Light-intensity Activity Research Articles

Update and Novel Validation of a Pregnancy Physical Activity Questionnaire.

The aim of this study was to update and validate the Pregnancy Physical Activity Questionnaire (PPAQ), using novel and innovative accelerometer and wearable camera measures in a free-living setting, to improve the measurement performance of this method for self-reporting physical activity. A prospective cohort of 50 eligible pregnant women were enrolled in early pregnancy (mean= 14.9 weeks' gestation). In early, middle, and late pregnancy, participants completed the updated PPAQ and, for 7 days, wore an accelerometer (GT3X-BT; ActiGraph, Pensacola, Florida) on the nondominant wrist and a wearable camera (Autographer; OMG Life (defunct)). At the end of the 7-day period, participants repeated the PPAQ. Spearman correlations between the PPAQ and accelerometer data ranged from 0.37 to 0.44 for total activity, 0.17 to 0.53 for moderate- to vigorous-intensity activity, 0.19 to 0.42 for light-intensity activity, and 0.23 to 0.45 for sedentary behavior. Spearman correlations between the PPAQ and wearable camera data ranged from 0.52 to 0.70 for sports/exercise and from 0.26 to 0.30 for transportation activity. Reproducibility scores ranged from 0.70 to 0.92 for moderate- to vigorous-intensity activity and from 0.79 to 0.91 for sports/exercise, and were comparable across other domains of physical activity. The PPAQ is a reliable instrument and a valid measure of a broad range of physical activities during pregnancy.

Factors impacting the anticipated pleasure of potential physical activity experiences: a conjoint investigation across involvement segments

ABSTRACT The anticipated pleasure of participating in physical activity (PA) is one factor that may increase the likelihood of engagement and may be particularly important for long-term engagement. However, the impact of PA characteristics (e.g., intensity, location) on anticipated pleasure of PA remain unclear. This study used a conjoint analytic approach to evaluate the impact of activity intensity, physical context, and social context on the anticipated pleasure of engaging in PA across involvement segments. In conjoint analysis, participants provide overall ratings of hypothetical options (called profiles) described using levels of the selected study factors. Eight-hundred seventy-one participants (mean 48.3, SD 16.5 years, 66.9% female) evaluated 18 PA profiles that varied based on activity intensity, physical context, and social context. Three PA involvement segments were identified (low, moderate, high). Physical context was most impactful for highly and moderately involved participants; activity intensity had the highest impact for the least involved. Light intensity, outdoor PA performed alone or with family/friends was anticipated to be most pleasant for most participants. Vigorous intensity PA, PA performed at a fitness facility, and PA performed as part of a group elicited anticipated displeasure for those with low involvement. Physical context was most important for most people. Activity intensity was most impactful for frequent targets of PA intervention. PA promotion efforts should focus on light intensity activity, performed outdoors either alone or with family or friends to maximise anticipated pleasure for those least active. Conjoint analysis and audience segmentation show promise for future pleasure-related PA research.

Physical activities patterns among Indonesian pregnant women: a cross-sectional study

Many evidence revealed that physical activity (PA) has positive effects on pregnancy outcomes. Healthy pregnant women are suggested to have a combination of PA in light to moderate-intensity activities for 150 minutes per week. The purpose of this study was to analyze the type, the intensity of PA of pregnant women, and the average energy expenditure per week. A cross-sectional study involving 110 pregnant women who came from four community health centers in Bandung city, Indonesia was carried out from April to June 2021. The pregnancy physical activity questionnaire (PPAQ) was used to collect data. Descriptive data were presented using median and percentile. Mann-Whitney and Kruskal Wallis test were used to statistical test. The results of the study where the median energy expenditure per week was 250.50 METs. Most of the PA was light-intensity activities and household/child caring activities. There were still 10% pregnant women who did not exercise. Employed pregnant women had energy expenditure per week higher compared to unemployed pregnant women. Sports/exercise activities were seldom been carried out. This study demonstrated that during pandemic COVID-19, pregnant women are still doing PA. During pandemic COVID-19, health care providers should motivate healthy pregnant women to exercise by creating innovations using social media or online platforms so that pregnant women can exercise at home safely.

Lifestyle physical activity and rapid-rate non-sustained ventricular tachycardia in arrhythmogenic cardiomyopathy

ObjectiveTo investigate the association of accelerometer-measured lifestyle physical activity with rapid-rate non-sustained ventricular tachycardias (RR-NSVTs) in patients with arrhythmogenic cardiomyopathy (AC).MethodsThis multicentre, observational study enrolled 72 patients with AC, including...

Increased Prolonged Sitting in Patients with Rheumatoid Arthritis during the COVID-19 Pandemic: A Within-Subjects, Accelerometer-Based Study

Social distancing measures designed to contain the COVID-19 pandemic can restrict physical activity, a particular concern for high-risk patient groups. We assessed rheumatoid arthritis patients' physical activity and sedentary behavior level, pain, fatigue, and health-related quality of life prior to and during the social distancing measures implemented in Sao Paulo, Brazil. Post-menopausal females diagnosed with rheumatoid arthritis were assessed before (from March 2018 to March 2020) and during (from 24 May to 7 July 2020) social distancing measures to contain COVID-19 pandemic, using a within-subjects, repeated-measure design. Physical activity and sedentary behavior were assessed using accelerometry (ActivPAL micro). Pain, fatigue, and health-related quality of life were assessed by questionnaires. Mean age was 60.9 years and BMI was 29.5 Kg/m2. Disease activity ranged from remission to moderate activity. During social distancing, there were reductions in light-intensity activity (13.0% [-0.2 h/day, 95% CI: -0.4 to -0.04; p = 0.016]) and moderate-to-vigorous physical activity (38.8% [-4.5 min/day, 95% CI: -8.1 to -0.9; p = 0.015]), but not in standing time and sedentary time. However, time spent in prolonged bouts of sitting ≥30 min increased by 34% (1.0 h/day, 95% CI: 0.3 to 1.7; p = 0.006) and ≥60 min increased by 85% (1.0 h/day, 95% CI: 0.5 to 1.6). There were no changes in pain, fatigue, and health-related quality of life (all p > 0.050). Imposed social distancing measures to contain the COVID-19 outbreak were associated with decreased physical activity and increased prolonged sedentary behavior, but did not change clinical symptoms sitting among patients with rheumatoid arthritis.

Physical Activity and Health-related Quality of Life from Diagnosis to One Year After Radical Cystectomy in Patients with Bladder Cancer: A Longitudinal Cohort Study.

Emerging evidence shows a positive impact of physical activity (PA) on health-related quality of life (HRQoL) in cancer patients. However, longitudinal evidence on PA and HRQoL in patients with bladder cancer (BC) undergoing radical cystectomy (RC) is lacking. To investigate PA levels, HRQoL outcomes and their relationship from diagnosis to one year after RC in BC patients. A longitudinal cohort study in 90 BC patients was conducted at Ghent and Leuven University Hospitals between April 2017 and December 2020. The Godin Leisure-Time Exercise Questionnaire (GLTEQ) and the EORTC QLQ-C30 and BLM30 were used to measure PA and HRQoL, respectively, before RC, one, three, six and twelve months after RC. Linear mixed models were used for statistical analyses. The majority was physically inactive before RC (58%), at month one (79%), three (53%), six (61%) and twelve (64%). Among (moderately) active patients, light-intensity activities (mainly walking) were important contributors to the total amount of PA. Clinically important and low HRQoL outcomes in different domains were identified with lowest scores at diagnosis and one month after RC. Active patients before RC have better physical functioning (mean difference (MD) -22.7, standard error (SE) 8.7, p = 0.011), global health status (MD -15.9, SE 6.9, p = 0.023) and fatigue (MD 19.9, SE 9.5, p = 0.038) one month after RC, compared to inactive patients. Active patients at month have better physical functioning (MD -16.2, SE 6.9, p = 0.023) and sexual functioning (MD -16.8, SE 5.4, p = 0.003; MD -13.5, SE 5.5, p = 0.017) at month six and twelve, respectively, compared to inactive patients. Higher PA levels are associated with better HRQoL outcomes for BC patients undergoing RC. The data suggests that PA interventions could be an asset to improve BC patients' HRQoL, but should be tested in future trials.

Association between physical activity and mortality in the Japanese general population with mild to moderate impaired renal function: the Jichi Medical School (JMS) cohort study.

The association between physical activity volume or intensity and mortality in general population with impaired renal function is unclear. We assessed these relationships among Japanese residents with impaired renal function. We analyzed 638 individuals with estimated creatinine clearance below 60ml/min in the Jichi Medical School cohort study. Exposures included the daily amount of physical activity converted to the physical activity index (PAI) used in the Framingham study and the activity time for each intensity. Physical activity intensity was classified into sedentary and nonsedentary. Nonsedentary activity was further divided into light-intensity and moderate-to-vigorous physical activity (MVPA). The outcome was all-cause mortality. Quartiles of the exposures were created, and hazard ratios (HRs) were calculated using the Cox proportional hazards model. The mean age of the subjects was 63.3years, and 72.4% were female. In total, 172 deaths were registered during 11,567 person-years. No significant association was found between PAI and mortality. A significant association was found between long sedentary time and increased mortality (p = 0.042). Regarding nonsedentary activity, the HRs [95% confidence intervals (CIs)] for Q2, Q3, and Q4 versus Q1 were 0.85 (0.55-1.31), 0.67 (0.41-1.08), and 0.90 (0.54-1.45), respectively. In the subdivided analysis for light-intensity activity, the HRs (95% CIs) of Q2, Q3, and Q4 versus Q1 were 0.53 (0.33-0.84), 0.51 (0.34-0.82), and 0.57 (0.34-0.96), respectively. No significant association was found between MVPA and mortality. Nonsedentary activity, especially light-intensity activity, significantly reduced mortality among residents with impaired renal function.

Analyzing the Spatially Heterogeneous Relationships between Nighttime Light Intensity and Human Activities across Chongqing, China

Nighttime light (NTL) intensity is highly associated with the unique footprint of human activities, reflecting the development of socioeconomic and urbanization. Therefore, better understanding of the relationship between NTL intensity and human activities can help extend the applications of NTL remote sensing data. Different from the global effect of human activities on NTL intensity discussed in previous studies, we focused more attention to the local effect caused by the spatial heterogeneity of human activities with the support of the multiscale geographically weighted regression (MGWR) model in this study. In particular, the Suomi National Polar Orbiting Partnership/Visible Infrared Imaging Radiometer Suite (NPP/VIIRS) NTL data within Chongqing, China were taken as example, and the point of interest (POI) data and road network data were adopted to characterize the intensity of human activity type. Our results show that there is significant spatial variation in the effect of human activities to the NTL intensity, since the accuracy of fitted MGWR (adj.R2: 0.86 and 0.87 in 2018 and 2020, respectively; AICc: 4844.63 and 4623.27 in 2018 and 2020, respectively) is better than that of both the traditional ordinary least squares (OLS) model and the geographically weighted regression (GWR) model. Moreover, we found that almost all human activity features show strong spatial heterogeneity and their contribution to NTL intensity varies widely across different regions. For instance, the contribution of road network density is more homogeneous, while residential areas have an obviously heterogeneous distribution which is associated with house vacancy. In addition, the contributions of the commercial event and business also have a significant spatial heterogeneity distribution, but show a distinct decrement when facing the COVID-19 pandemic. Our study successfully explores the relationship between NTL intensity and human activity features considering the spatial heterogeneity, which aims to provide further insights into the future applications of NTL data.

Association Between Accelerometer-Derived Physical Activity Measurements and Brain Structure: A Population-Based Cohort Study.

While there is growing evidence that physical activity promotes neuronal health, studies examining the relation between physical activity and brain morphology remain inconclusive. We therefore examined whether objectively quantified physical activity is related to brain volume, cortical thickness, and gray matter density in a large cohort study. In addition, we assessed molecular pathways that may underlie the effects of physical activity on brain morphology. We used cross-sectional baseline data from 2,550 eligible participants (57.6% women; mean age: 54.7 years, range: 30-94 years) of a prospective cohort study. Physical activity dose (metabolic equivalent hours and step counts) and intensity (sedentary and light-intensity and moderate-to-vigorous intensity activities) were recorded with accelerometers. Brain volumetric, gray matter density, and cortical thickness measures were obtained from 3T MRI scans using FreeSurfer and Statistical Parametric Mapping. The relation of physical activity (independent variable) and brain structure (outcome) was examined with polynomial multivariable regression, while adjusting for age, sex, intracranial volume, education, and smoking. Using gene expression profiles from the Allen Brain Atlas, we extracted molecular signatures associated with the effects of physical activity on brain morphology. Physical activity dose and intensity were independently associated with larger brain volumes, gray matter density, and cortical thickness of several brain regions. The effects of physical activity on brain volume were most pronounced at low physical activity quantities and differed between men and women and across age. For example, more time spent in moderate-to-vigorous intensity activities was associated with greater total gray matter volume, but the relation leveled off with more activity (standardized β [95% CIs]: 1.37 [0.35-2.39] and -0.70 [-1.25 to -0.15] for the linear and quadratic terms, respectively). The strongest effects of physical activity were observed in motor regions and cortical regions enriched for genes involved in mitochondrial respiration. Our findings suggest that physical activity benefits brain health, with the strongest effects in motor regions and regions with a high oxidative demand. While young adults may particularly profit from additional high-intensity activities, older adults may already benefit from light-intensity activities. Physical activity and reduced sedentary time may be critical in the prevention of age-associated brain atrophy and neurodegenerative diseases.

Two-year outcomes of Faith in Action/Fe en Acción: a randomized controlled trial of physical activity promotion in Latinas

BackgroundLatina women are less likely to report engaging in leisure-time physical activity (PA) than non-Latina white women. This study evaluated the 24-month impact of a faith-based PA intervention targeting Latinas.MethodsThe study is a cluster randomized controlled trial of a PA intervention or cancer screening comparison condition, with churches as the randomization unit. A total of 436 Latinas (aged 18-65 years) from 16 churches who engaged in low levels of self-report and accelerometer-based PA were enrolled. The experimental condition was a 24-month PA intervention, with in-person classes, social support, and environmental changes, led by community health workers (i.e., promotoras). At baseline, 12-, and 24 months, we assessed changes in accelerometer-based and self-reported moderate to vigorous physical activity (MVPA; primary outcomes). Secondary outcomes were light intensity activity, sedentary time, body mass index (BMI), and waist circumference.ResultsAfter adjusting for sociodemographic factors, a mixed effects analysis found significant increases in self-reported leisure time MVPA (p < 0.005) and marginal increases in accelerometer-assessed MVPA (p < 0.08) 24 months post-baseline in the intervention compared to the attention-control condition. Data showed significant associations between PA class attendance and engaging in MVPA as assessed by self-report and accelerometry. No significant changes were found for light activity, sedentary time, BMI, or waist circumference.ConclusionsParticipants who attended the PA classes at least once a month engaged in significantly higher MVPA compared to those who did not. Maximizing engagement and maintenance strategies to enhance PA maintenance could contribute to important long-term health benefits.Trial registrationNCT01776632, Registered March 18, 2011.

Transcriptomic and proteomic analyses reveal the common and unique pathway(s) underlying different skin colors of leopard coral grouper (Plectropomus leopardus)

To gain a comprehensive and unbiased molecular understanding of the different skin colors of P. leopardus, we used Illumina HiSeq 2500 and TMT (Tandem Mass Tag) to compare transcription and protein levels between red and black skin of P. leopardus. We identified 797 upregulated and 314 downregulated genes (differentially expressed genes; DEGs) in red (RG) compared with black (BG) skin of P. leopardus. We also identified 377 differentially abundant proteins (DAPs), including 314 upregulated and 63 downregulated proteins. These DEGs and DAPs were significantly enriched in melanin synthesis (e.g., pyrimidine metabolism, Phenylalanine, tyrosine, and tryptophan biosynthesis, melanogenesis, phenylalanine metabolism, and tyrosine metabolism), oxidative phosphorylation (e.g., phosphonate and phosphinate metabolism, and oxidative phosphorylation), energy metabolism (e.g., HIF-1, glycolysis/gluconeogenesis, fatty acid biosynthesis, and fatty acid degradation), and signal transduction (e.g., Wnt, calcium, MAPK, and cGMP-PKG signaling pathways), etc. Further analysis of MAPKs showed that the activation levels of its main members JNK1 and ERK1/2 differed significantly between red and black skin colors. After RNAi was used to interfere with ERK1/2, it was found that the local skin of the tail of P. leopardus would turn black. Combined transcriptome and proteome analysis showed that most DEGs-DAPs in red skin were higher than in black skin (58 were upregulated, 1 was downregulated, and 4 were opposite). These DEGs-DAPs showed that the differences between red and black skin tissues of P. leopardus were related primarily to energy metabolism, signal transduction and cytoskeleton. These findings are not only conducive to understand the skin color regulation mechanism of P. leopardus and other coral reef fish, but also provide an important descriptive to the breeding of color strains. Significance of the studyThe skin color of P. leopardus gradually darkens or blackens due to environmental factors such as changes in light intensity and human activities, and this directly affects its ornamental and economic value. In this study, RNAseq and TMT were used to conduct comparative quantitative transcriptomics and proteomics and analyze differences between red and black P. leopardus skin. The results showed that energy metabolism, signal transduction and cytoskeleton were the main metabolic pathways causing their skin color differences. These findings contribute to existing data describing fish skin color, and provide information about protein levels, which are of great significance to a deeper understanding of the skin color regulation mechanism in P. leopardus and other coral reef fishes.

Outdoor Cold Stress and Cold Risk for Children during Winter: A Study in China’s Severe Cold Regions

This study uses the universal thermal climate index (UTCI) and whole-body and local cooling assessment to determine the thermal benchmarks and cold risk for children in China’s severe cold regions. The relevant measurements and survey were conducted in four open spaces at a children’s park in Harbin, China. The findings of the study are as follows: (1) In winter, solar radiation and global temperature affects winter thermal sensation in male and female children the most. (2) Female children have a lower neutral UTCI (6.0 °C) than male children (7.3 °C), and female children have lower upper and lower thresholds of the neutral UTCI range (−1.3–13.4 °C) than male children (0.6–14.1 °C). (3) Children who engaged in light-intensity activities, were exposed to cold winds, and touched cold surfaces with their bare fingers are at risk of whole-body and local cooling. (4) Children prefer exercising (PFemale = 35.5%, PMale = 48.3%) and moving to sunshine for thermal adaptation (PFemale = 31.1%, PMale = 26.4%). (5) Winter travel guidelines, cold-risk-prevention measures, and safety guidelines for winter outdoor activities are proposed. The results provide references for the design of open spaces in urban parks in China’s severe cold regions.

Objective evaluation of the first post-lockdown on physical activity, sedentary behavior and food choice in a sample of French young adult students

From mid-March through early May 2020, France limited outdoor activities to one hour per day because of the Covid-19 epidemic. This inside lockdown could have a lasting impact on post-lockdown sedentary and physical activities and food choice. The aim of this study is to compare behaviors before and after the lockdown in a sample of French young adult students (sex ratio = 1:1, 22 ± 3 y old). Over a period of 4 days in both April and after mid-May 2020, 50 students used the WellBeNet smartphone application to record accelerometry data to evaluate their sedentary behavior and physical activity, and food consumption. Some behaviors remained stable for both periods: sedentary behavior, light-intensity activity, the number of meals per day, the number of portions of fruits, nuts, dairy products, vegetables, legumes and meat-fish-egg. Moderate-intensity activity duration was higher (+1.4%, p < 0.0001), whereas the food balance score was lower (−0.3, p = 0.06) during the return to free-living conditions. Different food behaviors in male and female students were observed between the two periods. The total daily number of food portions and of whole starchy products post lockdown was lower in female students (−1.07 and −0.47 portion/d, p = 0.07 and 0.04) but remained stable in male students, post-lockdown. The consumption of snacks was similar in men and women during the lockdown, whereas it was higher in men post-lockdown (+0.8 portion/d, p = 0.01). During the COVID-19 lockdown, food consumption choice was better overall and the moderate-intensity physical activity level was lower compared with the free-living subsequent period.

Behavioral and Emotional Changes One Year after the First Lockdown Induced by COVID-19 in a French Adult Population.

(1) Background: The lockdown had various consequences on physical activity and food consumption behaviors. The post-lockdown has been much less studied. The aim of this study is to compare behaviors one year after the first lockdown in a group of normal-weight (NW) or overweight French adults (OW). (2) Methods: Over a period of 4 days, both at the beginning of May 2020 (lockdown) and in June 2021 (free living post-lockdown), the same French adults used the WellBeNet smartphone application to record their sedentary behavior, physical activity (PA), food consumption and emotions. (3) Results: One year post first lockdown, the weight and body mass index increased (+1.1 kg; +0.4 kg.m−2, p < 0.01), and sedentary behaviors increased (+5.5%, p < 0.01) to the detriment of light-intensity activities (−3.3%, p = 0.10) in the whole group. Some food categories, such as alcohol, tended to be consumed more (+0.15 portion/day, p = 0.09), while fatty, salty and sugary products decreased (−0.25 portion/d, p = 0.02) but without a change in the food balance score. A higher number of both positive and negative emotions were scored per day (+9.5, p < 0.0001; +2.9, p = 0.03), and the positive ones were perceived stronger (+0.23, p = 0.09). Simultaneously, the desire to eat was lower (−11.6/100, p < 0.0001), and the desire to move remained constant. Sedentary/active behaviors and the desire to eat changed differently in NW and OW adults after the lockdown. (4) Conclusions: In general, the post-lockdown period was less favorable for physical activity practice and resulted in a similar food balance score but was more conducive to mental wellbeing.

Physical activity behaviour up to 1 year post-rehabilitation among adults with physical disabilities and/or chronic diseases: results of the prospective cohort study ReSpAct

BackgroundLittle is known of physical activity behaviour among adults with a disability and/or chronic disease during and up to 1 year post-rehabilitation. We aimed to explore (1) dose characteristics of...

Post-discharge light physical activity indicates recovery in acutely hospitalized older adults

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): The Netherlands Organization for Health Research and DevelopmentThe Dutch Research Council Introduction Physical activity levels might be a simple overall physical marker of recovery in acutely hospitalized older adults; however, cut-off values post discharge are lacking. Purpose We aim to identify cut-off values for post-discharge physical activity that indicate recovery among acutely hospitalized older adults and stratified for frailty. Methods Prospective observational cohort study including acutely hospitalized older adults (≥70 years) during hospitalization and at home. Frailty was assessed using Fried’s criteria. Steps and intensity of physical activity were assessed using Fitbit up to one week post discharge. The primary outcome was recovery at 3-months post discharge. ROC-curve analyses were used to determine cut-off values, and logistic regression analyses to calculate odds ratios (ORs). Results The analytic sample included 174 participants with a mean (standard deviation) age of 79.2 (6.7) years of whom 84/174 (48%) were frail and 67 (39%) had cardiac disease. At 3-months, 109/174 participants (63%) had recovered. In all participants, determined cut-off values were 1369 steps/day (OR: 2.5, 95% confidence interval [CI]: 1.3–4.6) and 76 minutes/day of light intensity activity (OR: 3.0, 95% CI: 1.6–5.8). In frail participants, cut-off values were 1043 steps/day (OR: 3.3, 95% CI: 1.3–8.4) and 72 minutes/day of light intensity activity (OR: 4.2, 95% CI: 1.6–10.8). Determined cut-off values were not significantly associated with recovery in non-frail participants. Conclusions We recommend at least 1369 steps per day and 76 minutes of light activity to help older patients’ recovery from an acute hospitalization.

Affective judgments, environmental determinants, and physical activity in emerging and young adults

Objective Affective judgements represent a promising target for promoting physical activity among adults. This study examined whether relations between affective judgments and physical activity are robust after adjusting for social, built, and natural environmental determinants. Design Prospective cross-sectional study with 173 adults (70.1% female) aged 18–29 years who self-reported less than 90 minutes of moderate-to-vigorous physical activity. Main Outcome Measure Physical activity volume (total daily step count, total activity counts) and durations of intensity-specific physical activity (light-intensity activity and moderate-to-vigorous intensity) were assessed for a seven-day period via waist-worn ActiGraph wGT3X-BT accelerometer. Results Affective judgements were not statistically associated with measures of physical activity volume or intensity-specific physical activity after adjusting for environmental influences. Support for exercise from friends was positively associated with measures of physical activity volume and moderate-to-vigorous physical activity duration. More favorable perceptions of the built environment were positively associated with moderate-to-vigorous intensity physical activity and negatively associated with duration of light-intensity physical activity. Longer photoperiods were associated with more light-intensity physical activity. Conclusion Physical activity interventions for young and emerging adults reporting inactivity should target environmental determinants first and possibly wait until participants have a motivational stake in physical activity before targeting affective judgments.

Alteration in central vascular and cognitive functions during simulated work conditions in males – a secondary analysis from a randomised controlled trial

Background: Alteration in the central vascular hemodynamics is speculated to influence cognitive functions, including executive functions in young adults. Prolonged sitting is associated with compromised central vascular functions, which activity micro-breaks could mitigate. However, the association between the carotid vascular hemodynamic alteration and the executive functions is yet to be explored. Methods: We administered a randomised controlled trial investigating the effects of various intensities' micro-breaks on central vascular and cognitive functions during simulated work conditions for four hours. The carotid artery hemodynamics and cognitive functions were measured by Duplex ultrasound at 0th, 2nd and 4th hour and computer-based Flanker tests at 0th, 1st, 2nd, 3rd and 4th hour of visit days, respectively. From the randomised controlled trial, we extracted the secondary data of carotid artery hemodynamics and cognitive functions change at the 4th hour from the baseline and analysed for any relation. Results: Though we observed linear relation between the carotid artery hemodynamics and the executive functions, the relation was not statistically significant. we found a significant reduction in carotid artery diameter during prolonged sitting (0.03 cm [95%CI 0.01, 0.05]), velocity (10.35 cm/s [95%CI -2.85, 17.86]) and shear rate during interrupted sitting (174.39 [95%CI 65.67, 283.11]) We found increased accuracy during prolonged sitting (12.7% [95%CI 0.66, 24.81]) and sitting with light-intensity activity breaks (6.92% [95%CI 1.39, 12.44]). We did not find any significant relation between the change in central vascular functions (carotid artery diameter, velocity, shear rate and blood flow) and the cognitive functions during three different work conditions. Conclusion: Though a significant relation between carotid artery function and cognitive function could not be established, microbreaks can mitigate the vascular and cognitive risks associated with prolonged sitting.

Alteration in central vascular and cognitive functions during simulated work conditions in males – a secondary analysis from a randomised controlled trial

Background: Alteration in the central vascular hemodynamics is speculated to influence cognitive functions, including executive functions in young adults. Prolonged sitting is associated with compromised central vascular functions, which activity micro-breaks could mitigate. However, the association between the carotid vascular hemodynamic alteration and the executive functions is yet to be explored. Methods: We administered a randomised controlled trial investigating the effects of various intensities' micro-breaks on central vascular and cognitive functions during simulated work conditions for four hours. The carotid artery hemodynamics and cognitive functions were measured by Duplex ultrasound at 0th, 2nd and 4th hour and computer-based Flanker tests at 0th, 1st, 2nd, 3rd and 4th hour of visit days, respectively. From the randomised controlled trial, we extracted the secondary data of carotid artery hemodynamics and cognitive functions change at the 4th hour from the baseline and analysed for any relation. Results: Though we observed linear relation between the carotid artery hemodynamics and the executive functions, the relation was not statistically significant. we found a significant reduction in carotid artery diameter during prolonged sitting (0.03 cm [95%CI 0.01, 0.05]), velocity (10.35 cm/s [95%CI -2.85, 17.86]) and shear rate during interrupted sitting (174.39 [95%CI 65.67, 283.11]) We found increased accuracy during prolonged sitting (12.7% [95%CI 0.66, 24.81]) and sitting with light-intensity activity breaks (6.92% [95%CI 1.39, 12.44]). We did not find any significant relation between the change in central vascular functions (carotid artery diameter, velocity, shear rate and blood flow) and the cognitive functions during three different work conditions. Conclusion: Though a significant relation between carotid artery function and cognitive function could not be established, microbreaks can mitigate the vascular and cognitive risks associated with prolonged sitting.

Associations Among Physical Activity, Skeletal Related Events, and Patient Reported Outcomes in Patients with Bone Metastases.

Emerging evidence supports exercise as a therapeutic intervention for patients with bone metastases. However, exercise prescription in practice is limited by concerns regarding skeletal-related events (SREs). This study examined associations among habitual physical activity levels, history of SREs, and patient reported outcomes in patients with bone metastases. A total of 58 patients with bone metastases (n = 45 breast cancer; n = 13 prostate cancer; mean time since cancer diagnosis 5.8 [4.7] years) were assessed. Habitual physical activity levels were collected by accelerometry. Standardized subjective assessment collected history of SREs, quality of life (EORTC-QLQ-C30 and EORTC-BM22), pain (Brief Pain Inventory), sleep quality (Pittsburgh Sleep Quality Questionnaire), and perceptions about exercise (Exercise Benefits/Barriers Scale). Participants spent a mean of 77.37% (standard deviation 14.3)% of waking hours sedentary and a mean of 20.14% (standard deviation 13.4)% of waking hours in light intensity activity. Almost half (n = 28) completed ≥150 min/wk moderate-to-vigorous intensity activity. Higher levels of moderate-to-vigorous intensity activity were associated with lower pain scores, better perceived physical function, lower functional interference scores, and better quality of life. Patients with a history of fracture since diagnosis spent more time sedentary and in light intensity activity in comparison to those with no fracture history (P < .05). Moderate-to-vigorous intensity physical activity may have multiple benefits for patients with bone metastases. Reducing sedentary behavior may be a key target for patients with a history of fracture. Oncology nurses play a key role in providing education on the benefits of exercise, overcoming barriers to physical activity and timely referrals.