Linear Wind Research Articles

Numerical and Experimental Investigation of the Reynolds Number and Reduced Frequency Effects on Low-Pressure Turbine Airfoils

Abstract This article compares experimental and numerical data for a low-speed high-lift low pressure turbine (LPT) cascade under unsteady flow conditions. Three Reynolds numbers representative of LPTs have been tested, namely, 5 × 104, 105, and 2 × 105; at two reduced frequencies, fr = 0.5 and 1, also representative of LPTs. The experimental data were obtained at the low-speed linear cascade wind tunnel at the Polytechnic University of Madrid using hot wire, Laser Doppler Velocimetry (LDV), and pressure tappings. The numerical solver employs a sixth-order compact scheme based on the flux reconstruction method for spatial discretization and a fourth-order Runge–Kutta method to march in time. The longest case ran 550 h on 40 GPUs to reach a statistically periodic state. Pressure coefficients around the profile, boundary layer profiles and exit cross section distributions of velocity, pressure loss defect, shear Reynolds stress, and angle are compared against high-quality experimental data. Cascade loss and exit angle have also been compared against the experimental data. Very good agreement between experimental and numerical data is seen. The results demonstrate the suitability of the present methodology to predict the aerodynamic properties of unsteady flows around LPT linear cascades accurately.

Assessing seal carcasses potentially subjected to grey seal predation

In order to conduct an objective evaluation of potential ecological effects of grey seal predation on marine mammals, it is essential to establish a broad knowledge base helping in the thorough identification of such cases during post-mortem examination. The aim of this work is to report and discuss outcomes resulting from a retrospective evaluation of harbour (Phoca vitulina) and grey seal (Halichoerus grypus) stranding and necropsy data (n = 3274). In addition, the results are compared to a recent case of definite grey seal predation from Germany as well as reports from other countries. Carcasses potentially subjected to grey seal predation show severe lacerations with a circular pattern leaving a smooth, linear and cut-like wound margin. Large parts of skin and underlying tissue are detached from the body and loss of blubber is common. Occurrence frequencies of encountered lesions are presented and a list of parameters to be used for the assessment of similar cases as well as a complementary decision tree are suggested. With the proposed parameters, categories and tools, a baseline can be built in order to facilitate the standardised recognition of predation cases during post-mortem examinations of seals between groups working with populations across several geographic ranges.

Towards an intelligent linear winding process through sensor integration and machine learning techniques

Industry 4.0 is associated with numerous technologies, which offer great potential for optimizing linear winding processes as used in electric motor manufacturing. To further increase flexibility and quality in the production of mass products like coils, data-driven techniques such as machine learning (ML) are increasingly moving into focus. To generate the required data, however, linear winding machines must be equipped with suitable sensors. Accordingly, this paper will first present all known influencing and quality parameters in linear winding based on earlier research work. Based on this, suitable data sources and sensor systems are identified and a concept for applying ML techniques is derived.

Evaluation of the wound-healing effect of an N-isopropenylimidazole zinc metal complex derivative on a linear skin wound model in rats

Evaluation of the wound-healing effect of an N-isopropenylimidazole zinc metal complex derivative on a linear skin wound model in rats

Sus Scrofa immune tissues as a new source of bioactive substances for skin wound healing.

Influence of a new protein-peptide complex on promoting skin wound healing in male BALB/c mice was studied. Protein-peptide complex, extracted from Sus scrofa immune organs, was percutaneously administered using two methods: by lecithin gel-like liquid crystals and by liquid microemulsion. On the fifth day, wound closure in mice with a linear wound model become faster in group (less 2 days comparison to other ones), which was treated with lecithin liquid crystals carrying the protein-peptide complex. This promoting healing can be caused by resorption of bioactive high-molecular compounds the animal skin. In mice with the linear wound model, the tensile strength of the scars were respectively higher both in mice, treated using lecithin liquid crystals with protein-peptide complex, and in mice, treated using microemulsion containing protein-peptide complex, by 215.4% and 161.5% relative to the animals, which did not receive bioactive substances for wound treatment. It was associated with the regeneratory effects of tissue- and species-specific protein-peptide complexes, including α-thymosin Sus scrofa (C3VVV8_PIG, m/z 3802.8) and other factors, which were described as parts of the new extracted complex. This reveals that percutaneous administration of the complex reliably activates local regenerative processes in animals.

Influence of plastic surgery for melanoma on progression-free survival in patients with skin melanoma according to the degree of tumor lymphoid infiltration

The aim of the study was to analyze the effect of plastic methods for closing the defect after excision of primary skin melanoma according to the degree of lymphoid infiltration of the tumor.
 Material and methods. Patients with primary skin melanoma (SM) treated in 2013 (n = 337) were studied; these patients were randomized into 2 groups using the method of blind selection to the main (n = 182). In these groups, the tumor removal operation in patients ended with plastic tissue defect and the group comparisons (n = 155) (after removal of the tumor, simple linear wound closure was performed).
 Results. It was found that pronounced lymphoid tumor infiltration in patients with primary skin melanoma as a predictor of a favorable prognosis (in terms of the occurrence of locoregional recurrence) is realized in patients with plastic defect replacement significantly 2 times more often than in patients without plastic surgery in the period from 12 to 60 months of observation.
 Discussion. The dependence of the occurrence of locoregional relapses in patients on lymphoid infiltration of the tumor and the performance of plastic surgery was revealed. In general, all patients who underwent plastic surgery have an advantage in terms of the occurrence of locoregional relapses in the long term for a period of up to 5 years by 12.5%. In patients with severe lymphoid infiltration and plastic surgery, locoregional relapses occur almost 2 times less often than in patients without plastic surgery, starting from a follow-up period of 1236 months by 20.6% (22.9% and 43.5%, respectively; p = 0.008), and in the period from 36 to 60 months of observation by 24.7% (25.3% and 50.0%, respectively; p = 0.002).
 Conclusion. The use of plastic techniques for closing a wound defect in patients with skin melanoma with pronounced lymphoid tumor infiltration reduces the risk of gross scarring and halves the risk of locoregional metastasis as compared to linear suturing of the postoperative defect.

Results of the surgical treatment of primary skin melanoma depending on the method of tumor excision and options for closing the surgical defect

The aim of the study was to analyze the results of the surgical treatment of patients with primary skin melanoma (SM) according to the location of the primary tumor, the type of incision, and the method of suturing the postoperative defect.
 Material and methods. Patients with primary SM, treated in 2013 (n = 337) were studied; these patients were randomized into two groups using the method of blind selection to the main (n = 182) comparisons (n = 155) (after removal of the tumor, simple linear wound closure was performed).
 Results. In patients with localized forms of SM, it was found necessary to perform a round incision when the tumor is localized on the trunk and an elliptical incision when localized on the extremities, followed by plastic replacement in all cases. In stage III patients with any tumor localization, the type of incision and suturing of the defect was not of fundamental importance.
 Discussion. It was revealed that patients with tumor on the trunk after rounded incision and plastic surgery had an advantage in progression-free survival (PFS) at all stages before an elliptical incision without plastic surgery during the entire observation period (123660 months) by 18.8%23%, 8%26.5% (p ˂ 0.050). Patients with localized forms of melanoma from stage 0 to IIc over the entire follow-up period of 123660 months had the greatest benefit in PFS from a round incision with plastic before conventional suturing without plastic surgery: from stage 0 to IIa by 22.0%31.8%32.0%, from stage IIb to IIc by 35.6%28.5%34.8%. In overall survival (OS), only patients with a rounded incision and plastic surgery in the initial stages of the disease stage 0 to IIa up to 36 and 60 months benefited by 24.4% and 29.3%, respectively. Compared with patients who underwent simple excision on the trunk, patients with stage IIbIIc with elliptical incisions and plasty had an advantage in PFS in the long term up to 3660 months of follow-up by 25.7% and in IDS with stages 0-IIa in the period 1236 months by 24.4%.
 With the localization of the primary tumor on the extremities, a statistical difference was revealed with the best indicators in patients with an elliptical incision and plastic surgery in the OS compared to patients with a rounded incision and plastic surgery in the period of 3660 months by 18.6% and 26.7%, respectively, as well as over patients with a conventional incision without plastic surgery in PFS as a whole in the subgroup at periods up to 36 and 60 months by 26.4% and 29.4% with a tendency to improve this indicator in the long term, as well as better SOS in the long term in these patients with a difference in OS of 19.3% (3660 months of observation).
 Conclusion. In patients with localized stages (0IIc), with the localization of the primary SM on the trunk, it is necessary to perform a round excision followed by plasty of the defect with displaced tissues; in addition, it is advisable to have an elliptical incision along the axial line for the limbs, followed by plasty of the defect. In patients with stage III, the shape of the incision and the method of suturing do not play a significant role in PFS and OS.

Mechanical Calculation of Flexible Wires in the Presence of Horizontal Concentrated Loads

The linear wind load on the wires and cables acting perpendicular to the wire depends on the angle between the direction of the wind and the axis of the overhead line. In the methodology of mechanical calculation of wires and cables, it is recommended to take the wind directed at an angle of 90° to the axis of span and it is not specified which side the wind blows from. For spans of air, this is not so much significant as for switchgear spans, where the deviations of the wires depend on the direction of action of the taps to the electrical apparatus. The article discusses various options for the location of taps and their effect on the wire, as well as changing the direction of the wind. An algorithm for calculating the horizontal deviation of a flexible wire and its increase coefficients in the presence of horizontal concentrated loads due to the action of windon spacers, barriers, taps to electrical apparatuses and other structural elements of substations and overhead lines is given. In the absence of wind, horizontal concentrated loads and deviations occur when an arrangement of the taps is non-keel. The formulas for calculating the horizontal component of the load coefficient to solve the equation of state in the presence of horizontal concentrated forces acting in any direction have been derived. The results of the mechanical calculation are obtained for the cases of one and two horizontal concentrated forces, differently oriented with respect to the distributed wind load. In design practice it is recommended to take the wind flow in the direction of the action of horizontal concentrated forces, since in this case the greatest horizontal deviations and load factors are obtained. The reduction in the coefficients of the horizontal load occurs when the current lead is unloaded because of the opposite directions of the wind and horizontal concentrated forces. In the absence of wind, it is proposed to use the formulas for calculating horizontal deviations and load after finding the product of the coefficient of increase in horizontal deviations and the horizontal component of the coefficient of load per linear load.

Evaluation of the lattice Boltzmann method for wind modelling in complex terrain

Abstract. The worldwide expansion of wind energy is making the choice of potential wind farm locations more and more difficult. This results in an increased number of wind farms being located in complex terrain, which is characterised by flow separation, turbulence and high shear. Accurate modelling of these flow features is key for wind resource assessment in the planning phase, as the exact positioning of the wind turbines has a large effect on their energy production and lifetime. Wind modelling for wind resource assessments is usually carried out with the linear model Wind Atlas Analysis and Application Program (WAsP), unless the terrain is complex, in which case Reynolds-averaged Navier–Stokes (RANS) solvers such as WindSim and Ansys Fluent are usually applied. Recent research has shown the potential advantages of large-eddy simulation (LES) for modelling the atmospheric boundary layer and thermal effects; however, LES is far too computationally expensive to be applied outside the research environment. Another promising approach is the lattice Boltzmann method (LBM), a computational fluid technique based on the Boltzmann transport equation. It is generally used to study complex phenomena such as turbulence, because it describes motion at the mesoscopic level in contrast to the macroscopic level of conventional computational fluid dynamics (CFD) approaches, which solve the Navier–Stokes (N–S) equations. Other advantages of the LBM include its efficiency; near-ideal scalability on high-performance computers (HPCs); and ability to easily automate the geometry, the mesh generation and the post-processing. However, the LBM has been applied very little to wind modelling in complex terrain for wind energy applications, mainly due to the lack of availability of easy-to-use tools as well as the lack of experience with this technique. In this paper, the capabilities of the LBM to model wind flow around complex terrain are investigated using the Palabos framework and data from a measurement campaign from the Bolund Hill experiment in Denmark. Detached-eddy simulation (DES) and LES in Ansys Fluent are used as a numerical comparison. The results show that there is in general a good agreement between simulation and experimental data, and the LBM performs better than RANS and DES. Some deviations can be observed near the ground, close to the top of the cliff and on the lee side of the hill. The computational costs of the three techniques are compared, and it has been shown that the LBM can perform up to 5 times faster than DES, even though the set-up was not optimised in this initial study. It can be summarised that the LBM has a very high potential for modelling wind flow over complex terrain accurately and at relatively low costs, compared to solving N–S equations conventionally. Further studies on other sites are ongoing.

Design and Analysis of a New Permanent Magnet Claw Pole Machine With S-Shape Winding

With the continuous improvement of magnetic and mechanical properties of soft magnetic composite (SMC) material, there is a trend to develop novel electrical machines with SMC cores for some special applications. Among these electrical machines, permanent magnet claw pole machine (CPM) has been extensively studied over the past few decades. As linear global winding has been used in this machine, it can be regarded as a linear winding CPM (LWCPM). To improve the performance of LWCPM, a new S-shape winding CPM (SWCPM) is proposed in this article. The main stator structures of the LWCPM and SWCPM are optimized to achieve maximum torque ability. Compared with LWCPM, SWCPM provides higher average torque, power factor, and higher efficiency. The main disadvantage of the proposed SWCPM is its lower flux weakening ability. 3-D finite element model is used to evaluate the performance of the proposed LWCPM and SWCPM. The accuracy of the 3-D finite element model is verified by using a previous prototype.

Experimental Analysis of Multiscale Vortex Shedding in Turbulent Turbomachine Blade Wakes

Wakes behind turbomachine blades are generally highly turbulent and seemingly chaotic. Within the apparent chaos, coherent structures of various strength and length scales are present that are challenging to identify within individual snapshots of the wake flowfield. We propose a strategy to identify and separate multiscale vortices in the turbulent wake of a turbomachine blade from experimental data. Uncorrelated velocity field snapshots were obtained in the wake of a compressor blade in a linear cascade wind tunnel at Reynolds using particle image velocimetry. The snapshots were analyzed using proper orthogonal decomposition to identify the most energetic mode pairs representing vortex shedding patterns of different length scales with their own shedding frequency. The phase angles associated with the individual shedding patterns are extracted for each snapshot based on the time coefficients of the mode pairs. By averaging snapshots with the same phase angle for selected mode pairs, we were able to calculate mode- or scale-dependent phase average flowfields. These scale-dependent phase averages visually highlight the multiscale vortex character of the turbulent wake and allow for a quantitative analysis of the size, emerging location, and shedding frequency of the different structures.

Surface Curvature Effects on Film Cooling Performance for Shaped Holes on a Model Turbine Blade

Abstract Surface curvature has been shown to have significant effects on the film cooling performance of round holes, but the literature include few studies of its effects on shaped holes despite their prevalence in gas turbines. Experiments were performed using two rows of holes placed on the suction side of a scaled-up turbine blade in a low Mach number linear cascade wind tunnel with low freestream turbulence. The rows were placed in regions of high and low convex surface curvature. Geometries and flow conditions for the rows were matched to those from previous flat plate studies. Comparison of the adiabatic effectiveness results from the high curvature and flat plate rows revealed the same trends as those in the literature using round holes, with increased performance for the high curvature row at lower blowing ratios and the opposite at higher ones. The low curvature row had similar performance to the flat plate row at lower blowing ratios, suggesting the mild convex curvature had little beneficial effect. At higher blowing ratios, the low curvature row had inferior performance, which was attributed to the local freestream adverse pressure gradient that generated additional turbulence, promoting jet-to-mainstream mixing and decreasing performance.

Wound healing effect benzosulfonate 1-ethyl-3-methyl-4,5-bis(n-methylcarbamoyl) imidazolium

Materials and methods. In experiments on 180 male rats weighing 180200 g, the wound-healing effect of derivatives of imidazole (IEM-1181) was evaluated as a 10% ointment on models of aseptic full-layer linear and planar skin wounds.
 Results. It was found that the compound IEM-1181 in the form of 10% ointment has a pronounced on skin wound healing effect, manifested in the qualitative features of the regenerative healing process. With local application of the ointment containing the tested compound, the strength of the tissue formed on the site of a full-layer linear skin wound was increased when its edges were stretched, and the healing time of full-layer planar wounds was reduced. The morphological picture of the tissue formed at the site of the wound defect corresponded to complete healing by primary tension with complete epithelization of the surface and squamous cell differentiation of the epithelial regenerate without signs of inflammation and scar formation.
 Conclusion. The results of the study on experimental models of full-layer linear and planar skin wounds indicate that the wound healing effect of the tested ointment is due to the anti-inflammatory activity of the IEM-1181 compound

Affine Quadratic Optimal Control and Aerospace Applications

This article proposes a class of mathematical models of aerospace control systems. The article has three main contributions. The first contribution is to present analytical solutions of optimal control problems with affine dynamics and quadratc cost with both cross terms and a tradeoff coefficient that weights time. A second contribution is to solve analytically a class of nonlinear optimal control problems with a single input and a conserved quantity. The analytical solution is obtained through a transformation of variables that leads to an equivalent affine quadratic problem. On a practical level, this article contributes by showing how the proposed class of problems can unify a class of applications in aeronautics and astronautics. The relevance of the proposed methodology is illustrated in examples of trajectory planning with linear drag and wind, as well as orbit intercept.

Skin tapes and tissue adhesive vs. either method alone for laceration repair in a porcine model.

To determine whether the combination of skin tapes and tissue adhesive is superior to either method alone for laceration repair. This was a prospective, longitudinal experiment on six anesthetized swine. Thirty-six full-thickness linear wounds were created using a metal template, then closed using one of three methods: skin tapes over benzoin, tissue adhesive, or a combination of both. The study was done in two parts. Group 1 (immediate excision) animals were euthanized at day zero for skin excision and tensile strength testing following wound repair. Group 2 (delayed excision) had initial wound repair; animals were euthanized at day 35 for skin excision and tensile strength testing. In Group 1, the combination of skin tapes and tissue adhesive provided the strongest immediate wound closure. Average mean force for disruption immediately after wound repair was 19.9 lbs. for the tapes and tissue adhesive group compared to 9.6 lbs. for adhesive alone and 8.9 lbs. for tapes alone. The difference in mean force for combination repair vs. tapes alone was 10.3 lbs. (95% CI 4.1, 16.7), and combination vs. adhesive alone was 10.9 lbs. (95% CI 4.7, 17.3). In Group 2, the mean force required for laceration disruption for those repaired with both tape and tissue adhesive was 188.9 lbs. The mean force until wound disruption for tape only was 165.6 lbs., and the mean force until wound disruption for tissue adhesive alone was 118.9 lbs. The difference in mean force required for wound disruption for those repaired with adhesive alone vs. combination repair is 66.5 lbs. (95% CI 21.2, 111.9). The difference in mean force required for wound disruption between the other two groups was not statistically significant. This study demonstrates that the combination of skin tapes and tissue adhesive provides superior immediate wound closure strength to either of these methods alone in a porcine model.

Recapitulation of normal collagen architecture in embryonic wounded corneas

Wound healing is characterized by cell and extracellular matrix changes mediating cell migration, fibrosis, remodeling and regeneration. We previously demonstrated that chick fetal wound healing shows a regenerative phenotype regarding the cellular and molecular organization of the cornea. However, the chick corneal stromal structure is remarkably complex in the collagen fiber/lamellar organization, involving branching and anastomosing of collagen bundles. It is unknown whether the chick fetal wound healing is capable of recapitulating this developmentally regulated organization pattern. The purpose of this study was to examine the three-dimensional collagen architecture of wounded embryonic corneas, whilst identifying temporal and spatial changes in collagen organization during wound healing. Linear corneal wounds that traversed the epithelial layer, Bowman´s layer, and anterior stroma were generated in chick corneas on embryonic day 7. Irregular thin collagen fibers are present in the wounded cornea during the early phases of wound healing. As wound healing progresses, the collagen organization dramatically changes, acquiring an orthogonal arrangement. Fourier transform analysis affirmed this observation and revealed that adjacent collagen lamellae display an angular displacement progressing from the epithelium layer towards the endothelium. These data indicate that the collagen organization of the wounded embryonic cornea recapitulate the native macrostructure.

Study on urban thermal environmental factors in a water network area based on CFD simulation

Abstract Cities on the Jianghan plain with a dense water network have a hot and humid climate and a long period of calm wind in the summer. Urban design guidance of a water network with a thermal environment as the starting point is a design control path that takes into account geographical features, climatic conditions and urban construction under complex constraints. Based on the current block division and development intensity, this study of the thermal environment of Xiantao adopts the methods of multiple linear regression and wind–thermal environment simulation. The results show that regional agglomeration shows the spatial distribution of the urban thermal environment in the water network area. The distribution of hot sensitive areas is closely related to the pattern of clusters. The business district, high-density urban area, basic energy facility area and transportation hub are the thermal environment areas. The experimental results show that residential and industrial land, proportion of water area, average elevation and urban development intensity are the main factors influencing the thermal environment of the water network, and the strengths of their effects are in the order of development intensity > water area proportion > industrial land proportion > residential land proportion > average elevation. The urban thermal environment of the dynamic construction area can be inferred. The improvement of urban wind and thermal environment quality is implemented in the urban space level by guiding the construction intensity, ventilation, greening and water, and paving and shading of the thermal environment control area. The exploration of the thermal environment improvement method in the urban design of a water network region provides the guidance for similar cities seeking to cope with climate change.

Efficacy of topical application of coumarin on incisional wound healing in BALB/c mice

Background: Wound healing is one of the main problems faced by medical scientists. Nowadays, herbal compounds are used to accelerate the repairing process. Coumarin is a plant compound with anti-inflammatory and anti-oxidant effects. In the present study, the benefits of using coumarin in accelerating wound healing were investigated in mice.Methods: Sixty male BALB/c mice were used. After making a linear wound on the dorsum of the animals, they were randomly divided into five equal groups: the first and second groups received topical cream of coumarin at concentrations of 1% and 2%; the third and fourth groups received nitrofurazone cream (positive control) and eucerin cream (negative control), respectively. The fifth group as the sham group was not treated. Then on days 4, 7, 10, and 14 of experiment, biopsies were performed on three mice from each group. Histological examination was performedusing hematoxylin and eosin and Masson trichrome staining. Data were analyzed by ANOVA and Tukey tests.Results: Inflammation significantly decreased in both experimental groups at days 4, 7, and 10, compared to the control groups. In the proliferation phase, fibroblast cells, granulation tissue formation, and epithelialization were significantly higher in both experimental groups than the control groups. In addition, collagen synthesis significantly increased in the experimental groups compared to the control groups.Conclusion: Topical application of coumarin had beneficial effects on different phases of wound healing in the skin of BALB/c mice.

The study of pharmacological activity of shampoo for seborea treatment

Over the years, the issues of clinical course and seborrheic dermatitis treatment in children and adults are actual. This is evidenced by numerous publications of domestic and foreign scientists. Seborrheic dermatitis occurs in 20-25 % of the population aged 16 to 35 years, the disease is more common in men than in women, which is associated with androgenic stimulation of the sebaceous glands. The cause of seborrheic dermatitis is the fungus Malassezia , and factors that contribute to the development of this disease are: endocrine pathology, neurological diseases, immunodeficiency, genetic predisposition, hyperhidrosis, vitamin deficiency, the effects of alkaline detergents on the skin and other. The correction of seborrheic dermatitis of the scalp is a complex process that must be comprehensive: to eliminate not only the symptoms, but also to effect on the causes of the disease. In the pharmaceutical market ofUkraine, the number of combined drugs used for the treatment and prevention of seborrheic dermatitis is quite limited. Because of that it is important to develop a new drug in the form of shampoo for the prevention and treatment of this hair disease. Aim. To study the toxicological characteristics and pharmacological activity of a new drug in the form of shampoo. Materials and methods. One of the most important requirements for drugs is their health safety. The study of toxicological properties of the new drug for the prevention and treatment of seborrheic dermatitis has been carried out according to the guidelines of the State Pharmacological Center of Ukraine. The study included the identification of possible toxic effects with a single injection, as well as application in the form of skin applications and «conjunctival test». The study of pharmacological activity included the research of antialterative effect on a model of linear wounds, as well as reparative effect on a model of a linear cut wound in rats. Results. The results of the study indicated the absence of toxic effects of the new drug under acute experimental conditions on two types of laboratory animals with two ways of administration. According to the classification of K. K. Sidorov, the studied agent belongs to the IV class of toxicity – low-toxic substances (LD > 2810 mg/kg). It has been found that this drug has no local irritant effect on contact with the skin and mucous membranes of the eye. During the study of antialterative activity of a new drug in the form of shampoo, it has been found that the expressive activity showed a sample with the following components: octopyrox – 0.5 %; α-lipoic acid – 0.5 %; urea – 5.0 % and the rate of wound healing on the 15th day of the experiment was not inferior to the reference drug «PhysiObebe Mustela Bebe». It has been confirmed that in the model of a linear cut wound in rats, the new drug in the form of shampoo shows a pronounced reparative activity and exceeds the same indicator of the comparison drug «PhysiObebe Mustela Bebe». Conclusions. The results of the study indicated the absence of toxic effects of the new drug (according to the classification of K. K. Sidorov belongs to the IV class of toxicity – low-toxic substances), as well as local irritation in the applied to the skin and mucous membranes of the eye. The new drug in the form of shampoo under the conditions of model pathology showed pronounced antialterative and reparative activity.

Effect of piridoxin on the skin reparation process under experimental insulin resistance

Topicality. According to WHO experts estimation, the worldwide prevalence of diabetes mellitus is pandemic, with more than 80 % of patients dying from the fatal effects of diabetic angiopathy. One of the most common complications of diabetes of both types is the formation of chronic wound defects, and eventually gangrene of the lower limbs with the transformation into sepsis, which cases to 3.2 % of deaths against the background of diabetes.Aim. To study the effect of combined medicine magnesium and pyridoxine on the course of the reparative skin process in rats with experimental insulin resistance.Materials and methods. The study has been carried out in 60 rats males weighing 180-220 g. Experimental insulin resistance in rats was induced under conditions of the hypercaloric diet and intraperitoneal administration of dexamethasone. Studies of the process of skin repair have been performed on models of full-layer stencil and linear cut wounds, as well as determination of carbohydrate metabolism markers and glycosylation products in serum and hemolysate.Results and discussion. The use of pyridoxine in combination with a reparant (retinol acetate) resulted in a significant reduction in wound area as early as 5 day of treatment and effectively reduced the total time of complete epithelialization; and also increased the load under tensiometry, which corresponded to 72.8 % of the reparative activity of this therapeutic scheme. Against the background of the pyridoxine the content of fructosamine and glycosylated hemoglobin also has been significantly reduced, which confirms the antiglycosylative properties of vitamin.Conclusions. Pyridoxine is able to potentiate the wound healing effect of reparants under the insulin resistance due to its antiglycosylation properties. The results of this study allow us to recommend further research of pyridoxine in combination with standard skin repairs in the treatment of wounds in patients with hyperglycemia and diabetes mellitus.