions in pediatric patients.

To evaluate the role of mast cells on angiogenesis in various grades of oral squamous cell carcinoma: A histochemical study

Abstract Background: Oral cancer is the sixth most common cancer, and 90% of them are oral squamous cell carcinomas (OSCC). As most OSCC are asymptomatic and are only detected at an advanced stage, the 5-year survival rate is only 50%. Thus, using novel prognosticators can minimise mortality and morbidity associated with OSCC. This study aims to evaluate the relationship between mast cells and angiogenesis in different grades of OSCC to analyse their role in its progression. Material and Methods: A total of 45 cases were included, comprising 10 well-differentiated SCCs (WDOSCC), 10 moderately differentiated SCCs (MDOSCC), and 10 poorly differentiated SCCs (PDOSCC). Additionally, five normal buccal mucosae (NBM) samples served as negative controls for OSCC. Five cases of neurofibroma and pyogenic granuloma were used as positive controls for mast cells and angiogenesis, respectively. Results: The mean MCD in WDOSCC, MDOSCC, and PDOSCC were 3.2620 ± 2.65177, 3.0310 ± 1.38276, and 4.1580 ± 2.49482, respectively. The MVD in WDOSCC, MDOSCC, and PDOSCC were 10.2850 ± 4.35032, 9.9240 ± 2.72533, and 7.1520 ± 2.26966, respectively. Discussion: MCD was the highest in PDOSCC, followed by WDOSCC and MDOSCC. These results indicate a redundant role of mast cells in OSCC, or they might jumpstart malignancy but are retarded with OSCC progression. The MVD decreased with higher grades, in contrast to the prevalent literature. The correlation analysis between MVD and MCD revealed no significant correlation between them. Conclusion: We found a non-significant role of mast cells in tumour biology and a decrease in vascularity with advancing grades. These results indicate a lower need for mast cell activation to augment vascularisation. A study with a larger sample size is needed to confirm our results.

UNILATERAL NASAL MASS: CASE SERIES WITH REVIEW OF DIFFERENTIAL DIAGNOSIS

Introduction: Unilateral nasal masses present diverse manifestations, posing risks of benign or malignant transformation if improperly diagnosed. A probe test is a basic clinical test to have an idea about the origin and nature of the polyp. Imaging studies such as computed tomography may give a detailed knowledge regarding origin and extent of polyposis. Material & Methods: We discuss a case series of 5 patients with diverse presentations and diagnosis for unilateral nasal polyposis. A brief review on differential diagnosis of unilateral nasal masses is also discussed in a tabular form with easy to remember mnemonic. Conclusion: There are diverse presentations and diagnosis of identically looking unilateral nasal masses. An excisional biopsy should always be sent for histopathological examination to know for the nature of disease and decide regarding further treatments. KEYWORDS: Unilateral, Mnemonic, Pyogenic granuloma, Vestibule

Surgical removal of giant cutaneous horn from a pyogenic granuloma

Surgical removal of giant cutaneous horn from a pyogenic granuloma

Dermatoscopic features of pyogenic granuloma in children

AbstractThe clinical appearances of Pyogenic granuloma (PG) in children are not as typical as in adults. Meanwhile, skin biopsy is hard to accept for parents in most of time. Therefore, data of PG in children has been deprived. To analyze the dermoscopic features of PG in children in order to improve the efficiency of diagnosis and treatment and to reduce the probability of invasive examination. A single‐center retrospective study conducted from 1 January 2022 to 30 August 2022 summarized and analyzed the clinical data and dermoscopic features of patients clinically diagnosed with PG. A total of 36 patients were involved, 61.11% were males, 72.22% occurred in the face. Over 50% patients had the following dermoscopic patterns: reddish homogeneous area (100%), white collarette (91.7%), yellow‐white scales (69.4%), vascular structures (52.8%), and white rail lines (55.6%). Regression analysis found that gender and courses of disease had a statistically significant impact on part of the dermoscopic patterns. The proportions of dermoscopic features with yellow‐white scales (69.4%), dark red scabs (27.8%), and bleeding (27.8%) in this study were higher than in previous studies (26.7%, 10%, and 10%, respectively). Dermoscope is a practical diagnostic tool for PG in children. It is necessary to consider gender, disease course and lesion locations when PG is diagnosed using dermoscope. The characteristics of yellow‐white scales, dark red scabs, and bleeding are the microscopic features that distinguish pediatric patients with PG from adult patients, which should be given special attention to in pediatric patients.

Pyogenic granuloma (lobular capillary hemangioma) in a 4-year-old girl after treatment of acute lymphoblastic leukemia

Pyogenic granuloma (lobular capillary hemangioma) in a 4-year-old girl after treatment of acute lymphoblastic leukemia

Sclerotherapy as a Treatment Option for Pyogenic Granuloma.

Sclerotherapy as a Treatment Option for Pyogenic Granuloma.

Soft tissue vascular tumor-like lesions in adults: imaging and pathological analysis pitfalls per ISSVA classification

ObjectivesTo compare the magnetic resonance imaging (MRI) and Doppler ultrasound (DUS) findings with the pathological findings of soft tissue vascular tumors (STVTs) according to the 2018 ISSVA (International Society for the Study of Vascular Anomalies) classification to differentiate vascular tumors from vascular malformations.MethodsThis retrospective study included patients with STVTs who underwent contrast-enhanced MRI and pathological analysis at our hospital between 2010 and 2020. The presumptive diagnosis based on the on-site imaging and histological analysis was compared with imaging and histological analysis conducted off-site utilizing the ISSVA criteria.ResultsThis study included 31 patients with 31 vascular tumors located in the head and neck (n = 3), trunk (n = 2), and extremities (n = 26). The off-site pathological analysis confirmed benign vascular tumors in 54.8% of cases (non-involuting congenital hemangioma: 35.5%; epithelioid hemangioma: 13%; pyogenic granuloma: 3%; and spindle cell hemangioma: 3%). Based on the off-site histological analysis, 25.8% were reclassified as having a vascular malformation whereas three had other benign lesions. Only phleboliths were associated with a vascular malformation (p = 0.03). The concordance between off-site MRI and pathological findings was fair (k = 0.3902 (0.0531–0.7274)), whereas that between on-site and off-site pathological analyses was poor (k = −0.0949 (−0.4661 to 0.2763)).ConclusionBenign vascular tumors have non-specific imaging features on imaging with some overlap with atypical vascular malformations. Therefore, histological analysis is recommended. Imaging and pathological analyses should be performed in accordance with the ISSVA classification to minimize inter-observer discrepancies.Critical relevance statementImaging features of benign vascular tumors on MRI are non-specific, leading to discrepancies with pathological findings and potential overlap with atypical vascular malformations. Imaging and histological analyses should be performed in accordance with ISSVA guidelines to improve patient management.Key PointsThe imaging features of benign vascular tumors are non-specific.Histological analysis is recommended for soft tissue vascular tumors in adults.Analyses of soft tissue vascular tumors should be performed in accordance with ISSVA guidelines.Graphical

Rapidly Growing Congenital Disseminated Pyogenic Granuloma in the Scalp Treated with Staged Embolization and Excision: A Case Report

Pyogenic granulomas are common, acquired vascular lesions that most often arise spontaneously or in sites of previous trauma. However, there are reports of a few cases that describe a rare condition, congenital disseminated pyogenic granuloma (CDPG), in which an infant either is born with or shortly after birth develops multiple pyogenic granulomas. A hallmark of CDPG is negative staining for glucose transporter 1 (GLUT-1) on immunohistochemistry, which helps distinguish it from the more common multifocal infantile hemangiomas. Because few case reports have described CDPG, much is unknown about its characteristics, clinical course, and most effective treatment options. Here, we present a case of an infant with a unique presentation of CDPG with lesions that are atypically large and growing at a rapid pace. We also describe a novel approach to treating large pyogenic granulomas in CDPG via staged glue embolization and surgical excision.

Prevalence of Histopathologic Types of Gingival Lesions in the Iranian Population: A 22-Year Retrospective Study.

Gingiva is one of the supporting tissues around the teeth that can be affected by various neoplastic or nonneoplastic lesions. Previous studies have examined several types of gingival lesions, but the lack of a standardized classification system has hindered meaningful comparisons. Additionally, many studies focused primarily on reactive lesions. Our study aims to contribute to the understanding of gingival lesions by investigating their prevalence across age groups, genders, sites, and by their clinical presentation. This research could lead to improved diagnostic accuracy and treatment strategies. This retrospective study explores the prevalence of gingival lesions based on biopsies during a 22-year span. The patient's demographic details, including age, gender, and lesion's clinical presentation were systematically collected. These lesions were categorized into six groups. Descriptive statistics, χ2 test of independence, and one-way ANOVA were used for data analysis. Among the 7668 biopsied lesions, 684 (8.9%) lesions were located in the gingiva, with a greater occurrence in women (63.5%). Soft tissue tumors represented the most prevalent group in the gingival lesions (72.1%), and peripheral giant cell granuloma (PGCG) was the most frequent lesion (21.2%), followed by, pyogenic granuloma (19.3%), peripheral ossifying fibroma (17.8%) and focal fibrous hyperplasia (7.6%); all of which predominantly affected women, with mean ages falling in the fourth decade of life. Squamous cell carcinoma was recognized as the most common malignancy. In this study, PGCG was found to be the most common lesion in the gingiva in Iranian population. Further analysis using a unanimous categorization is required to confirm these results.

Prevalence of Pregnancy Tumor in Tripoli, Libya: A Multicenter Cross-Sectional Study

Background and objectives. Pyogenic granuloma (pregnancy tumor) is one of the gingival inflammatory changes with an increased incidence during pregnancy. The present study aimed to determine the prevalence and characteristics of pregnancy tumors in pregnant Libyan women in Tripoli, Libya. Methods. In this descriptive cross-sectional study, pregnant Libyan women were assessed at the National Heart Center-Tajoura, Jalaa Maternity Hospital, and Tripoli University Hospital during the period from August to November 2023. Data were collected through interviewing and clinical examination of the participants and filling out a data form. Results. During four months period, of 402 pregnant Libyan women, 4 (1.0%) were clinically diagnosed with pregnancy tumors. The four cases were in their third trimester of pregnancy. Half (50%) of pregnancy tumor cases were more than 30 years old, and the other half (50%) were early 20 years old. The gingiva was the only site of the lesions, and were observed equally in the maxilla and the mandible. All pregnancy tumor cases have calculus on their teeth, bleeding gums, and poor oral hygiene status. All lesions were sessile had lobulated surfaces, and showed spontaneous and provoked bleeding. Conclusions. Although the results of this study indicate that the prevalence of pregnancy tumors in pregnant Libyan women is considered low (1.0%), oral health education programs are very important during pregnancy, and if pregnant women notice any abnormal growth during pregnancy in their mouth, they should consult a dentist.

Safety and efficacy of intralesional polidocanol sclerotherapy in the treatment of plantar warts: a pilot study.

Plantar warts are common skin lesions that continue to represent a therapeutic challenge. They are still resistant to therapy and are highly recurrent, despite the diverse number of treatments available. Therapies targeting vasculature, such as pulsed dye laser, have been used successfully in the treatment of plantar warts. Polidocanol, a detergent sclerosant approved for the sclerotherapy of incompetent and dilated saphenous veins, has also been used as an off-label therapy for a wide range of skin conditions with vascular components such as hemangiomas and pyogenic granuloma. The current, open-label, prospective, pilot study aimed to evaluate the safety and efficacy of the intralesional polidocanol 3% in the treatment of plantar warts. Twenty patients (11 females and 9 males), with plantar warts, aged 12-50 years received biweekly sessions of intralesional polidocanol 3% until complete clearance or for a maximum of 6 sessions. Response to treatment was graded as complete (100% clearance), partial (50-99%), and no response (< 50%). At the end of the study, 12 (60%) patients achieved complete clearance of their warts after 1-5 sessions, 5 (25%) patients had only partial response, and 3 (15%) patients did not achieve any clearance of their warts. The procedure was largely tolerable by patients. Pain at the injection site and bruises were reported by 9 (45%) and 2 (10%) patients, respectively. Both side effects resolved spontaneously and completely within a few days. The findings of the current study suggest that intralesional injection of 3% polidocanol in biweekly sessions may be a safe, effective, and tolerable method for the treatment of plantar warts.

Pyogenic granuloma of maxillary median gingiva in a pediatric patient: A case report and literature review

Pyogenic granuloma (PG) is a painless pedunculated granulomatous lesion that develops on the skin and mucous membranes. PG in children is relatively rare. We herein report a case of PG of the maxillary median gingiva in a pediatric patient. The patient was a 6-year-old Japanese boy who presented with a painless mass with bleeding after exfoliation of the left upper deciduous central incisor. The lesion had undergone continuous, rapid growth for approximately 10 days. Intraoral findings revealed a painless, elastic, soft, and non-pedunculated mass, measuring 15 &amp;times; 10 mm, in the left upper deciduous central incisor area. To differentiate it from malignancy, an excisional biopsy was performed on the patient under general anesthesia. Histological findings confirmed that the patient suffered from PG. At the time of writing this paper, the patient had been clinically followed up for the 18th month after the surgery, showing no signs of tumor recurrence.

Congenital Disseminated Pyogenic Granuloma: A Case With Numerous Mucocutaneous and Visceral Lesions

Abstract Congenital disseminated pyogenic granuloma (CDPG) is characterized by eruptive disseminated or localized lesions, which may arise spontaneously or secondary to predisposing factors. Even rarer is the occurrence of CDPG with numerous lesions affecting variable organs, which develop during the fetal period. This report describes the case of a 32-week-old fetus presenting with severe hydrocephalus and vascular intracranial and right lung masses on magnetic resonance imaging. Preterm labor occurred at the 32nd week due to preterm premature rupture of membranes, and the newborn died due to cardiac dysfunction within 2 hours postpartum. The subsequent autopsy revealed multiple violaceous to dark red papules, nodules, pedunculated and un-pedunculated mucocutaneous masses, as well as two brain lesions, a lung lesion, a thoracic wall intramuscular mass, and a pyloric mass. Microscopic examination and immunohistochemical evaluation for glucose transporter 1 (GLUT1) confirmed the diagnosis of CDPG. CDPG represents a rare condition with an elusive etiology and limited reports in the literature. Differential diagnosis from multifocal infantile hemangioma, based on GLUT1 negativity of CDPG, is imperative due to differing clinical course and treatment modalities. This report underscores a severe case of CDPG characterized by preterm labor and demise shortly after delivery, notable for its extensive involvement across multiple organs, including the brain, lung, intestine, musculoskeletal system, mucosal, and numerous cutaneous sites.

Pyogenic Granuloma with Calcification: An Enigmatic Case

Pyogenic Granuloma with Calcification: An Enigmatic Case