The large mining-height hydraulic support test-bed serves as a crucial tool for heavy hydraulic support factory inspections and type testing. With the successful development of the ZY29000/45/100D hydraulic support, the need for a large high-mining hydraulic support test-bed has become evident. This paper combines the theory of rigid-flexible coupling in virtual prototypes and ADAMS multi-body dynamic simulation technology to analyze the strength of the 50,000 kN hydraulic support test-bed. ANSYS classic modules were employed to address the flexibility of key components within the test-bed. The fatigue life of the test-bed was analyzed using NSOFT software, the von Mises yield criterion, and the Goodman modified curve. The S-N curve of material parameters for the test-bed components was used to conduct a shrinkage test. The results indicate that the lowest position is the most vulnerable during the shrinkage test. Among the key components, the stress on the pin bearing is 356.6 MPa, which is 167.9 %, 123.3 %, and 41.6 % higher than that of the pillar, movable beam, and base, respectively. The fatigue life of the base under low, medium, and high shrinkage conditions is1.1×107, 4.0×108, and 1.7×108, with damage values of 8.8×10-8, 2.5×10-9, and 5.7×10-9, respectively. The base’s life under low shrinkage conditions is the shortest, followed by that under high shrinkage conditions. These research findings provide technical guidance and an optimization foundation for the successful development of a 50000 kN hydraulic support test-bed. They also offer a new method and approach for analyzing and predicting the fatigue life of key components in large-scale industrial and mining equipment operating under complex conditions, with promising practical applications.