One-year of follow-up of levonorgestrel-releasing intrauterine system use in patients with hemostatic disorders with and without anticoagulant therapy

Abstract

The progestogens-only contraceptives methods seem not to impair blood coagulation. However, it is not known their effects in women with thrombophilia and/or previous venous thrombosis with or without anticoagulant therapy. Thus, our objective was to compare the effects of the levonorgestrel-releasing intrauterine system (LNG-IUS) on clinical parameters and complete blood count in women with hemostatic disorders with and without anticoagulant therapy. Prospective study. This study inclued 30 women between 18 to 40 years-old with thrombophilia and/or previous venous thrombosis. These women were divided into 2 groups: with anticoagulant therapy (ACO, n = 16) and without anticoagulant therapy (n = 14). All these women were selected in a planning family program. The variables analysed were blood pressure (BP), body mass index (BMI), complete blood count (CBC). These variables were analysed before, after 6 and 12 months of LNG-IUS insertion. The bleeding patterns in each group were also analysed. ANOVA with Tukey post-test was used for statistical analysis. There was no significant difference between the groups in term of age, BMI, BP and CBC. The bleeding patttern did not differ between the groups and amenorrhoea/infrequent bleeding were the most common patterns in both groups. The use of LNG-IUS has similar effects in clinical parameters and blood count in women with hemostatic disorders with and without anticoagulant therapy in 12 months of follow-up.