We show that computing the crossing number and the odd crossing number of a graph with a given rotation system is NP-complete. As a consequence we can show that many of the well-known crossing number notions are NP-complete even if restricted to cubic graphs (with or without rotation system). In particular, we can show that Tutte’s independent odd crossing number is NP-complete, and we obtain a new and simpler proof of Hliněný’s result that computing the crossing number of a cubic graph is NP-complete. We also consider the special case of multigraphs with rotation systems on a fixed number k of vertices. For k=1 we give an O(mlog m) algorithm, where m is the number of edges, and for loopless multigraphs on 2 vertices we present a linear time 2-approximation algorithm. In both cases there are interesting connections to edit-distance problems on (cyclic) strings. For larger k we show how to approximate the crossing number to within a factor of ${k+4\choose4}/5$ in time O(m k log m) on a graph with m edges.