where P and Q(t) are linear self-adjoint operators, and A(t, u) and F (t, u) are typically a divergence operator in u and a nonlinear driving force. Other versions of (1.1) were considered earlier by Levine [3–6], for which he introduced the important technique of “concavity” analysis of auxiliary second order differential inequalities. In all these papers the principal mechanism of blow–up was the assumption of negative initial energy. In an interesting paper [10], which has just appeared, Ono has also used concavity analysis to study blow–up, but in the more general case when the initial energy is allowed to take appropriately small positive values. His analysis primarily considers linear wave operators, and moreover is restricted to bounded domains in R. (It should, however, be added that Ono also allows Kirchhoff type operators, an added generalization but without serious affect on the principal ideas.) Here we discuss some extentions of Ono’s analysis to the abstract equation (1.1), see Theorem 1. Moreover, in concrete cases, we introduce appropriate methods to treat divergence structure operators in unbounded domains (including but not necessarily restricted to R). Our conclusions also yield a larger class of initial data than in [10] for which blow-up must occur; see Remark 1 in Section 3. In the next section we give a precise meaning to equation (1.1), and give our main abstract theorem. Section 3 discusses a divergence structure equation in R for which blow–up occurs for positive initial energy, even for unbounded domains. Here the primary new idea, in comparison with [7] and [10], is to introduce an appropriate coercive operator associated with the equation. Proofs of the results described here will appear in the forthcoming paper [13].