The current study was conducted to find out the relationship between psychological distress, hope, and quality of life among diabetic patients. In the present research, the correlational research design was used and 180 diabetic patients (90 males and 90 females) were selected through purposive sampling techniques from the different hospitals of Faisalabad city. The age range of the selected sample was 20 years to 70 years. A demographic information sheet and the translated versions of the Kessler Psychological Distress Scale, Hope Index, and Quality of Life Scale were used to measure study variables. The data was analyzed through the Statistical Package for Social Sciences (SPSS). The results reveal that the psychological distress was significantly negatively correlated with Hope and Quality of Life but Hope and Quality of Life were significantly positively correlated. Further, linear regression analysis showed that Hope was a significant predictor of Psychological distress and Quality of Life in diabetic patients. The t-test analysis indicates that females have significantly higher scores on psychological distress as compared to male diabetic patients. The younger patients score higher on psychological distress, hope, and quality of life as compared to older diabetic patients. The findings of the current study imply various health-related fields such as health professionals can use the findings of this study in the cure of patients who become the victim of life-threatening chronic illnesses like diabetes etc.