AbstractAmidst labor shortages, increasing land prices, and other aspects of the post‐pandemic world, our logistics chain must consider new technological alternatives. Automated material handling equipment often requires valuable floor space and specialized layouts. Uncrewed aerial vehicles, popularly called drones, offer a flexible and cost‐effective alternative. To explore the potential benefits and challenges of such systems, we used a version of the multi‐trip vehicle routing problem with time windows to model two realistic manufacturing environments as use cases. We provide the mixed integer linear programming formulation of this problem and compare results with those of a human‐only based system in a detailed simulated environment. Furthermore, as a physical proof‐of‐concept, we outfitted a commercially available drone with pick‐up and carry capabilities. We found that, even with limited drone carrying capacity, there are economic benefits realized from time savings, compared to ground‐based material handling systems. Besides these time savings, drones are sustainable as they operate on battery power and do not impair the air quality or the traffic experienced on the ground.
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