The alpine life zone is perhaps the only biome that occurs globally where mountains are high enough. At latitudinally varying elevation, the alpine belt hosts small stature plants that vary greatly in morphology, anatomy and physiology. In this contribution, I summarize a number of principles that govern life in what is often considered a cold and hostile environment. The 12 conceptual frameworks depicted include the key role of aerodynamic decoupling from free atmospheric climatic conditions, the problematic concepts of limitation and stress in an evolutionary context, and the role of developmental flexibility and functional diversity. With its topography driven habitat diversity, alpine plant diversity is buffered against environmental change, and the multitude of microclimatic gradients offers 'experiments by nature', the power of which awaits multidisciplinary exploration.