Homogeneous isotropic turbulence (HIT) has been a useful theoretical concept for more than fifty years of theory, modelling, and calculations. Some exact results are revisited in incompressible HIT, with special emphasis on the 4/5 Kolmogorov law. The finite Reynolds number effect (FRN), which yields corrections to that law, is investigated, using both Kármán–Howarth-type equations and a statistical spectral closure of the Eddy-Damped Quasi-Normal Markovian (EDQNM)-type. This discussion offers an opportunity to give an extended review of such spectral closures, from weak turbulence, as in wave turbulence theory, to a strong one. Extensions of the 4/5 or 4/3 Kolmogorov/Monin laws to anisotropic cases, such as stably stratified and MHD turbulence, are briefly touched on. Before addressing more recent work on compressible isotropic turbulence, the simplest case of quasi-incompressible turbulence subjected to externally imposed isotropic compression or dilatation is presented. Rapid distortion theory is found to be a poor model in this isotropic case, in contrast with its relevance in strongly anisotropic flow cases. Accordingly, a fully nonlinear approach based on a rescaling of all fluctuating variables is used, in order to show its interplay with the linear operator. This opens the discussion on the cases of homogeneous incompressible turbulence, where RDT and nonlinear models are relevant, provided that anisotropy is accounted for. Finally, isotropic compressible flows of increasing complexity are considered. Recent studies using weak turbulence theory, modelling, and DNS are discussed. A final unpublished study involves interactions between the solenoidal mode, inherited from incompressible turbulence, and the acoustic and entropic modes, which are specific to the compressible problem. An approach to acoustic wave turbulence, with resonant triads, is revisited on this occasion.