Objectives: To detect the levels of salivary amylase with mobile usage and its correlation with sleep deprivation and impaired Health related quality of life (HRQL) in a sample of Egyptian elderly. Methodology: This study was conducted on 100 elderly, all participants underwent comprehensive geriatric assessment. Sleep assessment was done using the ― Pittsburgh Sleep Quality Index (PSQI)‖ and assessment of QOL using The SF-12 and saliva was collected in a sterile suitable sampling devise for Salivary amylase measurement. Results: Significant correlations were found between hours of mobile usage and age, both components of HRQL and quality of sleep but insignificant relation to salivary amylase, Yet, there was a significant correlation between absolute usage and non-usage of the mobile and salivary amylase level X2=0.901, p=0.036 (mean users=53.44, nonusers=37.97). There was significantly higher salivary amylase levels with poor quality of sleep (x2=13.873, p=0.001). Conclusion: Significant correlations were found between hours of mobile usage and age, both components of HRQL and quality of sleep.