Palaeoglacier modelling is a crucial approach for reconstructing palaeoclimate. Although the timing of glaciations during the Little Ice Age (LIA) and Neoglacial in the central Gangdise Mountains has been partially determined, there are still undated fresh-looking moraines. This study utilized coupled mass balance and ice flow models to simulate the palaeoclimate during the five LIA glacial events (LIA-1 to LIA-5) and two Neoglacial glacial events (Neo-1 and Neo-2). The results revealed that the glacial volumes in the Gangdise Mountains during the LIA and Neoglacial periods ranged from ∼1.10 to 1.57 km3. Comparing the reconstructed climate with other proxies, it was found that Neo-2 and Neo-1 exhibited temperatures 0.54 to 0.82 °C and 0.7 to 1.0 °C lower than the present, respectively, with precipitation levels at 110–140% of the present. The temperatures during the LIA periods were 0.36 to 1 °C lower than the present, with precipitation levels at 80–120% of the present. The interannual variability of climate at decadal or centennial scales may have played a significant role in the formation of the LIA moraines.