The multi-input multi-output (MIMO) technique is becoming grown and integrated into wireless wideband communication. MIMO techniques suffer from a large-scale linear dynamic problem, it will be easy to adjust the proportional-integral-derivative (PID) of a continuous system, unlike the nonlinear model. This work displays the tuning of the PID controller for MIMO systems utilizing a statistical grey wolf optimization (GWO) and evaluated by objective function as integral time absolute error (ITAE). The instantaneous adjusting characteristic GWO approach is the criterion that distinguishes such a combination-proposed strategy from that existing in the traditional PID approach. The GWO algorithm searching-based methodology is used to determine the adequate gain factors of the PID controller. The suggested approach guarantees stability as the initial scheme for a steady state condition. A combination of ITAE combined with the GWO reduction method is adopted to reduce the steady-state transient time responses between the higher-order initial scheme and the unit amplitude response. Simulation outcomes are illustrated using MATLAB software to show the capability of adopting the GWO scheme for PID controlling.