Based on the study of the litho- and biofacies of the Vendian Nepa Horizon in the central area of the Siberian Platform inland, a paleoecological model for the Vendian microbiota has been developed. The sedimentation environments of the Katanga saddle have been reconstructed, and three sedimentary systems have been recognized: (1) lower continental, formed by the deposits of proluvial fans and riverbeds of temporary streams; (2) middle transgressive, made up of littoral sand facies in the lower part and of fine-clastic shelf strata in the upper part; and (3) upper, of sea highstand, composed of alternating sand bank facies and fine-clastic lagoon deposits. Four biofacies have been recognized in the fine-terrigenous deposits of the Nepa Horizon: (1) Appendisphaera, represented by a Doushantuo-Pertatataka acanthomorph assemblage; (2) Transitional, with a great diversity of plankton and benthic (including complex) taxa; (3) Vanavarataenia, dominated by Vanavarataenia complex benthic algae; and (4) Oscillatoriopsis, represented by taxonomically poor biotas with morphologically simple (mainly prokaryotic) remains. These biofacies are confined to the following sedimentation environments: Appendisphaera is widespread in the distal open-sea areas; the Transitional biofacies is localized in the distal environments of the semi-isolated inner basin; Vanavarataenia occurs in the proximal areas; and Oscillatoriopsis is typical of the shallow-water environments, both extended (corresponding to the highstand period) and local.