The study of gas phase dispersion at the intake of submersible pumping equipment is an actual issue, since changes in gas phase dispersion can lead to changes in natural separation. At the same time, the gas separation efficiency can be affected by the presence of solid phase in the well products, which would change the structure of gas-liquid mixture and operation mode of electric submersible pump. The results of the research are novel, which takes into account the influence of the properties of multi-component gas-liquid mixture on the character of operation of ESP well. The new dependences of gas bubble diameter at the submersible equipment intake on gas content for four model gas-liquid mixtures: «water – air», «water – surfactants – air», «water – air – solids» and «water – surfactants – air – solids» with the concentration of suspended particles in the flow of 1.0 g/l have been experimentally obtained in conditions of gauge pressure at the intake 0.04 - 0.05 MPa, gas content of mixture was increased up to 71%, liquid flow rate was changed in the range of values from 13 to 68 m3/day. High-speed video recording with fixing the structure of gas-liquid mixture in the near-intake space of the ESP was carried out during the tests. Visualization allows us to clarify the boundary of the flow regime transition from «bubble» to «slug/churn» compared to the Caetano method. There were developed new correlations of natural gas separation coefficient taking into account the influence of solid phase at different operating modes of ESP well. Keywords: gas-liquid mixture (GLM); gas bubble; natural gas separation; solid particles; surfactants.