Resilience and social support are variables related to life satisfaction. Nonetheless, these relationships could be different for boys and girls. This study aimed to analyze the links among life satisfaction, resilience (novelty seeking, emotional regulation and future positive orientation) and social support in early adolescents by exploring possible gender differences. In this study, 552 adolescents aged 10–13 years (52% girls) participated. The results showed stronger positive correlations between life satisfaction and novelty seeking in boys, and positive correlations between life satisfaction and emotional regulation only for girls. Social support was a significant predictor of life satisfaction for both genders, but some resilience dimensions showed differences in their predictive capacity according to gender. Emotional regulation and future positive orientation were predictors of life satisfaction, but only for girls, while novelty seeking was a predictor of life satisfaction for boys. These results highlight the importance of maintaining a gender perspective in research on life satisfaction in early adolescence, and the need to consider gender differences in interventions to enhance their positive development.