The article is devoted to the problem of interpersonal interaction of technical profile students. In particular, the results of a comparative study of the peculiarities of interpersonal interaction creation by technical profile students of different genders are described.
 In the article, interaction is considered as a process of direct or indirect interaction of subjects with each other, which creates their mutual state and relations. According to the results of the empirical research, it was found that male students of a technical profile have a dominant tendency in interaction, while girls have a tendency to be sensitive and friendly. Common to both boys and girls is a high level of sociability, which contributes to the emergence of attraction. Technical profile students have a high level of striving for people and a relatively significant fear of being rejected. At the same time, boys and girls have certain differences in the manifestation of affiliative tendencies. Girls are more eager to establish friendships with others than boys, but they are also more afraid of being rejected in communication and interaction than boys.
 Determining the peculiarities of the interpersonal interaction creation, which are inherent to male and female technical profile students, proved that male students have an active desire to win leadership positions, social recognition, and a high status in the system of interpersonal relations. They are able to take responsibility and to be persistent in their beliefs, to insist on their own. Instead, girls have an internal desire to accept group standards, values, traditions, a desire to form emotional connections with the surrounding people, that is, the ability to make contact. Such traits as modesty, timidity, shyness, and the ability to forgive are inherent to them. Girls strive to take care of close people, show tolerance towards others.
 We came to the conclusion that male and female technical profile students have different specifics of interpersonal interaction creation, in particular, they have different factors of interpersonal interaction and strategies for interpersonal relationships creation.