Electro-Fenton (EF) is considered to be an effective water treatment technology for the purification of organic wastewater. However, the complicated and unfriendly process hinder the development of bimetallic electrodes in EF system. In this work, the novel bimetallic electrode (CoFeC) derived from Fe, Co-based prussian blue analogue (PBA) was synthesized by simple liquid phase epitaxial (LPE) method and pyrolysis treatment, and applied to EF degradation of ornidazole (ONZ). Significantly, the prepared CoFeC electrode exhibited superior degradation efficiency for almost complete removal of 50 mg/L ONZ in 120 min with optimal mineralization current efficiency (MCE) and energy consumption (EC). The stability of electrode was greatly improved, still maintaining above 90 % removal even after 10 cycles of degradation experiment. The results of mechanism exploration show that ONZ was removed via three degradation paths under the attack of the ·OH and SO4·−. Remarkably, the biotoxicity assessment of degraded intermediates analyzed by ECOSAR and T.E.S.T software indicated the environmentally friendly features of the EF degradation process. This work offers a green and efficient EF system using active bimetallic electrode, which has a broad application prospect in the field of watertreatment for organic wastewater.