IntroductionChildren with dyslexia face persistent difficulties in reading acquisition, which results in poor reading accuracy. In addition to the commonly studied reading errors such as omissions, additions, substitutions, and letter reversals, they also make guessing errors characterized by replacing a word with an orthographic neighbor. These errors, which occur in the context of isolated words and sentence or text reading, might be linked to the inhibition issues that have already been demonstrated in connection to dyslexia. However, to the best of our knowledge, there is no experimental evidence that children with dyslexia make more guessing errors than typically developing children, as is the case for sequential errors. The current study aimed to evaluate whether children with dyslexia made more guessing errors than typically developing children and whether these errors were more frequent in an isolated word or sentence context.MethodsTwenty-eight children with dyslexia from Grade 4 were matched with typically developing children by either chronological age or reading level. Reading was assessed through word and text reading tasks. Error types were classified into seven categories and analyzed.Results and conclusionA repeated-measure ANOVA showed that children with dyslexia made more guessing errors, particularly visual and morphemic errors, than typically developing children. Moreover, these errors were found at both the single word and sentence levels. These findings suggest that children with dyslexia tend to use a global treatment of words, relying on incomplete information to compensate for their difficulties. The findings have practical implications for pedagogical and therapeutic approaches.