To evaluate the cost-effectiveness of levonorgestrel-releasing intrauterine system (LNG-IUS) as a long-term contraceptive method compared with similar methods, from the state perspective A Markov chain model is developed to evaluate pregnancies avoided as outcome of interest. The model was built in monthly cycles at a five-year time horizon for a hypothetical cohort of 1,000 women of childbearing age and includes probabilities of pregnancy, ectopic pregnancy, suspension because bleeding and other causes, and other adverse events by using either LNG-IUS, etonogestrel Implants, levonorgestrel implants or copper T (last-two included in health care plan). Effectiveness, adverse events and adherence were taken from previously published studies and the costs were taken from database of patients in Colombia and are expressed in Colombian pesos (COP). An expert gynecologist reviewed data. Threshold was estimated in $6.823.583 by calculating the costs assigned by the public health care system in Colombia to health care during the first five years of life of children and cost of delivery care. A sensitivity analysis was developed using a Montecarlo simulation and a Tornado analysis. TOTAL OF 13.87 pregnancies occurred with using LNG-IUS as compared with 40.39 using Copper T, 30.08 using etonorgestrel implant, and 29.55 using levonorgestrel implant for the base case analyzed. Cost of LNG-IUS arm was COP$ 633,747,545 compared with copper T (COP$ 456,638,680), the less expensive. Applying a discount rate of 3% LNG-SIU was dominant versus implant etonogestrel and very cost-effective compared with levonorgestrel implant (ICER $631,682.98) and cost-effective compared with Copper T (ICER COP$ 6,678,395.53). Sensitivity analyses confirm that LNG-UIS keeps its benefits against etonogestrel and levonorgestrel in most cases. The use of LNG-IUS would be an adequate option for patients seeking a long-acting contraceptive method and its use could be envisaged by the health-care system due to its cost-benefits in Colombia.