Lip Sinuses Research Articles

先天性下しんろうの１例

Congenital lower lip fistulas are considered to be relatively rare developmental anomalies. These fistulas are usually symmetrically situated on the vermilion portion of the lower lip as a well-marked, circular depression. Frequently, these lesions are associated with bilateral or unilateral cleft of the lip-jaw-palate.We have experienced a case (2.7-year-old boy) of bilateral congenital fistulas on the vermilion of the lower lip. There was associated with the left cleft of lip and upper jaw. In the treatment, surgical excision was performed.The clinical and histopathological findings of these lesions were reported and the literature was reviewed.

Congenital lip pits and facial clefts

Two families with congenital lower lip pits in association with cleft lip and palate, and isolated cleft palate are described. The presentation, mode of inheritance, aetiology, treatment and genetic significance are reviewed.

Lower lip sinuses: I. Epidemiology, microforms and transverse sulci

The numerous hypotheses advanced to explain the pathogenesis of lip sinuses have been reviewed by Warbrick et al. (1952) who suggested that the sinuses are remnants of the lateral sulci of the lower lip at the 6.5512.6mm embryonal stage (32-40 days). This theory is now generally accepted by such authorities as Gorlin et ul. (1976) and Wang and Macomber (1977). The sinuses usually appear together with or in families who present with various types of clefts. This distinct clinical syndrome is thought to be transmitted through an autosomal dominant gene with an estimated penetrance of 800,” and variable expressivity (Cervenka et al., 1967). Lip sinuses have also been described in the popliteal pterygium syndrome (Rintala and Lahti, 1970b) and occasionally with other malformations such as Hirschprung’s disease (Schwartz et aI., 1979). Over 500 cases have been reported in the literature and the incidence of the syndrome has been estimated as 1: 100,000 in the general white population (Cervenka et al., 1967) and as 0.9 (j,,, in patients who have cleft lip and/or cleft palate (Rintala and Lahti, 1970a). The typical sinuses are bilateral symmetrically placed openings on the upper border of the lower lip which extend as canals lined by labial mucosa and surrounded by mucous glands towards the labio-gingival sulcus for a varying distance of 1 to 25mm. The canals always end as blind sacs. Sometimes there may be only conical elevations and/or surface openings without any deeper sinuses at the typical sites. presumably representing microforms of the syndrome and very rarely unilateral or median sinuses may be encountered. Some of the latter are bipartite in their deeper parts (Rintala and Lahti, 1973) and in some it is difficult to decide whether they are truly median or paramedian. Their location may also vary in an anterio-posterior direction from the vermilion border to the mucosal side of the lip.

Congenital lip pits and Hirschsprung's disease

A newborn infant with aganglionosis of the entire colon and terminal ileum also had congenital lip pits and a submucous cleft palate. These anomalies may be added to the growing list of conditions associated with Hirschsprung's disease.

Congenital Lower Lip Fistula (Report of Six Cases)

SummarySix cases of the congenital lower lip fistula are described. Included in this is a brief summary of three cases all present in one family. The suggested factors in ctiology are mentioned.

A case of congenital lower lip fistula with lip and palate

A case of congenital lower lip fistula with lip and palate

Lateral congenital sinus of the upper lip

Most congenital lip sinuses are located in the lower lip and are often associated with other congenital anomalies, mainly cleft lip and palate. Sinuses of the upper lip are rare, and are usually found in the midline. It is therefore of interest to present a case of a lateral sinus of the upper lip.

On so-called median lowerlip sinuses. Case report.

In one case, the so-called median lower lip sinus appeared at operation to be in its deeper part bipartite— like a pair of trousers. In another case, the isolated sinus was slightly asymmetrical, but was not distinctly unilateral. There seem to be distinct transitional forms between median sinuses, which have proved impossible to account for on the basis of embryonic development, and lateral sinuses. Consequently, the anomaly in question seems to be one and the same as far as embryonic development is concerned.

Congenital lip sinuses: Hereditary aspects and their relationship to cleft lip and palate

Summary Congenital lip sinuses (labial fistulae, lip pits, mucous cysts) occur in the lower lip and are usually associated with cleft lip and palate. This paper reviews the literature, discusses the embryology and possible aetiological factors, and presents 13 cases of lip sinuses. Five of these cases had associated clefts of the lip and/or palate. Twelve of the cases occurred in three families. Pedigrees revealed other members of the families with clefts of the lip and/or palate without lip sinuses. One case had no associated anomalies and a negative family history.

Congenital lip sinuses.

A family has been traced through four generations with six members presenting with congenital lip sinuses. Five in this series were male and only one female. Two of the patients had associated clefts of the lip and palate. The literature on congenital lip sinuses is reviewed and the œtiological, clinical and histopathological features are discussed. The methods currently in use for their treatment are described.

Cleft lip, cleft palate, and congenital fistulas of the lower lip

Cleft lip, cleft palate, and congenital fistulas of the lower lip

Congenital sinuses of the lower lip

Nine cases of congenital lip sinuses in members of four unrelated families have been presented. In two families several members were involved, and in the remaining two families only a single member presented the malformation. Of the nine patients, four had clefts of the soft palate and one had a cleft uvula. No cleft lips were observed. Only one girl had two papillae and a cleft soft palate. One boy presented bilateral ankyloblepharon as well as adhesions between the alveolar processes of the maxilla and mandible, a papilla and sinus on the left side, and a cleft soft palate.