Human Life Expectancy Research Articles

ECG Biomarker based Heart Disease Automation Detection Scheme

Background/Objectives: With the development of medical technology and the improvement of sanitary environment, human life expectancy has been increasing overcoming fatal diseases, but some diseases still remain as major causes of death. Among them, heart disease is one of the most common causes of death in the world, always in 1st or 2nd place for causes of death. Methods/Statistical analysis: In order to minimize the death from heart disease, prevention and early diagnosis should be done rather than treatment, and in general, ECG measurement can be used to diagnose heart disease. The ECG is a measurement of the electrical signal of the heart using an ECG measuring instrument, which is diagnosed by a specialist, which causes the problem that the patient has to visit the hospital every time. With the recent development of ICT technology, wearable ECG measurement devices are now available for measuring ECG in real life, and by using them it is possible to detect heart disease by measuring ECG without visiting a hospital. Findings: This paper proposes an ECG heart disease detection scheme and infrastructure to diagnose and prescribe heart disease remotely by extracting ECG biomarker from a patient through a wearable ECG measurement device. ECG biomarker can be extracted to provide real-time comparative analysis of heart disease ECG signatures to detect heart disease in an ECG analyzer without the help or expertise of a specialist. Improvements/Applications: Through the proposed ECG biomarker-based heart disease detection scheme and infrastructure, patients and average people can prevent heart disease early and cope with it early.

MP-1™ Polyimide for Medical Devices: 1. Pre Clinical Studies

Due to constant increase in human life expectancy, more people require primary and revision total hip replacement surgeries, costing billions of US$ per year. Currently used ceramic on X-linked Polyethylene appears to be the best choice by default, but it still wears. The wear particles generated, are the major cause of osteolysis and joint failure. During 2011-14, leading orthopedic companies suffered global recalls of their MoM hip systems resulting in thousands of revision surgeries. The search continues for new and more durable materials bearing materials. Developments in medical technology have increased the demand for advanced materials due to aging population, advanced medical procedures and contagious diseases. Metals and ceramics are prevalent in the medical industry. However, the unique properties of polymeric materials exhibit potential as better replacements for conventional materials. MMATECH Ltd. has developed a new articulation liner made of a revolutionary material of the Polyimide family, MP-1™, a spin-off of the Aerospace industry. MP-1™ has proved to be biocompatible, heat-resistant, highly crosslinked, combining unusual strength, toughness, self-lubrication, excellent friction and wear durability, as well as resistance to fatigue, creep, impacts and chemicals. These properties lead to longer life span and safer articulating implanted components. MMATECH received the CE and ISO certificates for its MP-1™ Acetabular liner of hip implant based on a pilot clinical study conducted in New-Zealand with excellent 13y follow-up results. Ethical Committee approval was granted for a clinical study of 100 patients in New Zealand. The results of the first 82 surgeries follow-up demonstrated normal blood parameters, no osteolysis, and improved quality of life. The performance of MP-1™ even at 13 years is very promising and is now being applied to younger patients (~ 40 Y old) in view of the retrieval data. Part 1 of this research will summarize the pre-clinical studies while Part 2 will deal with the clinical studies.

Structure and Cytoarchitectonics of Lymphoid Tissue in Appendiсes of Elderly and Senile People

The phenomenon of population aging has been observed in many countries in recent years due to the increase in human life expectancy. Therefore, studies of lymphoid tissue, which supports the immune processes in the human body, are now of particular importance. The lymphoid tissue of appendices from humans of age groups of 54–81 years and 26–35 years was histologically studied, and the results were statistically treated. The lymphoid tissue belonging to senile age groups showed reductions and rearrangements with partial integrity of the modified lymphoid nodules. The majority of nodules were without lighter-stained germinal centers, and the processes of blast transformation were preserved therein. Mitoses were observed in the central zones of nodules with lighter centers. Lymphocytes actively migrate to lymphatic capillaries. The condition of lymphoid tissue in the appendix depends on the individual body parameters. In some cases, the lymphoid tissue is completely reduced, and the organ’s lumen is closed.

Metabolic Biomarkers in Aging and Anti-Aging Research.

Although human life expectancy has increased significantly over the last two centuries, this has not been paralleled by a similar rise in healthy life expectancy. Thus, an important goal of anti-aging research has been to reduce the impact of age-associated diseases as a way of extending the human healthspan. This review will explore some of the potential avenues which have emerged from this research as the most promising strategies and drug targets for therapeutic interventions to promote healthy aging.

Response time in the emergency services. Systematic review.

The growth of the urban population raises concern about municipal public managers in the sense of providing emergency medical services (EMS) that are aligned with the needs of prehospital emergency medical care demanded by the population. The literature review aims at presenting the response time of emergency medical services in several parts of the world and discussing some factors that interfere in the result of this indicator such as GDP (Gross Domestic Product) percentage spent on health and life expectancy of countries. The study will also show that in some of the consulted articles, authors suggest to EMS recommendations for decreasing the response time using simulations, heuristics and metaheuristics. Response time is a basic indicator of emergency medical services, in such a way that researchers use the descriptive statistics to evaluate this parameter. Europe and the USA outstand in the publication of studies that present this information. Some articles use stochastic and mathematical methods to suggest models that simulate scenarios of response time reduction and suggest such proposals to the local EMS. Countries in which the response time was identified have a high index of human development and life expectancy between 74.7 and 83.7 years.

Putting a strain on diversity.

Human life expectancy is increasing on a global scale, but healthspan—the period of life free from age‐associated ill health—is not improving at a comparable rate. This disconnect means that a greater proportion of the general population will spend a longer period of their life suffering from one or more debilitating age‐associated diseases, such as cardiovascular disease, Alzheimer9s disease, osteoporosis, sarcopenia and various cancers. Understanding the processes underlying ageing and age‐related diseases is therefore a major and pressing research challenge in biomedical research.

Hyperinsulinemia is associated with increasing insulin secretion but not with decreasing insulin clearance in an age-related metabolic dysfunction mice model.

Human life expectancy is increasing faster lately and, consequently, the number of patients with age-related diseases such as type 2 diabetes (T2D) is rising every year. Cases of hyperinsulinemia have been extensively reported in elderly subjects and this alteration in blood insulin concentration is postulated to be a cause of insulin resistance, which in some cases triggers T2D onset. Thus, it is important to know the underlying mechanisms of age-dependent hyperinsulinemia to find new strategies to prevent T2D in elderly subjects. Two processes control blood insulin concentration: Insulin secretion by the endocrine portion of the pancreas and insulin clearance, which occurs mainly in the liver by the action of the insulin-degrading enzyme (IDE). Here, we demonstrated that 10-month-old mice (old) display increased body and fat pad weight, compared with 3-month-old mice (control), and these alterations were accompanied by glucose and insulin intolerance. We also confirm hyperinsulinemia in the old mice, which was related to increased insulin secretion but not to reduced insulin clearance. Although no changes in insulin clearance were observed, IDE activity was lower in the liver of old compared with the control mice. However, this decreased IDE activity was compensated by increased expression of IDE protein in the liver, thus explaining the similar insulin clearance observed in both groups. In conclusion, at the beginning of aging, 10-month-old mice do not display any alterations in insulin clearance. Therefore, hyperinsulinemia is initiated primarily due to a higher insulin secretion in the age-related metabolic dysfunction in mice.

Key periods of cognitive decline in a nonhuman primate model of cognitive aging, the common marmoset (Callithrix jacchus).

It is well established that human life expectancy increases considerably with an ever-growing number of people suffering from age-related cognitive decline and degenerative brain diseases. This necessitates the development of animal models to counteract or stop the progression of the decline early enough. Presently, primate models are few, and many studies argue for the marmoset as an interesting primate model presenting a short life span and being easily available in research laboratories. In this article, we propose the marmoset as a valid model for cognitive decline. Using a computer touch screen, we trained 35 marmosets from 2 to 14years of age to perform reversal learning and delayed-matching-to-position tasks. We found typical age-related cognitive deficits related to executive functions and spatial working memory. Applying a recursive algorithm, we detected 2 critical periods from which deficits appear. Mainly, response strategy deficits appear from age 4, whereas impairments in inhibitory control appear from age 7-8. Furthermore, the presence of outliers, sometimes at an early age, suggests pathological cognitive deficits that would require imaging exploration in parallel to behavior.

Godność, codzienność, wsparcie osób starszych z niepełnosprawnością

Bernadeta Szczupał, Dignity, everyday life, support for seniors with disabilities, Interdisciplinary Contexts of Special Pedagogy, No. 22, Poznań 2018. Pp. 15–26. Adam Mickiewicz University Press. ISSN 2300-391X. DOI: https://doi.org/10.14746/ikps.2018.22.02
 The process of ageing is an inevitable life phenomenon in both the individual and social aspects. With the growing life expectancy of humans, the way of living in the old age becomes a challenge in the context of respect for the dignity of the elderly. In this article, I present selected theoretical issues concerning the sense of dignity, everyday life and helplessness of elderly people with disabilities, which is unfortunately often associated with it. I also show the complexity of contemporary problems and expectations and the challenges faced by older people with disabilities.

European dog owner perceptions of obesity and factors associated with human and canine obesity

Obesity is a common nutrition-related disorder leading to reduced life expectancy in both humans and dogs. With the aim of identifying new prevention and control options, the study objectives were (1) to investigate dog-owner perceptions about obesity in terms of themselves and their dogs, and (2) to identify factors associated with obesity and possible social, environmental and economic drivers for its development in dog owners and their pets. A cross-sectional questionnaire-based study was performed across multiple countries. The questionnaire focused on human and canine obesity, associated factors and potential drivers, and was distributed online and in the form of hard copies among dog owners in 11 European countries. In total, 3,185 responses from ten countries were included in multivariable analyses. Between 19.1% and 48.8% of the dog owners reported to be overweight/obese. Owner-reported overweight/obesity in dogs ranged from 6.0% to 31.3% based on body condition score charts, and 31.8% to 69.4% based on body fat index charts. Common factors associated with obesity in owners and their dogs were age, gender and owners’ attitudes to diet and physical activity. Dog owners who did not consider obesity to be a disease were more likely to have obese dogs.

Working memory in older adults declines with age, but is modulated by sex and education.

Working memory (WM), which underlies the temporary storage and manipulation of information, is critical for multiple aspects of cognition and everyday life. Nevertheless, research examining WM specifically in older adults remains limited, despite the global rapid increase in human life expectancy. We examined WM in a large sample ( N = 754) of healthy older adults (aged 58-89) in a non-Western population (Chinese speakers) in Taiwan, on a digit n-back task. We tested not only the influence of age itself and of load (1-back vs. 2-back) but also the effects of both sex and education, which have been shown to modulate WM abilities. Mixed-effects regression revealed that, within older adulthood, age negatively impacted WM abilities (with linear, not nonlinear, effects), as did load (worse performance at 2-back). In contrast, education level was positively associated with WM. Moreover, both age and education interacted with sex. With increasing age, males showed a steeper WM decline than females; with increasing education, females showed greater WM gains than males. Together with other findings, the evidence suggests that age, sex, and education all impact WM in older adults, but interact in particular ways. The results have both basic research and translational implications and are consistent with particular benefits from increased education for women.

The Tiny Drosophila Melanogaster for the Biggest Answers in Huntington's Disease.

The average life expectancy for humans has increased over the last years. However, the quality of the later stages of life is low and is considered a public health issue of global importance. Late adulthood and the transition into the later stage of life occasionally leads to neurodegenerative diseases that selectively affect different types of neurons and brain regions, producing motor dysfunctions, cognitive impairment, and psychiatric disorders that are progressive, irreversible, without remission periods, and incurable. Huntington’s disease (HD) is a common neurodegenerative disorder. In the 25 years since the mutation of the huntingtin (HTT) gene was identified as the molecule responsible for this neural disorder, a variety of animal models, including the fruit fly, have been used to study the disease. Here, we review recent research that used Drosophila as an experimental tool for improving knowledge about the molecular and cellular mechanisms underpinning HD.

Aqua Zumba versus Aqua Jogging: Comparative effects on health parameters among obese middle age women

Background:Obesity is major contributor to diseases and mortality. Constant weight loss significantly reverses the diseases related to obesityand prolonged human life expectancy. Limited scientific evidence comparing the effectiveness between Aqua Zumba® Fitness program and aqua jog in obese women. Thus, the purpose of this study was to compare the effects between 12 weeks of Aqua Zumba® Fitness and aqua jog on health parameters among middle-age women.Methods:A total of sixty previously sedentary obese women (BMI >30 kg/m2), aged 40-59 years old were randomized to either Aqua Zumba® Fitness (AZ, n=20), aqua jog (AJ, n=20) or control group (C, n=20). Exercise groups were involved in 12-weeks of different aqua exercise programmes, 3 times per week, 60 minutes per session, with the intensity of 50-75% of maximum heart rate. Body mass (BM), lean mass (LM), body fat percentage (BF%), abdominal fat (WC), upper and lower body strength (UBS and LBS), cardiorespiratory fitness (CRF), and flexibility were measured at baseline (week-0) and post-exercise intervention (week-13). Result:Both trained groups demonstrated significant changes (p<0.05) in all selected health parameters following 12 weeks of exercise programmes. However, this study found that AZ group produced significant superior change on the improvement of LM, WC, UBS and LBS (P<0.05) compared to AJ group. Conclusion: As a result, Aqua Zumba® Fitness elicits better improvement on health among obese middle-age women compared aqua jog.

The Influence of Ageing and Gender in Musculoskeletal Stem Cell.

Multipotent Mesenchymal Stromal Cells (MSCs) are the most common type of stem cell used in the regeneration of skeletal tissue. These cells have multipotent, angiogenic, paracrine, anti-fibrotic and immunological properties. They are readily available, easily isolated and have many therapeutic applications. The ageing population is on the increase and with this comes an upsurge in medical conditions that may benefit from novel stem cell-based therapies to treat ageingassociated diseases. Given that autologous implantations have shown to be beneficial in these targeted therapies, questions are raised regarding the effect of ageing and gender on the efficacy of stem cells. In this review, we look at the ageing process and look at the effects of ageing and gender on the characterization, proliferation and differentiation of mesenchymal stem cells. We also discuss future therapeutic strategies that may be used to overcome these effects and cell senescence. Advancements in modern technology and experimental techniques have provided an insight into how ageing affects properties of MSCs. However, it is evident that further work needs to be conducted due to many mixed reviews and conflicting data. Given that the human life expectancy is expected to increase the topic of cell ageing and therapeutic applications will remain a hot topic in years to come.

Curcuma longa (Theracumin®): A Bioavailable Form of Curcumin and Its Cognitive Benefits.

As human life expectancy increases, there is a corresponding increase in the incidence of chronic diseases such as dementia. Individuals with cognitive impairment, a known precursor to dementia, experience a decline in previously attained cognitive function. The manifestation of dementia usually occ

The Stochastic Determinism of Aging and Death

Background. We have studied human life expectancy in Croatia. Materials and Methods. Local daily papers reported obituitairies for 447 men and 366 who died in a month period. The data were analyzed with the median derivative power function model. Results. The median age of death was 76 and 81 years for men and women, respectively. Cummulative mortality increases at a constant rate after the age 60 y and 65 y for men and women, respectively (r2 = 0.99 and 0.98). Conclusions. Individual life span is a stochastic (random) biological event within the deterministic frame of cumulative mortality.

Expert Panel Discusses the Importance of Systems Medicine

Expert Panel Discusses the Importance of Systems Medicine

Finally, a Regimen to Extend Human Life Expectancy.

The United States has the most expensive healthcare system worldwide. Yet measures of health span and life expectancy are well below the major industrialized nations. With the U.S. population aged 65 years and older projected to double by mid-century, a healthcare crisis is looming. Within this context, huge interest and investment have emerged in technologies and drugs to address aging with an expected benefit to health span. The thesis being that such basic interventions will reduce morbidity caused by many chronic diseases wherein biological age itself is the major risk factor. In the light of limited progress to date, a recent study out of the Harvard School of Public Health is quite refreshing: less than half dozen lifestyle interventions can greatly increase health span. Perhaps these are familiar: cessation of smoking, ≥30 minutes of moderate daily exercise, high-quality diet (limited processed food), modest alcohol intake, and maintenance of an optimal body mass index of 18.5-24.9 kg/m2. From age 50 years, women engaging in all of these behaviors versus those who do zero can expect to have a life expectancy of 43.1 additional years (an extra 14 years) with men gaining 37.6 years (an extra 12.2 years). A regimen to extend life expectancy is at hand. However, there is room for optimization by including the effects of sleep, intermittent fasting, and/or caloric restriction. Moreover, the extension of life expectancy by adherence to a healthy lifestyle revises the health span threshold for antiaging treatments under development and should provide a better set of controls for clinical trials investigating novel treatments of aging.

Social stress shortens lifespan in mice.

SummaryStress and low socioeconomic status in humans confer increased vulnerability to morbidity and mortality. However, this association is not mechanistically understood nor has its causation been explored in animal models thus far. Recently, cellular senescence has been suggested as a potential mechanism linking lifelong stress to age‐related diseases and shorter life expectancy in humans. Here, we established a causal role for lifelong social stress on shortening lifespan and increasing the risk of cardiovascular disease in mice. Specifically, we developed a lifelong chronic psychosocial stress model in which male mouse aggressive behavior is used to study the impact of negative social confrontations on healthspan and lifespan. C57BL/6J mice identified through unbiased cluster analysis for receiving high while exhibiting low aggression, or identified as subordinate based on an ethologic criterion, had lower median and maximal lifespan, and developed earlier onset of several organ pathologies in the presence of a cellular senescence signature. Critically, subordinate mice developed spontaneous early‐stage atherosclerotic lesions of the aortic sinuses characterized by significant immune cells infiltration and sporadic rupture and calcification, none of which was found in dominant subjects. In conclusion, we present here the first rodent model to study and mechanistically dissect the impact of chronic stress on lifespan and disease of aging. These data highlight a conserved role for social stress and low social status on shortening lifespan and increasing the risk of cardiovascular disease in mammals and identify a potential mechanistic link for this complex phenomenon.

Impact of Dietary Pattern on Human Life Quality and Life Expectancy: A Mini-Review

Impact of Dietary Pattern on Human Life Quality and Life Expectancy: A Mini-Review